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1601 - 1650 of 8510 citations for 6 Chloro 2 3 diphenylimidazo 1 2 b pyridazine since 2019

• Retinoic acid treatment recruits macrophages and increases axonal regeneration after optic nerve injury in the frog Rana pipiens

  Valeria De La Rosa-Reyes, et al., bioRxiv - Neuroscience 2021

  Quote: ... which were anti-Arginase 1 (1:50; catalog # sc-271430; Santa Cruz Biotechnology), anti-CD68 (ED1 ...
• PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins

  Ying Liu, et al., bioRxiv - Microbiology 2020

  Quote: ... or Western blotting: anti-PSGL-1 (Santa Cruz Biotech, sc-13535, 1:200), anti-cofilin (Cell Signaling ...
• Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover

  Seda Yasa, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-Lamp1 (WB: 1:1000, IF: 1:100, Santa Cruz Biotech sc-19992), anti-Lamp2a (WB ...
• Synergistic induction of blood-brain barrier properties

  Gergő Porkoláb, et al., bioRxiv - Bioengineering 2023

  Quote: ... rabbit anti-PECAM-1 (Santa Cruz, cat# sc-1506-R, AB_831096, 1:200), rabbit anti-β-catenin (Sigma-Aldrich ...
• Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators

  Ingrid M. Saldana-Guerrero, et al., bioRxiv - Cancer Biology 2022

  Quote: ... MASH1 (ASCL1) (Abcam, Ab211327, 1:100 or Santa Cruz, SC-374104, 1:500); Ki67 (Abcam ...
• Actin nucleators safeguard replication forks by limiting nascent strand degradation

  Jadwiga Nieminuszczy, et al., bioRxiv - Molecular Biology 2023

  Quote: ... DIAPH1 (Bethyl, A300-077A-T, 1:1000; Santa Cruz, sc-373807, 1:500), CHK1 – phospho S345 (Cell Signalling ...
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... and Myosin ID (1:500; H-1; sc-515292; Santa Cruz Biotechnology, Inc). For fluorescence intensity measurements ...
• Chlamydial protease-like activating factor targets SLC7A11 for degradation to induce ferroptosis and facilitate dissemination

  Wentao Chen, et al., bioRxiv - Microbiology 2023

  Quote: ... fibroblast-specific protein 1 (FSP1; 1:500, Santa Cruz Biotechnology Cat# sc-377120), TfR1(1:500 ...
• NCLX controls hepatic mitochondrial Ca²⁺ extrusion and couples hormone-mediated mitochondrial Ca²⁺ oscillations with gluconeogenesis

  Mahmoud Taha, et al., bioRxiv - Physiology 2024

  Quote: ... for 1 h or an anti-mouse (1:5000, sc-2005, Santa Cruz) solution for 1 h ...
• The Parkinson’s Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

  Katy R. McCarron, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-ALIX (1:1,000 WB, 1:500 IF, Santa Cruz Biotechnology; sc-53540), anti-Cathepsin D (1:2,000 WB ...
• Native size exclusion chromatography-based mass spectrometry (SEC-MS) identifies novel components of the Heat Shock Protein 90-dependent proteome

  Rahul S. Samant, et al., bioRxiv - Biochemistry 2022

  Quote: ... Antibodies for HSP90α/β (sc-7947, 1:500), CDC37 (sc-5617, 1:500), and AHA1 (sc-50527, 1:500) were from Santa Cruz Biotechnology ...
• Long-term dynamic changes of NMDA receptors following an excitotoxic challenge

  Alberto Granzotto, et al., bioRxiv - Neuroscience 2022

  Quote: ... Cells were incubated for 1 h at RT with anti-GluN1 antibody (1:200, Alomone) and anti-NOS1 antibody (1:50, Santa Cruz Biotechnology) in the blocking solution ...
• Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons

  Rosa Woldegebriel, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit α-GAPDH 1:1000 (#14C10, Cell Signalling) with secondary 1:5000 (#111-035-144, Jackson) and mouse α-NEFL 1:1000 (#sc39073, Santa Cruz) with secondary 1:5000 (#115-035-146 ...
• High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

  Kayleigh Slater, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and probed with primary antibodies (CysLT1 : Abcam [ab151484], 1:1000, CysLT2 : Cayman Chemical [CAY120560] 1:1000, Alpha-Tubulin : Santa Cruz, 1:200). Secondary antibodies were anti-mouse IgG HRP-linked (Cell Signalling [7076S] 1:1000) ...
• Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues

  Joel Pinczewski, et al., bioRxiv - Pathology 2020

  Quote: Working concentrations of antibodies to βcat (1:500, Epitomics, Burlingame, CA # 1247-1) and phospho-βcat (pS33-βcat 1:200, Santa Cruz, Santa Cruz, CA # SC-16743-R ...
• Site-Specific Knockdown of Microglia in the Locus Coeruleus Regulates Hypervigilant Responses to Social Stress in Female Rats

  Brittany S. Pate, et al., bioRxiv - Neuroscience 2022

  Quote: ... PVDF membranes incubated overnight at 4°C with the following primary antibodies diluted in 1:1 Blok/0.1M PBS + 0.2% Tween-20 : mouse anti-GAPDH (1:1000, Santa Cruz, Santa Cruz, CA), rabbit anti-CX3CL1 (1:1000 ...
• Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner

  Masaya Harada, et al., bioRxiv - Neuroscience 2024

  Quote: ... before staining with the respective primary antibodies (NAc and LH with αGFP chicken 1:1000, Aves Labs ref GFP-1010; αmCherry rabbit, 1:1000, abcam ab167453; and αOrexin goat, 1:500, Santa Cruz Biotech ...
• IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency

  Marco Flores-Mendez, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1:1000; CD68, Bio Rad MCA1957, 1:250; NEUN, Millipore MAB377, 1:2000; GFAP, Aves Lab 75-240, 1:1000, S6, Santa Cruz sc74459 ...
• Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human System

  Ibrahim Jubber, et al., bioRxiv - Evolutionary Biology 2023

  Quote: ... sc-15179 (Goat polyclonal) at 1:400 dilution for zebrafish tissue and 1:100-1:400 dilution for human tissue (Santa Cruz Biotechnology), Cytokeratin 5/6 (mouse monoclonal ...
• Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

  Xianping Wang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and rabbit anti-HA (CST, 1:200), rabbit anti-Flag (CST, 1:200) and mouse anti- Su(H) (Santa Cruz, 1:100), mouse anti-NICD (DSHB ...
• Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes in R6/2 mice

  Danielle A. Simmons, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-OCT3/4 (sc-5279, 1:200), anti-SOX2 (sc-365823, 1:200), anti-NANOG (sc-293121, 1:200) (all from Santa Cruz Biotechnology), anti-PAX6 (DSHB ...
• A pseudotyped lentivirus-based assay to titer SARS-CoV-2 neutralizing antibodies in Mexico

  José Antonio Cruz-Cardenas, et al., bioRxiv - Microbiology 2022

  Quote: ... Briefly 3 x105 cells were incubated on ice with mouse anti-human ACE2 monoclonal antibody conjugated to AF-647 (Santa Cruz Biotechnology, USA, cat. SC-390851) following manufacturer’s instructions ...
• ZNF143 binds DNA and stimulates transcription initiation to activate and repress direct target genes

  Jinhong Dong, et al., bioRxiv - Genomics 2024

  Quote: ... was aliquoted into each of 3 tubes with antibody (2µg anti-HA Invitrogen #26183, 8µg anti-SP1 Santa Cruz Biotechnology sc-17824 X, or mock IP) and incubated with end-over-end rotation at 4°C overnight ...
• FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation

  Kai T. Richter, et al., bioRxiv - Cell Biology 2019

  Quote: ... Mouse α-Myc (9E10, 1:500), rabbit α-SKP1 (H-163, 1:1000) and mouse α-ubiquitin (P4D1, 1:1000) were obtained from Santa Cruz. Mouse α-Nucleophosmin (NPM ...
• Clostridioides difficile spore-entry into intestinal epithelial cells contributes to recurrence of the disease

  Pablo Castro-Córdova, et al., bioRxiv - Microbiology 2020

  Quote: ... in PBS–1% BSA 1 h RT and 1:400 anti-goat conjugated with CFL 488 secondary antibody (green) (SC362255, Santa Cruz Biotechnologies, USA) in PBS–1% BSA for 1 h RT ...
• CRL5-dependent regulation of Arl4c and Arf6 controls hippocampal morphogenesis

  Jisoo S. Han, et al., bioRxiv - Developmental Biology 2020

  Quote: ... washed with TBS-T and incubated overnight with primary antibodies (anti-Actin 1:10000 Santa Cruz Biotechnology #sc1616; anti-Dab1 1:2000 Sigma-Aldrich #HPA052033, anti-Fyn 1:1000 Santa Cruz Biotechnology #sc-16 ...
• Is zebrafish heart regeneration “complete”? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts

  Alberto Bertozzi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... anti-Col1a1a (Developmental Studies Hybridoma Bank #SP1.D8, 1:50), anti-embMHC (Developmental Studies Hybridoma bank, # N2.261, 1:50) and anti-Mef2 (Santa Cruz #SC313, 1:50). Secondary antibodies conjugated to Alexa 488 ...
• Monoallelically-expressed Noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

  Qinyu Hao, et al., bioRxiv - Cell Biology 2022

  Quote: ... Coverslips were then incubated with primary antibodies (anti-FBL, 1:500, Novus Biologicals, NB300-269; anti-RPA194, 1:50, Santa Cruz, sc-48385; anti-UBF, 1:50, Santa Cruz, sc-13125 ...
• Transcriptional networks are dynamically regulated during cell cycle progression in human Pluripotent Stem Cells

  Anna Osnato, Stephanie Brown, Ludovic Vallier, bioRxiv - Cell Biology 2022

  Quote: ... Cells were washed with 1% PBS/BSA and incubated in 1% PBS/BSA with anti-TRA-1-60-antibody mouse monoclonal IgM (1:100, Santa Cruz Biotechnology, Inc.) for 20 min on ice ...
• Distinct TORC1 signalling branches regulate Adc17 proteasome assembly chaperone expression

  Thomas D. Williams, et al., bioRxiv - Cell Biology 2023

  Quote: ... CST, 4370S; αAdc17, Sheep, 1:200, DSTT, DU66321; αP-Rps6, Rabbit, 1:1000, CST, 2211; αHA, Mouse, 1:1000, Santa Cruz Sc-7392) overnight ...
• Substrate-mediated regulation of the arginine transporter of Toxoplasma gondii

  Esther Rajendran, et al., bioRxiv - Microbiology 2019

  Quote: ... or goat anti-mouse (1:5,000 to 1:10,000 dilution; Santa Cruz, sc-2005) secondary antibodies.
• PAX2 Induces Tubular-Like Structures in Normal and Ovarian Cancer Cells

  Kholoud Alwosaibai, et al., bioRxiv - Cancer Biology 2020

  Quote: ... or 1 hour at room temperature for anti-rabbit PAX2 (1:1000, Santa Cruz). After washing in phosphate-buffered saline (PBS) ...
• Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation

  Steven Swendeman, et al., bioRxiv - Biochemistry 2022

  Quote: ... and probed with antibodies to ICAM-1 (1:1000, sc-8439, Santa Cruz Biotech) and Actin (1:5000 ...
• Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

  Tolulope Sokoya, et al., bioRxiv - Cell Biology 2022

  Quote: ... goat polyclonal anti-calnexin (Santa Cruz, sc-6495; IF 1:200, IB 1:1,000), rabbit polyclonal anti-β-calnexin (Abcam ...
• Delta/Notch signaling controls neuroepithelial morphogenesis in the zebrafish spinal cord

  Priyanka Sharma, et al., bioRxiv - Developmental Biology 2019

  Quote: ... Mouse@DeltaA58 (1:250, ZIRC 18D2);Rabbit@aPKC28 (1:250, Santa Cruz sc-216); Mouse@ZO159 (1:500 ...
• G-Protein signaling accelerates stem cell divisions in Drosophila males

  Manashree Malpe, et al., bioRxiv - Developmental Biology 2019

  Quote: ... Goat anti-Vasa antibody (1:50 to 1:300) was obtained from Santa Cruz Biotechnology Inc ...
• Optogenetic control of PRC1 reveals that bridging fibers promote chromosome alignment by overlap length-dependent forces

  Mihaela Jagrić, et al., bioRxiv - Cell Biology 2020

  Quote: ... mouse monoclonal anti-Eg5 antibody (1:100; A-1; sc-365681, Santa Cruz Biotechnology). After washing of primary antibodies with PBS ...
• The dynamic equilibrium of nascent and parental MCMs safeguards replicating genomes

  Hana Sedlackova, et al., bioRxiv - Cell Biology 2019

  Quote: ... MCM7 (mouse, Santa Cruz, sc-9966, 1:1000 for IF, 1:1000 for WB), MCMBP (rabbit ...
• PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

  James S. Chavez, et al., bioRxiv - Immunology 2020

  Quote: ... Chromatin was subsequently incubated with 1 μg PU.1 antibody (Santa Cruz; sc-390405) and rotated overnight at 4°C ...
• Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain

  Annemarie Dedek, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-Fyn (1:1000) and anti-β-actin (1:10 000) from Santa Cruz; anti-non-phospho-STEP (1:1000 ...
• Suppression of aminoglycoside-induced premature termination codon readthrough by the TRP channel inhibitor AC1903

  Alireza Baradaran-Heravi, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... DO-1 mouse anti-p53 antibody (1:400, Santa Cruz sc-126, TX, USA) and mouse anti-vinculin antibody (1:600 ...
• Myoglobin promotes cardiomyocyte differentiation through oxidatively modulating the Hippo Kinase Pathway

  Krithika Rao, et al., bioRxiv - Cell Biology 2022

  Quote: ... Mb (1:1000, LS-C144978 LS Bio or 1:1000, sc-393020 Santa Cruz), Tubulin (1:1000 ...
• A genetic and physiological model of renal dysfunction in Lowe syndrome

  Navyashree A Ramesh, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1:1000 anti-mcherry (Thermo, PA5-34974) 1:2000 anti-GFP (Santa cruz, sc9996). Following this ...
• PGM3 inhibition Shows cooperative Effects With Erastin inducing Pancreatic cancer cell death via activation of the Unfolded Protein Response

  Barbara Zerbato, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Keap1 (sc-365626, 1:1000) and Vinculin (#sc-5573, 1:10000) from Santa Cruz Biotechnology Inc ...
• The large GTPase Guanylate-Binding Protein-1 (GBP-1) promotes mitochondrial fission in glioblastoma

  Ryan C. Kalb, et al., bioRxiv - Cancer Biology 2024

  Quote: ... The primary antibodies were rat anti-hGBP-1 (1b1) (Santa Cruz Biotechnology 1:10,000); mouse anti-MMP1 Mab 901 (R&D Systems 1:750) ...
• Human ADA2 deficiency is characterized by the absence of an intracellular hypoglycosylated form of adenosine deaminase 2

  Lisa Ehlers, et al., bioRxiv - Immunology 2024

  Quote: ... anti-LAMP-1 (clone H4A3, #sc-20011; 1:500; Santa Cruz Biotechnology; RRID: AB_626853), anti-CD98 (clone E-5 ...
• TGF-β inhibitor accelerates BMP4-induced cochlear gap junction formation during in vitro differentiation of embryonic stem cells

  Ichiro Fukunaga, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1 μM PD0325901 (Santa Cruz), and 1,000 U ml−1 of leukemia inhibitory factor (Millipore).
• Endoplasmic Reticulum Associated Degradation (ERAD) Deficiency Promotes Mitochondrial Dysfunction and Transcriptional Rewiring in Human Hepatic Cells

  Xiaoqing Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... JNK1 (Santa Cruz, 1:800), RIPK1 (Affinity ...
• Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay

  Annika Zink, et al., bioRxiv - Cell Biology 2020

  Quote: ... SOX2 (Santa Cruz, 1:100), TUJ1 (Sigma-Aldrich ...
• Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay

  Annika Zink, et al., bioRxiv - Cell Biology 2020

  Quote: ... OCT4 (Santa Cruz, 1:300), TRA-1-60 (Millipore ...