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2251 - 2300 of 8862 citations for 6 1 4 dioxa 8 azaspiro 4.5 decan 8 yl 3 hydroxy 2 iminopyrimidin 4 amine since 2019

• Modulation of fibroblasts phenotype by colorectal cancer cells-secreted factors is mostly independent of oncogenic KRAS

  Patrícia Dias Carvalho, et al., bioRxiv - Cancer Biology 2022

  Quote: ... with the respective primary antibody (KRAS-LS-Bio, LS-C175665; 1:4000; α-SMA-Abcam, ab7817, 1:250; GAPDH-Santa Cruz Biotechnology, sc-47724, 1:10000), diluted in 5% non-fat milk in PBS+ 0.5% Tween 20 (Sigma-Aldrich) ...
• Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation

  Jinglong Wang, et al., bioRxiv - Genomics 2022

  Quote: ... Indicated antibodies (anti-Flag, 1:2000, 12793S, Cell Signaling Technology; anti-Rabbit-IgG, 1:2000, G-21234, Thermo Scientific; anti-β-actin, 1:4000, SC-47778, Santa Cruz Biotechnology) and HRP substrate (K-12042-D10 ...
• DNA hypomethylation activates Cdk4/6 and ATR to cause dormant origin firing and cell cycle arrest that restricts liver outgrowth in zebrafish

  Bhavani P. Madakashira, et al., bioRxiv - Developmental Biology 2023

  Quote: ... pH 8.0) for 1 hour at room temperature and incubated overnight in primary antibody (1:100 anti-Dnmt1 polyclonal, Santa Cruz, 1:1000 H3 polyclonal, Santa Cruz) diluted in blocking buffer at 4°C ...
• Repair of Noise-Induced Damage to Stereocilia F-actin Cores is Facilitated by XIRP2

  E.L. Wagner, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse monoclonal IgG1 γ-actin antibody (1-24: sc- 65635, Santa Cruz Biotechnology, Inc., 1:100). Alexa Fluor-488 ...
• Inverse correlation between heme synthesis and the Warburg effect in cancer cells

  Yuta Sugiyama, et al., bioRxiv - Biochemistry 2019

  Quote: ... COX IV-1 (sc-58348, 1:200 dilution, mouse monoclonal, Santa Cruz Biotechnology, Dallas, Texas, USA); and Actin (08691001 ...
• Regulation of HDAC2-PDX1 by RNF125 defines pancreatic cancer development

  Erez Hasnis, et al., bioRxiv - Cancer Biology 2020

  Quote: ... NR5A2 (Invitrogen; #DA5-28347, western blot dilution 1:1000, IHC/IF dilution 1:100; Santa Cruz; #sc-393369 ...
• Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs

  Carlo Brighi, et al., bioRxiv - Neuroscience 2020

  Quote: ... and for 1 hour with monoclonal mouse anti-GAPDH antibody (sc-32233 Santa Cruz, 1:3000) as loading control ...
• Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

  Loganathan Palanikumar, et al., bioRxiv - Cancer Biology 2020

  Quote: ... the membrane was probed with 1:5000 dilution of anti-GFP antibody (1:400; Santa Cruz) to detect YFP-tagged p53 DBDWT and p53 DBDR248W.
• NLRP3 controls ATM activation in response to DNA damage

  Mélanie Bodnar-Wachtel, et al., bioRxiv - Cancer Biology 2020

  Quote: ... from Bethyl Laboratories, anti-p53 (clone DO7 1:2000) and anti-NOXA (114C307, 1:1000) from Santa Cruz, anti-ATM (#ab32420 ...
• Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension

  Monika Lakk, et al., bioRxiv - Cell Biology 2021

  Quote: ... Primary antibodies (rabbit anti-TRPV4, 1:1000, Lifespan Biosciences, mouse anti-flotillin, 1:200, Santa Cruz; mouse anti-caveolin ...
• The cell cycle state defines TACC3 as a regulator gene in glioblastoma

  Holly Briggs, et al., bioRxiv - Cancer Biology 2020

  Quote: ... dilution: 1:2000) or normal mouse control immunoglobulin (sc-3877, Santa Cruz Biotechnology; dilution: 1:2000). The protein precipitates were separated by SDS-PAGE followed by Coomassie staining ...
• Amino Acids Promote Mitochondrial-Derived Compartment Formation in Mammalian Cells

  Max-Hinderk Schuler, et al., bioRxiv - Cell Biology 2020

  Quote: ... The indicated primary antibody (Tomm70A (Sigma HPA048020, 1:400 and Santa Cruz sc-390545, 1:200), Tomm20 (Millipore MABT116 ...
• The DNA end-binding protein Ku associates with human telomeres primarily via protein-protein interactions

  Ann T. Sukumar, et al., bioRxiv - Molecular Biology 2019

  Quote: ... anti-Ku80 (sc-9034, Santa Cruz, 1:1000 dilution; sc-5280, Santa Cruz, 1:250 dilution), anti-Ku70 (MS-329-P1 ...
• S. cerevisiae Srs2 helicase ensures normal recombination intermediate metabolism during meiosis and prevents accumulation of Rad51 aggregates

  Laura J Hunt, et al., bioRxiv - Genetics 2019

  Quote: ... Mouse anti-yeast Rad51 antibody (Santa Cruz, sc-133089, 1:200 in 1% skim milk, PBS) was added at 150 μl per slide and slides were incubated at 4°C overnight ...
• Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease

  How-Wing Leung, et al., bioRxiv - Neuroscience 2019

  Quote: ... followed by primary antibodies incubation for 1 h (anti-Arc, 1:1000, Santa Cruz, sc-17839) in 1x TBST at rtp ...
• MicroRNA arm switching regulated by uridylation

  Haedong Kim, et al., bioRxiv - Molecular Biology 2020

  Quote: ... RRID:AB_2072134, 1:1,000), and Cyclin D1 (sc-753, RRID:AB_2070433, 1:1,000) were purchased from Santa Cruz Biotechnology ...
• The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A)-translation

  Andrea Hildebrandt, et al., bioRxiv - Molecular Biology 2019

  Quote: ... Cells were treated with the proteasome inhibitors bortezomib (1 μM, 8h, replicate 1; Santa Cruz Biotechnology) or MG132 (10 μM ...
• Neurodegeneration induces a developmental RNA processing program by calpain-mediated MBNL2 degradation

  Lee-Hsin Wang, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-CAPN2 (sc-373966, 1:10000 for immunoblotting and 1:250 for immnostaining, Santa Cruz Biotechnology), anti-NeuN (ab177487 ...
• An early cell shape transition drives evolutionary expansion of the human forebrain

  Silvia Benito-Kwiecinski, et al., bioRxiv - Evolutionary Biology 2020

  Quote: ... mouse anti-Vimentin (V9) (Santa Cruz, sc-6260, IF 1:200, WB 1:1000 in BSA) rabbit anti-PAX6 (Abcam ...
• Substrate-mediated regulation of the arginine transporter of Toxoplasma gondii

  Esther Rajendran, et al., bioRxiv - Microbiology 2019

  Quote: ... goat anti-rabbit (1:5,000 to 1:10,000 dilution; Santa Cruz, sc-2004, or Abcam, ab97051), or goat anti-mouse (1:5,000 to 1:10,000 dilution ...
• Repair of Noise-Induced Damage to Stereocilia F-actin Cores is Facilitated by XIRP2

  E.L. Wagner, et al., bioRxiv - Neuroscience 2021

  Quote: ... monoclonal mouse IgG1 γ-actin antibody (1-24: sc-65635, Santa Cruz Biotechnology, Inc., 1:1000), and mouse monoclonal β-actin antibody (AC-15 ...
• A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons

  Monika Moissidis, et al., bioRxiv - Neuroscience 2024

  Quote: ... The following primary antibodies were used: mouse anti-PGC-1⍺ (1:200, Santa Cruz #sc-518025), rabbit anti-MEF2c (1:500 ...
• Myocardin-related transcription factor drives epithelial fibrogenesis in polycystic kidney disease

  Zsuzsanna Lichner, et al., bioRxiv - Cell Biology 2024

  Quote: ... The following primary antibodies were used: Polycystin 1 (1:200 sc-130554, Santa Cruz Biotechnology, TX), Polycystin 2 (1:500 ...
• An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development

  Athina Varveri, et al., bioRxiv - Cancer Biology 2023

  Quote: ... RT) and stained with the following primary antibodies: Lamp-1 (rat; 1:400; Santa Cruz Biotechnology), p62 MBL (rabbit ...
• Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons

  Tetsushi Yamagata, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-TBR1 antibody (1:1,000; ab31940, Abcam or 1:500; SC-376258, Santa Cruz Biotechnology), rabbit anti-FEZF2 antibody (1:500 ...
• HSV-1 miRNAs are posttranscriptionaly edited in latently infected human ganglia

  Andreja Zubković, et al., bioRxiv - Microbiology 2023

  Quote: ... and mouse monoclonal α-ADAR2 IgG (Santa Cruz; diluted 1:100 in 1% BSA in PBS) over 12 hours in a humid chamber at 4°C ...
• Collapse of late endosomal pH elicits a rapid Rab7 response via V-ATPase and RILP

  R.J. Mulligan, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-HA (mouse monoclonal; 1:100 IF, 1:1000 WB; Santa Cruz sc-7392; RRID: AB_627809); anti-HA (rabbit ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... The following primary antibodies were used: rat anti-LAMP-1 (1:400, Santa Cruz sc-19992), mouse anti-LAMP-1 (1:1000 ...
• Autophagy promotes cell and organismal survival by maintaining NAD(H) pools

  Lucia Sedlackova, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1% soybean flour (Santa Cruz Biotechnology), 3% treacle (Bidfood) ...
• Early growth response 2 (EGR2) is a novel regulator of the senescence program

  Eleanor J. Tyler, et al., bioRxiv - Cell Biology 2020

  Quote: ... rabbitαEGR2 (1:250, H220 Santa Cruz), goatαIL-6 (1:100 ...
• Boron induces osteogenesis by stimulating NaBC1 in cooperation with BMPR1A

  Patricia Rico, et al., bioRxiv - Cell Biology 2020

  Quote: ... Osteopontin (Santa cruz Biotechnology, 1:100), Osteocalcin (abcam ...
• Phase-separation of EML4-ALK variant 3 is dependent upon an active ALK conformation

  Josephina Sampson, et al., bioRxiv - Cell Biology 2020

  Quote: ... SOS1 (1:100; Santa Cruz Biotechnology). Secondary antibodies were Alexa Fluor-488 and -594 goat anti-rabbit and goat anti-mouse IgGs (1:200 ...
• BRAWNIN: A sORF-encoded Peptide Essential for Vertebrate Mitochondrial Complex III Assembly

  Shan Zhang, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1:500 (Santa Cruz, sc-13561); anti-CS ...
• BRAWNIN: A sORF-encoded Peptide Essential for Vertebrate Mitochondrial Complex III Assembly

  Shan Zhang, et al., bioRxiv - Cell Biology 2020

  Quote: ... 1:2000 (Santa Cruz, SC-390693); anti-ATP5A ...
• mRNA translation control by Dhx36 binding to 5’UTR G-quadruplex structures is essential for skeletal muscle stem cell regenerative functions

  Xiaona Chen, et al., bioRxiv - Cell Biology 2020

  Quote: ... MyoD (Santa Cruz Biotechnology; 1:1000), Gnai2 (Abcam ...
• mRNA translation control by Dhx36 binding to 5’UTR G-quadruplex structures is essential for skeletal muscle stem cell regenerative functions

  Xiaona Chen, et al., bioRxiv - Cell Biology 2020

  Quote: ... Dhx9 (Santa Cruz Biotechnology; 1:5,000). For immunofluorescence staining ...
• mRNA translation control by Dhx36 binding to 5’UTR G-quadruplex structures is essential for skeletal muscle stem cell regenerative functions

  Xiaona Chen, et al., bioRxiv - Cell Biology 2020

  Quote: ... HnrnpL (Santa Cruz Biotechnology; 1:5,000), Dhx9 (Santa Cruz Biotechnology ...
• mRNA translation control by Dhx36 binding to 5’UTR G-quadruplex structures is essential for skeletal muscle stem cell regenerative functions

  Xiaona Chen, et al., bioRxiv - Cell Biology 2020

  Quote: ... CCND1 (Santa Cruz Biotechnology; 1:5000), CCNA1 (Santa Cruz Biotechnology) ...
• Loss of Protein Kinase D2 Activity Protects Against Bleomycin-induced Dermal Fibrosis in Mice

  Liping Chen, et al., bioRxiv - Genetics 2021

  Quote: ... anti-PKD1 (Santa Cruz, 1:1000), anti-p-PKD1 (ser744/748 ...
• Antiviral effects of miRNAs in extracellular vesicles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mutations in SARS-CoV-2 RNA virus

  Jae Hyun Park, et al., bioRxiv - Molecular Biology 2020

  Quote: ... CD63 (1:1,000, Santa Cruz Biotechnology) TSG 101 (1:500 ...
• Antiviral effects of miRNAs in extracellular vesicles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mutations in SARS-CoV-2 RNA virus

  Jae Hyun Park, et al., bioRxiv - Molecular Biology 2020

  Quote: ... CD9 (1:1,000, Santa Cruz Biotechnology), CD63 (1:1,000 ...
• The cell-cell adhesion protein JAM3 determines nuclear deformability by regulating microtubule organization

  Mar Arias-Garcia, et al., bioRxiv - Cell Biology 2020

  Quote: ... EB1 Antibody (Santa Cruz, 1:100), YAP (G6 ...
• The cell-cell adhesion protein JAM3 determines nuclear deformability by regulating microtubule organization

  Mar Arias-Garcia, et al., bioRxiv - Cell Biology 2020

  Quote: ... JAM-C (Santa Cruz, 1:200), EB1 Antibody (Santa Cruz ...
• The cell-cell adhesion protein JAM3 determines nuclear deformability by regulating microtubule organization

  Mar Arias-Garcia, et al., bioRxiv - Cell Biology 2020

  Quote: ... YAP (G6) (Santa Cruz, 1:200), YAP/TAZ [67.3] (Santa Cruz ...
• Rapid and efficient in vivo astrocyte-to-neuron conversion with regional identity and connectivity?

  Lei-Lei Wang, et al., bioRxiv - Neuroscience 2020

  Quote: ... ALDOC (Goat; 1:100; Santa Cruz), BrdU (Rat ...
• Safb1 regulates cell fate determination in adult neural stem cells by enhancing Drosha cleavage of NFIB mRNA

  Niklas Iffländer, et al., bioRxiv - Neuroscience 2021

  Quote: ... Sox10 (Santa Cruz, goat, 1:500) and GFAP (Sigma ...
• Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation

  Tomoki Kuwahara, et al., bioRxiv - Molecular Biology 2020

  Quote: ... vacuolin-1 (500 nM, Santa Cruz), Torin 1 (1 μM ...
• Cardiac Gq receptors and calcineurin activation are not required for the hypertrophic response to mechanical left ventricular pressure overload

  Ze-Yan Yu, et al., bioRxiv - Molecular Biology 2020

  Quote: ... CaMKIIδ (1:1000; Santa Cruz Biotechnology), p-HDAC4 (1:1500 ...
• Cardiac Gq receptors and calcineurin activation are not required for the hypertrophic response to mechanical left ventricular pressure overload

  Ze-Yan Yu, et al., bioRxiv - Molecular Biology 2020

  Quote: ... GATA4 (1:1000; Santa Cruz Biotechnology), CaMKIIδ (1:1000 ...
• The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress

  Brian Hurwitz, et al., bioRxiv - Cell Biology 2022

  Quote: ... 1/500 LaminB1 (Santa Cruz, 374015); 1/500 α-tubulin (BD Biosciences ...