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2751 - 2800 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Braf-mutant Schwann cells divert to a repair phenotype to induce congenital demyelinating neuropathy

  Elise Marechal, et al., bioRxiv - Developmental Biology 2024

  Quote: ... mouse monoclonal to Erbb3 at 1/100 (#MAB348; R&D Systems), rabbit polyclonal to S100b at 1/1000 (#HPA015768 ...
• Midline Assembloids Reveal Regulators of Human Axon Guidance

  Massimo M. Onesto, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-hROBO3 antibody (1:100 dilution, goat, R&D Systems, AF3076).
• Reproducible differentiation of pure ovarian support cells from clinical-grade hiPSCs as a novel infertility treatment

  Bruna Paulsen, et al., bioRxiv - Bioengineering 2024

  Quote: ... goat polyclonal antibody against SOX2 (1:50; AF2018, R&D systems), goat polyclonal antibody against NANOG (1:50 ...
• Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature

  Charlie J. Childs, et al., bioRxiv - Bioengineering 2024

  Quote: ... goat anti-E-Cadherin 1:500 (R&D Systems Cat# AF748), mouse anti-E-Cadherin 1:500 (BD Transduction Laboratories Cat# 610181) ...
• The ER stress transcription factor Luman/CREB3 is a novel regulator of Schwann cell survival and myelinating capacity through the activation of the unfolded protein response and cholesterol biosynthesis pathways

  Justin Michael A. Naniong, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 10 ng mL-1 neuregulin/NRG1-β1 (R&D Systems) in a humidified 5% CO2 incubator at 37°C ...
• Transient upregulation of procaspase-3 during oligodendrocyte fate decisions

  Yasmine Kamen, et al., bioRxiv - Neuroscience 2024

  Quote: ... rat anti-CA II (R&D Systems, Cat# MAB2184, 1:200), mouse anti-CC1 (Millipore ...
• Müller glia cell cycle re-activation by simultaneous cyclin D1 overexpression and p27^kip1 knockdown promotes retinal regeneration in mice

  Zhifei Wu, et al., bioRxiv - Neuroscience 2024

  Quote: ... goat anti-Otx2 antibody (1:200, AF 1979; R&D systems), mouse anti-HuC/D antibody (1:200 ...
• Local keratinocyte-nociceptor interactions enhance obesity-mediated small fiber neuropathy via NGF-TrkA-PI3K signaling axis

  Yuta Koui, et al., bioRxiv - Neuroscience 2024

  Quote: ... Goat anti-TrkB antibody (R&D Systems, AF1494-SP, 1:100), and Goat anti-TrkC antibody (R&D Systems ...
• Local keratinocyte-nociceptor interactions enhance obesity-mediated small fiber neuropathy via NGF-TrkA-PI3K signaling axis

  Yuta Koui, et al., bioRxiv - Neuroscience 2024

  Quote: ... Goat anti-TrkA antibody (R&D Systems, AF1056-SP, 1:100), Goat anti-TrkB antibody (R&D Systems ...
• Glial scar formation by reactive astrocytes derived from oligodendrocyte progenitor cells after closed-head injury

  Hinata Matsuda, et al., bioRxiv - Neuroscience 2024

  Quote: ... goat anti-PDGFRα (1:40; R&D Systems, Minneapolis, MN, USA), goat anti-PDGFRβ (1:200 ...
• Nephron progenitors rhythmically alternate between renewal and differentiation phases that synchronize with kidney branching morphogenesis

  Sachin N. Davis, et al., bioRxiv - Developmental Biology 2024

  Quote: ... goat anti-JAG1 (1:150, AF599, R&D Systems, RRID: AB_2128257), goat anti-GATA3 (1:20 ...
• G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

  Yi-Hong Li, et al., bioRxiv - Immunology 2024

  Quote: ... and Mouse IL-1 beta DuoSet ELISA (R&D Systems, DY401) following the manufacturer’s instruction ...
• Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

  Peiyuan Chai, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 1 µg/mL of recombinant human IgG1 Fc (R&D Systems), Siglec-1 Fc chimera protein (R&D Systems) ...
• Eosinophils promote monocyte to macrophage differentiation and anti-bacterial immunity

  Gillian J Wilson, et al., bioRxiv - Immunology 2024

  Quote: ... Lyve-1- Alexa Fluor 488 (223322) was from R&D Systems, and ALOX15 Alexa Fluor 488 (AA 581-662 ...
• Defining a Muscle Stem Cell matrisome signature: from transcriptome data to extracellular matrix niche topology.

  Emilie Guillon, et al., bioRxiv - Cell Biology 2024

  Quote: ... sheep anti-human M-cadherin (R&D Systems AFH096; 1/100); rat anti-mouse PDGFRA (Invitrogen 17-1401-81 ...
• A second wave of Notch signaling diversifies the intestinal secretory lineage

  Eleanor Zagoren, et al., bioRxiv - Cell Biology 2024

  Quote: ... Goat anti-Notch2 (1:100 15min, R&D Systems, AF1190-SP), Rabbit anti-Muc2 (1:1000 O/N ...
• A bioengineered model of human placental exposure to environmental metals during pregnancy

  Pouria Fattahi, et al., bioRxiv - Bioengineering 2024

  Quote: ... and Human TGF Beta 1 ELISA Kit (DY240, R&D Systems).
• Fluid Flow Impacts Endothelial-Monocyte Interactions in a Model of Vascular Inflammatory Fibrosis

  Isabelle Linares, et al., bioRxiv - Bioengineering 2024

  Quote: ... 100 ng/ml of MCP-1 (R&D Systems, 279-MC) was infused into the bottom channel of devices immediately before monocyte addition.
• Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial maturity

  E O’Loughlin, et al., bioRxiv - Cancer Biology 2024

  Quote: ... total FRS2 (1:500 for immunoblot; R&D Systems clone 462910), β-tubulin (1:2000 for immunoblot ...
• Reconstitution of Human Brain Cell Diversity in Organoids via Four Protocols

  Julia Naas, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 200 ng ml-1 Noggin (R&D Systems, cat. no. 6057), 10 µM SB431542 (Stemgent ...
• Phospholipase D3 regulates TFEB/TFE3 metabolism to maintain lysosomal homeostasis

  Yongchao Wang, et al., bioRxiv - Cell Biology 2024

  Quote: ... goat anti-LCTSB (AF965, R&D systems, 1:1000 for WB), goat anti-CTSD (AF1014 ...
• Phospholipase D3 regulates TFEB/TFE3 metabolism to maintain lysosomal homeostasis

  Yongchao Wang, et al., bioRxiv - Cell Biology 2024

  Quote: ... goat anti-CTSD (AF1014, R&D systems, 1:1000 for WB), mouse anti-ubiquitin (13-1600 ...
• Non-cell-autonomous control of gastruloid development by the lncRNA T-UCstem1 through DKK1-dependent modulation of WNT signalling

  Arianna Coppola, et al., bioRxiv - Developmental Biology 2024

  Quote: ... DKK-1 recombinant protein (R&D systems, cat: 5439-10 μg) was dissolved in PBS 1X containing at least 0.1% BSA at a concentration of 100 μg/mL and used at a concentration of 200 ng/mL ...
• The pericardium forms as a distinct structure during heart formation

  Hannah R. Moran, et al., bioRxiv - Developmental Biology 2024

  Quote: ... The sFRP1 (Recombinant Human sFRP-1 Protein, CF, R&D systems) solution was freshly prepared for each treatment by dissolving in phosphate-buffered saline (PBS ...
• LFA-1 signals to promote actin polymerization and upstream migration in T cells

  Nathan H Roy, et al., bioRxiv - Cell Biology 2020

  Quote: ... Recombinant mouse ICAM-1-Fc and VCAM-1-Fc were purchased from R&D Systems. Antibodies for flow cytometery were from BioLegend ...
• Optimization of long-term human iPSC-derived spinal motor neuron culture using a dendritic polyglycerol amine-based substrate

  Louise Thiry, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-FORKHEAD BOX PROTEIN 1 (FOXP1) (1/100; R&D Systems; Cat. No. AF4534); and mouse anti-neurofilament protein (2H3 ...
• Common variation in EDN1 regulatory regions highlights the role of PPARγ as a key regulator of Endothelin in vitro

  Mauro Lago-Docampo, et al., bioRxiv - Cell Biology 2021

  Quote: We quantified ET-1 levels using the Endothelin-1 Quantikine ELISA kit (R&D systems). First we diluted the media 1/125 in the appropriate buffer and used 75 μL of the dilution for the assay ...
• Drug connectivity mapping and functional analysis reveals therapeutic small molecules that differentially modulate myelination

  F Pieropan, et al., bioRxiv - Systems Biology 2020

  Quote: ... goat anti-PDGFRα (1:200, R&D Systems; mouse anti-APC (CC1; 1:300, Millipore); rabbit anti-GFAP (1:300 ...
• Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells

  Kaitlin E. Murtha, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and appropriate Alexa Fluor (Thermo 1:200) and Northern Lights (R&D Systems 1:200) conjugated secondary antibodies were incubated for 2 hours at 37ºC ...
• Recovery of cryo-injured rabbit urethras by biofabricated C-shaped adipose-derived mesenchymal cell structures

  Sudha Silwal Gautam, et al., bioRxiv - Bioengineering 2020

  Quote: ... STRO-1 (1:100, animal poly- or mono-, R&D System, Inc., Minneapolis, MN, USA) and the extracellular markers anti-integrin β1 (1:50 ...
• Langerhans islets induce anti-tumor immunity at the expense of glycemic control and predict chemotherapy response in pancreatic cancer

  Azaz Ahmed, et al., bioRxiv - Cancer Biology 2021

  Quote: ... NKp46 (1:175, HIER 1, monoclonal mouse, clone 195314, R&D Systems, USA; MAB1850-500), FoxP3 (1:100 ...
• MEKK3-TGFβ crosstalk regulates inward arterial remodeling

  Hanqiang Deng, et al., bioRxiv - Pathology 2021

  Quote: Endothelin-1 ELISA was performed on plasma using Endothelin-1 Immunoassay kit (R&D Systems) according to manufacturer’s instructions ...
• SorCS2 deletion leads to altered neuronal lysosome activity

  Sérgio Almeida, et al., bioRxiv - Cell Biology 2021

  Quote: ... and SorCS2 (R&D systems, AF4237, 1:1000 in WB and 1:100 in ICC).
• Novel insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis

  Yasuaki Uehara, et al., bioRxiv - Molecular Biology 2021

  Quote: ... and MCP-1 (CCL2 /JE/MCP-1 ELISA kit, R&D Systems Inc., Minneapolis, MN) in mouse serum ...
• Characterization of human-iPSCs derived spinal motor neurons by single-cell RNA sequencing

  Louise Thiry, et al., bioRxiv - Neuroscience 2020

  Quote: ... goat anti-FORKHEAD BOX PROTEIN 1 (FOXP1) (1/100; R&D Systems; Cat. No. AF4534), and guinea pig anti-SCIP (1/16,000 ...
• Towards Modular Engineering of Cell Signalling: Topographically-Textured Microparticles Induce Osteogenesis via Activation of Canonical Hedgehog Signalling

  Fatmah I. Ghuloum, et al., bioRxiv - Bioengineering 2023

  Quote: ... human/mouse GLI-1 affinity purified polyclonal (1:100; AF3455, R&D systems, RRID: AB_2247710), RUNX2 (27-K ...
• Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow

  Tongling Huang, et al., bioRxiv - Molecular Biology 2023

  Quote: ... or CD31/PECAM-1 Alexa Fluor 488-conjugated Antibody (1:200; R&D system #FAB3628G). After primary antibody incubation ...
• A Mem-dELISA platform for dual color and ultrasensitive digital detection of colocalized proteins on extracellular vesicles

  Himani Sharma, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Human Glypican 1 (GPC-1) biotinylated antibody was purchased from R&D systems (MN, USA). Biotinylated anti-CD63 ...
• Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

  Louise Thiry, et al., bioRxiv - Neuroscience 2024

  Quote: ... goat anti-FORKHEAD BOX PROTEIN 1 (FOXP1) (1/100; R&D Systems; Cat. No. AF4534); mouse anti-neurofilament protein (2H3 ...
• The activation of INF2 by Piezo1/Ca²⁺ is required for mesenchymal to amoeboid transition in confined environments

  Neelakshi Kar, et al., bioRxiv - Cell Biology 2024

  Quote: ... were coated with VCAM-1 (1 µg/mL) (cat no. 862-VC; R&D Systems) overnight at 4 °C.
• Dual role of brain endothelial Gpr126 in blood-brain barrier development and ischemic stroke

  Nikolaos Kakogiannos, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-m/rCD31/PECAM-1 Alexa Fluor 488 Conjugated (1:50, FAB3628G; R&D Systems); Claudin-5 (1:200 ...
• RNA-sensing pattern-recognition receptors synergize with TLR2 or dectin-1 to trigger high production of IL-12p70 by human dendritic cells

  Brian C. Gilmour, et al., bioRxiv - Immunology 2022

  Quote: ... 50 μL/well of a 1:1 solution of H2O2 (R&D Systems, part #895000) and tetramethylbenzidine (R&D Systems ...
• Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens

  Aereas Aung, et al., bioRxiv - Immunology 2021

  Quote: ... Cathepsin D (1029-AS-010, R&D Systems), Cathepsin S (50769-M08H ...
• Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration

  Pabitra K. Sahoo, et al., bioRxiv - Neuroscience 2024

  Quote: ... or poly-D-lysine + aggrecan (R&D Systems) coated coverslips ...
• Relative Mutant N501Y SARS-CoV-2 Spike Protein RBD Inhibition of Anti-Spike Protein IgG and ACE-2 Binding to Spike Protein Species

  Melvin E. Klegerman, et al., bioRxiv - Biochemistry 2021

  Quote: ... Test wells were coated with 5 µg recombinant spike protein (rSP; S1+S2; R&D Systems, Minneapolis, MN)/ml coating buffer (0.05 M sodium bicarbonate ...
• UBE2N is essential for maintenance of skin homeostasis and suppression of inflammation

  Min Jin Lee, et al., bioRxiv - Pathology 2023

  Quote: ... Cells were filtered through 40µm cell strainer with 4mL of RPMI + 5% FBS (R&D Systems, Minneapolis, MN), and the unfiltered tissues were further digested with 4mL of 0.05% Trypsin and incubated at 37°C for 10 minutes ...
• Aggressive KRAS mutations direct TGF-β response towards partial EMT in patient-derived colorectal cancer tumoroids

  Theresia Mair, et al., bioRxiv - Cancer Biology 2024

  Quote: ... ENAS + 5 ng/ml TGF-β1 (Recombinant Human TGF-β1 Protein, R&D Systems, Cat. No. 240-B). Basal medium + solvent ...
• Potent antitumor activity of a designed interleukin-21 mimic

  Jung-Ho Chun, et al., bioRxiv - Biochemistry 2024

  Quote: ... 1x mIL-21 (14.9 µg per mouse, n=5 mice; R&D Systems Cat# 594-ML-100/CF), 10x mIL-21 (149 µg per mouse ...
• GPR43 in eosinophils prevents the emergence of pathogenic Siglec-F^hi neutrophils in allergic airway inflammation

  Jihyun Yu, et al., bioRxiv - Immunology 2024

  Quote: ... The mediium was then changed to new culture medium containing 10 ng/ml IL-5 (R&D Systems). On days 8 and 11 ...
• Human Surfactant Protein D Binds S1 and Receptor Binding Domain of Spike protein and acts as an entry inhibitor of SARS-CoV-2 Pseudotyped viral particles in vitro

  Miao-Hsi Hsieh, et al., bioRxiv - Microbiology 2020

  Quote: ... the wells were washed and then incubated with human SP-D detecting antibody (0.5 μg/ml) (R&D Systems; 1:180) for 2 h at room temperature ...