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1851 - 1900 of 8862 citations for 6 1 4 dioxa 8 azaspiro 4.5 decan 8 yl 3 hydroxy 2 iminopyrimidin 4 amine since 2019

• BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss

  Mario A. Shields, et al., bioRxiv - Pathology 2023

  Quote: ... Zo-1 (Santa Cruz Biotech #sc-33725, 1:200), Amylase (Santa Cruz Biotech #sc-46657 ...
• Deamidated TPI is an efficacious target for cell-selective therapy in triple-negative breast cancer

  Sergio Enríquez-Flores, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Bax (B-9) and β-Actin (C-2) (Santa Cruz Biotechnology, Santa Cruz, CA, USA) at a dilution of 1:1000 in 0.1% TBS-Tween-20 and 1% BSA and washed three times with the same buffer ...
• Deamidated TPI is an efficacious target for cell-selective therapy in triple-negative breast cancer

  Sergio Enríquez-Flores, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Bax (B-9) and β-Actin (C-2) (Santa Cruz Biotechnology, Santa Cruz, CA, USA) at a dilution of 1:1000 in 0.1% TBS-Tween-20 and 1% BSA and washed three times with the same buffer ...
• Quantification of extracellular vesicles with unaltered surface membranes using an internalized oligonucleotide tracer and droplet digital PCR applied to modeling of in vivo kinetics

  Thomas De Luca, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-GM130 (clone B-10, 2 μg/mL, cat. no. sc-55591, Santa Cruz Biotechnology), anti α-actinin (clone H-2 ...
• Human PUM1 and PUM2 exhibit regulation of divergent mRNA targets in male germ cells

  Maciej Jerzy Smialek, et al., bioRxiv - Molecular Biology 2019

  Quote: TCam-2 cells were transfected with siRNA using PUM1 siRNA (sc-62912 Santa Cruz Biotechnology), PUM2 siRNA (sc-44773 ...
• Astrocytes express DMT1 and transferrin receptors, which transport iron thus activating Ca²⁺ signalling: possible role in neuroprotection against iron overload?

  Maosheng Xia, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Na+/K+-ATPase alpha1/2 antibody and the secondary antibodies were bought from Santa Cruz Biotechnology (Santa Cruz ...
• VHL ligand binding increases intracellular level of VHL

  Julianty Frost, Sonia Rocha, Alessio Ciulli, bioRxiv - Biochemistry 2021

  Quote: ... Protein lysates were incubated with 2 μg of HIF-1α antibody (Santa Cruz; sc-53546) or 2 μg of mouse IgG control antibody (Sigma ...
• Early detection of SARS-CoV-2 in circulating immune cells in a mouse model

  Tingting Geng, et al., bioRxiv - Microbiology 2021

  Quote: ... hACE2 (Mouse-anti-Human ACE-2, Cat# sc-390851, clone E-11, Santa Cruz Biotechnology) indirectly labeled with goat-anti-mouse Alexa Fluor 594 ...
• Regulation of DNA damage response by trimeric G-protein Signaling

  Amer Ali Abd El-Hafeez, et al., bioRxiv - Cancer Biology 2021

  Quote: Pooled guide RNA plasmids (commercially obtained from Santa Cruz Biotechnology; Cat# sc-402236-KO-2) were used ...
• Antibodies control metabolism by regulating insulin homeostasis

  Timm Amendt, et al., bioRxiv - Immunology 2021

  Quote: ... Chemical thiol-crosslinking was done using 1,2-Phenylen-bis-maleimide (Santa Cruz, 13118-04-2) at 100 μg/mL for 48 h at room temperature (dark ...
• An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

  Dianne Lumaquin, et al., bioRxiv - Cell Biology 2020

  Quote: ... Cells were fixed with 2% paraformaldehyde (Santa Cruz Biotechnology, Santa Cruz, USA, Catalog #sc-281692) for 45 minutes ...
• The Cytomegalovirus M35 Protein Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes by Direct Promoter Binding

  Hella Schwanke, et al., bioRxiv - Molecular Biology 2023

  Quote: ... HRP-coupled GFP-antibody (clone B-2, #sc-9996 HRP) was purchased from Santa Cruz Biotechnology (Heidelberg ...
• Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia

  Laura R. Nementzik, et al., bioRxiv - Neuroscience 2023

  Quote: ... The ubiquilin 2 antibody used here (mouse monoclonal anti-ubiquilin IgG2a, Santa Cruz #SC-100612) has been used by us previously for the detection of neuropathological aggregates [18 ...
• Structure and activity of botulinum neurotoxin X

  Markel Martínez-Carranza, et al., bioRxiv - Biochemistry 2023

  Quote: ... Primary antibodies used were against VAMP-2 (custom made) and VAMP4 (Santa Cruz sc-365332). The secondary antibodies were HRP-conjugated ant-rabbit IgG (Sigma A6154 ...
• Morphogen-driven human iPSCs differentiation in 3D in vitro models of gastrulation is precluded by physical confinement

  Haneen S. Alsehli, et al., bioRxiv - Cell Biology 2023

  Quote: ... goat anti-SOX17 (R&D, 1:50) were diluted and YAP 1 (Santa Cruz, 1:50) were diluted in the blocking buffer and incubated for 48 h in the dark at 4°C on a shaker ...
• Nano-particles carried by multiple dynein motors: A Self-Regulating Nano-Machine

  I. Fayer, et al., bioRxiv - Biophysics 2020

  Quote: ... the membrane was washed 3 times with PBST and incubated with an anti-Mouse HRP conjugated secondary antibody (Santa Cruz, sc-2005) diluted 1 ...
• A thermostable, closed, SARS-CoV-2 spike protein trimer

  Xiaoli Xiong, et al., bioRxiv - Biochemistry 2020

  Quote: ... Presence of His-tagged protein was detected by chemical luminescence using His-probe (H-3) HRP (sc-8036 HRP, Santa Cruz Biotechnology) monoclonal antibody horseradish peroxidase (HRP ...
• The mitotic checkpoint protein MAD2 delivers monoamine transporters to endocytosis

  Florian Koban, Michael Freissmuth, bioRxiv - Neuroscience 2021

  Quote: HEK-293 cells in different culture formats were transfected with 3 target-specific siRNAs against human MAD2 (sc-35837, Santa Cruz Biotechnology) or siRNA against Luciferase (Dharmacon ...
• Differences in the metabolite profiles of tender leaves of wheat, barley, rye and Triticale based on LC-MS

  Piyi Xing, Zhenqiao Song, Xingfeng Li, bioRxiv - Plant Biology 2020

  Quote: ... The sample components were separated on a C18 olumn (Hypersil GOLD C18; 4.6 mm × 100 mm; 3 µm particle size; Agilent, Santa Cruz, CA, USA). The column was eluted at 0.3 mL/min with a gradient from 95% solvent A (0.1% formic acid in water ...
• Histone marks are drivers of the splicing changes necessary for an epithelial-to-mesenchymal transition

  A. Segelle, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 3% BSA) for 30min on rotating wheel at room temperature and successively incubated with CTNND1 e2 primary antibody (Santa Cruz sc-23873) for 1h30 on rotating wheel at room temperature ...
• Global Profiling of c-Jun and JunB transcription factor binding sites in an ALK+ ALCL cell line

  Zuoqiao Wu, et al., bioRxiv - Cancer Biology 2022

  Quote: ... The anti-Bid mAb (B-3) for EMSAs and anti-β-actin mAb (DM1A) used in western blotting experiments were also purchased from Santa Cruz Biotechnology ...
• Invadopodia enable cooperative invasion and metastasis of breast cancer cells

  L. Perrin, et al., bioRxiv - Cancer Biology 2022

  Quote: ... blocked with 5% BSA/TBST for 3 h at room temperature and incubated with anti-β-actin (Santa Cruz Biotechnology, sc-47778), anti-cortactin (Abcam ...
• Combination of arsenic trioxide epigallocatechin-3-gallate and Resveratrol synergistically suppresses the growth and invasion in Brain tumor cell lines

  Roshanak S. Sajjadi, et al., bioRxiv - Cancer Biology 2020

  Quote: ... the membrane was washed with TBST (5min × 3) and then incubated in m-IgGκ BP-HRP secondary antibody (Santa Cruz, sc-516102) for 1h at room temperature ...
• Role of Ribeye PXDLS/T-binding cleft in normal synaptic ribbon function

  Jie Zhu, et al., bioRxiv - Neuroscience 2023

  Quote: The primary antibodies used for cell staining and zebrafish were CtBP [CtBP (B-3, Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA)] ...
• Structure-function analysis reveals a DNA polymerization-independent role for mitochondrial DNA polymerase IC in African trypanosomes

  Jonathan C Miller, et al., bioRxiv - Microbiology 2019

  Quote: ... blocked and re-probed with specific Crithidia fasciculata anti-Hsp70 (1:5000, 1 h) (Johnson and Englund, 1998) and secondary chicken anti-rabbit-HRP (1:2000, 1 h) (Santa Cruz, sc-516087). Signal was detected with Clarity™ ECL Blotting Substrate (NEB ...
• rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin

  Hua Yu, et al., bioRxiv - Cell Biology 2021

  Quote: ... followed by incubation overnight with primary antibodies (1:200, Nucleolin, CST, 145745; 1:400, NPM1, Sigma, B0556; 1:200, Fibrillarin, Abcam, ab4566; RPA194, 1:50, Santa Cruz, sc-48385) at 4 degree or for 1hr at 37 °C ...
• rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin

  Hua Yu, et al., bioRxiv - Cell Biology 2021

  Quote: ... for 10 min at RT and then stained with a primary antibody (1:200, Nucleolin, CST, 145745; 1:400, NPM1, Sigma, B0556; 1:200, Fibrillarin, Abcam, ab4566; RPA194, 1:50, Santa Cruz, sc-48385) for 12 h at 4 °C ...
• Tel1 activation by the MRX complex is sufficient for telomere length regulation but not for the DNA damage response in S. cerevisiae

  Rebecca Keener, et al., bioRxiv - Molecular Biology 2019

  Quote: ... Invitrogen 22C5D8 Pgk1 at 1:6,000; Roche 12CA5 HA at 1:2,000; Invitrogen R960-25 V5 at 1:2,000; Santa Cruz 9E10 c-myc at 1:10,000). The membrane was washed in 1x Tris Buffered Saline with Tween-20 (TBST ...
• Syndecan-4^-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components

  Sissel Beate Rønning, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-fibromodulin (1:500, 1% casein, sc-33772, Santa Cruz), anti-pSer2448-mTOR (1:1000 ...
• Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

  Flora Magnotti, et al., bioRxiv - Immunology 2021

  Quote: ... anti-human Caspase-1 (Santa Cruz, sc515, 1: 1,000 dilution), anti-human GSGMD (sigma ...
• RhoA- and Ran-induced antagonistic forces underlie symmetry breaking and spindle rotation in mouse oocytes

  Benoit Dehapiot, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Rock-1 (1/100, Goat polyclonal; Santa Cruz sc-6056). Secondary antibodies were Alexa Fluor 488-conjugated donkey anti-goat ...
• CDK5 influences the organization of the Circadian Machinery in peripheral clocks

  Jürgen Ripperger, Urs Albrecht, Andrea Brenna, bioRxiv - Molecular Biology 2021

  Quote: ... while Tubulin by Abcam (1:1000) and Lamin B by Santa Cruz (1:1000). The day after ...
• GPCR-mediated clearance of tau in post-synaptic compartments attenuates tau pathology in vivo

  Ari W. Schaler, et al., bioRxiv - Neuroscience 2020

  Quote: ... CamKIIα (1:2000, A-1, sc13141) was from Santa Cruz Biotechnology ...
• Phenomenon of music-induced opening of the blood-brain barrier in healthy mice

  O. Semyachkina-Glushkovskaya, et al., bioRxiv - Neuroscience 2020

  Quote: ... ZO-1 (1:500; Santa Cruz Biotechnology, Santa Cruz, USA), OCC and NG2 (1:500 ...
• Phenomenon of music-induced opening of the blood-brain barrier in healthy mice

  O. Semyachkina-Glushkovskaya, et al., bioRxiv - Neuroscience 2020

  Quote: ... ZO-1 (1:500; Santa Cruz Biotechnology, Santa Cruz, USA), OCC and NG2 (1:500 ...
• Klebsiella pneumoniae reduces SUMOylation to limit host defence responses

  Joana Sá-Pessoa, et al., bioRxiv - Microbiology 2020

  Quote: ... anti-Cullin-1 (1:200, Santa Cruz Biotechnology sc-12761), anti-Flag M2 (1 μg ...
• Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

  Robin M. Delaine-Smith, et al., bioRxiv - Cancer Biology 2021

  Quote: ... GLI-1 Antibody (C-1, sc-515751) from Santa Cruz Biotechnology.
• APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy

  Leslie A. Bruggeman, et al., bioRxiv - Pathology 2019

  Quote: ... rabbit polyclonal WT-1 (1:200 dilution, Santa Cruz Biotech). Podocyte counts ...
• Reliance of neuronal gene expression on cohesin scales with chromatin loop length

  Lesly Calderon, et al., bioRxiv - Genomics 2022

  Quote: ... CUX-1 (1:400; rabbit polyclonal sc-13024, Santa Cruz) and anti phospho-histone H3 (Ser10 ...
• Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation

  Stacia M. Dolliver, et al., bioRxiv - Microbiology 2022

  Quote: ... TIA-1 (1:200; goat, Santa Cruz Biotechnology, sc-1751); TIAR (1:1000 ...
• Multiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health

  James L. Daly, et al., bioRxiv - Neuroscience 2022

  Quote: ... VPS29 (Santa Cruz; D-1; sc-398874; 1:500 WB), VPS35 (Abcam ...
• Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models

  Yibo Zuo, et al., bioRxiv - Microbiology 2022

  Quote: ... anti-Ubiquitin (Ub) (Santa Cruz, 12987-1-AP, 1:1000), anti-K48 Ub (Cell Signaling Technology ...
• A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons

  Monika Moissidis, et al., bioRxiv - Neuroscience 2024

  Quote: ... mouse anti-PGC-1⍺ (1:200, Santa Cruz #sc-518025), mouse anti-Kv1.1 (1:1,000 ...
• The phospho-regulated amphiphysin/endophilin interaction is required for synaptic vesicle endocytosis

  Christiana Kontaxi, Michael A. Cousin, bioRxiv - Neuroscience 2023

  Quote: ... goat syndapin 1 (1:1000; Santa Cruz Biotechnology, sc-10412), and mouse PSD95 (1:1000 ...
• Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

  Adam Myszczyszyn, et al., bioRxiv - Cell Biology 2023

  Quote: ... rat anti-Zo-1 (1:200, Santa Cruz, sc-33725), mouse anti-MDR1 (1:50 ...
• A chemical probe to modulate human GID4 Pro/N-degron interactions

  Dominic D.G Owens, et al., bioRxiv - Molecular Biology 2023

  Quote: ... ARMC8 (E-1, sc-365307; Santa Cruz Biotechnology, 1:500), WDR26 (ab85962 ...
• The large GTPase Guanylate-Binding Protein-1 (GBP-1) promotes mitochondrial fission in glioblastoma

  Ryan C. Kalb, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Anti-GBP-1 (1b1) (1:25; Calbiochem or Santa Cruz), anti-myc (1:50 ...
• Production of human translation-competent lysates using dual centrifugation

  Lukas-Adrian Gurzeler, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Puromycin control reactions contained 320 μg/ml puromycin (Santa Cruz Biotechnology, Cat. No. 58-58-2). Before adding reporter mRNAs ...
• Quantification of extracellular vesicles with unaltered surface membranes using an internalized oligonucleotide tracer and droplet digital PCR applied to modeling of in vivo kinetics

  Thomas De Luca, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-cytochrome c1 (clone A-5, 2 μg/mL, cat. no. sc-514435, Santa Cruz Biotechnology), anti-GM130 (clone B-10 ...
• Probing host-anaerobe interactions in innovative human gut cellular models

  Blessing O Anonye, et al., bioRxiv - Microbiology 2019

  Quote: The Snapwell insert was incubated with mucin 2 anti-rabbit primary antibody (Santa Cruz Biotechnology, US) overnight at 4°C followed by Alexa Fluor 488 goat anti-rabbit secondary antibody (New England Biolabs ...