6 Chloro 2 3 diphenylimidazo 1 2 b pyridazine citations for Santa Cruz

Quote: ... Differentiated T37i brown adipocytes were transfected with a pool of 3 target-specific siRNAs against FXN mRNA FXN or scramble siRNAs (Santa Cruz Biotechnology, Dallas, TX, USA) by using DeliverX Plus kit (Affymetrix ...

Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia

Jan Zlamal, et al., bioRxiv - Immunology 2022

Quote: ... 75 μL of wPLTs were pretreated with the Fc-gamma-RIIA blocking monoclonal antibody (moAb) anti-CD32 (moAb IV.3; Stemcell™ technologies, Vancouver, Canada) or a monoclonal isotype control (clone SC-2025; Santa Cruz Biotechnology, Dallas, USA) for 30 min at RT prior to HIT IgG treatment ...

Dose escalation pre-clinical trial of novel DOK7-AAV in mouse model of DOK7 congenital myasthenia

Judith Cossins, et al., bioRxiv - Neuroscience 2024

Quote: Nitrocellulose was incubated in blocking buffer (PBS containing 3% powdered skimmed milk) for 30 minutes at rt and then incubated with primary mouse anti-DOK7 antibody (Santa Cruz cat no sc-390856) diluted 1:250 in blocking buffer for 1 hour at rt with gentle agitation ...

A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation

Sierra Swords, et al., bioRxiv - Cell Biology 2023

Quote: Neurobasal medium) every 3 days. Neurons were co-transfected with Control shRNA (Cat. sc108060) or DnaJC13 (RME-8) shRNA (Santa Cruz, Cat. sc-77968-SH) with GFP-LC3 ...

Alternative splicing in neuroblastoma generates RNA-fusion transcripts and is associated with vulnerability to spliceosome inhibitors

Yao Shi, et al., bioRxiv - Cancer Biology 2020

Quote: ... Following primary antibodies were used: BAG2(sc-390262, 1:200), phospho-ser396-Tau(sc-101815, 1:1000), HSC70(sc-7298, 1:200) from Santa Cruz; phosphor-ser404-Tau(44-758G ...

In vivo-mimicking 3D cultures secrete distinct extracellular vesicles upon cancer cell invasion

Jens C. Luoto, et al., bioRxiv - Cell Biology 2020

Quote: ... anti-APOA1 (sc-376818, 1:100), anti-ITGB4 (sc-514426, 1:300) and anti-VCL (sc-73614, 1:500) was bought from Santa Cruz Biotechnology.

Circumventing drug treatment? Polyethylenimine functionalized nanoparticles inherently and selectively kill patient-derived glioblastoma stem cells

Neeraj Prabhakar, et al., bioRxiv - Cancer Biology 2020

Quote: ... and incubated with a primary antibody PARP-1 (sc-7150, 1:1000) and P62 (sc-28359, 1:500 dilution) from Santa Cruz Biotechnology ...

The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2

Ana Domingo-Muelas, et al., bioRxiv - Neuroscience 2022

Quote: ... 1:800 rat anti-BrdU, Abcam ab6326; 1:400 chicken anti-DCX, Abcam ab153668; 1:300 goat anti-DCX, Santa Cruz sc-8066 ...

Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues

Joel Pinczewski, et al., bioRxiv - Pathology 2020

Quote: Working concentrations of antibodies to βcat (1:500, Epitomics, Burlingame, CA # 1247-1) and phospho-βcat (pS33-βcat 1:200, Santa Cruz, Santa Cruz ...

Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon navigation

Hiroki Takechi, et al., bioRxiv - Neuroscience 2020

Quote: ... rat antibody to CadN (Ex#8, 1:50, DSHB), mouse antibody to Repo (8D12, 1:20, DSHB) mouse antibody to myc (4E10, 1:100, Santa Cruz), rabbit antibody to RFP (1:500 ROCKLAND) ...

The Splicing Factor XAB2 interacts with ERCC1-XPF and XPG for RNA-loop processing during mammalian development

Evi Goulielmaki, et al., bioRxiv - Genetics 2020

Quote: ... 1:50), XPA (wb: 1:500), XPF (F-11, wb: 1:500) and XPG (sc12558, wb: 1:200) were from Santa Cruz Biotechnology ...

Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders

Pallavi M. Gosavi, et al., bioRxiv - Molecular Biology 2021

Quote: ... MOLM-13 and K562 cells were transduced by spinfection at 1,800 × g for 1.5 h at 37 °C with 5 μg ml-1 and 1 μg ml-1 polybrene (Santa Cruz Biotechnology), respectively ...

Isoform-specific Disruption of the TP73 Gene Reveals a Critical Role for TAp73gamma in Tumorigenesis via Leptin

Xiangmudong Kong, et al., bioRxiv - Cancer Biology 2022

Quote: ... anti-p21 (sc-53870, 1:3000), anti-p130 (sc-374521, 1:3000) and anti-PML (sc-377390, 1:3000) were purchased from Santa Cruz Biotechnology ...

Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB

Zhicheng Cui, et al., bioRxiv - Cell Biology 2022

Quote: ... antibodies to GAPDH (6C5) (Cat# sc-32233 - 1:15000 WB) and LAMP-1 (H4A3) (Cat# sc-20011 - 1:500 IF) were from Santa Cruz; antibody to HA.11 Epitope Tag (Cat# 901513 ...

α-syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson’s disease

A Anandhan, et al., bioRxiv - Neuroscience 2022

Quote: ... anti-GPx4 (1:1000, sc-166570), anti-AKR1C1 (1:1000, sc-398596), and anti-GCLM (1:1000, sc-166603) were from Santa Cruz Biotechnology (Dallas ...

Site-Specific Knockdown of Microglia in the Locus Coeruleus Regulates Hypervigilant Responses to Social Stress in Female Rats

Brittany S. Pate, et al., bioRxiv - Neuroscience 2022

Quote: ... PVDF membranes incubated overnight at 4°C with the following primary antibodies diluted in 1:1 Blok/0.1M PBS + 0.2% Tween-20 : mouse anti-GAPDH (1:1000, Santa Cruz, Santa Cruz, CA), rabbit anti-CX3CL1 (1:1000 ...

Haloperidol-induced immediate early genes in striatopallidal neurons requires the converging action of cAMP/PKA/DARPP-32 and mTOR pathways

Oriane Onimus, et al., bioRxiv - Neuroscience 2022

Quote: ... Antibodies for cFos (1:400, #sc-52), Arc (1:400, #sc-17839), and Zif268 (1:400, #sc-189) were purchased from Santa Cruz Biotechnology [29] ...

The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells

Chengfang Pan, et al., bioRxiv - Physiology 2024

Quote: ... Cells were then incubated in primary antibody solution (primary antibody (anti-EP1: 1:200, Ab217925, Abcam, UK; anti-EP2: 1:200, Ab167171, Abcam; anti-EP3: 1:200, Sc-57105, Santa Cruz Biotechnology ...

Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

Niklas J. Lang, et al., bioRxiv - Cell Biology 2023

Quote: ... 10% normal donkey serum or 1% BSA were used for blocking nonspecific binding and primary antibodies were incubated (VWA1 1:100, Proteintech, 14322-1-AP; CLDN5 1:100, Santa Cruz, sc-374221 ...

A potent agonist-based PROTAC targeting Pregnane X Receptor that delays colon cancer relapse

Lucile Bansard, et al., bioRxiv - Cancer Biology 2024

Quote: ... final dilution: 1/500), Ubiquitin (sc-166553, final dilution: 1/500) and PXR (sc-48340, final dilution: 1/500) from Santa Cruz, GSPT1 (ab126090 ...

Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

Peng Xie, et al., bioRxiv - Molecular Biology 2024

Quote: Antibody against HAND1 (sc-390376) (WB: 1:1000, IF for embryos: 1:100, IF for cells: 1:200) was purchased from Santa Cruz. Antibody against FOXF1 (Abclonal ...

Annexin A2 and lamin B join membrane recycling compartments for the assembly of biomolecular condensates operating in mitotic partitioning

Ann Kari Grindheim, et al., bioRxiv - Cell Biology 2024

Quote: ... while the mouse monoclonal antibody against LAMP-1 (H5G11; 1:200 dilution) and rabbit polyclonal antibody against Rab7 (R4779; 1:50 dilution) were purchased from Santa Cruz Biotechnology and Sigma ...

G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

Yi-Hong Li, et al., bioRxiv - Immunology 2024

Quote: ... followed by incubation at 4◦C overnight with primary antibodies diluted in the blocking buffer (rabbit anti-Dclk1 1:1000, Abcam, ab31704; rabbit anti-Dclk1-488 1:1000, Abcam, ab202754; rabbit anti-Gnat3 1:500, Santa Cruz Biotechnology ...

EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells

Irini Topalidou, et al., bioRxiv - Cell Biology 2019

Quote: ... mouse monoclonal anti-GFP (1:200 to 1:350, Santa Cruz, #sc-9996), mouse monoclonal anti-insulin (1:350 ...

Syndecan-4^-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components

Sissel Beate Rønning, et al., bioRxiv - Cell Biology 2020

Quote: ... anti-Pax-7 (1:500, sc-81648, 1:500, 1x casein, Santa Cruz) anti-decorin (1:500 ...

Inhibitors of the Bub1 spindle assembly checkpoint kinase: Synthesis of BAY-320 and comparison with 2OH-BNPP1

Ilma Amalina, et al., bioRxiv - Cell Biology 2020

Quote: ... mouse anti-p53 (DO-1) (Santa Cruz Biotechnology cat#sc-126, 1:1000). Membranes were then washed three times in TBST and incubated for at least 1 hr with appropriate horseradish-peroxidase-conjugated secondary antibodies (1:2000) ...

Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

Kuan Zhang, et al., bioRxiv - Developmental Biology 2021

Quote: ... rat anti-PECAM-1 (CD31) (1:150, Santa Cruz Biotechnology, Cat# sc-18916), rabbit anti-PDGFRA (1:150 ...

The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

Swati Mishra, et al., bioRxiv - Cell Biology 2022

Quote: ... Lysosome associated membrane protein-1 (LAMP1) at 1:250 (#sc 2011; Santa Cruz); Tropomyosin receptor kinase B (TRKB ...

Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols Towards Downstream Isolation and Analysis

Roberto Frigerio, et al., bioRxiv - Biochemistry 2020

Quote: ... anti-TSG101 (1:1000, Novus Bio) and anti-Apo1 (1:1000, Santa Cruz). After washing with T-TBS ...

IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic SNCA mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium release

Peter A. Barbuti, et al., bioRxiv - Neuroscience 2020

Quote: ... –TUBB3 (1:300; Covance, MRB-435P) -Vimentin (1:100; Santa Cruz, sc-373717). Secondary antibodies used were ...

Translational profiling of mouse dopaminoceptive neurons reveals a role of PGE2 in dorsal striatum

Enrica Montalban, et al., bioRxiv - Neuroscience 2020

Quote: ... Vehicle (DMSO in PBS, 1/1) or misoprostol (Santa Cruz Biotechnology, #SC-201264), were infused at a dose of 50 μg.kg−1.day−1 ...

A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding

Lei Wang, et al., bioRxiv - Neuroscience 2022

Quote: ... anti-SATB2 (Millipore, ABE600, 1:2,000; Santa Cruz Biotechnology, sc-81376, 1:50), anti-TBR1 (Millipore ...

Neonatal endotoxin stimulation was associated with long- term innate immune markers and an anti-allergic response in bronchiolar epithelium in spite of allergen challenge

Luciana N García, et al., bioRxiv - Cell Biology 2019

Quote: ... TSLP (1:200- Gene Tex, USA) or pEGFR (1:50 - Santa Cruz Biotechnology), with bound antibodies being detected using anti-rabitt (for SP-D ...

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion

Aowen Zhuang, et al., bioRxiv - Molecular Biology 2019

Quote: ... OST48 (H-1; 1:100 dilution; SC-74408; Santa Cruz biotechnologies, United States), nephrin (1:100 dilution ...

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion in experimental diabetic kidney disease via promotion of endoplasmic reticulum stress

Aowen Zhuang, et al., bioRxiv - Molecular Biology 2019

Quote: ... OST48 (H-1; 1:100 dilution; SC-74408; Santa Cruz biotechnologies, United States), GRP78 (A-10 ...

Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function

Manish Kumar, et al., bioRxiv - Cancer Biology 2020

Quote: ... 53BP1 (1:200, CST) or anti-BRCA1 primary antibody (1:500, Santa Cruz) overnight at 4°C ...

Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation

Amit Benbenishty, et al., bioRxiv - Neuroscience 2019

Quote: ... and endothelial cells with anti-CD31 (PCAM-1) antibody (1:500; Santa Cruz). A secondary Alexa 647 antibody (1:600 ...

Specificity of Gβ and γ subunits to the SNARE complex both at rest and after α_2a adrenergic receptor stimulation

Yun Young Yim, et al., bioRxiv - Biochemistry 2021

Quote: ... and rabbit anti-Gβ (Santa Cruz, sc-378, 1:10,000 and 1:5000) were used ...

Inhibitory effect of the TSG-6 on the BMP-4/Smad signaling pathway and odonto/osteogenic differentiation of dental pulp stem cells

Ying Wang, et al., bioRxiv - Cell Biology 2020

Quote: The antibodies used for immunohistochemistry included DMP-1 (1:100 dilution, Santa Cruz), DSPP (1:100 dilution ...

Inhibitory effect of the TSG-6 on the BMP-4/Smad signaling pathway and odonto/osteogenic differentiation of dental pulp stem cells

Ying Wang, et al., bioRxiv - Cell Biology 2020

Quote: ... the primary antibodies were as follows: DMP-1 (1:200 dilution, Santa Cruz) and DSPP (1:200 dilution ...

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