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1451 - 1500 of 8510 citations for 6 Chloro 2 3 diphenylimidazo 1 2 b pyridazine since 2019

• Structure-function analysis reveals a DNA polymerization-independent role for mitochondrial DNA polymerase IC in African trypanosomes

  Jonathan C Miller, et al., bioRxiv - Microbiology 2019

  Quote: ... blocked and re-probed with specific Crithidia fasciculata anti-Hsp70 (1:5000, 1 h) (Johnson and Englund, 1998) and secondary chicken anti-rabbit-HRP (1:2000, 1 h) (Santa Cruz, sc-516087). Signal was detected with Clarity™ ECL Blotting Substrate (NEB ...
• rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin

  Hua Yu, et al., bioRxiv - Cell Biology 2021

  Quote: ... followed by incubation overnight with primary antibodies (1:200, Nucleolin, CST, 145745; 1:400, NPM1, Sigma, B0556; 1:200, Fibrillarin, Abcam, ab4566; RPA194, 1:50, Santa Cruz, sc-48385) at 4 degree or for 1hr at 37 °C ...
• rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin

  Hua Yu, et al., bioRxiv - Cell Biology 2021

  Quote: ... for 10 min at RT and then stained with a primary antibody (1:200, Nucleolin, CST, 145745; 1:400, NPM1, Sigma, B0556; 1:200, Fibrillarin, Abcam, ab4566; RPA194, 1:50, Santa Cruz, sc-48385) for 12 h at 4 °C ...
• Tel1 activation by the MRX complex is sufficient for telomere length regulation but not for the DNA damage response in S. cerevisiae

  Rebecca Keener, et al., bioRxiv - Molecular Biology 2019

  Quote: ... Invitrogen 22C5D8 Pgk1 at 1:6,000; Roche 12CA5 HA at 1:2,000; Invitrogen R960-25 V5 at 1:2,000; Santa Cruz 9E10 c-myc at 1:10,000). The membrane was washed in 1x Tris Buffered Saline with Tween-20 (TBST ...
• Syndecan-4^-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components

  Sissel Beate Rønning, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-fibromodulin (1:500, 1% casein, sc-33772, Santa Cruz), anti-pSer2448-mTOR (1:1000 ...
• Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

  Flora Magnotti, et al., bioRxiv - Immunology 2021

  Quote: ... anti-human Caspase-1 (Santa Cruz, sc515, 1: 1,000 dilution), anti-human GSGMD (sigma ...
• RhoA- and Ran-induced antagonistic forces underlie symmetry breaking and spindle rotation in mouse oocytes

  Benoit Dehapiot, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Rock-1 (1/100, Goat polyclonal; Santa Cruz sc-6056). Secondary antibodies were Alexa Fluor 488-conjugated donkey anti-goat ...
• GPCR-mediated clearance of tau in post-synaptic compartments attenuates tau pathology in vivo

  Ari W. Schaler, et al., bioRxiv - Neuroscience 2020

  Quote: ... CamKIIα (1:2000, A-1, sc13141) was from Santa Cruz Biotechnology ...
• Phenomenon of music-induced opening of the blood-brain barrier in healthy mice

  O. Semyachkina-Glushkovskaya, et al., bioRxiv - Neuroscience 2020

  Quote: ... ZO-1 (1:500; Santa Cruz Biotechnology, Santa Cruz, USA), OCC and NG2 (1:500 ...
• Phenomenon of music-induced opening of the blood-brain barrier in healthy mice

  O. Semyachkina-Glushkovskaya, et al., bioRxiv - Neuroscience 2020

  Quote: ... ZO-1 (1:500; Santa Cruz Biotechnology, Santa Cruz, USA), OCC and NG2 (1:500 ...
• Klebsiella pneumoniae reduces SUMOylation to limit host defence responses

  Joana Sá-Pessoa, et al., bioRxiv - Microbiology 2020

  Quote: ... anti-Cullin-1 (1:200, Santa Cruz Biotechnology sc-12761), anti-Flag M2 (1 μg ...
• Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

  Robin M. Delaine-Smith, et al., bioRxiv - Cancer Biology 2021

  Quote: ... GLI-1 Antibody (C-1, sc-515751) from Santa Cruz Biotechnology.
• APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy

  Leslie A. Bruggeman, et al., bioRxiv - Pathology 2019

  Quote: ... rabbit polyclonal WT-1 (1:200 dilution, Santa Cruz Biotech). Podocyte counts ...
• Reliance of neuronal gene expression on cohesin scales with chromatin loop length

  Lesly Calderon, et al., bioRxiv - Genomics 2022

  Quote: ... CUX-1 (1:400; rabbit polyclonal sc-13024, Santa Cruz) and anti phospho-histone H3 (Ser10 ...
• Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation

  Stacia M. Dolliver, et al., bioRxiv - Microbiology 2022

  Quote: ... TIA-1 (1:200; goat, Santa Cruz Biotechnology, sc-1751); TIAR (1:1000 ...
• Multiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health

  James L. Daly, et al., bioRxiv - Neuroscience 2022

  Quote: ... VPS29 (Santa Cruz; D-1; sc-398874; 1:500 WB), VPS35 (Abcam ...
• Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models

  Yibo Zuo, et al., bioRxiv - Microbiology 2022

  Quote: ... anti-Ubiquitin (Ub) (Santa Cruz, 12987-1-AP, 1:1000), anti-K48 Ub (Cell Signaling Technology ...
• A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons

  Monika Moissidis, et al., bioRxiv - Neuroscience 2024

  Quote: ... mouse anti-PGC-1⍺ (1:200, Santa Cruz #sc-518025), mouse anti-Kv1.1 (1:1,000 ...
• The phospho-regulated amphiphysin/endophilin interaction is required for synaptic vesicle endocytosis

  Christiana Kontaxi, Michael A. Cousin, bioRxiv - Neuroscience 2023

  Quote: ... goat syndapin 1 (1:1000; Santa Cruz Biotechnology, sc-10412), and mouse PSD95 (1:1000 ...
• Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

  Adam Myszczyszyn, et al., bioRxiv - Cell Biology 2023

  Quote: ... rat anti-Zo-1 (1:200, Santa Cruz, sc-33725), mouse anti-MDR1 (1:50 ...
• A chemical probe to modulate human GID4 Pro/N-degron interactions

  Dominic D.G Owens, et al., bioRxiv - Molecular Biology 2023

  Quote: ... ARMC8 (E-1, sc-365307; Santa Cruz Biotechnology, 1:500), WDR26 (ab85962 ...
• The large GTPase Guanylate-Binding Protein-1 (GBP-1) promotes mitochondrial fission in glioblastoma

  Ryan C. Kalb, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Anti-GBP-1 (1b1) (1:25; Calbiochem or Santa Cruz), anti-myc (1:50 ...
• Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis

  Katsuhiro Togami, et al., bioRxiv - Cancer Biology 2020

  Quote: ... The blots were washed 3 times in TBS with 0.1% Tween-20 before being incubated with either rabbit (Santa Cruz Biotechnology, SC-2004) or mouse (Santa Cruz Biotechnology ...
• EpCAM Aptamer siRNA chimeras: Therapeutic efficacy in epithelial cancer cells

  Jayashree Balasubramanyam, et al., bioRxiv - Cancer Biology 2019

  Quote: ... Then the blot was washed 3 times with PBST and probed with secondary anti-mouse conjugated with HRP (Santa Cruz Biotechnology: sc-2005) at 1:4500 dilution for 1 h ...
• Uncoating of COPII from ER exit site membranes precedes cargo accumulation and membrane fission

  Olga Shomron, et al., bioRxiv - Cell Biology 2019

  Quote: ... at 4 °C followed by 3–18 h rotated incubation with protein A/G agarose beads (Santa Cruz Biotechnology, Santa Cruz, CA, USA) at 4 °C ...
• Uncoating of COPII from ER exit site membranes precedes cargo accumulation and membrane fission

  Olga Shomron, et al., bioRxiv - Cell Biology 2019

  Quote: ... at 4 °C followed by 3–18 h rotated incubation with protein A/G agarose beads (Santa Cruz Biotechnology, Santa Cruz, CA, USA) at 4 °C ...
• The metronomic combination of paclitaxel with cholinergic agonists inhibits triple negative breast tumor progression. Participation of M₂ receptor subtype

  Alejandro J. Español, et al., bioRxiv - Pharmacology and Toxicology 2019

  Quote: ... The results of the densitometric analysis of the bands were expressed as optical density (O.D.) units relative to the expression of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (Santa Cruz Biotechnology Inc., USA) [20].
• Female specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and Estrogen Receptor α

  Gemma Molinaro, et al., bioRxiv - Neuroscience 2024

  Quote: ... Then 10% of the lysate was set aside for use as an input control and the rest was tumbled overnight at 4°C with 7 µl of ERα antibody or 1.4 µg of Homer antibody (Santa Cruz Biotechnology, D-3). The same isotype IgG was used as control for the specificity of the ERα (Abcam #ab172730 ...
• HIV-1 binds dynein directly to hijack microtubule transport machinery

  Somayesadat Badieyan, et al., bioRxiv - Microbiology 2023

  Quote: ... To determine interaction between BicDR1 and the viral capsid protein p24 cells were permeabilized and blocked using 3% donkey serum followed by incubation with primary antibodies targeting p24 (Santa Cruz sc-69728) and BicDR1 (Atlas Antibodies HPA041309) ...
• Autophagy suppression in DNA damaged cells occurs through a newly identified p53-proteasome-LC3 axis

  D’Feau J. Lieu, et al., bioRxiv - Cell Biology 2024

  Quote: ... Stabilization of p53 as a consequence of Nutlin-3 treatment was assessed through immunoblot analysis for an increase in the total cellular levels of total p53 in monolayers incubated in the presence of Nutlin-3 (20 μM) using primary antibodies specific to p53 (#sc-126, Santa Cruz Biotechnology, USA).
• Mutation of the allexivirus-specific P40 gene of Wineberry latent virus, an isolate of Blackberry virus E, greatly reduces virus multiplication

  Wendy McGavin, et al., bioRxiv - Plant Biology 2024

  Quote: ... The GFP gene with an in-frame foot and mouth disease virus (FMDV) 2A autocatalytic peptidase domain at its 3’ end was PCR amplified from pTXS.GFP-CP (Santa Cruz et al., 1996), using primers 4456 (WLV CP promoter+5’GFP plus sense ...
• Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis

  Andreas Brunner, et al., bioRxiv - Cell Biology 2024

  Quote: ... S% C02 in DMEM supplemented with 40 μM BrdU/BrdC (ratio 3:l, BrdU: BS002, Sigma-Aldrich, BrdC: sc-284SSS, Santa Cruz Biotech). Degradation of EGFP-AID-STAG2 was induced by the addition of S00 µM Inole-3-acetic acid (IAA ...
• High Sucrose Diets Contribute to Brain Angiopathy with Impaired Glucose Uptake, and Psychosis-related Higher Brain Dysfunctions in Mice

  Shinobu Hirai, et al., bioRxiv - Neuroscience 2021

  Quote: ... PV-235; 1:1000), rabbit anti-glucose transporter 1 (Glut1, Frontier Institute, Af1020; 1:1000) and mouse anti-tubulin (Santa Cruz, sc-32293; 1:10000). After washing three times with TBST ...
• Melanoma Addiction to GCDH is Mediated by NRF2 Tumor Suppressor Function

  Sachin Verma, et al., bioRxiv - Cancer Biology 2021

  Quote: ... (dilution 1:1,000) Mcl-1 Antibody (22) (dilution, 1: 1,000) and HSP90 (F-8) (dilution, 1: 5,000) from Santa Cruz Biotechnology ...
• Nucleotide Biosynthesis Links Glutathione Metabolism to Ferroptosis Sensitivity

  Amy Tarangelo, et al., bioRxiv - Cancer Biology 2021

  Quote: ... human p53 (Cat #SC-126, DO-1, Santa Cruz, 1:1000), p21 C’-terminus (Cat# 2947 ...
• Chlamydia coinfection inhibits HPV-induced safeguards of the cellular and genomic integrity in patient-derived ectocervical organoids

  Stefanie Koster, et al., bioRxiv - Cancer Biology 2021

  Quote: ... mouse-anti-p53 (DO-1) (1:500, Santa Cruz, # sc-126), mouse-anti-Chlamydia Hsp60 (A57-E4 ...
• Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins

  Yulia Steblyanko, et al., bioRxiv - Cell Biology 2020

  Quote: ... mouse anti-PRC1 (C-1) (1:500; Santa Cruz, sc-3769839), mouse anti-NDC80/HEC1 (1:2000 ...
• Syndecan-4^-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components

  Sissel Beate Rønning, et al., bioRxiv - Cell Biology 2020

  Quote: ... and anti-LOX (1:500, 1% casein, sc-32409, Santa Cruz). Anti-rabbit IgG HRP (NA934V ...
• Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at the base of primary cilia and suppresses ciliary elongation

  Stine Kjær Morthorst, et al., bioRxiv - Cell Biology 2022

  Quote: ... mouse anti-PALS-1 (Santa Cruz, cat#sc-365411; 1:50), goat anti-MYC (Abcam ...
• Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

  Philip McGoldrick, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-Importin β-1 (Santa Cruz sc-11367, 1:50), goat anti-Lamin B (Santa Cruz sc-6217 ...
• Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

  Philip McGoldrick, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-Importin β-1 (Santa Cruz sc-1863, 1:50), mouse anti-Importin β-1 (Santa Cruz sc-137016 ...
• Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

  Philip McGoldrick, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-Importin β-1 (Santa Cruz sc-137016, 1:50), rabbit anti-Importin β-1 (Santa Cruz sc-11367 ...
• Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

  Philip McGoldrick, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-Importin β-1 (Santa Cruz sc-1863, 1:50), mouse anti-Importin β-1 (Santa Cruz sc-137016 ...
• CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal

  Lisa Crozier, et al., bioRxiv - Cancer Biology 2021

  Quote: ... mouse anti-p53 (DO-1) (Santa Cruz, sc-126; 1/1000), rabbit anti-actin (Sigma ...
• Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

  Hyosung Kim, et al., bioRxiv - Neuroscience 2022

  Quote: ... mouse anti-VCAM-1 (1:200 dilution, sc-13160, Santa Cruz), goat anti-VE-cadherin (1:300 dilution ...
• Extended longevity geometrically-inverted proximal tubule organoids for protein uptake studies

  Eric Parigoris, et al., bioRxiv - Bioengineering 2022

  Quote: ... mouse anti-aquaporin-1 (Santa Cruz #sc-32737, 1:200 dilution), mouse anti-ezrin/villin-2 (BD #610602 ...
• Pharmacological tuning of microRNAs in FAP-derived Extracellular Vesicles by HDAC inhibitors promotes regeneration and reduces fibrosis in dystrophic muscles

  M. Sandonà, et al., bioRxiv - Cell Biology 2020

  Quote: ... rabbit anti-Flotillin-1 (1/200, H-104, Santa Cruz Biotechnology), mouse anti-Alix (3A9 ...
• Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

  Philip McGoldrick, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-Importin β-1 (Santa Cruz sc-137016, 1:1000) and mouse anti-Ran-GTPase (BD Biosciences 610340 ...
• Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

  Philip McGoldrick, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-Importin β-1 (Santa Cruz sc-137016, 1:50), mouse anti-KPNA (BD Biosciences 610485 ...
• Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production

  Seok Hee Lee, et al., bioRxiv - Developmental Biology 2022

  Quote: ... monocarboxylic acid transporter 1 (MCT1, 1:200; sc-365501, Santa Cruz), lactate dehydrogenase A (LDHA ...