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501 - 550 of 1267 citations for 2 CHLOROMETHYL 6 METHOXY 1H BENZO D IMIDAZOLE since 2020

• Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

  Lilija Wehling, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and pLATS1/2 (1:500, Cell Signaling Technology, #8654, RRID:AB_10971635) and Cytochrome P450 2E1 (1:500 ...
• Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

  Yian Guan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-pERK1/2 (1:5000, Cat#9101, Cell Signaling Technology), anti-PTPN12 (1:500 ...
• Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

  Yian Guan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-ERK1/2 (1:3000, Cat#4695, Cell Signaling Technology), anti-pERK1/2 (1:5000 ...
• Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

  Laura Virtanen, et al., bioRxiv - Molecular Biology 2022

  Quote: ... rabbit monoclonal pERK1/2 (1:1000, D13.14.4E, Cell Signaling Technologies), rabbit monoclonal cleaved PARP-1 (1:1000 ...
• Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

  Hiroki Yagi, et al., bioRxiv - Pathology 2022

  Quote: ... rabbit polyclonal anti-ERK1/2 antibody (Cell Signaling Technology, #9102), rabbit monoclonal anti-phosphorylated p38 MAPK antibody (Thr180/Tyr182 ...
• IFT20 is critical for early chondrogenesis during endochondral ossification

  Hiroyuki Yamaguchi, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-phospho ERK1/2 (Cell Signaling technology; #4376, 1:1,000), anti-ERK1/2 (Cell Signaling technology ...
• A noble TGFβ biogenesis inhibitor exhibits both potent anti-fibrotic and anti-inflammatory capabilities

  Han-Soo Kim, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... ERK 1/2 from Cell Signaling Technology (Danver, MA, USA). All antibodies were diluted to 1:1000 v/v in 5% BSA in DPBS (Welgene).
• Sortilin exhibits tumor suppressor-like activity by limiting EGFR transducing function

  E. Lapeyronnie, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pERK1/2 (Thr202/Thr204, #4370, 1:1000 dilution, Cell Signaling), ERK1/2 (#9102 ...
• Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer

  Laura K. Godfrey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p-ERK1/2 (#4376, RRID:AB_331772, Cell Signaling Technology, 1:15), Vinculin (#13901 ...
• PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

  Eyleen Corrales, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho(Thr44/Tyr42)-ERK1/2 (1:1000; 9101; Cell Signaling), Erk1/2 (1:1000 ...
• ASPP2/PP1 complexes maintain the integrity of pseudostratified epithelia undergoing remodelling during morphogenesis

  Christophe Royer, et al., bioRxiv - Developmental Biology 2020

  Quote: ... rabbit anti-phospho-Myosin light chain 2 (Cell Signaling, #3674), 1:100 ...
• SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells

  Yuichiro J. Suzuki, et al., bioRxiv - Pathology 2020

  Quote: ... the mouse anti-MEK1/2 antibody (Catalog #4694; Cell Signaling), the rabbit anti-phospho-Akt (Ser473 ...
• Carbamazepine restores neuronal signaling, protein synthesis and cognitive function in a mouse model of fragile X syndrome

  Qi Ding, Fan Zhang, Yue Feng, Hongbing Wang, bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-pERK1/2 (Cell Signaling, Cat#9101, 1:2000), rabbit anti-Akt (Cell Signaling ...
• Carbamazepine restores neuronal signaling, protein synthesis and cognitive function in a mouse model of fragile X syndrome

  Qi Ding, Fan Zhang, Yue Feng, Hongbing Wang, bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-ERK1/2 (Cell Signaling, Cat#9102, 1:1000), rabbit anti-pERK1/2 (Cell Signaling ...
• V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis

  Miriam Formica, et al., bioRxiv - Genetics 2020

  Quote: ... rabbit anti-ERK 1/2 1:1000 (4695, Cell Signaling). Western blots protein levels were analyzed using Image Lab (Biorad).
• The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

  Leila Revollo, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti p-Erk1/2(T202/Y204) (Cell Signaling Technology, #4370), anti Erk1/2(Cell Signaling Technology ...
• Activation of proneuronal transcription factor Ascl1 in maternal liver ensures a healthy pregnancy

  Joonyong Lee, et al., bioRxiv - Physiology 2021

  Quote: ... p-ERK1/2 (T202/Y204, Cell Signaling, 4377, 1:2,000), GAPDH (Cell Signaling ...
• IFT20 is critical for early chondrogenesis during endochondral ossification

  Hiroyuki Yamaguchi, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-phospho ERK1/2 (Cell signaling technology; #4376, 1:100) antibodies were used for immunostaining ...
• Addressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation

  Xiaotong Zhu, et al., bioRxiv - Biochemistry 2021

  Quote: ... Anti-Phospho-Erk1/2 (Cell signaling technology, cat. no. 4370); anti-Erk1/2 (Cell signaling technology ...
• THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

  Jiali Zhang, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-phospho-ERK1/2 (Thr202/Tyr204, Cell Signaling Technology, 92711), anti-SHP1 (Santa Cruz ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-PAK1/2/3 (Cell Signaling 2604, 1:1000), rabbit anti-phospho-Cofilin (S3 ...
• Sex differences in cardio-pulmonary pathology of SARS-CoV2 infected and Trypanosoma cruzi co-infected mice

  Dhanya Dhanyalayam, et al., bioRxiv - Pathology 2021

  Quote: ... Hexokinase 2-specific rabbit monoclonal antibody (#2867S, Cell Signaling Technology), β1 adrenergic receptor-specific rabbit polyclonal antibody (#12271S ...
• ADAP1 promotes latent HIV-1 reactivation by selectively tuning a T cell signaling-transcriptional axis

  Nora-Guadalupe P. Ramirez, et al., bioRxiv - Microbiology 2021

  Quote: Anti-phos-ERK1/2 Thr202/Tyr204 (Cell Signaling Technology, 4370) (1:1000 ...
• LPA/PKD-1 signaling promotes development of arteriolar niche that supports self-renewal of breast cancer stem cells and stemness

  Yinan Jiang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and human/mouse Erk (1/2) (137F5) (Cell Signaling Technology), ALDH1A1 (AF5869 ...
• Long-lasting tagging of neurons activated by seizures or cocaine administration in Egr1-CreER^T2 transgenic mice

  Sophie Longueville, et al., bioRxiv - Neuroscience 2020

  Quote: ... phospho-ERK1/2 (Thr202/204) (1:1000, #9101, Cell Signaling), Fos (1:1000 ...
• SCARF1-induced efferocytosis plays an immunomodulatory role in humans, and autoantibodies targeting SCARF1 are produced in patients with systemic lupus erythematosus

  April M. Jorge, et al., bioRxiv - Immunology 2021

  Quote: ... Erk1/ 2 p-44/42-Alexa488 (Cell Signaling clone 137F5), and MAPK p38-Alexa488 (Thr180/Tyr182 ...
• Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during aging

  Yasmeen M. Farra, et al., bioRxiv - Bioengineering 2022

  Quote: ... anti-actin-α-2 (#48938S, Cell Signaling, 1:200 dilution), anti-Piezo1 ...
• Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

  Johanna Lilja, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phopho-ERK1/2 (Thr202/Tyr204) (Cat. no. 4370S, Cell Signaling), ERK1/2 (Cat ...
• Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

  Hiroki Yagi, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... rabbit polyclonal anti-ERK1/2 antibody (Cell Signaling Technology, #9102), rabbit monoclonal anti-EGR1 antibody (Cell Signaling Technology ...
• ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS

  Andrea Magrì, et al., bioRxiv - Neuroscience 2023

  Quote: ... phospho-ERK1/2 (Cell Signaling, ref. no. 4370, 1:1000), STAT3 (Cell Signaling ...
• PKC-alpha promotes phosphorylation of KRAS suppressing its oncogenic properties

  Tejashree Joglekar, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-phospho-p44/42 MAPK (Erk1/2) (Cell Signaling #4370); anti-p44/42 MAPK (Erk1/2 ...
• RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells

  Shuyu Liu, et al., bioRxiv - Developmental Biology 2022

  Quote: ... rabbit phospho-ERK1/2 (1:400, Cell Signaling Technologies, 4370S), rabbit total ERK1/2 (1:400 ...
• RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells

  Shuyu Liu, et al., bioRxiv - Developmental Biology 2022

  Quote: ... rabbit total ERK1/2 (1:400, Cell Signaling Technologies, 4695), rabbit phospho-AKT (1:400 ...
• RhoA activation promotes glucose uptake to elevate proliferation in MAPK inhibitor resistant melanoma cells

  Vasanth Siruvallur Murali, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Myosin Light Chain 2 1:1000(Cell Signaling Technology, 3672), Thr18/Ser19 Phospho-Myosin Light Chain 2 1:1000(Cell Signaling Technology ...
• The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer’s disease

  Felipe C. Ribeiro, et al., bioRxiv - Neuroscience 2023

  Quote: ... phospho-ERK1/2 Thr202/Tyr204 (#4370, 1:1,000; Cell Signaling), ERK1/2 (#9102 ...
• Bat RNA viruses employ viral RHIMs orchestrating species-specific cell death programs linked to Z-RNA sensing and ZBP1-RIPK3 signaling

  Sanchita Mishra, et al., bioRxiv - Immunology 2024

  Quote: ... anti-SARS-CoV-2 N protein (Cell Signaling Technology, 33717). HRP-conjugated secondary antibodies used in this study were Jackson Immuno Research Laboratories anti-rabbit (111-035-047 ...
• Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

  Chikako Okubo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit monoclonal anti-ERK1/2 (1:50, Cell Signaling Technology), rabbit monoclonal anti- phospho-ERK1/2 (Thr202/Tyr204 ...
• Endosome dysfunction leads to gain-of-function TLR7 and human lupus

  Harshita Mishra, et al., bioRxiv - Immunology 2023

  Quote: ... anti-p44/42 (ERK1/2) (1:1000, 137F5, Cell Signaling), anti-IκBα (1:1000 ...
• Keratinocyte desmosomal cadherin Desmoglein 1 as a mediator and target of paracrine signaling in the melanoma niche

  Hope E. Burks, et al., bioRxiv - Cancer Biology 2022

  Quote: ... The MEK1/2 inhibitor (U0126) was purchased from Cell Signaling and used at a 5 μM final concentration ...
• Repurposing of the antibiotic nitroxoline for the treatment of mpox

  Denisa Bojkova, et al., bioRxiv - Microbiology 2022

  Quote: ... phospho-ERK1/2 T202/Y204 (Cell Signaling, #9106, 1:1000), GAPDH (Cell Signaling ...
• Repurposing of the antibiotic nitroxoline for the treatment of mpox

  Denisa Bojkova, et al., bioRxiv - Microbiology 2022

  Quote: ... phospho-MEK1/2 S217/221 (Cell Signaling, #9121, 1:1000). Protein bands were visualized using IRDye-labeled secondary antibodies at dilution 1:40000 (LI-COR Biotechnology ...
• Development and Optimisation of in vitro Sonodynamic Therapy for Glioblastoma

  Andrew Keenlyside, et al., bioRxiv - Bioengineering 2023

  Quote: ... phospho Thr202/Tyr204 p44/42 ERK1/2 (Cell Signaling #4376), and GAPDH (Cell Signaling #5174).
• Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis

  Victor M. Bii, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-p-LATS1/2 (1:500, Cell Signaling, #9159), mouse anti-p-AKT (1:1000 ...
• Polarity-driven three-dimensional spontaneous rotation of a cell doublet

  Linjie Lu, et al., bioRxiv - Biophysics 2022

  Quote: ... Anti-Phospho-Myosin Light Chain 2 (Cell signaling technology, #3674), Anti-Paxillin (Abcam ...
• Phencyclidine disrupts neural coordination and cognitive control by dysregulating translation

  Eun Hye Park, et al., bioRxiv - Neuroscience 2023

  Quote: ... phospho-ERK1/2 (Cell Signaling Technology, Cat.No.9101S, 1:1000), ERK1/2 (Cell Signaling Technology ...
• In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma

  Jerry J. Fan, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-pERK1/2 (Cell Signaling Technology #4370, 1:200), rabbit anti-pERM (Cell Signaling Technology #3726 ...
• Loss of presenilin-1 in smooth muscle cells ameliorates elastin aortopathy

  Junichi Saito, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-PSEN-2 (Cell Signaling Technology, 9979; 1:250), rabbit anti-HES1 (Cell Signaling Technology ...
• Tumor suppressor let-7 acts as a key regulator for maintaining pluripotency gene expression in Muse cells

  Gen Li, Shohei Wakao, Masaaki Kitada, Mari Dezawa, bioRxiv - Cell Biology 2023

  Quote: ... p44/p42 MEK/ERK (ERK1/2; 1:1000, Cell Signaling), β-actin (1:10000 ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-myosin light chain 2 (Cell signaling, 1:100), mouse anti-phospho myosin light chain 2 (Cell signaling ...
• Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular cells

  Yihong Chen, et al., bioRxiv - Cell Biology 2023

  Quote: ... p42/44 MAPK (ERK1/2, Cell Signaling Technology, Danvers, MA), phosphor-p42/44 MAPK (p-ERK1/2 ...