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2051 - 2100 of 8862 citations for 6 1 4 dioxa 8 azaspiro 4.5 decan 8 yl 3 hydroxy 2 iminopyrimidin 4 amine since 2019

• The anti-tubercular activity of simvastatin is mediated by cholesterol-dependent regulation of autophagy via the AMPK-mTORC1-TFEB axis

  Natalie Bruiners, et al., bioRxiv - Immunology 2020

  Quote: ... A total of 2 × 106 macrophages were lysed in 100μL RIPA lysis buffer (Santa Cruz Biotechnology, Dallas, TX). Subcellular Protein Fractionation Kit for Cultured Cells (Thermo Fischer Scientific ...
• CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae

  Akaash Kannan, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... and 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx) were purchased from Santa Cruz. The polyaromatic hydrocarbons ...
• Reconstruction of the urinary tract at the appropriate time reduces fibrosis of the metanephros in rats as judged by imaging

  Kotaro Nishi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... the tissues were thinly sliced to 2 μm and stained for TGF-β1 (sc-130348: Santa Cruz, CA), collagen-α1 type 1 (sc-293182 ...
• AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression

  Chi Thi Kim Nguyen, et al., bioRxiv - Cancer Biology 2019

  Quote: ... Primary antibodies used in this study were anti-AIRE (C-2, Santa Cruz Biotechnology, Santa Cruz, CA, USA) for detection of human AIRE ...
• AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression

  Chi Thi Kim Nguyen, et al., bioRxiv - Cancer Biology 2019

  Quote: ... Primary antibodies used in this study were anti-AIRE (C-2, Santa Cruz Biotechnology, Santa Cruz, CA, USA) for detection of human AIRE ...
• Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

  Sofie J. Desmet, et al., bioRxiv - Molecular Biology 2024

  Quote: ... After fixation, endogenous PPARα was visualized using mouse anti-PPARα (H-2, sc-398394) antibody (Santa Cruz Biotechnology), followed by Alexa Fluor 568 anti-mouse IgG (Molecular Probes ...
• Multimodal Hox5 activity generates motor neuron diversity

  Ritesh KC, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 200 μg of precleared lysate was incubated with 2 μg of goat anti-Scip (Santa Cruz Biotechnology, RRID:AB_2268536) and incubated for 1 hour on a rocker at 4°C ...
• Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus

  Katharina Klinger, et al., bioRxiv - Neuroscience 2023

  Quote: ... the AChE inhibitor physostigmine hemisulfate (PHY; 2 μM; Cat.-No. sc-203661; Santa Cruz Biotechnology, Dallas, Texas, USA) or PHY combined with BIBP3226 (1 μM ...
• Leucine zipper-based sorting system enables generation of multi-functional CAR T cells

  Scott E. James, et al., bioRxiv - Synthetic Biology 2023

  Quote: ... Transfected cells were selected one day after transfection with puromycin 2 μg/mL (Santa Cruz Biotech, sc-108071B) or blasticidin 10 μg/mL (Santa Cruz Biotechnology ...
• EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells

  Irini Topalidou, et al., bioRxiv - Cell Biology 2019

  Quote: ... mouse monoclonal anti-GFP (1:200 to 1:350, Santa Cruz, #sc-9996), mouse monoclonal anti-insulin (1:350 ...
• Syndecan-4^-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components

  Sissel Beate Rønning, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-Pax-7 (1:500, sc-81648, 1:500, 1x casein, Santa Cruz) anti-decorin (1:500 ...
• Inhibitors of the Bub1 spindle assembly checkpoint kinase: Synthesis of BAY-320 and comparison with 2OH-BNPP1

  Ilma Amalina, et al., bioRxiv - Cell Biology 2020

  Quote: ... mouse anti-p53 (DO-1) (Santa Cruz Biotechnology cat#sc-126, 1:1000). Membranes were then washed three times in TBST and incubated for at least 1 hr with appropriate horseradish-peroxidase-conjugated secondary antibodies (1:2000) ...
• Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

  Kuan Zhang, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rat anti-PECAM-1 (CD31) (1:150, Santa Cruz Biotechnology, Cat# sc-18916), rabbit anti-PDGFRA (1:150 ...
• The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

  Swati Mishra, et al., bioRxiv - Cell Biology 2022

  Quote: ... Lysosome associated membrane protein-1 (LAMP1) at 1:250 (#sc 2011; Santa Cruz); Tropomyosin receptor kinase B (TRKB ...
• Extracellular Vesicles Analysis in the COVID-19 Era: Insights on Serum Inactivation Protocols Towards Downstream Isolation and Analysis

  Roberto Frigerio, et al., bioRxiv - Biochemistry 2020

  Quote: ... anti-TSG101 (1:1000, Novus Bio) and anti-Apo1 (1:1000, Santa Cruz). After washing with T-TBS ...
• IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic SNCA mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium release

  Peter A. Barbuti, et al., bioRxiv - Neuroscience 2020

  Quote: ... –TUBB3 (1:300; Covance, MRB-435P) -Vimentin (1:100; Santa Cruz, sc-373717). Secondary antibodies used were ...
• Translational profiling of mouse dopaminoceptive neurons reveals a role of PGE2 in dorsal striatum

  Enrica Montalban, et al., bioRxiv - Neuroscience 2020

  Quote: ... Vehicle (DMSO in PBS, 1/1) or misoprostol (Santa Cruz Biotechnology, #SC-201264), were infused at a dose of 50 μg.kg−1.day−1 ...
• A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding

  Lei Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-SATB2 (Millipore, ABE600, 1:2,000; Santa Cruz Biotechnology, sc-81376, 1:50), anti-TBR1 (Millipore ...
• Neonatal endotoxin stimulation was associated with long- term innate immune markers and an anti-allergic response in bronchiolar epithelium in spite of allergen challenge

  Luciana N García, et al., bioRxiv - Cell Biology 2019

  Quote: ... TSLP (1:200- Gene Tex, USA) or pEGFR (1:50 - Santa Cruz Biotechnology), with bound antibodies being detected using anti-rabitt (for SP-D ...
• Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion

  Aowen Zhuang, et al., bioRxiv - Molecular Biology 2019

  Quote: ... OST48 (H-1; 1:100 dilution; SC-74408; Santa Cruz biotechnologies, United States), nephrin (1:100 dilution ...
• The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion in experimental diabetic kidney disease via promotion of endoplasmic reticulum stress

  Aowen Zhuang, et al., bioRxiv - Molecular Biology 2019

  Quote: ... OST48 (H-1; 1:100 dilution; SC-74408; Santa Cruz biotechnologies, United States), GRP78 (A-10 ...
• Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function

  Manish Kumar, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 53BP1 (1:200, CST) or anti-BRCA1 primary antibody (1:500, Santa Cruz) overnight at 4°C ...
• Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation

  Amit Benbenishty, et al., bioRxiv - Neuroscience 2019

  Quote: ... and endothelial cells with anti-CD31 (PCAM-1) antibody (1:500; Santa Cruz). A secondary Alexa 647 antibody (1:600 ...
• Specificity of Gβ and γ subunits to the SNARE complex both at rest and after α_2a adrenergic receptor stimulation

  Yun Young Yim, et al., bioRxiv - Biochemistry 2021

  Quote: ... and rabbit anti-Gβ (Santa Cruz, sc-378, 1:10,000 and 1:5000) were used ...
• Inhibitory effect of the TSG-6 on the BMP-4/Smad signaling pathway and odonto/osteogenic differentiation of dental pulp stem cells

  Ying Wang, et al., bioRxiv - Cell Biology 2020

  Quote: The antibodies used for immunohistochemistry included DMP-1 (1:100 dilution, Santa Cruz), DSPP (1:100 dilution ...
• Inhibitory effect of the TSG-6 on the BMP-4/Smad signaling pathway and odonto/osteogenic differentiation of dental pulp stem cells

  Ying Wang, et al., bioRxiv - Cell Biology 2020

  Quote: ... the primary antibodies were as follows: DMP-1 (1:200 dilution, Santa Cruz) and DSPP (1:200 dilution ...
• Retinoic acid treatment recruits macrophages and increases axonal regeneration after optic nerve injury in the frog Rana pipiens

  Valeria De La Rosa-Reyes, et al., bioRxiv - Neuroscience 2021

  Quote: ... which were anti-Arginase 1 (1:50; catalog # sc-271430; Santa Cruz Biotechnology), anti-CD68 (ED1 ...
• PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins

  Ying Liu, et al., bioRxiv - Microbiology 2020

  Quote: ... or Western blotting: anti-PSGL-1 (Santa Cruz Biotech, sc-13535, 1:200), anti-cofilin (Cell Signaling ...
• NCLX controls hepatic mitochondrial Ca²⁺ extrusion and couples hormone-mediated mitochondrial Ca²⁺ oscillations with gluconeogenesis

  Mahmoud Taha, et al., bioRxiv - Physiology 2024

  Quote: ... for 1 h or an anti-mouse (1:5000, sc-2005, Santa Cruz) solution for 1 h ...
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... and Myosin ID (1:500; H-1; sc-515292; Santa Cruz Biotechnology, Inc). For fluorescence intensity measurements ...
• Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover

  Seda Yasa, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-Lamp1 (WB: 1:1000, IF: 1:100, Santa Cruz Biotech sc-19992), anti-Lamp2a (WB ...
• Synergistic induction of blood-brain barrier properties

  Gergő Porkoláb, et al., bioRxiv - Bioengineering 2023

  Quote: ... rabbit anti-PECAM-1 (Santa Cruz, cat# sc-1506-R, AB_831096, 1:200), rabbit anti-β-catenin (Sigma-Aldrich ...
• Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators

  Ingrid M. Saldana-Guerrero, et al., bioRxiv - Cancer Biology 2022

  Quote: ... MASH1 (ASCL1) (Abcam, Ab211327, 1:100 or Santa Cruz, SC-374104, 1:500); Ki67 (Abcam ...
• Actin nucleators safeguard replication forks by limiting nascent strand degradation

  Jadwiga Nieminuszczy, et al., bioRxiv - Molecular Biology 2023

  Quote: ... DIAPH1 (Bethyl, A300-077A-T, 1:1000; Santa Cruz, sc-373807, 1:500), CHK1 – phospho S345 (Cell Signalling ...
• Chlamydial protease-like activating factor targets SLC7A11 for degradation to induce ferroptosis and facilitate dissemination

  Wentao Chen, et al., bioRxiv - Microbiology 2023

  Quote: ... fibroblast-specific protein 1 (FSP1; 1:500, Santa Cruz Biotechnology Cat# sc-377120), TfR1(1:500 ...
• The Parkinson’s Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

  Katy R. McCarron, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-ALIX (1:1,000 WB, 1:500 IF, Santa Cruz Biotechnology; sc-53540), anti-Cathepsin D (1:2,000 WB ...
• Native size exclusion chromatography-based mass spectrometry (SEC-MS) identifies novel components of the Heat Shock Protein 90-dependent proteome

  Rahul S. Samant, et al., bioRxiv - Biochemistry 2022

  Quote: ... Antibodies for HSP90α/β (sc-7947, 1:500), CDC37 (sc-5617, 1:500), and AHA1 (sc-50527, 1:500) were from Santa Cruz Biotechnology ...
• Long-term dynamic changes of NMDA receptors following an excitotoxic challenge

  Alberto Granzotto, et al., bioRxiv - Neuroscience 2022

  Quote: ... Cells were incubated for 1 h at RT with anti-GluN1 antibody (1:200, Alomone) and anti-NOS1 antibody (1:50, Santa Cruz Biotechnology) in the blocking solution ...
• Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons

  Rosa Woldegebriel, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit α-GAPDH 1:1000 (#14C10, Cell Signalling) with secondary 1:5000 (#111-035-144, Jackson) and mouse α-NEFL 1:1000 (#sc39073, Santa Cruz) with secondary 1:5000 (#115-035-146 ...
• High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

  Kayleigh Slater, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and probed with primary antibodies (CysLT1 : Abcam [ab151484], 1:1000, CysLT2 : Cayman Chemical [CAY120560] 1:1000, Alpha-Tubulin : Santa Cruz, 1:200). Secondary antibodies were anti-mouse IgG HRP-linked (Cell Signalling [7076S] 1:1000) ...
• Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues

  Joel Pinczewski, et al., bioRxiv - Pathology 2020

  Quote: Working concentrations of antibodies to βcat (1:500, Epitomics, Burlingame, CA # 1247-1) and phospho-βcat (pS33-βcat 1:200, Santa Cruz, Santa Cruz, CA # SC-16743-R ...
• Site-Specific Knockdown of Microglia in the Locus Coeruleus Regulates Hypervigilant Responses to Social Stress in Female Rats

  Brittany S. Pate, et al., bioRxiv - Neuroscience 2022

  Quote: ... PVDF membranes incubated overnight at 4°C with the following primary antibodies diluted in 1:1 Blok/0.1M PBS + 0.2% Tween-20 : mouse anti-GAPDH (1:1000, Santa Cruz, Santa Cruz, CA), rabbit anti-CX3CL1 (1:1000 ...
• IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency

  Marco Flores-Mendez, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1:1000; CD68, Bio Rad MCA1957, 1:250; NEUN, Millipore MAB377, 1:2000; GFAP, Aves Lab 75-240, 1:1000, S6, Santa Cruz sc74459 ...
• Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner

  Masaya Harada, et al., bioRxiv - Neuroscience 2024

  Quote: ... before staining with the respective primary antibodies (NAc and LH with αGFP chicken 1:1000, Aves Labs ref GFP-1010; αmCherry rabbit, 1:1000, abcam ab167453; and αOrexin goat, 1:500, Santa Cruz Biotech ...
• Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human System

  Ibrahim Jubber, et al., bioRxiv - Evolutionary Biology 2023

  Quote: ... sc-15179 (Goat polyclonal) at 1:400 dilution for zebrafish tissue and 1:100-1:400 dilution for human tissue (Santa Cruz Biotechnology), Cytokeratin 5/6 (mouse monoclonal ...
• Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

  Xianping Wang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and rabbit anti-HA (CST, 1:200), rabbit anti-Flag (CST, 1:200) and mouse anti- Su(H) (Santa Cruz, 1:100), mouse anti-NICD (DSHB ...
• A pseudotyped lentivirus-based assay to titer SARS-CoV-2 neutralizing antibodies in Mexico

  José Antonio Cruz-Cardenas, et al., bioRxiv - Microbiology 2022

  Quote: ... Briefly 3 x105 cells were incubated on ice with mouse anti-human ACE2 monoclonal antibody conjugated to AF-647 (Santa Cruz Biotechnology, USA, cat. SC-390851) following manufacturer’s instructions ...
• ZNF143 binds DNA and stimulates transcription initiation to activate and repress direct target genes

  Jinhong Dong, et al., bioRxiv - Genomics 2024

  Quote: ... was aliquoted into each of 3 tubes with antibody (2µg anti-HA Invitrogen #26183, 8µg anti-SP1 Santa Cruz Biotechnology sc-17824 X, or mock IP) and incubated with end-over-end rotation at 4°C overnight ...
• FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation

  Kai T. Richter, et al., bioRxiv - Cell Biology 2019

  Quote: ... Mouse α-Myc (9E10, 1:500), rabbit α-SKP1 (H-163, 1:1000) and mouse α-ubiquitin (P4D1, 1:1000) were obtained from Santa Cruz. Mouse α-Nucleophosmin (NPM ...
• Clostridioides difficile spore-entry into intestinal epithelial cells contributes to recurrence of the disease

  Pablo Castro-Córdova, et al., bioRxiv - Microbiology 2020

  Quote: ... in PBS–1% BSA 1 h RT and 1:400 anti-goat conjugated with CFL 488 secondary antibody (green) (SC362255, Santa Cruz Biotechnologies, USA) in PBS–1% BSA for 1 h RT ...