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3001 - 3050 of 8862 citations for 6 1 4 dioxa 8 azaspiro 4.5 decan 8 yl 3 hydroxy 2 iminopyrimidin 4 amine since 2019

• Microglia and meningeal macrophages depletion delay the onset of experimental autoimmune encephalomyelitis

  Alejandro Montilla, et al., bioRxiv - Neuroscience 2022

  Quote: ... mouse anti-CD31 (1:100; Santa Cruz), rat anti-GFP (1:200; ...
• SARS-CoV-2 entry route impacts a range of downstream viral and cellular processes

  Bingqian Qu, et al., bioRxiv - Microbiology 2022

  Quote: ... Bafilomycin A1 (1 μM; Santa Cruz Biotechnology) was used for 1 h pre-treatment but not for post treatment due to high cytotoxicity.
• Gut microbiota promotes pain chronicity in Myosin1A deficient male mice

  Ana Reynders, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-PKCγ (1:500, Santa Cruz), rabbit anti-PGP9.5 (1:200 ...
• Deletion of transglutaminase 2 from astrocytes significantly improves their ability to promote neurite outgrowth on an inhibitory matrix

  Jacen Emerson, et al., bioRxiv - Neuroscience 2023

  Quote: ... and Homer (1:200) (Santa Cruz #17842) were diluted in blocking buffer and incubated overnight on the coverslips in the combinations indicated ...
• Transcriptomic analyses reveal prenatal stress promotes late-onset neural stem cell proliferation in adult male offspring

  Z. Wang, et al., bioRxiv - Neuroscience 2023

  Quote: ... DCX (Santa Cruz sc-8066, 1:400), RBFOX3 (Abcam ab177487 ...
• The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex

  Walter R Mancia Leon, et al., bioRxiv - Neuroscience 2023

  Quote: ... Cux1 (Santa Cruz Biotechnology, 1:100 AB_2261231), GABA (Sigma-Aldrich,1:250 ...
• CLIP-Seq Analysis Enables the Design of Ribosomal RNA Bait Oligonucleotides That Protect Against C9ORF72 ALS/FTD-Associated Poly-GR Pathophysiology

  Juan A. Ortega, et al., bioRxiv - Neuroscience 2022

  Quote: ... NPM1 (mouse, 1:500, Santa Cruz Biotechnology). The next day ...
• RHINO restricts MMEJ activity to mitosis

  Alessandra Brambati, et al., bioRxiv - Molecular Biology 2023

  Quote: ... GAPDH (0411, Santa Cruz; 1: 10000 dilution), LaminB1 (ab16048 ...
• RHINO restricts MMEJ activity to mitosis

  Alessandra Brambati, et al., bioRxiv - Molecular Biology 2023

  Quote: ... p53 (sc126; Santa Cruz; 1: 1000 dilution), RAD1 (NB100-346 ...
• Eos promotes T_H2 differentiation by propagating the IL-2/STAT5 signaling pathway

  Jasmine A. Tuazon, et al., bioRxiv - Immunology 2022

  Quote: ... mouse anti-rabbit (Santa Cruz, 1:15,000).
• Actin nucleators safeguard replication forks by limiting nascent strand degradation

  Jadwiga Nieminuszczy, et al., bioRxiv - Molecular Biology 2023

  Quote: ... WASp (Santa Cruz, sc-5300, 1:500), N-WASp (Abcam ...
• Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability and Working Memory

  Jing Wu, et al., bioRxiv - Neuroscience 2023

  Quote: ... and MAP2 (1:200, Santa Cruz Biotechnology) overnight at 4 °C ...
• Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids

  Tomoki Kodera, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-LHX6 (1:100, mouse; Santa Cruz), anti-OLIG2 (1:500 ...
• Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids

  Tomoki Kodera, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-NKX2.1 (1:500, mouse; Santa Cruz), anti-LHX6 (1:100 ...
• Dysregulation of mTOR Signaling Mediates Common Neurite and Migration Defects in Both Idiopathic and 16p11.2 Deletion Autism Neural Precursor Cells

  Smrithi Prem, et al., bioRxiv - Neuroscience 2022

  Quote: ... Tau (1:500, Santa Cruz, Sc-5587), O4 (R&D Systems ...
• Dysregulation of mTOR Signaling Mediates Common Neurite and Migration Defects in Both Idiopathic and 16p11.2 Deletion Autism Neural Precursor Cells

  Smrithi Prem, et al., bioRxiv - Neuroscience 2022

  Quote: ... GalC (Santa Cruz 1:250 sc-518055), and Glial fibrillary acidic protein (GFAP ...
• Age-dependent NMDA receptor function is regulated by the Amyloid Precursor Protein

  Joana Rajão-Saraiva, et al., bioRxiv - Neuroscience 2022

  Quote: ... GluN2A (1:200, sc-136004, Santa Cruz), GluN2B (1:1000 ...
• Store-operated Ca²⁺ entry regulatory factor (SARAF) alters murine metabolic state age-dependent via hypothalamic pathways

  Diana Gataulin, et al., bioRxiv - Physiology 2022

  Quote: ... goat anti-doublecortin (1:100; Santa Cruz). Slices/cells were first incubated for 1.5 h at room temperature in a blocking solution containing 20% normal horse serum (NHS ...
• History of previous midlife estradiol treatment permanently alters interactions of brain insulin-like growth factor-1 signaling and hippocampal estrogen synthesis to enhance cognitive aging in a rat model of menopause

  Nina E. Baumgartner, et al., bioRxiv - Neuroscience 2022

  Quote: ... and total ERα (1:1000, Santa Cruz). Samples from cytosolic fractions were incubated with antibodies for cytosolic loading control Enolase (1:1000 ...
• TOB is an effector of the hippocampus-mediated acute stress response

  Mohieldin Youssef, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-MKP-1 RpAb (Santa Cruz, USA), anti-LCN2 goat polyclonal antibody (R&D systems ...
• Age-dependent NMDA receptor function is regulated by the Amyloid Precursor Protein

  Joana Rajão-Saraiva, et al., bioRxiv - Neuroscience 2022

  Quote: ... β-actin (1 :1000, sc-47778, Santa Cruz), GAPDH (1:1000 ...
• Familial Alzheimer’s disease mutation undermines axonal transport by enhancing dynactin recruitment to the APP motor assemblies

  Monica Feole, Gorazd B. Stokin, bioRxiv - Neuroscience 2022

  Quote: ... anti-Goat 1:1000 (Santa Cruz 2354), and Clean-Blot™ IP Detection Reagent 1:200 (Thermo Scientific 21230).
• Dysregulation of mTOR Signaling Mediates Common Neurite and Migration Defects in Both Idiopathic and 16p11.2 Deletion Autism Neural Precursor Cells

  Smrithi Prem, et al., bioRxiv - Neuroscience 2022

  Quote: ... Oct4 (1:250, Santa Cruz, Sc-5279), Nestin (1:2000–1:5000 ...
• Encoding of hunger by the neuronal epigenome slows aging in Drosophila

  KJ Weaver, RA Holt, E Henry, SD Pletcher, bioRxiv - Physiology 2022

  Quote: ... rabbit anti-ubiquitin (Santa Cruz 1:5000), Rabbit anti-histone H4 (abcam ...
• Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

  Yoichiro Harada, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-ORC2 (1:10,000, 3G6, Santa Cruz), and anti-CDC45 (1:1,000 ...
• Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

  Yoichiro Harada, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-H2AX (1:2,000, 938CT5.1.1, Santa Cruz), anti-phospho-H2AX (Ser139 ...
• Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

  Yoichiro Harada, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-MCM7 (1:5,000, 141.2, Santa Cruz), anti-CDT1 (1:10,000 ...
• CHK2 Regulates MUS81-EME2 Function in Response to Replication Stress and BRCA2 Deficiency

  Eva Malacaria, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-EME1 (Santa Cruz Biotechnology, 1:500), anti-EME2 (Thermo Fisher ...
• CHK2 Regulates MUS81-EME2 Function in Response to Replication Stress and BRCA2 Deficiency

  Eva Malacaria, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-GFP (Santa Cruz Biotechnology, 1:1000), anti-pS1981ATM (Cell signaling ...
• CHK2 Regulates MUS81-EME2 Function in Response to Replication Stress and BRCA2 Deficiency

  Eva Malacaria, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-CHK2 (Santa Cruz Biotechnology, 1:1000), anti-BRCA2 (Bethyl ...
• Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

  Li Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... SOX10 (Santa Cruz, sc-365692, 1:50) and DLX5 (Sigma ...
• PP2B-dependent cerebellar plasticity sets the amplitude of an innate reflex during juvenile development

  Bin Wu, et al., bioRxiv - Neuroscience 2024

  Quote: ... Dyn1 (1:1000, mouse monoclonal, Santa cruz), and probed with secondary antibodies subsequently ...
• Sensory perception of fluctuating light in Arabidopsis

  Antonela Belmonte, et al., bioRxiv - Plant Biology 2024

  Quote: ... anti-CHS (Santa Cruz Biotechnology, 1:10000), and anti-Actin (A0480 ...
• NCLX controls hepatic mitochondrial Ca²⁺ extrusion and couples hormone-mediated mitochondrial Ca²⁺ oscillations with gluconeogenesis

  Mahmoud Taha, et al., bioRxiv - Physiology 2024

  Quote: ... MCU (1:1000, sc-515930, Santa Cruz) and VDAC1 (1:500 ...
• NCLX controls hepatic mitochondrial Ca²⁺ extrusion and couples hormone-mediated mitochondrial Ca²⁺ oscillations with gluconeogenesis

  Mahmoud Taha, et al., bioRxiv - Physiology 2024

  Quote: ... Sigma-Aldrich),1 µM dexamethasone (SC-29059, Santa Cruz) and100 nM insulin (Actrapid ...
• Cardiac Localized Polycystin-2 plays a Functional Role in Natriuretic Peptide Production and its Absence Contributes to Hypertension

  Brandon Elliott, et al., bioRxiv - Physiology 2024

  Quote: ... atrial natriuretic peptide (1:100; Santa Cruz), B-type natriuretic peptide (1:100 ...
• Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex

  Qian Guo, et al., bioRxiv - Cell Biology 2024

  Quote: ... DMT-1(sc-166884, Santa Cruz Biotechnology) (1:1,000 for WB) ...
• Atypical Cell Cycle Regulation Promotes Mammary Stem Cell Expansion and Therapeutic Resistance

  Bre-Anne Fifield, et al., bioRxiv - Cancer Biology 2024

  Quote: ... PCNA (1:500; sc-9857; Santa Cruz); cleaved caspase-3 (1:250 ...
• Evidence that the monoamine oxidase B (MAO-B) plays a central role in the inotropic dysfunction induced by genetic deletion of the Mas-related-G protein-coupled receptor D (MrgD) in mice

  Lucas Rodrigues-Ribeiro, et al., bioRxiv - Physiology 2024

  Quote: ... and GAPDH (1:3000; Santa Cruz Biotechnology). Immunodetection was carried out using enhanced chemiluminescence detected with LAS 4000 equipment (GE HealthCare Life Science) ...
• Quinoline-based compounds can inhibit diverse enzymes that act on DNA

  Jujun Zhou, et al., bioRxiv - Molecular Biology 2024

  Quote: ... p53 (DO-1; Santa Cruz, sc-126), phosphor p53 (Ser15 ...
• Emx2 is an essential regulator of ciliated cell development across embryonic tissues

  Thanh Khoa Nguyen, et al., bioRxiv - Developmental Biology 2024

  Quote: ... anti-aPKC diluted 1:500 (Santa Cruz) was used.
• ROSALIND protects the mitochondrial translational machinery from oxidative damage

  Vicky Katopodi, et al., bioRxiv - Molecular Biology 2024

  Quote: ... TOM20 (F-10; Santa Cruz, 1:500), MRPL38 (PA5-118074 ...
• Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus

  Eugene Gil, et al., bioRxiv - Neuroscience 2024

  Quote: ... goat anti-SOX2 (1:300, Santa Cruz) rabbit anti-PROX1 (1:300 ...
• A RALF-Brassinosteroid morpho-signaling circuit regulates Arabidopsis hypocotyl cell shape

  David Biermann, et al., bioRxiv - Plant Biology 2024

  Quote: ... α-GFP (1:5000, sc-9996, Santa Cruz). Blots were developed with Pierce ECL/ECL Femto Western Blotting Substrate (Thermo Scientific) ...
• A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

  Maritza Puray-Chavez, et al., bioRxiv - Microbiology 2024

  Quote: ... Vinculin (Santa Cruz #sc-73614, 1:2000), pSTAT1-Y701 (Cell Signaling #9167 ...
• RNA G-quadruplex dynamic steers the crosstalk between protein synthesis and energy metabolism

  Leïla Dumas, et al., bioRxiv - Cancer Biology 2024

  Quote: ... SOD2 (1:1000, Santa Cruz sc-133134), GALNT2 (1:1000 ...
• Exploiting a metabolic vulnerability in brain tumour stem cells using a brain-penetrant drug with safe profile

  Audrey Burban, et al., bioRxiv - Cancer Biology 2024

  Quote: ... SOX2 (1:200, Santa Cruz, #sc-365823), α-tubulin (1:10000 ...
• Cell polarity proteins promote macropinocytosis in response to metabolic stress

  Guillem Lambies, et al., bioRxiv - Cancer Biology 2024

  Quote: ... CREM (Santa Cruz sc-101530, 1:100), Myc (CST 71D10 ...
• Nucleoporin93 (Nup93) Limits Yap Activity to Prevent Endothelial Cell Senescence

  Tung D. Nguyen, et al., bioRxiv - Physiology 2023

  Quote: ... anti-Yap (1:250, Santa Cruz, sc101199); anti-GFP (1:250 ...
• Nucleoporin93 (Nup93) Limits Yap Activity to Prevent Endothelial Cell Senescence

  Tung D. Nguyen, et al., bioRxiv - Physiology 2023

  Quote: ... anti-GFP (1:250, Santa Cruz, sc9996). Cells were then incubated with corresponding AlexaFluor secondary antibodies (2 hours ...