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2851 - 2900 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Anti-inflammatory role of GM1 and modulatory effects of gangliosides on microglia functions

  Danny Galleguillos, et al., bioRxiv - Neuroscience 2020

  Quote: ... and Mouse/Rat IGF-1 Quantikine ELISA kit (R&D Systems, MG100), respectively ...
• AraC binds the p75^NTR transmembrane domain to induce neurodegeneration in mature neurons

  Vanessa Lopes-Rodrigues, et al., bioRxiv - Cell Biology 2021

  Quote: ... monoclonal anti–β-III tubulin (R&D systems, Cat: MAB1195, 1:10000), polyclonal anti-p75NTR (Neuromics ...
• Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta

  Darcy T. Ahern, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 1:50 for the PIGF ELISA (R&D Systems, Minneapolis, MN).
• Zfp503/Nlz2 is Required for RPE Differentiation and Optic Fissure Closure

  Elangovan Boobalan, et al., bioRxiv - Developmental Biology 2022

  Quote: ... goat polyclonal anti-OTX2 (R&D Systems, Minneapolis, MN, AF1979, 1:2000), goat polyclonal anti-Chx10/Vsx2 (Santa Cruz Biotechnology ...
• Isoform-specific O-glycosylation dictates Ebola virus infectivity

  Ieva Bagdonaite, et al., bioRxiv - Microbiology 2022

  Quote: ... goat anti-E-cadherin (1:200, R&D Systems Cat. Nr. AF648), rabbit anti-Myc (1:200 Abcam Cat ...
• Extracellular vesicles induce aggressive lung cancer via non-canonical integrin-EGFR-KRAS signaling

  Karla Rubio, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Antibodies used were specific for ITGB2 (1:500 dilution, R&D Systems), and VIM (1:500 dilution ...
• Early precision of radial patterning of the mouse cochlea is achieved by a linear BMP signaling gradient and is further refined by SOX2

  Matthew J. Thompson, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and goat-anti-SOX2 (1:400, R&D Systems #AF2018 Lot KOYO418121) in PBS-T with 2% DS ...
• Osteopontin deficiency leads to the resolution of prostatic fibrosis and inflammation

  Petra Popovics, et al., bioRxiv - Pathology 2021

  Quote: ... and anti-OPN (AF808, R&D Systems, Minneapolis, MN, 1:100 dilution) were added overnight ...
• The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

  Pierre-Luc Rochon, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-Osteopontin (1:1000, R&D Systems, Minneapolis, MN, RRID: AB_2194992); goat anti-VAChT (1:1000 ...
• An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis

  Raphaëlle Lesage, et al., bioRxiv - Systems Biology 2021

  Quote: ... Recombinant Mouse IGF-I/IGF-1 Protein (10ng/ml, R&D Systems), Transforming Growth Factor (TGF)β1 (10ng/ml ...
• Histone demethylase UTX regulates glioblastoma progression through affecting periostin expression

  Yan Luan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... VCAM1 and Pro-Collagen I alpha 1 ELISA kit (R&D Systems) according to the manufacturer’s instructions ...
• Kallikrein-related peptidase 14 activates zymogens of membrane type matrix metalloproteinases (MT-MMPs) - a CleavEx library-based analysis

  Katherine Falkowski, et al., bioRxiv - Biochemistry 2020

  Quote: ... and 1 μg ProMMP17 (catalog no. 7796-MP-010, R&D systems) were separately incubated in 10 μl with a range of KLK14 concentrations (25-250 nM ...
• LTBP1 promotes fibrillin incorporation into the extracellular matrix

  Matthias Przyklenk, et al., bioRxiv - Cell Biology 2021

  Quote: ... A goat anti-LAP (TGF□1) antibody was from R&D Systems.
• Dissecting Mammalian Spermatogenesis Using Spatial Transcriptomics

  Haiqi Chen, et al., bioRxiv - Genomics 2020

  Quote: ... Sheep anti-acetyl histone H4 antibody (1:100, AF5215, R&D Systems), and Alexa Fluor 594- ...
• The MEMIC: An ex vivo system to model the complexity of the tumor microenvironment

  Libuše Janská, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 10 ng/mL Recombinant Mouse CSF-1 (R&D Systems, 416-ML), and 1x Antibiotic-Antimycotic (Gibco ...
• Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts

  Odemaris Narvaez del Pilar, Jichao Chen, bioRxiv - Developmental Biology 2021

  Quote: ... goat anti-hedgehog-interacting protein (HHIP, 1:1000, R&D Systems, AF1568), guinea pig anti-lysosomal-associated membrane protein 3 (LAMP3 ...
• BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoids

  Michael Notaras, et al., bioRxiv - Neuroscience 2021

  Quote: ... Primary antibodies comprised SOX2 (1:1000; R&D Systems, CAT#: MAB2018-SP), PAX6 (1:1000 ...
• Nef dimerization defect abrogates HIV viremia and associated immune dysregulation in the Bone Marrow-Liver-Thymus-Spleen (BLTS) humanized mouse model

  Shivkumar Biradar, et al., bioRxiv - Immunology 2021

  Quote: ... IL-6 (1000 U/mL; R&D Systems Cat# 206–1 L), and PGE2 (2 μM ...
• Human Surfactant Protein D Binds S1 and Receptor Binding Domain of Spike protein and acts as an entry inhibitor of SARS-CoV-2 Pseudotyped viral particles in vitro

  Miao-Hsi Hsieh, et al., bioRxiv - Microbiology 2020

  Quote: ... the wells were incubated with streptavidin-HRP (1:40; R&D Systems) for 20 min ...
• PD-1 dependent expansion of Amphregulin⁺FOXP3⁺ cells is associated with oral immune dysfunction in HIV patients on therapy

  N Bhaskaran, et al., bioRxiv - Immunology 2021

  Quote: ... and the chimeric PDL-1-Fc were purchased from R&D systems. Appropriate secondary antibodies such as secondary donkey anti-mouse IgG-BV421 (for IL1-RI staining) ...
• Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor Sema 3A

  Blake A. Creighton, et al., bioRxiv - Cell Biology 2021

  Quote: ... or Ephrin A5 (1 µg/ml, R&D Systems, Cat. 374-EA) for 1 ...
• Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model

  Felicia Reinitz, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Goat antibody to Sox2 (anti-Sox2) (1:50; R&D Systems AF2018) and rabbit anti-GFAP (1:500 ...
• Antibody-directed extracellular proximity biotinylation reveals Contactin-1 regulates axo-axonic innervation of axon initial segments

  Yuki Ogawa, et al., bioRxiv - Neuroscience 2023

  Quote: ... goat polyclonal anti-Cntn1 (1:500; R&D Systems Cat# AF904, RRID:AB_2292070), mouse monoclonal anti-Myc (1:2000 ...
• Targeting the MR1-MAIT Cell Axis Improves Vaccine Efficacy and Affords Protection against Viral Pathogens

  Rasheduzzaman Rashu, et al., bioRxiv - Immunology 2023

  Quote: ... or 1 μg of recombinant mouse interferon-β (rmIFNβ) (R&D Systems), all in PBS.
• Neural Extracellular Matrix Remodeling Signatures in Genetic and Acquired Mouse Models of Epilepsy

  Armand Blondiaux, et al., bioRxiv - Neuroscience 2023

  Quote: ... sheep anti-neurocan (R&D Systems, AF5800; 1:200 for WB; RRID:AB_2149717); goat anti-Tenascin-R (Santa-Cruz ...
• A novel ILK/STAT3 pathway controls plasticity in a neural stem cell model of glioblastoma

  Alexander E. P. Loftus, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 1 µg/mL laminin-I (R&D Systems; #3446-005-01). Cells were passaged every second day by dissociation with accutase (Sigma-Aldrich ...
• Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state but is not necessary for differentiation

  Sonia Nocera, et al., bioRxiv - Neuroscience 2023

  Quote: ... Primary antibodies used were anti-PDGFRα 1:150 (goat, R&D system), anti-CC1 1:100 (mouse ...
• A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis

  Max L. Cohen, et al., bioRxiv - Cell Biology 2023

  Quote: ... sFRP2 (cat. no. 6838-FR, R&D Systems, 60 ng ml−1) and KN93 (cat ...
• Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolism

  Mariana I. Tsap, et al., bioRxiv - Neuroscience 2023

  Quote: ... mouse anti-CathepsinL (#1515-CY-010, 1:400) from R&D Systems; rabbit anti-Cas3 (#9662 ...
• Primary human lung fibroblasts exhibit trigger- but not disease-specific cellular senescence and impair alveolar epithelial cell progenitor function

  Nora Bramey, et al., bioRxiv - Cell Biology 2023

  Quote: ... human Serpin E1/PAI-1 Duo Set (R&D Systems, cat.# DY1786), and human total MMP-3 (R&D Systems ...
• Decline of DNA damage response along with myogenic differentiation

  Haser Hasan Sutcu, et al., bioRxiv - Cell Biology 2023

  Quote: ... mouse anti-PARP1 (R&D Systems, Bio-Techne, 4338-MC; 1:1,000); rabbit anti-RAD51 (Abcam ...
• Cyclic mechanical stretching stimuli promotes angiocrine signals during in vitro liver bud formation from human pluripotent stem cells

  Koki Yoshimoto, et al., bioRxiv - Bioengineering 2023

  Quote: ... and 10 ng mL− 1 FGF-10 (human recombinant) (R&D Systems). The cells were then treated with RPMI medium GlutaMax™ Supplement containing 2% (v/v ...
• Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter Deficiency

  Léa Broca-Brisson, et al., bioRxiv - Neuroscience 2023

  Quote: ... A control measurement with isotype-matched control (1:100, R&D Systems) was included ...
• Neural Extracellular Matrix Remodeling Signatures in Genetic and Acquired Mouse Models of Epilepsy

  Armand Blondiaux, et al., bioRxiv - Neuroscience 2023

  Quote: ... goat anti-Hapln1 (R&D Systems, AF2608, 1:200 for WB; RRID:AB_2116135); goat anti-Hapln4 (R&D Systems ...
• Antagonism between viral infection and innate immunity at the single-cell level

  Frederic Grabowski, et al., bioRxiv - Systems Biology 2022

  Quote: ... anti-human interferon beta (catalog number MAB8142; R&D Systems; 1:100).
• Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation

  Jiageng Liu, et al., bioRxiv - Bioengineering 2024

  Quote: ... goat anti-E-cadherin (1:200, AF748, R&D systems, RRID: AB_355568), rat anti-PDGFRA (1:200 ...
• Structural insights into CXCR4 modulation and oligomerization

  Kei Saotome, et al., bioRxiv - Biochemistry 2024

  Quote: ... or 1 mM AMD3100 (AMD 3100 octahydrochloride, R&D Systems Catalog #: 3299), or ∼1 to 1.5 mg/mL REGN7663 Fab and incubated on ice for ∼1 hour ...
• An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma

  Annegret Holm, et al., bioRxiv - Molecular Biology 2024

  Quote: An anti-mouse-specific CD31 monoclonal antibody (1:100, R&D Systems,) was used to quantify mouse vessels in the Matrigel implants ...
• Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment

  Ilaria Aurigemma, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and 1 ng/ml human BMP4 (R&D Systems Cat# 314-BP). The media were changed to serum-free differentiation media without additional growth factors after 2 days ...
• iSCORE-PD: an isogenic stem cell collection to research Parkinson’s Disease

  Oriol Busquets, et al., bioRxiv - Neuroscience 2024

  Quote: ... + Dibutyryl-cAMP (SelleckChem; 0.5 mM) + TGFꞵ3 (R&D Systems; 1 ng/ml) + DAPT (ToCris ...
• Hypoxia disrupts circadian rhythms in astrocytes and causes synapse engulfment defects

  Li Li, et al., bioRxiv - Neuroscience 2024

  Quote: ... 20 ng ml−1 epidermal growth factor (R&D Systems, 236-EG) and 20 ng ml−1 basic fibroblast growth factor (R&D Systems ...
• Atacama Clear for Complex 3D Imaging of Organs

  Neranjan de Silva, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and cardiac Troponin-T (NB110-2546, R&D Systems, at 1:500). Minimally cross-absorbed Alexa Flour secondary antibodies were used to detect primary antibodies.
• Low intensity repetitive transcranial magnetic stimulation enhances remyelination by newborn and surviving oligodendrocytes in the cuprizone model of toxic demyelination

  Phuong Tram Nguyen, et al., bioRxiv - Neuroscience 2024

  Quote: ... Primary antibodies included goat anti- PDGFRα (1:100, R&D Systems AF1062), rabbit anti-OLIG2 (1:400 ...
• Common genetic variation impacts stress response in the brain

  Carina Seah, et al., bioRxiv - Genetics 2023

  Quote: ... 40 ng ml–1 brain-derived neurotrophic factor (BDNF, R&D Systems), 40 ng ml–1 glial cell line-derived neurotrophic factor (GDNF ...
• FoxO transcription factors actuate the formative pluripotency specific gene expression programme

  Laura Santini, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1:100 for anti-ESRRB (mouse; R&D Systems, PP-H6705-00), 1:250 for anti-FLAG M2 (mouse ...
• The CCR4/CCL17 axis drives intestinal acute Graft versus Host disease after allogeneic bone marrow transplantation

  Sebastian Schlaweck, et al., bioRxiv - Immunology 2024

  Quote: ... 1% P/S containing CCL17 (800ng/ml, R&D Systems, #529-TR), when indicated ...
• CXCL4 signaling and gene induction in human monocytes

  Chao Yang, et al., bioRxiv - Immunology 2024

  Quote: ... and labeled with anti-CXCL4-PE (1:50) (R&D system, IC7952P) and anti-TLR4 (10 µg/ml ...
• Classification of iPSC-Derived Cultures Using Convolutional Neural Networks to Identify Single Differentiated Neurons for Isolation or Measurement

  Purva Patel, et al., bioRxiv - Neuroscience 2023

  Quote: ... The primary antibodies tested are 1:75 SOX1 (AF3369, R&D Systems), 1:500 Olig2 rIgG (AB9610 ...
• iSCORE-PD: an isogenic stem cell collection to research Parkinson’s Disease

  Oriol Busquets, et al., bioRxiv - Neuroscience 2024

  Quote: ... + Dibutyryl-cAMP (SelleckChem; 0.5 mM) + TGFꞵ3 (R&D Systems; 1 ng/ml) + CHIR99021 (SelleckChem ...
• Highly-parallel production of designer organoids by mosaic patterning of progenitors

  Catherine M. Porter, et al., bioRxiv - Bioengineering 2023

  Quote: ... sheep anti-human Nephrin (1:40, AF4269-SP, R&D Systems, RRID:AB_2154851), goat anti-human RET (1:50 ...