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4851 - 4900 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Engineered chimeric T cell receptor fusion construct (TRuC)-expressing T cells prevent translational shutdown in SARS-CoV-2-infected cells

  Ira Godbole, et al., bioRxiv - Bioengineering 2021

  Quote: ... anti-human ACE2 (R&D Systems, #HK0320042), PE-labelled anti-human IgG (Southern Biotech ...
• Fgf/Ets signalling in Xenopus ectoderm initiates neural induction and patterning in an autonomous and paracrine manners

  Ikuko Hongo, Harumasa Okamoto, bioRxiv - Developmental Biology 2020

  Quote: ... and mouse Fgf8 from R&D Systems Inc (Minneapolis ...
• Early neuroadaptations to an obesogenic diet identify the schizophrenia-related ErbB4 receptor in obesity-induced hippocampal abnormalities

  Julio David Vega-Torres, et al., bioRxiv - Neuroscience 2021

  Quote: Plasma samples were assayed for FGF-21 levels using an ELISA kit from R&D Systems (MF2100, R&D Systems, Minneapolis MN, USA) according to the manufacturer’s instructions ...
• Amino Acids Promote Mitochondrial-Derived Compartment Formation in Mammalian Cells

  Max-Hinderk Schuler, et al., bioRxiv - Cell Biology 2020

  Quote: ... 250 nM Torin1 (R&D Systems; 4247), 2 mM concanamycin A (Santa Cruz Biotechnology ...
• Lymphoid follicle formation and human vaccination responses recapitulated in an organ-on-a-chip

  G. Goyal, et al., bioRxiv - Immunology 2021

  Quote: ... CXCL13 (#DY801) were from R&D Systems. Protein standards for recombinant IFN-γ (#285-IF-100) ...
• Progranulin deficiency results in reduced bis(monoacylglycero)phosphate (BMP) levels and gangliosidosis

  Sebastian Boland, et al., bioRxiv - Cell Biology 2021

  Quote: ... human progranulin (R&D systems, Cat#AF2420), an anti-mouse progranulin polyclonal antibody that recognizes an epitope at amino acids 198–21430 ...
• Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s Disease

  Michael J. D. Daniels, et al., bioRxiv - Neuroscience 2022

  Quote: ... 10 ng/μL mCSF1 (R&D Systems). Microglia were counted using a haemocytometer and plated out onto 24 or 96-well plates (Corning ...
• YTHDF2 in dentate gyrus is the m⁶A reader mediating m⁶A modification in hippocampus-dependent learning and memory

  Mengru Zhuang, et al., bioRxiv - Neuroscience 2022

  Quote: ... Prox1 (R&D Systems, AF2727, 0.2ng/ml), Elavl2 (Abclonal ...
• Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem Cells

  Liangwen Zhong, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Activin A (R&D Systems or Peprotech) was added at designed timepoints ...
• Origin and segregation of the human germline

  Aracely Castillo-Venzor, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 100 ng/ml SCF (R&D systems), 50 ng/ml EGF (R&D Systems) ...
• Origin and segregation of the human germline

  Aracely Castillo-Venzor, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 50 ng/ml EGF (R&D Systems), 10 μM ROCKi ...
• B cell receptor induced IL-10 production from neonatal CD19+CD43- cells depends on STAT5 mediated IL-6 secretion

  Jiro Sakai, et al., bioRxiv - Immunology 2022

  Quote: ... recombinant mouse IL-6 (R&D Systems), recombinant mouse IL-21 (R&D Systems) ...
• Schistosoma mansoni cercarial invadolysin cleaves complement C3 and suppresses proinflammatory cytokine production

  Jacob R. Hambrook, Patrick C. Hanington, bioRxiv - Immunology 2022

  Quote: ... recombinant human MMP-8 (R&D Systems) was subjected to the same conditions ...
• B cell receptor induced IL-10 production from neonatal CD19+CD43- cells depends on STAT5 mediated IL-6 secretion

  Jiro Sakai, et al., bioRxiv - Immunology 2022

  Quote: ... recombinant mouse IL-21 (R&D Systems), recombinant mouse IL-10 (R&D Systems) ...
• Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening

  Azucena Ramos, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-IFNγR1/CD119 (R&D Systems, MAB10261), anti-STAT1 (Cell Signaling Technology ...
• Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

  Maxime R. F. Gosselin, et al., bioRxiv - Pathology 2022

  Quote: ... IGF-I (R&D Systems 791-MG) and HGF (R&D Systems 2207-HG) ...
• Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

  Maxime R. F. Gosselin, et al., bioRxiv - Pathology 2022

  Quote: ... and HGF (R&D Systems 2207-HG). Cells were left for 12 hours before fixation in buffered formalin (Sigma HT501128 ...
• Periostin⁺ stromal cells guide lymphovascular invasion by cancer cells

  Jamie L. Null, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Pdpn (R&D Systems AF3244;Cy5 secondary), and the DNA stain Syto83 (Thermo S11364 ...
• CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer

  Julia M. Houthuijzen, et al., bioRxiv - Cancer Biology 2022

  Quote: ... CD49f-AF700 (R&D systems clone GoH3), CD45-AF700 (Invitrogen ...
• The translational role of SOS1 in colorectal cancer

  Diego Alem, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 50ng/mL hEGF (R&D Systems, 236EG200), 100ng/mL human FGF (R&D Systems ...
• Cancer cells communicate with macrophages to prevent T cell activation during development of cell cycle therapy resistance

  Jason I. Griffiths, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 20ng/μL IL-18 (R&D Systems), 5μM ribociclib (Selleck Chemicals) ...
• Tumor-educated Gr1⁺CD11b⁺ cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6–JAK signaling

  Sanam Peyvandi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-mouse Oncostatin M (R&D systems), anti-mouse IL-6 (BioxCell) ...
• A non-ligand surrogate agonist antibody that enhances canonical Wnt signaling and bone regeneration

  Nam-Kyung Lee, et al., bioRxiv - Bioengineering 2022

  Quote: ... or as recombinant products (R&D Systems).
• SRSF2 is required for mRNA splicing and spermatogenesis

  Wen-Long Lei, et al., bioRxiv - Developmental Biology 2022

  Quote: ... PLZF antibody (goat, AF2944, R&D Systems); SFRS2 polyclonal antibody (rabbit ...
• Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay

  Arend W. Overeem, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 50 ng/ml SCF (R&D Systems) and 50 ng/ml EGF (R&D Systems) ...
• A filamentous phage triggers antiviral responses in cystic fibrosis basal airway epithelial cells

  Medeea C Popescu, et al., bioRxiv - Cell Biology 2022

  Quote: ... IL-8/CXCL8 kits (R&D systems), CXCL5 (Biolegend ...
• pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells

  Payam E. Farahani, et al., bioRxiv - Cell Biology 2022

  Quote: ... 20 ng/mL EGF (R&D Systems), 0.5 µg/mL hydrocortisone (Corning) ...
• More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway

  Jonathan J. Hodgins, et al., bioRxiv - Cancer Biology 2022

  Quote: ... or human IgG1 control (R&D Systems), afatinib (Selleck Chemicals) ...
• Mitochondrial defects leading to arrested spermatogenesis and ferroptosis in a mouse model of Leigh Syndrome

  Enrico Radaelli, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti HNE (R&D system 198960, RRID:AB_664165), anti-Citrate synthase (Abcam ab96600 ...
• Germ-cell specific eIF4E1B regulates maternal RNA translation to ensure zygotic genome activation

  Guanghui Yang, et al., bioRxiv - Developmental Biology 2022

  Quote: ... anti-SOX2 (R&D Systems, Cat# MAB2018), anti-POLR1D (Proteintech ...
• Environmental and genetic drivers of population differences in SARS-CoV-2 immune responses

  Yann Aquino, et al., bioRxiv - Genomics 2022

  Quote: ... The MAB285 antibody clone (R&D Systems) was biotinylated (biotin/antibody ratio = 40:1 ...
• RNA-sensing pattern-recognition receptors synergize with TLR2 or dectin-1 to trigger high production of IL-12p70 by human dendritic cells

  Brian C. Gilmour, et al., bioRxiv - Immunology 2022

  Quote: ... and tetramethylbenzidine (R&D Systems, part #895001) was added for approx ...
• CXCR7 promotes foetal myoblast fusion at muscle fiber tips independently of Myomaker via a ß1integrin-EGFR-dependent mechanism

  Sonya Nassari, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and recombinant CXCL12 protein (R&D System) was added at 50ng/ml ...
• Specific Deletion of Axin1 Leads to Activation of β-Catenin/BMP Signaling Resulting in Fibular Hemimelia Phenotype in Mice

  Rong Xie, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Wnt3a (100 ng/ml, R&D systems, cells were incubated in serum-free medium for 20 hours ...
• Non-classical glycosylation determines intracellular trafficking of APP and Aβ production

  Yuriko Tachida, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-ppGalNAc-T3 (sheep, R&D Systems), anti-ppGalNAc-T6 (rabbit ...
• A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability

  Emily A. Voigt, et al., bioRxiv - Immunology 2022

  Quote: ... (R&D Systems, Minneapolis, MN; #10549-CV) in phosphate-buffered saline (PBS ...
• Translation of dipeptide repeat proteins in C9ORF72-ALS/FTD through unique and redundant AUG initiation codons

  Yoshifumi Sonobe, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 10 ng/ml GDNF (R&D Systems), and 10 ng/ml GDNF (R&D Systems) ...
• Iron Chelation Improves Ineffective Erythropoiesis and Iron Overload in Myelodysplastic Syndrome Mice

  Wenbin An, et al., bioRxiv - Pathology 2022

  Quote: ... Serum mouse EPO (Quantikine, R&D Systems) was measured by enzyme-linked immunosorbent assay (ELISA ...
• Inflammation-mediated Upregulation of VCAM-1 but not KIM-1 during Acute Kidney Injury to Chronic Kidney Disease Transition

  Isabel Melchinger, et al., bioRxiv - Pathology 2022

  Quote: ... 20 ng/mL TNFα (R&D Systems), 100 ng/mL interferon γ (R&D Systems) ...
• Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson’s disease by targeting receptor interleukin-6

  Meritxell Pons-Espinal, et al., bioRxiv - Neuroscience 2022

  Quote: ... mouse anti-IL6R (R&D Systems, MAB2271), rabbit anti-P-STAT3 (Tyr705 ...
• Mutation in the TRKB cholesterol recognition site that blocks antidepressant binding does not influence the basal or BDNF-stimulated activation of TRKB

  Caroline Biojone, et al., bioRxiv - Neuroscience 2022

  Quote: ... goat anti-TRKB (R&D System, #AF1494) or anti-β-actin mouse monoclonal antibody (Sigma-Aldrich ...
• Binucleated cells generated by nuclear movement during neural transdifferentiation from human bone marrow-derived mesenchymal cells

  Carlos Bueno, et al., bioRxiv - Neuroscience 2022

  Quote: ... supplemented with N2-supplement (R&D systems), 0.6% glucose (Sigma-Aldrich) ...
• Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

  Guilherme Dias de Melo, et al., bioRxiv - Neuroscience 2022

  Quote: ... Goat anti-CD31 (AF3628, R&D Systems) diluted 1:300 ...
• Nuclear lamina strain states revealed by intermolecular force biosensor

  Brooke E. Danielsson, et al., bioRxiv - Biophysics 2022

  Quote: ... recombinant human TGF-β1 (R&D systems) was used to induce EMT at a concentration of 2 ng/mL for 24 h ...
• mRNA interactions with disordered regions control protein activity

  Yang Luo, et al., bioRxiv - Molecular Biology 2023

  Quote: ... goat anti-MAX (AF4304, R&D systems).
• CiDRE⁺ M2c macrophages hijacked by SARS-CoV-2 cause COVID-19 severity

  Yuichi Mitsui, et al., bioRxiv - Immunology 2022

  Quote: ... goat anti-ACE2 antibody (R&D Systems) and Alexa Flour 647-conjugated anti-goat IgG antibody (Abcam ...
• C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress

  ME Cicardi, et al., bioRxiv - Neuroscience 2023

  Quote: Colorimetric-based ELISA (R&D Systems #M6000B) kit was used to measure IL-6 concentration in cortical neuron media ...
• Temporal regulation of AgRP neurons mediates context-induced feeding

  Felicia Reed, et al., bioRxiv - Neuroscience 2023

  Quote: Purified rat ghrelin (R&D Systems, USA) was dissolved in saline on the day of injection ...
• Amino acid substitutions in norovirus VP1 dictate cell tropism via an attachment process dependent on membrane mobility

  Jake T. Mills, et al., bioRxiv - Microbiology 2023

  Quote: ... anti-CD300lf monoclonal (MAB27881, R&D Systems), anti-GAPDH monocolonal (60004-1 ...
• Amino acid substitutions in norovirus VP1 dictate cell tropism via an attachment process dependent on membrane mobility

  Jake T. Mills, et al., bioRxiv - Microbiology 2023

  Quote: ... and anti-rabbit (HAF008, R&D Systems) HRP conjugates were employed as a secondary antibody ...