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5051 - 5100 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

  Maxime R. F. Gosselin, et al., bioRxiv - Pathology 2022

  Quote: ... and HGF (R&D Systems 2207-HG). Cells were left for 12 hours before fixation in buffered formalin (Sigma HT501128 ...
• Periostin⁺ stromal cells guide lymphovascular invasion by cancer cells

  Jamie L. Null, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Pdpn (R&D Systems AF3244;Cy5 secondary), and the DNA stain Syto83 (Thermo S11364 ...
• CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer

  Julia M. Houthuijzen, et al., bioRxiv - Cancer Biology 2022

  Quote: ... CD49f-AF700 (R&D systems clone GoH3), CD45-AF700 (Invitrogen ...
• The translational role of SOS1 in colorectal cancer

  Diego Alem, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 50ng/mL hEGF (R&D Systems, 236EG200), 100ng/mL human FGF (R&D Systems ...
• Cancer cells communicate with macrophages to prevent T cell activation during development of cell cycle therapy resistance

  Jason I. Griffiths, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 20ng/μL IL-18 (R&D Systems), 5μM ribociclib (Selleck Chemicals) ...
• Tumor-educated Gr1⁺CD11b⁺ cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6–JAK signaling

  Sanam Peyvandi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-mouse Oncostatin M (R&D systems), anti-mouse IL-6 (BioxCell) ...
• A non-ligand surrogate agonist antibody that enhances canonical Wnt signaling and bone regeneration

  Nam-Kyung Lee, et al., bioRxiv - Bioengineering 2022

  Quote: ... or as recombinant products (R&D Systems).
• SRSF2 is required for mRNA splicing and spermatogenesis

  Wen-Long Lei, et al., bioRxiv - Developmental Biology 2022

  Quote: ... PLZF antibody (goat, AF2944, R&D Systems); SFRS2 polyclonal antibody (rabbit ...
• Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay

  Arend W. Overeem, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 50 ng/ml SCF (R&D Systems) and 50 ng/ml EGF (R&D Systems) ...
• A filamentous phage triggers antiviral responses in cystic fibrosis basal airway epithelial cells

  Medeea C Popescu, et al., bioRxiv - Cell Biology 2022

  Quote: ... IL-8/CXCL8 kits (R&D systems), CXCL5 (Biolegend ...
• pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells

  Payam E. Farahani, et al., bioRxiv - Cell Biology 2022

  Quote: ... 20 ng/mL EGF (R&D Systems), 0.5 µg/mL hydrocortisone (Corning) ...
• More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway

  Jonathan J. Hodgins, et al., bioRxiv - Cancer Biology 2022

  Quote: ... or human IgG1 control (R&D Systems), afatinib (Selleck Chemicals) ...
• Mitochondrial defects leading to arrested spermatogenesis and ferroptosis in a mouse model of Leigh Syndrome

  Enrico Radaelli, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti HNE (R&D system 198960, RRID:AB_664165), anti-Citrate synthase (Abcam ab96600 ...
• Germ-cell specific eIF4E1B regulates maternal RNA translation to ensure zygotic genome activation

  Guanghui Yang, et al., bioRxiv - Developmental Biology 2022

  Quote: ... anti-SOX2 (R&D Systems, Cat# MAB2018), anti-POLR1D (Proteintech ...
• Environmental and genetic drivers of population differences in SARS-CoV-2 immune responses

  Yann Aquino, et al., bioRxiv - Genomics 2022

  Quote: ... The MAB285 antibody clone (R&D Systems) was biotinylated (biotin/antibody ratio = 40:1 ...
• RNA-sensing pattern-recognition receptors synergize with TLR2 or dectin-1 to trigger high production of IL-12p70 by human dendritic cells

  Brian C. Gilmour, et al., bioRxiv - Immunology 2022

  Quote: ... and tetramethylbenzidine (R&D Systems, part #895001) was added for approx ...
• CXCR7 promotes foetal myoblast fusion at muscle fiber tips independently of Myomaker via a ß1integrin-EGFR-dependent mechanism

  Sonya Nassari, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and recombinant CXCL12 protein (R&D System) was added at 50ng/ml ...
• Specific Deletion of Axin1 Leads to Activation of β-Catenin/BMP Signaling Resulting in Fibular Hemimelia Phenotype in Mice

  Rong Xie, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Wnt3a (100 ng/ml, R&D systems, cells were incubated in serum-free medium for 20 hours ...
• Non-classical glycosylation determines intracellular trafficking of APP and Aβ production

  Yuriko Tachida, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-ppGalNAc-T3 (sheep, R&D Systems), anti-ppGalNAc-T6 (rabbit ...
• A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability

  Emily A. Voigt, et al., bioRxiv - Immunology 2022

  Quote: ... (R&D Systems, Minneapolis, MN; #10549-CV) in phosphate-buffered saline (PBS ...
• Translation of dipeptide repeat proteins in C9ORF72-ALS/FTD through unique and redundant AUG initiation codons

  Yoshifumi Sonobe, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 10 ng/ml GDNF (R&D Systems), and 10 ng/ml GDNF (R&D Systems) ...
• Iron Chelation Improves Ineffective Erythropoiesis and Iron Overload in Myelodysplastic Syndrome Mice

  Wenbin An, et al., bioRxiv - Pathology 2022

  Quote: ... Serum mouse EPO (Quantikine, R&D Systems) was measured by enzyme-linked immunosorbent assay (ELISA ...
• Inflammation-mediated Upregulation of VCAM-1 but not KIM-1 during Acute Kidney Injury to Chronic Kidney Disease Transition

  Isabel Melchinger, et al., bioRxiv - Pathology 2022

  Quote: ... 20 ng/mL TNFα (R&D Systems), 100 ng/mL interferon γ (R&D Systems) ...
• Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson’s disease by targeting receptor interleukin-6

  Meritxell Pons-Espinal, et al., bioRxiv - Neuroscience 2022

  Quote: ... mouse anti-IL6R (R&D Systems, MAB2271), rabbit anti-P-STAT3 (Tyr705 ...
• Mutation in the TRKB cholesterol recognition site that blocks antidepressant binding does not influence the basal or BDNF-stimulated activation of TRKB

  Caroline Biojone, et al., bioRxiv - Neuroscience 2022

  Quote: ... goat anti-TRKB (R&D System, #AF1494) or anti-β-actin mouse monoclonal antibody (Sigma-Aldrich ...
• Binucleated cells generated by nuclear movement during neural transdifferentiation from human bone marrow-derived mesenchymal cells

  Carlos Bueno, et al., bioRxiv - Neuroscience 2022

  Quote: ... supplemented with N2-supplement (R&D systems), 0.6% glucose (Sigma-Aldrich) ...
• Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

  Guilherme Dias de Melo, et al., bioRxiv - Neuroscience 2022

  Quote: ... Goat anti-CD31 (AF3628, R&D Systems) diluted 1:300 ...
• Nuclear lamina strain states revealed by intermolecular force biosensor

  Brooke E. Danielsson, et al., bioRxiv - Biophysics 2022

  Quote: ... recombinant human TGF-β1 (R&D systems) was used to induce EMT at a concentration of 2 ng/mL for 24 h ...
• mRNA interactions with disordered regions control protein activity

  Yang Luo, et al., bioRxiv - Molecular Biology 2023

  Quote: ... goat anti-MAX (AF4304, R&D systems).
• CiDRE⁺ M2c macrophages hijacked by SARS-CoV-2 cause COVID-19 severity

  Yuichi Mitsui, et al., bioRxiv - Immunology 2022

  Quote: ... goat anti-ACE2 antibody (R&D Systems) and Alexa Flour 647-conjugated anti-goat IgG antibody (Abcam ...
• C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress

  ME Cicardi, et al., bioRxiv - Neuroscience 2023

  Quote: Colorimetric-based ELISA (R&D Systems #M6000B) kit was used to measure IL-6 concentration in cortical neuron media ...
• Temporal regulation of AgRP neurons mediates context-induced feeding

  Felicia Reed, et al., bioRxiv - Neuroscience 2023

  Quote: Purified rat ghrelin (R&D Systems, USA) was dissolved in saline on the day of injection ...
• Amino acid substitutions in norovirus VP1 dictate cell tropism via an attachment process dependent on membrane mobility

  Jake T. Mills, et al., bioRxiv - Microbiology 2023

  Quote: ... anti-CD300lf monoclonal (MAB27881, R&D Systems), anti-GAPDH monocolonal (60004-1 ...
• Amino acid substitutions in norovirus VP1 dictate cell tropism via an attachment process dependent on membrane mobility

  Jake T. Mills, et al., bioRxiv - Microbiology 2023

  Quote: ... and anti-rabbit (HAF008, R&D Systems) HRP conjugates were employed as a secondary antibody ...
• Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver

  Hitoshi Tsugawa, et al., bioRxiv - Microbiology 2023

  Quote: ... anti-Gas6 (R&D Systems, cat# AF986), anti-ZO-1 (Invitrogen ...
• Defining T cell receptor repertoires using nanovial-based affinity and functional screening

  Doyeon Koo, et al., bioRxiv - Bioengineering 2023

  Quote: ... and TNF-α (R&D Systems, 210TA020) for 2 hours at 37°C ...
• Defining T cell receptor repertoires using nanovial-based affinity and functional screening

  Doyeon Koo, et al., bioRxiv - Bioengineering 2023

  Quote: ... anti-TNF-α (R&D Systems, BAF210), anti-IL-2 (BD Sciences ...
• Human Vascularized Bile Duct-on-a Chip: A multi-cellular micro-physiological system for studying Primary Sclerosing Cholangitis

  Yu Du, et al., bioRxiv - Bioengineering 2023

  Quote: ... 20 ng/ml EGF (R&D Systems), 500 ng/ml R-spondin (R&D Systems ...
• ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation

  Rui Sun, Hyeyoon Lee, Christof Niehrs, bioRxiv - Bioengineering 2022

  Quote: ... ZNRF3ECDFc (R&D systems 7994-RF-025) or RNF43ECDFc (R&D systems 7964-RN-050 ...
• Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge

  Christopher M. Schafer, et al., bioRxiv - Cell Biology 2023

  Quote: ... IL-1β (R&D Systems: #401-ML), or IL-18 (R&D Systems ...
• Actin networks modulate heterogenous NF-κB dynamics in response to TNFα

  Francesca Butera, et al., bioRxiv - Cancer Biology 2023

  Quote: ... TNFα was sourced from R&D Systems and diluted in 0.1% BSA/PBS for all other experiments.
• T cell Aryl Hydrocarbon Receptor Activity Tunes the Gut Microenvironment to Sustain Autoimmunity and Neuroinflammation

  Andrea R. Merchak, et al., bioRxiv - Immunology 2022

  Quote: ... with 10% FBS (R&D Systems; S12450H). The samples were then centrifuged at 260 g for 8 minutes ...
• Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers

  Shenjie Wu, et al., bioRxiv - Biochemistry 2022

  Quote: ... and 25ng/ml FGF8b (R&D Systems) with a media change every day ...
• Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers

  Shenjie Wu, et al., bioRxiv - Biochemistry 2022

  Quote: ... 200 ng/ml SHH (R&D Systems) and 25ng/ml FGF8b (R&D Systems ...
• HSV-1 Oncolytic Virus Targeting CEACAM6-Expressing Tumors Using a Bispecific T-Cell Engager

  Yanal M. Murad, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and granzyme B ELISA (R&D Systems) after 48 hours of incubation at 37°C ...
• Intermediate filament dysregulation and astrocytopathy in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN)

  Rachel Battaglia, et al., bioRxiv - Cell Biology 2023

  Quote: ... and EGF (20ng/mL, R&D Systems). Media was changed daily for days 7-16 and every other day for days 17-25 ...
• ERBB-activated myofibroblastic cancer-associated fibroblasts promote local metastasis of pancreatic cancer

  Gianluca Mucciolo, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Phospho-RTK assays (ARY014; R&D Systems) were performed using 300 μg protein and following the Manufacturer’s instructions.
• McLTP1, a lipid transfer protein isolated from noni seeds induces effective healing of superficial burns

  Bianca Moreira Kurita, et al., bioRxiv - Immunology 2023

  Quote: ... Color reagent o-phenylenediamine (R&D Systems) was added and plates were incubated in the absence of light ...
• Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

  Jie Wang, Amir Rattner, Jeremy Nathans, bioRxiv - Immunology 2023

  Quote: ... goat anti-S100A8 (R&D Systems AF3059); rabbit anti-ERG (Cell Signaling Technologies 97249) ...
• Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice

  Eirini Maniou, et al., bioRxiv - Developmental Biology 2023

  Quote: ... goat anti-FoxA2 (AF2400, R&D Systems). Sections were washed ...