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1951 - 2000 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Mutagenesis of human cytomegalovirus glycoprotein L disproportionately disrupts gH/gL/gO over gH/gL/pUL128-131

  Eric P. Schultz, et al., bioRxiv - Microbiology 2021

  Quote: ... supplemented with 5% heat-inactivated fetal bovine serum (FBS) (R&D Systems, Minneapolis, MN, USA) and 5% Fetalgro® (Rocky Mountain Biologics ...
• Phenotypic, molecular and functional characterisation of human in vitro-generated IL-17A+ CD8+ T-cells

  Elizabeth H. Gray, et al., bioRxiv - Immunology 2022

  Quote: ... neutralising anti-IFNγ or isotype control (mouse IgG2b, both 5 μg/mL, R&D Systems) were added to cultures ...
• Epigenetic memory acquired during long-term EMT induction governs the recovery to the epithelial state

  Paras Jain, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Cells were treated with 5 ng/mL recombinant human TGFβ1 (R&D Systems, 240-B) prepared according to the manufacture’s specifications ...
• Gut microbiota gate host exposure to metabolites from dietary Solanums

  Catherine S. Liou, et al., bioRxiv - Microbiology 2024

  Quote: ... BChE activity was analogously measured using 5 ng of recombinant human BChE (R&D Systems) and butyrylthiocholine iodide ...
• CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan

  Linda Heilig, et al., bioRxiv - Microbiology 2023

  Quote: ... Hyphae were incubated with soluble CD56 (5 µg/mL, R&D Systems, Minneapolis, MN, USA) or BSA (control ...
• Innate extracellular Hsp70 inflammatory properties are mediated by the interaction of Siglec-E and LOX-1 receptors

  Thiago J. Borges, et al., bioRxiv - Immunology 2023

  Quote: ... 5 µg/ml of recombinant mouse Siglec-E-Fc chimera (R&D Systems, Cat. 5806) in 100 μl of buffer (10mM Tris-HCl (pH7.4) ...
• Interaction of osteoprotegerin with fibulin-1 is essential for extracellular matrix deposition in fibrotic lung tissue

  Y Liu, et al., bioRxiv - Pathology 2024

  Quote: ... Some cells then treated with 5 ng/mL TGFβ1 (cat#7666-MB, R&D Systems) and incubate for 24 hours ...
• A Novel C. elegans Model for Tau Spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation

  Carl Alexander Sandhof, et al., bioRxiv - Cell Biology 2024

  Quote: ... supplemented with 10 ng/mL BDNF and 5 ng/mL GDNF (both R&D Systems), 200 µM Ascorbic Acid ...
• Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes Towards a Purkinje Fiber Fate

  David M. Gonzalez, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Medium was changed to differentiation medium supplemented with 5 ng/ml VEGF (R&D Systems) and 5 μmol/L XAV (Stemgent) ...
• Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes Towards a Purkinje Fiber Fate

  David M. Gonzalez, et al., bioRxiv - Developmental Biology 2024

  Quote: ... medium was changed to differentiation medium supplemented with 5 ng/ml VEGF (R&D Systems). After Day 8 ...
• Puromycin selection of cells with a high expression of the cytochrome P450 CYP3A4 gene activity from a patient with drug-induced liver injury (DILI) and their lifespan prolongation using a combination of CDK4^R24C, cyclin D1 and TERT

  Shoko Miyata, et al., bioRxiv - Cell Biology 2020

  Quote: ... α-fetoprotein (R&D Systems, MAB1368, diluted at 1/100), and CYP3A4 (SANTA CRUZ BIOTECHNOLOGY ...
• Defining Epidermal Stem Cell Fate Infidelity and Immunogenicity in Hidradenitis Suppurativa at the Single-Cell Resolution

  Meaghan Marohn, et al., bioRxiv - Cell Biology 2020

  Quote: ... goat anti-Klf5 (1:500, R&D Systems, AF3758), rabbit anti-Cldn1 (1:100 ...
• Defining Epidermal Stem Cell Fate Infidelity and Immunogenicity in Hidradenitis Suppurativa at the Single-Cell Resolution

  Meaghan Marohn, et al., bioRxiv - Cell Biology 2020

  Quote: ... mouse anti-Sox10 (1:800, R&D Systems, MAB2864), rabbit anti-Sox9 (1:1000 ...
• Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts

  Lara-Jane Kepser, et al., bioRxiv - Cell Biology 2020

  Quote: ... mouse anti-GAPDH (1:10,000, #MAB5718, R&D Systems)
• Extraembryonic endoderm cells induce neuroepithelial tissue in gastruloids

  Noémie M. L. P. Bérenger-Currias, et al., bioRxiv - Developmental Biology 2021

  Quote: ... goat anti-GATA6 (1:200, AF1700, R&D Systems), rabbit anti-Laminin (1:200 ...
• Extraembryonic endoderm cells induce neuroepithelial tissue in gastruloids

  Noémie M. L. P. Bérenger-Currias, et al., bioRxiv - Developmental Biology 2021

  Quote: ... goat anti-T (1:100, AF2085, R&D systems), mouse anti-DAB2 (1:100 ...
• Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad

  Chloé Mayère, et al., bioRxiv - Developmental Biology 2021

  Quote: ... goat anti-SOX9 (1:1000, AF3075, R&D Systems), rat anti-LAMB1 (1:500 ...
• Aire-dependent transcripts escape H3K36me3 and Raver2 induced alternative splicing to sustain central immune tolerance

  Francine Padonou, et al., bioRxiv - Immunology 2021

  Quote: ... and TGF-β (1 ng/mL) (R&D Systems). The medium 1 was changed every day ...
• Single-cell transcriptomics of the early developing mouse cerebral cortex disentangles the spatial and temporal components of neuronal fate acquisition

  Matthieu X. Moreau, et al., bioRxiv - Developmental Biology 2020

  Quote: ... goat anti-Nurr1 (R&D systems AF2156, 1:200), mouse anti-Meis2 (Sigma WH0004212M1 ...
• Zfp36l1 and Zfp36l2 balances proliferation and differentiation in the developing retina

  Fuguo Wu, et al., bioRxiv - Developmental Biology 2020

  Quote: ... goat anti-Isl1 (R&D systems AF1837, 1:100), mouse anti-Nr2e3 (R&D systems PP-H7223,1:100) ...
• Early cis-regulatory events in the formation of retinal horizontal cells

  Estie Schick, et al., bioRxiv - Developmental Biology 2020

  Quote: ... goat anti-Otx2 (Af1979, R&D Systems,1:400), and mouse IgG2b anti-HNF-6 (sc-376308 ...
• Self-organized stem cell-derived human lung buds with proximo-distal patterning and novel targets of SARS-CoV-2

  E.A. Rosado-Olivieri, et al., bioRxiv - Developmental Biology 2021

  Quote: ... goat anti-SOX2 (R&D Systems; AF2018; 1:250), rabbit anti-NKX2.1 (Abcam ...
• Hypoxia induces a transcriptional early primitive streak signature in pluripotent cells enhancing spontaneous elongation and lineage representation in gastruloids

  Natalia López-Anguita, et al., bioRxiv - Developmental Biology 2022

  Quote: ... goat anti-SOX2 (R&D Systems, AF2018; 1:500), goat anti-FOXA2 (Santa Cruz ...
• Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection

  Kyung Ku Jang, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-BRG1 (1:250, R&D systems, MAB5738), mouse anti-FOXM1 (1:100 ...
• Physiological basis underlying antidepressant-induced activation of TrkB receptors

  Okko Alitalo, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-mTrkB (#AF1494, RRID:AB_2155264, 1:1000, R&D Systems), anti-GSK3β (#9315 ...
• Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke

  Takashi Irie, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-HBEGF (1:200, AF259; R&D Systems), mouse anti-HBEGF (1:500 ...
• Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain

  Marie Karam, Guy Malkinson, Isabelle Brunet, bioRxiv - Neuroscience 2021

  Quote: ... anti-ephb4 (R&D Systems, AF446-SP, 1:100), anti-SMA (Sigma ...
• The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

  Katie J Smith, et al., bioRxiv - Immunology 2022

  Quote: ... CD31 (rat polyclonal, R&D Systems, #AF3628, 1:100), peripheral node addressin (MECA-79 ...
• Gastric metabolomics analysis supports H. pylori’s catabolism of organic and amino acids in both the corpus and antrum

  Daniela Keilberg, et al., bioRxiv - Microbiology 2020

  Quote: ... 1 μg/mL mouse R-spondin (R&D systems), 100 ng/mL Noggin (Peprotech) ...
• A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

  Ryan J. Geusz, et al., bioRxiv - Genomics 2020

  Quote: ... goat anti-SOX17 (1:300 dilution, R&D systems); goat anti-HNF4A (1:1000 dilution ...
• A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

  Ryan J. Geusz, et al., bioRxiv - Genomics 2020

  Quote: ... goat anti-FOXA2 (1:300 dilution, R&D systems); goat anti-SOX17 (1:300 dilution ...
• Neutralizing PD-L1 and PD-L2 Enhances the Efficacy of Immune Checkpoint Inhibitors in Ovarian Cancer

  Yu Rebecca Miao, et al., bioRxiv - Cancer Biology 2020

  Quote: ... αHuman PD-L1 1:500 (#AF154, R&D systems,
• Generation of neuronal diversity from common progenitors via Notch signaling in the cerebellum

  Tingting Zhang, et al., bioRxiv - Developmental Biology 2020

  Quote: ... goat anti-Olig2 (1:500, R&D systems, AF2418) and Guinea pig anti-Tbr1 (1:500 ...
• The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels

  Andrew P. Porter, et al., bioRxiv - Cell Biology 2020

  Quote: Tiam1 (R&D Systems, AF5038, sheep 1:200, methanol)
• Constitutively active TrkB kinase signalling reduces actin filopodia dynamics and cell migration

  Rohini Gupta, et al., bioRxiv - Neuroscience 2020

  Quote: ... goat anti-TrkB (R&D Systems, AF1494, 1:1,000), rabbit anti-pY674/675-TrkA (anti-pY706/707– TrkB ...
• Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages

  Nisha Kriplani, et al., bioRxiv - Microbiology 2021

  Quote: ... human type I IFN (R&D systems, 11415-1) was typically added at a final concentration of 150 U/ml ...
• Microbiota-derived short chain fatty acids promote Aβ plaque deposition

  Alessio Vittorio Colombo, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-ADAM10 N-terminal (1:1000; R&D Systems) and anti-BACE1 (1:1000 ...
• Androgen regulation of bowel function in mice and humans

  Daniella Rastelli, et al., bioRxiv - Neuroscience 2020

  Quote: ... Goat anti-SCFR 1:500 (R&D Systems AF1356), Rabbit anti-SMA 1:200 (Abcam ab-5694) ...
• SARS-CoV-2 infects brain choroid plexus and disrupts the blood-CSF-barrier

  Laura Pellegrini, et al., bioRxiv - Neuroscience 2020

  Quote: ... goat anti-ACE2 (1:100, R&D Systems, AF933), rabbit anti-HTR2C (1:500 ...
• Role of PARP1 in oligodendrocyte differentiation during developmental myelination and remyelination after myelin damage

  Yan Wang, et al., bioRxiv - Neuroscience 2021

  Quote: ... PDGFRα (1:100, AF1062, RRID: AB_2236897, R&D System), EYFP (1:200 ...
• SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection

  Rayan Khaddaj-Mallat, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-ACE2 (R&D systems; AF3437; 1/200), rabbit anti-fibronectin (Abcam ...
• Olig3 acts as a master regulator of cerebellar development

  Elijah D. Lowenstein, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-Caspase3 (1:1000, R&D Systems, AF835), goat anti-Foxp2 (1:1000 ...
• Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

  Hao Wang, et al., bioRxiv - Neuroscience 2020

  Quote: Human amyloid beta 1-40 (R&D Systems DAB140B) and 1-42 (R&D Systems DAB142 ...
• Time-dependent dual effect of NLRP3 inflammasome in brain ischemia

  Alejandra Palomino-Antolin, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-pro IL-1β (1:1000; R&D Systems), anti-Claudin-5 (1:500 ...
• Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

  Sunny Z. Wu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-FAP (1:100; R&D Systems #FAB3715P-025) and anti-CD36 (1:100 ...
• The connection between Rap1 and Talin1 in CD4⁺ T Lymphocytes

  Frederic Lagarrigue, et al., bioRxiv - Cell Biology 2021

  Quote: ... Recombinant mouse MAdCAM-1 was from R&D Systems.
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Goat anti-Desmin (R&D Systems # AF3844; 1:500), Anti-trimethyl-Histone H3 (Lys27 ...
• BSG/CD147 and ACE2 receptors facilitate SARS-CoV-2 infection of human iPS cell-derived kidney podocytes

  Titilola D. Kalejaiye, et al., bioRxiv - Bioengineering 2021

  Quote: ... Human TRA-1-85/CD147 (R&D systems, MAB3195), Cathepsin L (Santa Cruz Biotechnology ...
• Soft, dynamic hydrogel confinement improves kidney organoid lumen morphology and reduces epithelial–mesenchymal transition in culture

  Floor A.A. Ruiter, et al., bioRxiv - Bioengineering 2021

  Quote: ... and FGF-9 (200 ng·ml-1, R&D Systems). By day 7 ...
• Salmonella exploits OmpR to switch essential morphogenetic peptidoglycan synthases in response to intracellular cues

  David López-Escarpa, et al., bioRxiv - Microbiology 2021

  Quote: ... mouse monoclonal anti-6xHis (1:2500; R&D Systems), rabbit polyclonal anti-PBP2 (1:1000 ...