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1301 - 1350 of 3059 citations for 6 Boc 1 oxa 6 azaspiro 3.3 heptan 3 one since 2019

• Ptbp1 deletion does not induce glia-to-neuron conversion in adult mouse retina and brain

  Thanh Hoang, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-Otx2 (1:200, R&D systems, #AF1979), rabbit anti-Gfap (1;300 ...
• Sustained TREM2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

  Rahul Dhandapani, et al., bioRxiv - Neuroscience 2021

  Quote: ... Sheep anti-Trem2 (1:500; R&D systems, AF1729), Rat anti-CD68 (1:500 ...
• Sustained TREM2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

  Rahul Dhandapani, et al., bioRxiv - Neuroscience 2021

  Quote: ... Goat anti-Olig2 (1:300; R&D systems, AF2418), Rat anti-C4b (1:100 ...
• RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

  Carolina Nunes, et al., bioRxiv - Cancer Biology 2020

  Quote: ... PDGF-AA and PDGF-BB were obtained from PeproTech and IGF-1 was obtained from R&D Systems. B27 minus vitamin A and N-2 Supplements were obtained from Fischer Scientific ...
• Temporal analysis of enhancers during mouse brain development reveals dynamic regulatory function and identifies novel regulators of cerebellar development

  Miguel Ramirez, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-Pax3 (1:500, R&D systems, MAB2457), rabbit anti-Pax2 (1:200 ...
• Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain

  Marie Karam, Guy Malkinson, Isabelle Brunet, bioRxiv - Neuroscience 2021

  Quote: ... anti-Ephb4 (R&D Systems, AF446-SP, 1:100). Followed by 4 days incubation at 37°C with rotation ...
• A cell-ECM mechanism for connecting the ipsilateral eye to the brain

  Jianmin Su, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-nephronectin (diluted 1:40, R&D systems). On the next day ...
• Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes

  Lucile Ben Haim, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-Olig2 (AF2418, R&D Systems, 1:50), mouse anti-APC (clone CC1 ...
• Lumican regulates cervical corticospinal axon collateralization via non-autonomous crosstalk between distinct corticospinal neuron subpopulations

  Yasuhiro Itoh, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-Lumican (R&D Systems, AF2745, 1:200). HRP-conjugated secondary antibodies (Abcam ...
• Single cell transcriptomics reveals functionally specialized vascular endothelium in brain

  Hyun-Woo Jeong, et al., bioRxiv - Physiology 2022

  Quote: ... goat anti CD31 (R&D Systems AF3628, 1:200), rabbit anti-CD206 (Abcam ab64693 ...
• Single cell transcriptomics reveals functionally specialized vascular endothelium in brain

  Hyun-Woo Jeong, et al., bioRxiv - Physiology 2022

  Quote: ... goat anti-Olig2 (R&D Systems AF2418, 1:100), rabbit anti-MHC Class II (Abcam ab180779 ...
• Expression and T cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube

  Joshua Johnson, et al., bioRxiv - Physiology 2020

  Quote: ... PD-1 blocking antibody (R&D Systems/Techne, #AF1086) was included at the 10 µg/ml ...
• Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regeneration

  Maximilian Strunz, et al., bioRxiv - Systems Biology 2019

  Quote: ... goat anti-Pdpn (1:200; R&D Systems, AF3244). Cell nuclei were stained with DAPI (40,6-diamidino-2-phenylindole ...
• Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regeneration

  Maximilian Strunz, et al., bioRxiv - Systems Biology 2019

  Quote: ... goat anti-Pdpn (1:200; R&D Systems, AF3244), rabbit anti-SPC (1:150 ...
• NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development

  Jie Li, et al., bioRxiv - Developmental Biology 2019

  Quote: ... anti-PDGFR-β (R&D Systems, AF1042, 1:50), anti-Ikaros (Santa Cruz ...
• Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

  Yuancheng Lu, et al., bioRxiv - Molecular Biology 2019

  Quote: ... Goat anti-Klf4 (1:100, R&D system, AF3158), Rabbit anti-phosphorylated S6 Ser235/236 (1:100 ...
• Dorsal-to-ventral neocortical expansion is physically primed by ventral streaming of early embryonic preplate neurons

  Kanako Saito, et al., bioRxiv - Neuroscience 2019

  Quote: ... anti-TAG1 (goat, AF1714, R&D Systems, 1:400), anti–βIII-tubulin (mouse ...
• Telophase correction refines division orientation in stratified epithelia

  Kendall J. Lough, et al., bioRxiv - Cell Biology 2019

  Quote: ... E-cadherin (goat, R&D System AF748, 1:1,000), α-catenin (rabbit ...
• STAT pathway activation limits the Ascl1-mediated chromatin remodeling required for neural regeneration from Müller glia in adult mouse retina

  Nikolas L. Jorstad, et al., bioRxiv - Developmental Biology 2019

  Quote: ... goat anti-Otx2 (R&D Systems, 1:100, BAF1979), goat anti-Sox2 (Santa Cruz ...
• Robo recruitment of the Wave Regulatory Complex plays an essential and conserved role in midline repulsion

  Karina Chaudhari, et al., bioRxiv - Developmental Biology 2020

  Quote: ... goat anti-Robo3 (1:200, R&D systems, #AF3076), Cy3 donkey anti-goat (1:500 ...
• An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants

  Maria Paz Zafra, et al., bioRxiv - Cancer Biology 2019

  Quote: ... goat anti-CPA1 (1:400, R&D Systems AF2765), rabbit anti-αSMA (1:400 ...
• Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signaling

  Sandra Segura-Bayona, et al., bioRxiv - Molecular Biology 2019

  Quote: ... STING (R&D Systems MAB7169, clone 723505, 1:1000). These were detected with appropriate secondary antibodies conjugated to HRP and visualized by ECL-Plus (GE Healthcare).
• Dot1L methyltransferase activity is a barrier to acquisition of pluripotency but not transdifferentiation

  Coral K. Wille, Rupa Sridharan, bioRxiv - Developmental Biology 2020

  Quote: ... anti-human NANOG (R&D Systems AF1997, 1:100), anti-TUJ1 (Novus Biologicals MAB1195 ...
• Distinct cancer-associated fibroblast states drive clinical outcomes in high-grade serous ovarian cancer and are regulated by TCF21

  Ali Hussain, et al., bioRxiv - Cancer Biology 2019

  Quote: ... mouse-anti-human-FAP (R&D Systems, 1:50), and either mouse-anti-pan-Cytokeratin (Abcam ...
• Transient receptor vanilloid 4 (TRPV4) channels are essential for alveolar epithelial cell function

  Jonas Weber, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti-podoplanin (goat, R&D Systems AF3244, 1:500), secondary anti-goat IgG (whole molecule)-peroxidase (Sigma A5420-1ML ...
• Male sex hormones increase excitatory neuron production in developing human neocortex

  Iva Kelava, et al., bioRxiv - Developmental Biology 2020

  Quote: ... sheep anti-TBR2 (R&D Systems, AF6166, 1:200).
• Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

  Shintaro Ide, et al., bioRxiv - Cell Biology 2021

  Quote: ... KIM1 (R&D Systems, Minneapolis, MN, AF1817, 1:400), NGAL (Abcam ...
• TRPM2 deficiency protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophages

  Pengyu Zong, et al., bioRxiv - Physiology 2021

  Quote: ... (MCP-1) (R&D systems, 279-MC-050/CF). All chemicals for making Tyrode solution and recording solution (see U73122ow ...
• Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis

  L Almeida, et al., bioRxiv - Immunology 2019

  Quote: ... rhIL-23 (20 ng mL−1, R&D Systems), rhIL-6 (20 ng mL−1 ...
• Robust three-dimensional expansion of human adult alveolar stem cells and SARS-CoV-2 infection

  Jeonghwan Youk, et al., bioRxiv - Cell Biology 2020

  Quote: ... rat anti-SCGB1A1 (1:200, R&D systems, MAB4218), rabbit anti-KRT5 (1:500 ...
• Deficiency of complement component C1Q prevents cerebrovascular damage and white matter loss in a mouse model of chronic obesity

  Leah C. Graham, et al., bioRxiv - Neuroscience 2020

  Quote: ... and goat anti-C3 (1:75, R&D systems). After primary antibodies incubation ...
• Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection

  Constantina Borg, et al., bioRxiv - Microbiology 2019

  Quote: ... Recombinant mouse IFN-β (R&D Systems, 12400-1) was used as a standard.
• Molecular and genetic regulation of pig pancreatic islet cell development

  Seokho Kim, et al., bioRxiv - Developmental Biology 2020

  Quote: ... goat anti-PDX1 (R&D systems, AF2419, 1:200), mouse anti-human NKX6.1 (R&D systems ...
• Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis

  Christopher S. Smillie, et al., bioRxiv - Genomics 2019

  Quote: ... goat anti-CD138 (1:100, R&D Systems AF2780), mouse anti-HLA-DR/DP/DQ (1:200 ...
• NG2 glia are required for maintaining microglia homeostatic state

  Yingjun Liu, Adriano Aguzzi, bioRxiv - Neuroscience 2019

  Quote: ... anti-CD13 (1:200, R&D Systems, AF2335-SP), anti-MBP (1:500 ...
• Biomimetic Aorta-Gonad-Mesonephros-on-a-Chip to Study Human Developmental Hematopoiesis

  Ryohichi Sugimura, et al., bioRxiv - Bioengineering 2019

  Quote: ... and 80 ng mL−1 VEGF (R&D systems). After two more days in culture ...
• The H2A.J histone variant contributes to Interferon-Stimulated Gene expression in senescence by its weak interaction with H1 and the derepression of repeated DNA sequences

  Adèle Mangelinck, et al., bioRxiv - Genetics 2020

  Quote: ... anti-IL6 (R&D Systems, AF-206, 1:200), anti-STAT1 (Invitrogen ...
• Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents

  Raghu Ram Katreddi, et al., bioRxiv - Developmental Biology 2021

  Quote: ... *Goat anti-NeuroD1 (1:500, AF2746, R&D Systems), *Rabbit anti-Notch1 (1:50 ...
• Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation

  Mark A. Landy, et al., bioRxiv - Neuroscience 2020

  Quote: ... goat anti-TRKA (1:20; R&D Systems AF1056), rabbit anti-RUNX3 (1:50,000 ...
• Time-resolved proteomic profiling of the ciliary Hedgehog response reveals that GPR161 and PKA undergo regulated co-exit from cilia

  Elena A. May, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-GLI3 (R&D Systems nachuryAF3690, goat 1:1,000) anti-actin (self-made ...
• Characterisation of the transcriptional dynamics underpinning the function, fate, and migration of the mouse Anterior Visceral Endoderm

  Shifaan Thowfeequ, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 1:100 Goat anti-PlexinA1 (R&D Systems, AF4309), 1:200 Rabbit anti-Oct4 (Abcam ...
• Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

  Alexandro E. Trevino, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-SOX9 (Goat, 1:500, R&D Systems, AF3075), anti-SPARCL1 (Goat ...
• Hyperoxia Inhibits the Growth of Mouse Forebrain Oligodendrocyte Progenitors

  Lisamarie Moore, et al., bioRxiv - Neuroscience 2021

  Quote: ... 1 ng/mL recombinant rat CNTF (R&D Systems) [29] ...
• Differentiation of human adult-derived stem cells towards a neural lineage involves a de-differentiation event prior to re-differentiation to neural phenotypes

  Carlos Bueno, et al., bioRxiv - Neuroscience 2021

  Quote: ... and IGF-1 (10□ng/ml; R&D systems). We perform time-lapse phase-contrast microscopy within the first 24 hr after neural induction media was added directly to the cells.
• Production and secretion of functional full-length SARS-CoV-2 spike protein in Chlamydomonas reinhardtii

  Anna Kiefer, et al., bioRxiv - Synthetic Biology 2021

  Quote: ... mouse anti-RBD (MAB105401, R&D Systems, 1:2,000) and mouse anti-ACE2 (sc-390851 ...
• DDR1-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS DRIVE PANCREATIC CANCER METASTASIS

  Jenying Deng, et al., bioRxiv - Cancer Biology 2020

  Quote: ... or anti-myeloperoxidase (1:150 dilution; R&D Systems). After being washed with PBS ...
• JAG1 intracellular domain acts as a transcriptional cofactor that forms an oncogenic transcriptional complex with DDX17/SMAD3/TGIF2

  Eun-Jung Kim, et al., bioRxiv - Molecular Biology 2021

  Quote: ... anti-SOX2 (1:1000, Cat. #AF2018; R&D Systems), anti-DDX17 (1:1000 ...
• Neural plate targeting by in utero nanoinjection (NEPTUNE) reveals a role for Sptbn2 in neurulation and abdominal wall closure

  Katrin Mangold, et al., bioRxiv - Developmental Biology 2020

  Quote: ... goat-anti Olig1 (MAB2417, R&D systems 1:100); guinea pig anti-Dcx (AB2253 ...
• Zfp36l1 and Zfp36l2 balances proliferation and differentiation in the developing retina

  Fuguo Wu, et al., bioRxiv - Developmental Biology 2020

  Quote: ... goat anti-Nrl (R&D systems AF2945, 1:200), rabbit anti-Otx2 (Sigma B74059 ...
• Arap1 Loss Causes RPE Phagocytic Dysfunction and Subsequent Photoreceptor Death

  Andy Shao, et al., bioRxiv - Molecular Biology 2021

  Quote: ... and normal goat IgG (1:50, R&D Systems).