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651 - 700 of 1267 citations for 2 CHLOROMETHYL 6 METHOXY 1H BENZO D IMIDAZOLE since 2020

• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK (Erk1/2) (3A7) Mouse mAb (Cell Signaling Technology)/Phospho-p44/42 MAPK (Erk1/2 ...
• Calcineurin associates with centrosomes and regulates cilia length maintenance

  Eirini Tsekitsidou, et al., bioRxiv - Cell Biology 2022

  Quote: ... Proteins were analyzed on 6% acrylamide SDS-PAGE gels followed by immunoblotting with rabbit anti-myc (1:3000, 71D10, Cell Signaling Technology, 2278S). In vitro dephosphorylation experiments were performed in three biological replicates.
• Evaluating sickness-induced anxiety versus lethargy at the behavioral and neuronal activity level

  Hunter T. Lanovoi, Rumi Oyama, Ioana Carcea, bioRxiv - Neuroscience 2022

  Quote: ... To detect changes in IL-6 signal transduction we used primary monoclonal rabbit anti-Stat3α (D1A5) from Cell Signaling Technologies (Cat no. 8768S) and used the same secondary anti-rabbit antibodies described above.
• miRNA family miR-29 inhibits PINK1-PRKN dependent mitophagy via ATG9A

  Briana N Markham, et al., bioRxiv - Neuroscience 2024

  Quote: ... 96-well Meso Scale Discovery assay plates (MSD, L15XA-6) were coated with 30 μl of pS65-Ub capturing antibody (Cell Signaling Technology, 62802) with a final concentration of 1 µg/ml in 200 mM sodium carbonate coating buffer (pH 9.7 ...
• Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy

  Nipun Verma, et al., bioRxiv - Genetics 2024

  Quote: ... and then fixed at different time points (1 hour, 3 hours, 6 hours and 24 hours) before staining for DNA damage markers: ψH2AX (Cell Signaling Technology # 9718T), 53BP1 ((Novus Biologicals # NB100-904 ...
• An immunohistochemical atlas of necroptotic pathway expression

  Shene Chiou, et al., bioRxiv - Cell Biology 2024

  Quote: ... co-housed 6-month-old female C57BL/6J wildtype mice were administered either: 1) 6mg/kg of Necrostatin1s (Cell Signaling Technologies Cat#17802) in dimethyl sulfoxide via intraperitoneal injection then 15-30 minutes later given 150 μg/kg TNF (BioTimes Inc ...
• Identification of Arhgef12 and Prkci as Genetic Modifiers of Retinal Dysplasia in the Crb1^rd8 Mouse Model

  Sonia M. Weatherly, et al., bioRxiv - Genetics 2021

  Quote: ... Membranes were washed in TBS-T and incubated with HRP-conjugated anti-goat IgG (R&D, HAF017) or anti-rabbit IgG (Cell Signaling, 7074S) antibody in Blotto A (1:1000 ...
• Transcription Factor NRF2 is Activated by Erythrophagocytosis of Oxidized Red Blood Cell Products and Suppresses the IL-12-IFNg-IL-10 Axis in a Murine Model of Hyperinflammatory Disease

  Paul M. Gallo, et al., bioRxiv - Immunology 2023

  Quote: ... cycloheximide (CHX) final concentration of 8 ug/mL was used to arrest protein translation and Actinomycin D (Cell Signaling Technology, Cat. 15021) was used to arrest transcription by treating cells with 10 ug/mL Actinomycin D where indicated ...
• Behavioral and Neurostructural changes associated with Chronic Amygdala Hyperactivation

  Keith A. Misquitta, et al., bioRxiv - Neuroscience 2021

  Quote: ... sections were placed overnight at 4°C in a solution containing 2% donkey serum and primary antibodies for post-synaptic density protein 95 (PSD95; rabbit host, 1:100, Cell Signaling Technology, Danvers, MA, product #2507, lot 2), vesicular glutamate transporter 1 (VGLUT1 ...
• Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density

  Keith A. Misquitta, et al., bioRxiv - Neuroscience 2021

  Quote: ... Sections were incubated overnight at 4°C in PBS containing 2% donkey serum and primary antibodies for post-synaptic density protein 95 (PSD95; rabbit host, 1:100, Cell Signaling Technology, Danvers, MA, product #2507, lot 2), and vesicular glutamate transporter 1 (VGLUT1 ...
• Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

  Honglin Jiang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Phospho-Erk1/2 (Thr202/Tyr204) (Cell Signaling Technology, 4370, Dilution: 1:1000); Erk1/2 (Cell Signaling Technology ...
• Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

  Elena Vasileva, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-Phospho-p44/42 MAPK (Erk1/2) Thr202/Tyr204 (4370S, Cell Signaling) at 1:200 overnight ...
• Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations

  Andreas Damianou, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, 4370) GAPDH (Sigma-Aldrich ...
• Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells

  Dhruv Raina, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Primary antibodies used were anti-pERK1/2 1:200 (4370S, Cell Signaling), anti-E-Cad 1:200 (M108 ...
• Endothelial cell polarity and extracellular matrix production rely on functional ATP6AP2 during developmental and pathological angiogenesis

  NR Patel, A Blanks, Y Li, MC Prieto, SM Meadows, bioRxiv - Molecular Biology 2021

  Quote: ... anti-phospho-p44/42 MAPK (pErk1/2) (Cell signaling, 9101, 1:1000), anti-Collagen type III (Abcam ...
• RNA-protein interaction mapping via MS2 or Cas13-based APEX targeting

  Shuo Han, et al., bioRxiv - Molecular Biology 2020

  Quote: ... the other used 2 μL rabbit monoclonal anti-HA antibody (Cell Signaling) as a control IgG for pulldown ...
• The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress

  Brian Hurwitz, et al., bioRxiv - Cell Biology 2022

  Quote: ... 1/100 Phospho-Myosin Light Chain 2 (Ser19) (Cell Signaling Technologies, 3675); 1/250 p62/SQSTM (Cell Signaling Technologies ...
• A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

  Jianting Shi, et al., bioRxiv - Cell Biology 2022

  Quote: ... A pool of 2 μg Rabbit anti-GABARAP (Cell Signaling Technology 13733S) and 2 μg Rabbit anti-GABARAP (N-term ...
• Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome

  Li Zhang, et al., bioRxiv - Genetics 2020

  Quote: ... anti-phospho-p44/42 MAPK(Erk1/2) (Cell Signaling Technologies, catalog #9106), anti-p44/42 MAPK(Erk1/2 ...
• Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

  Timothy N. Hoang, et al., bioRxiv - Immunology 2020

  Quote: ... pSTAT3 (Cell Signaling; Cat. No. 9145L at 1:200 for 2 hours), Iba-1 (BioCare ...
• Conditioned media from MCF7 and BT474 breast cancer cells induce insulin resistance in skeletal muscle myotubes

  Mona S. Ali, et al., bioRxiv - Cancer Biology 2020

  Quote: ... The primary antibodies used were Akt 2 (#3063, Cell Signaling Technology (CST)) ...
• A novel mechanism of bulk cytoplasmic transport by cortical dynein in Drosophila ovary

  Wen Lu, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit phospho-MLC (pMLC 2/Ser19, 1:100, Cell Signaling, Cat# 3671); mouse monoclonal anti-DHC antibody (2C11-2 ...
• Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation

  Hiroko Katsuno-Kambe, et al., bioRxiv - Cell Biology 2021

  Quote: ... and rabbit anti-p44/42 MAPK (Erk1/2) (9102; Cell Signaling Technology). AIIB2 antibody for blocking integrin β1 was purchased from Developmental Studies Hybridoma Bank and treated at 15 μg/ml in this study.
• SILAC phosphoproteomics reveals unique signaling circuits in CAR-T cells and the inhibition of B cell-activating phosphorylation in target cells

  Alijah A. Griffith, et al., bioRxiv - Cell Biology 2021

  Quote: ... α-pERK1/2 (T202/Y204) antibody (Cell Signaling cat. 9101, Danvers, MA), α-Erk1/2 (Cell Signaling cat ...
• Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder

  Shinsuke Oda, et al., bioRxiv - Pathology 2021

  Quote: ... Immunostaining for pERK1/2 (Clone D13.14.4E, Cell Signaling Technology, Danvers, MA, USA) and Ki67 (Clone MIB-1 ...
• Oral administration of bacterial Beta cell expansion factor A (BefA) alleviates diabetes in mice with Type 1 and Type 2 diabetes

  Huan Wang, et al., bioRxiv - Biochemistry 2021

  Quote: ... anti-Bcl-2-associated X protein (Bax) (Cell Signaling Technology, USA, # 5023S), anti-B cell lymphoma-2 (Bcl-2 ...
• Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance

  Li Li, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Integrin ß1(D2E5) and Bcl-2 were purchased from Cell Signaling Technology. GFP antibody and HER2/neu Ab-8 (Clone e2-4001 ...
• DNA damage and oxidizing conditions activate p53 through differential upstream signaling pathways

  Tao Shi, et al., bioRxiv - Cell Biology 2020

  Quote: ... pp38MAPK (Thr180/Tyr182) and pATF-2 (Thr71) were from Cell Signaling Technology. Phospho-Histone H2AX (Ser139 ...
• Negative durotaxis: cell movement toward softer environments

  Aleksi Isomursu, et al., bioRxiv - Biophysics 2020

  Quote: ... rbt anti-ERK1/2 (Cell Signaling Technology, 9102, 1:1000 for WB), rbt anti-p-ERK1/2 (T202/Y204 ...
• Melanomagenesis driven by a kinase-dead mutant BRAF lacking codons 600-618

  Megan A. Girtman, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Total MEK1/2 (#4694S) all purchased from Cell Signaling Technology (Davers, MA), BRAF (Santa Cruz Biotechnology ...
• Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

  Parishmita Sarma, et al., bioRxiv - Biochemistry 2022

  Quote: ... and anti-tERK1/2 (1:5000; Cell Signaling Technology, Cat. no. 9102). CXCR7pp2 was synthesized at the Tufts University Core Facility.
• Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington’s disease mouse phenotype

  Jordi Creus-Muncunill, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-p44/42 MAPK (Erk1/2) Antibody (1:1000, #9102, Cell Signaling), anti-C1q [4.8] (1:500 ...
• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

  Jason J. Northey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p44/42 MAPK (ERK1/2) (Cell Signaling Technology, Cat. #: 9102, 1:1000), phospho-PR (S294 ...
• Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells

  Marianne R. Spalinger, et al., bioRxiv - Microbiology 2020

  Quote: ... incubated with 2 μl anti-PTPN2 antibody (Clone D7T7D, Cell Signaling Technologies) over night ...
• Transferrin-dependent crosstalk between the intestinal tract and commensal microbes contributes for immune tolerance

  Xiaopeng Tang, et al., bioRxiv - Immunology 2020

  Quote: ... anti-total-IκBα (1:2□000 dilution, 4814T, Cell Signaling Technology, USA), anti-phospho-NF-κB p65 (1:1□000 dilution ...
• HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

  Claudio Laquatra, et al., bioRxiv - Biochemistry 2020

  Quote: ... rabbit polyclonal anti-phospho-ERK1/2 was from Cell Signaling (Cat.# 9101); rabbit polyclonal anti-glucose transporter GLUT1 was from Abcam (Cat.# ab652).
• Biased agonists of the chemokine receptor CXCR3 differentially drive formation of G_αi:β-arrestin complexes

  Kevin Zheng, et al., bioRxiv - Biochemistry 2020

  Quote: ... phosphorylated extracellular regulated kinase 1/2 (ERK) (Cell Signaling Technology, Danvers, MA) and total ERK (Millipore ...
• Jak2^V617F Reversible Activation Shows an Essential Requirement for Jak2^V617F in Myeloproliferative Neoplasms

  Andrew Dunbar, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and phospho-44/42 MAPK (Erk1/2) (Cell Signaling 4376, 1:100). Pictures were taken at 100X ...
• Cortical ChAT⁺ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner

  Adam J Granger, et al., bioRxiv - Neuroscience 2020

  Quote: ... Session 2 for PSD-95 (rabbit α-PSD95, 3450 Cell Signaling Tech.), Session 3 for VGAT (rabbit α-VGAT ...
• NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

  Carolina Marques, et al., bioRxiv - Cancer Biology 2020

  Quote: ... ERK1/2 (Cell Signaling Technology, #9102, 1:1000; Abcam #ab17942, 1:1000), p-MEK (S217/221 ...
• ATP allosterically stabilizes Integrin-linked kinase for efficient force generation

  Isabel M. Martin, et al., bioRxiv - Biophysics 2021

  Quote: ... phospho-Myosin Light Chain 2 (Thr18/Ser19) (Cell Signaling; 3674; 1:200), Paxillin (BD Transduction Laboratories ...
• Oxidative Stress and Neuroinflammation in a Rat Model of Co-Morbid Obesity and Psychogenic Stress

  Jose M. Santiago Santana, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-rabbit SOD-2 (1:2000; catalog #13141S; Cell Signaling, Danvers, MA); anti-rabbit GFAP (1:5000 ...
• Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

  Odessa R. Yabut, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit anti-phospho-Erk1/2 (1:250 dilution; Cat. #: 4370, Cell Signaling); γH2AX (1:100 dilution ...
• Perineuronal net receptor PTPσ regulates retention of memories

  Angelina Lesnikova, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-p44/42 MAPK (Erk1/2) rabbit pAb (Cell Signaling Technology, #9102); anti-p70 S6 kinase rabbit pAb (Cell Signaling Technology ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-phospho-ERK1/2 (T202/Y204) (Cell Signaling 4370, 1:2000), rabbit anti-ERK1/2 (Cell Signaling 4695 ...
• TOP-2 is differentially required for the proper maintenance of cohesin on meiotic chromosomes in C. elegans spermatogenesis and oogenesis

  Christine Rourke, Aimee Jaramillo-Lambert, bioRxiv - Genetics 2021

  Quote: ... rabbit anti-AIR-2 [(1:500) Figure 2B] (Cell Signaling Technology, 2914S), Histone H3 phospho-T3 (1:750 ...
• Venous activation of MEK/ERK drives development of arteriovenous malformation and blood flow anomalies with loss of Rasa1

  Jasper Greysson-Wong, et al., bioRxiv - Developmental Biology 2021

  Quote: Phospho-p44/42 MAPK (ERK1/2) (Thr2020/Tyr204) antibody (Cell Signaling, #9101) staining was performed as previously published (Randlett et al. ...
• A dynamic equilibrium between TTP and CPEB4 controls mRNA stability and inflammation resolution

  Clara Suñer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Phospho-p44/42 (Erk1/2) (Thr202/Try204) (Cell Signaling Clon E10, 9106); SOCS1 (Abcam Ab9870) ...
• A BTB-Domain Transcription factor Recruits Chromatin Remodelers and a Histone Chaperone during the exit from Pluripotency

  Daniel Olivieri, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Separate membranes were probed with Erk1/2 antibody (Cell Signaling Technology, #9102) or Phospho-Erk1/2 antibody (Cell Signaling Technology ...
• Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt

  Brittany L. Dunkerly-Eyring, et al., bioRxiv - Cell Biology 2021

  Quote: ... and anti-p44/42 MAPK (ERK1/2) (Cell Signaling Technology, 1:1000). Total protein stain used was Revert Total Protein Stain (Licor) ...