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2701 - 2750 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Methionine availability influences essential H3K36me3 dynamics during cell differentiation

  Yudong Sun, et al., bioRxiv - Cell Biology 2023

  Quote: ... all diluted 1:1000: Myosin Heavy Chain (R&D System mAB4470), ActB (CST 8457T) ...
• c-Src induced vascular malformations require localised matrix degradation at focal adhesions

  Patricia Essebier, et al., bioRxiv - Cell Biology 2023

  Quote: ... goat anti-VE-cadherin (R&D systems, AF938, WB 1:2000), goat anti-VEGFR2 (R&D systems ...
• The activation of INF2 by Piezo1/Ca²⁺ is required for mesenchymal to amoeboid transition in confined environments

  Neelakshi Kar, et al., bioRxiv - Cell Biology 2024

  Quote: ... VCAM-1 (cat no. 862-VC; R&D Systems, Minneapolis, MN) or BSA (cat no ...
• Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches

  John M. Viola, et al., bioRxiv - Bioengineering 2023

  Quote: ... goat anti-ITGA8 (1:20, AF4076, R&D systems, RRID: AB_2296280), rabbit anti-LEF1 (1:200 ...
• A clinical stage LMW-DS drug inhibits cell infection by coronaviruses and modulates reactive cytokine release from microglia

  Ann Logan, et al., bioRxiv - Immunology 2022

  Quote: ... MCP-1 and TNFα by Luminex (R&D Systems; LXSAHM-04).
• De-differentiation and Proliferation of Artery Endothelial Cells Drive Coronary Collateral Development

  Gauri Arolkar, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Anti-VEGFR2 (1:125, R&D Systems, Catalog# AF644, RRID: AB_355500). Secondary antibodies ...
• Dual role of brain endothelial Gpr126 in blood-brain barrier development and ischemic stroke

  Nikolaos Kakogiannos, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-integrin β1 (1:10, AF 2325; R&D Systems; EM), anti-integrin α1 goat (1:500 ...
• Cell surface receptors TREM2, CD14 and integrin α_Mβ₂ drive sinking engulfment in phosphatidylserine-mediated phagocytosis

  Daan Vorselen, et al., bioRxiv - Cell Biology 2022

  Quote: ... or CD14 (R&D systems, 982-CD-100, 1 mg/mL). Strips were washed 3 × (5 minutes agitation each ...
• Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

  Junedh M. Amrute, et al., bioRxiv - Immunology 2022

  Quote: ... and IL-1b (R&D systems, AF-401-NA, 1:50) co-stained with an appropriate secondary antibody ...
• Polar growth protein Wag31 undergoes changes in homo-oligomeric network topology, and has distinct functions at both cell poles and the septum

  Neda Habibi Arejan, et al., bioRxiv - Microbiology 2022

  Quote: Cultures were stained with 1 μg/mL HADA (R&D systems) for 15 minutes with rolling and incubation at 37°C ...
• Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable

  Kseniia Sarieva, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-SOX2 (goat, 1:500, R&D Systems, Cat. no. AF2018), anti-PAX6 (mouse ...
• The novel coronary artery disease risk factor ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1

  M. Amin Sharifi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and goat anti-Timp-1 (#cnl0320021; R&D Systems, Minneapolis, USA) as primary antibodies overnight at 4 °C ...
• An Activity-Based Nanosensor for Minimally-Invasive Measurement of Protease Activity in Traumatic Brain Injury

  Julia A. Kudryashev, et al., bioRxiv - Bioengineering 2022

  Quote: ... and incubated with 1:200 streptavidin-HRP (R&D Systems, DY998) for 1 hour ...
• Human Abdominal Subcutaneous-Derived Active Beige Adipocytes Carrying FTO rs1421085 Obesity-Risk Alleles Exert Lower Thermogenic Capacity

  Attila Vámos, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-UCP1 (1:750, R&D Systems, Minneapolis, MN, USA, MAB6158), anti-OXPHOS (1:1000 ...
• Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells

  Liliana M. Sanmarco, et al., bioRxiv - Immunology 2023

  Quote: ... goat anti-HIF-1α (R&D Systems, 1:100, AF1935-SP), rabbit anti-NDUFA4L2 (Proteintech ...
• The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions

  Zheng Fan, et al., bioRxiv - Cell Biology 2022

  Quote: ... and antibodies against CD31 (PECAM1) (AF3628, R&D Systems, 1:250) or ERG (#97249 ...
• Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme

  Amy H. Chan, et al., bioRxiv - Immunology 2023

  Quote: ... human IL-1β (goat polyclonal antibody, 1:1000, R&D Systems), caspase-1 (D7F10 ...
• The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

  Claudia Carlantoni, et al., bioRxiv - Developmental Biology 2023

  Quote: ... goat anti-VE-cadherin (Cat#: AF1002, R&D Systems, 1:1000), rabbit anti-CLDN5 (Cat# ...
• The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

  Claudia Carlantoni, et al., bioRxiv - Developmental Biology 2023

  Quote: ... goat anti-VE-cadherin (Cat#: AF1002, R&D Systems, 1:200) rabbit anti-LYVE1 (Cat# ...
• Transformation of primary murine peritoneal mast cells by constitutive KIT activation as a result of lost Cdkn2a/Arf expression

  Sandro Capellmann, et al., bioRxiv - Immunology 2023

  Quote: ... and anti-TNF antibodies (1:250, R&D Systems, #BAF-410) diluted in PBS+1% BSA for 45 minutes and 2 hours ...
• Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme

  Amy H. Chan, et al., bioRxiv - Immunology 2023

  Quote: ... human IL-1β (goat polyclonal antibody, 1:1000, R&D Systems), caspase-1 (D7F10 ...
• SMAD4: A Critical Regulator of Cardiac Neural Crest Cell Fate and Vascular Smooth Muscle Differentiation

  Brianna E. Alexander, Huaning Zhao, Sophie Astrof, bioRxiv - Developmental Biology 2023

  Quote: ... and Goat anti-VEGFR2 (1:200, R&D Systems Inc., AF644). Primary antibodies were detected with secondary antibodies from Invitrogen (1:300) ...
• Myosin inhibitor reverses hypertrophic cardiomyopathy in pediatric iPSC-cardiomyocytes to mirror variant correction

  Caroline Kinnear, et al., bioRxiv - Genetics 2023

  Quote: ... or anti-MYH7 antibody (1:500, R&D systems, Minneapolis, MN) by shaking gently overnight at 4 °C ...
• Progranulin inhibits phospholipase sPLA2-IIA to control neuroinflammation

  Huan Du, et al., bioRxiv - Neuroscience 2023

  Quote: ... goat anti-CathD (R&D systems, AF1029, 1:100 for immunostaining), sheep anti-mouse sPLA2-IIA (ThermoFisher Scientific ...
• Stem cells tightly regulate dead cell clearance to maintain tissue fitness

  Katherine S Stewart, et al., bioRxiv - Cell Biology 2023

  Quote: ... and rat anti-Axl-AlexaFluor700 (R&D Systems, FAB8541N, 1:200). Secondary antibodies were used as follows ...
• Stem cells tightly regulate dead cell clearance to maintain tissue fitness

  Katherine S Stewart, et al., bioRxiv - Cell Biology 2023

  Quote: ... rat anti-Tyro3/Dtk-AlexaFluor700 (R&D Systems, FAB759N, 1:200), rat anti-Mertk-AlexaFluor700 (R&D Systems ...
• Inhibition of Inflammatory Osteoclasts Enhances CGRP⁺TrkA⁺ Signaling and Accelerates Callus Remodeling in Osteoporotic Fractures

  Yuexia Shu, et al., bioRxiv - Pathology 2024

  Quote: ... GSK3β and p-GSK3β (1:500, AF1590-SP, R&D Systems), GAPDH (1:500 ...
• Identification of a targetable ST2-expressing fibroblast subset driving Peutz-Jeghers syndrome polyposis

  Eva Domènech-Moreno, et al., bioRxiv - Cancer Biology 2024

  Quote: ... R-Spondin 1 (R&D Systems 3474-RS; 250 ng/ml) and N-acetylcysteine (A0737 ...
• Turnover of PPP1R15A mRNA encoding GADD34 controls the molecular memory of the cellular integrated stress response

  Vera Magg, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-phospho-Akt (R&D systems, Cat# AF887; 1:1,000; BSA), anti-HCV NS5A (NS5A 9E10 was a gift from Charles Rice ...
• Nephron progenitors rhythmically alternate between renewal and differentiation phases that synchronize with kidney branching morphogenesis

  Sachin N. Davis, et al., bioRxiv - Developmental Biology 2024

  Quote: ... sheep anti-NPHS1 (1:40, AF4269, R&D Systems, RRID: AB_2154851), and biotinylated LTL (1:300 ...
• Nephron progenitors rhythmically alternate between renewal and differentiation phases that synchronize with kidney branching morphogenesis

  Sachin N. Davis, et al., bioRxiv - Developmental Biology 2024

  Quote: ... goat anti-GATA3 (1:20, AF2605, R&D Systems, RRID: AB_2108571), sheep anti-NPHS1 (1:40 ...
• Maternal Immune Activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells

  Sandra M. Martín-Guerrero, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-β-III tubulin 1:100 (R&D Systems, MAB1195-SP), anti-GFAP 1:100 (Cell Signaling ...
• Enhancing oncolytic virotherapy by exosome-mediated microRNA reprograming of the tumour microenvironment

  Victoria A. Jennings, et al., bioRxiv - Cancer Biology 2024

  Quote: ... were coated with mouse anti-CD63 (1:250) (R&D systems) overnight at 4°C ...
• Reversing Pdgfrβ Signaling Restores Metabolically Active Beige Adipocytes by Alleviating ILC2 Suppression in Aged and Obese Mice

  Abigail M. Benvie, Daniel C. Berry, bioRxiv - Cell Biology 2024

  Quote: ... rat anti-F4/80 (1:200; R&D Systems MAB5580-SP). Secondary antibodies from Invitrogen or Jackson ImmunoResearch were used at 1/200 dilutions and incubated for 2 hours at room temperature ...
• Reproducible differentiation of pure ovarian support cells from clinical-grade hiPSCs as a novel infertility treatment

  Bruna Paulsen, et al., bioRxiv - Bioengineering 2024

  Quote: ... goat polyclonal antibody against NANOG (1:50; AF1997, R&D systems), and Alexa Fluor 488 mouse monoclonal antibody against TRA-1-60 (1:100 ...
• Single-cell profiling of penta- and tetradactyl mouse limb buds identifies mesenchymal progenitors controlling digit numbers and identities

  Victorio Palacio, et al., bioRxiv - Developmental Biology 2024

  Quote: ... For detecting GREM1 we utilized (1:100, R&D Systems, AF956) and for p-SMAD1.5.9 we applied (1:100 ...
• BMP4 regulates asymmetric Pkd2 distribution in mouse nodal immotile cilia and ciliary mechanosensing required for left–right determination

  Takanobu A. Katoh, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μg/mL for Noggin treatment (1967-NG; R&D Systems), 1% v/v of phosphate-buffered saline (PBS ...
• A sexually dimorphic hepatic cycle of periportal VLDL generation and subsequent pericentral VLDLR-mediated lipoprotein re-uptake

  Tomaz Martini, et al., bioRxiv - Physiology 2024

  Quote: ... and goat anti-E-CAD (R&D systems AF478, 1 : 200). After washes with 1x PBS ...
• Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic mice

  Jason C. Hsu, et al., bioRxiv - Pathology 2024

  Quote: ... and ACE2 (R&D Systems, AF933, Minneapolis, MN, USA, 1:250); IBA1 (GeneTex ...
• Dynamic changes in structure and function of brain mural cells around chronically implanted microelectrodes

  Steven M. Wellman, et al., bioRxiv - Bioengineering 2024

  Quote: ... goat anti-PDGFRβ (1:100, AF1042, R&D Systems, Minneapolis, MN), mouse anti-Ki67 (1:100 ...
• The transcriptomic landscape of spinal V1 interneurons reveals a role for En1 in specific elements of motor output

  Alexandra J. Trevisan, et al., bioRxiv - Neuroscience 2024

  Quote: ... mouse anti-Nr3b3 (1:2000, R&D Systems #PP-H6812-00); rabbit anti-Nr4a2 (1:500 ...
• Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

  Peiyuan Chai, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Anti-VEGF-A165 (R&D Systems, AF293-NA, immunoblot 1:1000) and donkey anti-Goat IgG secondary antibody (LI-COR Biosciences ...
• Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

  Nobuyuki Nosaka, et al., bioRxiv - Immunology 2024

  Quote: ... CXCL-1 (Mouse CXCL1/KC DuoSet ELISA, DY453, R&D Systems), IL-18 (Mouse IL-18 Matched ELISA Antibody Pair Set ...
• Altered striosome-matrix distribution and activity of striatal cholinergic interneurons in a model of autism-linked repetitive behaviors

  Jordan Molitor, et al., bioRxiv - Neuroscience 2024

  Quote: ... goat anti-ephrin-A4 (EphA4, 1:150, R&D systems, AF641); guinea-pig anti-TSHZ3 (1:2000 ...
• Oligodendrocyte precursor cells exacerbate acute CNS inflammation via macrophage and T cell activation in a mouse model of multiple sclerosis

  Kana Ohashi, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-CD45 (AF114-SP, goat IgG, 1:50; R&D Systems), anti-CD11c (14-0114-82 ...
• Combining Scalable Organ Chip Platform with Deep Learning-Based Imaging Analysis for Cancer Therapeutic Screening

  Yu-Chieh Yuan, et al., bioRxiv - Bioengineering 2024

  Quote: ... Rat Tail Collagen Type 1 (R&D Systems, 3447-020-01) prepared at 4 mg/mL with a 1:1:8 ratio of 3.7% (w/v ...
• Seoul orthohantavirus evades innate immune activation by reservoir endothelial cells

  Stefan Klimaj, et al., bioRxiv - Microbiology 2024

  Quote: ... Recombinant rat IFNβ was purchased from R&D Systems (13400–1) and used at 10-150U/milliliter ...
• Let-7 restrains an oncogenic epigenetic circuit in AT2 cells to prevent ectopic formation of fibrogenic transitional cell intermediates and pulmonary fibrosis

  Matthew J. Seasock, et al., bioRxiv - Cell Biology 2024

  Quote: ... Rat anti-RAGE/AGER (1:100, R&D Systems, MAB1179-100),
• Hedgehog-dependent and Hedgehog-independent roles for Growth Arrest Specific 1 in mammalian kidney morphogenesis

  Nicole E. Franks, Benjamin L. Allen, bioRxiv - Developmental Biology 2024

  Quote: ... and goat anti-GAS1 (1:900, R&D Systems; Cat#AF2544) or goat anti- GFRA1 (1:500 ...
• Hedgehog-dependent and Hedgehog-independent roles for Growth Arrest Specific 1 in mammalian kidney morphogenesis

  Nicole E. Franks, Benjamin L. Allen, bioRxiv - Developmental Biology 2024

  Quote: ... or goat anti- GFRA1 (1:500, R&D Systems, Cat# AF560) overnight at 4°C ...