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151 - 200 of 8014 citations for 1 6 Chloropyridazin 3 yl piperidine 4 carboxamide since 2020

• SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

  Brianna R. Daley, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-RSK (B-4) (Santa Cruz sc-74575; 1:1000) anti-pS6 Ser235/236 (Cell Signaling 4858 ...
• “Identification of microRNAs regulated by E2F transcription factors in human pluripotent stem cells”

  María Soledad Rodríguez-Varela, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Anti-OCT-4 (1:1000) primary antibody from Santa Cruz Biotechnology (sc-5279 ...
• How scars shape the neural landscape: key molecular mediators of TGF-β1’s anti-neuritogenic effects

  Kye-Im Jeon, Krystel R. Huxlin, bioRxiv - Neuroscience 2020

  Quote: ... and a mouse monoclonal antibody to acetylated α-tubulin (Ac-Tub; 1:5000, 6-11B-1, Santa Cruz Biotechnology). Responsiveness to NGF was assayed by probing for the expression of tropomyosin receptor kinase A (Trk-A ...
• P4HA2: A link between tumor-intrinsic hypoxia, partial EMT and collective migration

  Vaishali Aggarwal, et al., bioRxiv - Cancer Biology 2022

  Quote: ... P4HA2 was inhibited by using 20 μmol/L 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA) (SC-200758, Santa Cruz, USA). 1,4-DPCA ...
• Anti-cancer properties of cannabidiol and Δ9-tetrahydrocannabinol and potential synergistic effects with gemcitabine, cisplatin and other cannabinoids in bladder cancer

  Andrea M. Tomko, Erin G. Whynot, Denis J. Dupré, bioRxiv - Cancer Biology 2021

  Quote: ... and incubated overnight at 4 °C with their respective primary antibodies (cleaved Caspase 3 (p11): sc-271759 from Santa Cruz Biotechnologies) ...
• Hepatitis B virus x (HBx) protein increases cellular OCT3/4 and MYC and facilitates cellular reprogramming

  Madhusudana Girija Sanal, et al., bioRxiv - Cell Biology 2023

  Quote: ... the membrane was washed once with TBST and incubated with rabbit antibodies against human OCT-3/4 antibody (Santa Cruz Biotechnology Inc. ...
• SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells

  Lilian Sluimer, et al., bioRxiv - Cancer Biology 2022

  Quote: ... mouse anti-Smad2/3 (C-8) (Santa Cruz, sc-133098; 1:1,000), rabbit anti-phospho-EGFR Tyr1173 (Cell Signaling Technology ...
• Vascular Injury Changes Topology of Vessel Network to Adapt to Partition of Blood Flow for New Arteriovenous Specification

  Kyung In Baek, et al., bioRxiv - Molecular Biology 2020

  Quote: ... platelet endothelial adhesion molecule 1 (H-3, Santa Cruz Biotechnology Inc., TX) and 4′,6-diamidino-2-phenylindole (SC-3598 ...
• Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites

  Jacqueline M Tokarew, et al., bioRxiv - Neuroscience 2020

  Quote: ... as well as anti-LAMP-3/CD63 (Santa Cruz, SC5275; 1:100), anti-LC3B (Sigma ...
• Differences in neuronal numbers, morphology and developmental apoptosis in mice nigra provide experimental evidence of ontogenic origin of vulnerability to Parkinson’s disease

  D J Vidyadhara, et al., bioRxiv - Neuroscience 2021

  Quote: ... and caspase-3 (1:200, SC-7148, Santa Cruz Biotechnology Inc, USA) as well as GDNF (1:200 ...
• Maspin/SerpinB5 is a cytoskeleton-binding protein that regulates epithelial cell shape

  Luiz E. da Silva, et al., bioRxiv - Cell Biology 2024

  Quote: ... mouse anti-Zeb1 (1:1000, H-3, sc-515797, Santa Cruz Biotech.), mouse anti-GFP (1:1000 ...
• CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate Immunity

  Naru Sato, et al., bioRxiv - Cell Biology 2024

  Quote: ... or anti-AKT1/2/3 (Santa Cruz Biotechnology, sc-81434, 1:20) antibody using Dynabeads Protein G (Thermo Fisher Scientific ...
• A genome-wide genetic screen uncovers novel determinants of human pigmentation

  Vivek K. Bajpai, et al., bioRxiv - Cell Biology 2021

  Quote: ... goat SOX10 (1:50; 4°C overnight; Santa Cruz, sc-17342), mouse HMB45 (1:20 ...
• The beta-tubulin isotype TUBB6 controls microtubule and actin dynamics in osteoclasts

  Justine Maurin, et al., bioRxiv - Cell Biology 2021

  Quote: ... or α-tubulin (1:200, YOL3/4 Santa Cruz Biotechnologies sc53030), ARHGAP10 (1:200) ...
• PLD2-phosphatidic acid recruit ESCRT-I to late endosomes for exosome biogenesis

  Antonio Luis Egea-Jimenez, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-CD81 (D-4, sc-166028, Santa Cruz, 1:1000 dilution), anti-flotillin-1 (610820 ...
• Endogenous retroviruses promote prion-like spreading of proteopathic seeds

  Shu Liu, et al., bioRxiv - Neuroscience 2022

  Quote: ... mouse anti PiT-2 B-4 (1:1000; Santa Cruz Biotechnology); rabbit anti-V5 D3H8Q (1:1000 ...
• CREB-mediated transcriptional activation of NRMT1 drives muscle differentiation

  John G. Tooley, et al., bioRxiv - Biochemistry 2021

  Quote: ... mouse anti-Elf1 (C-4) (1:1000; sc-133096, Santa Cruz), mouse anti-Ets-1 (C-4 ...
• Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastrointestinal inflammation

  Marta Gómez-Ferrer, et al., bioRxiv - Cell Biology 2023

  Quote: ... and anti-CD9 (dilution 1/500; Santa Cruz Biotechnology; C-4). Secondary antibodies were anti-IgG rabbit (dilution 1/4000 ...
• Rejuvenation of aged oocyte through exposure to young follicular microenvironment

  HaiYang Wang, et al., bioRxiv - Developmental Biology 2024

  Quote: ... mouse anti-Oct3/4 (sc-5279, Santa Cruz Biotechnology; 1:50), rabbit anti–CDX2 (NB100-2136 ...
• Endogenously produced hydrogen cyanide serves as a novel mammalian gasotransmitter

  Karim Zuhra, et al., bioRxiv - Biochemistry 2024

  Quote: ... were seeded at 70–80 % confluence in a 6-well plate and transiently transfected 4-6 h later with the TST shRNA plasmid (sc-36418-SH : Santa Cruz Biotechnology Inc., Santa Cruz, CA 95060), a packaging plasmid pLP1 ...
• Dynamic modelling of the PI3K/mTOR signalling network uncovers biphasic dependence of mTORC1 activation on the mTORC2 subunit Sin1

  Milad Ghomlaghi, et al., bioRxiv - Systems Biology 2020

  Quote: ... anti-14-3-3 (Santa Cruz, sc-629).
• T606-phosphorylation deprives the function of Kaiso as a transcription and oncogenic factor

  Wei Tian, et al., bioRxiv - Molecular Biology 2021

  Quote: ... pan-14-3-3 (sc-629, Santa Cruz), 14-3-3 family (α/β ...
• MARK3-mediated Slingshot-1 phosphorylation is essential for polarized lamellipodium formation

  Toshiaki Mishima, et al., bioRxiv - Cell Biology 2023

  Quote: ... 14-3-3 (H-8; Santa Cruz Biotechnology), MARK3 (G-7 ...
• Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase

  Junjie Xu, et al., bioRxiv - Genetics 2022

  Quote: ... anti-14-3-3 (Santa Cruz, sc-23957) antibodies were purchased from commercial sources ...
• Multimodal profiling of chordoma immunity reveals distinct immune contextures

  S. van Oost, et al., bioRxiv - Cancer Biology 2023

  Quote: ... pan-cytokeratin (AE-1/AE-3 & C11, both 1:50, Novus & Santa Cruz, NBP2-33200AF647 & SC-8018) and Ki-67 (8D5 ...
• EPSTEIN-BARR VIRUS LMP1 ENHANCES LEVELS OF MICROVESICLE-ASSOCIATED PD-L1

  Monica Abou Harb, Li Sun, David G. Meckes Jr., bioRxiv - Microbiology 2022

  Quote: ... HSC70 (B-6; Santa Cruz), Caveolin-1 (D46G3 ...
• Persistence of backtracking by human RNA polymerase II

  Kevin B Yang, et al., bioRxiv - Molecular Biology 2023

  Quote: ... TCEA1 (B-6; Santa Cruz), B-actin (C4 ...
• Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

  YiQing Lü, et al., bioRxiv - Cancer Biology 2022

  Quote: ... FBXO42 (Santa Cruz FL-6), GAPDH HRP-conjugated antibody (BioLegend W17079A) ...
• Translation rescue by targeting Ppp1r15a upstream open reading frame in vivo

  Ashley Kidwell, et al., bioRxiv - Physiology 2021

  Quote: ... supernatants were incubated with anti-PP1 antibody conjugated to agarose for 3 hrs at 4 °C (E-9, sc-7482 AC, 25% agarose, Santa Cruz). Samples were washed with washing buffer 5 times (20 mM Tris pH 8 ...
• SARS-CoV-2 ORF9b Antagonizes Type I and III Interferons by Targeting Multiple Components of RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING Signaling Pathways

  Lulu Han, et al., bioRxiv - Microbiology 2020

  Quote: ... Supernatants were transferred into new tubes after centrifugation for 10 min at 14,000g and further incubated with the indicated antibodies for 3 hours at 4 □ followed by the addition of protein A/G beads (Santa Cruz), or with Anti-Flag magnetic beads (Bimake) ...
• TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

  Yan Xiong, et al., bioRxiv - Cell Biology 2023

  Quote: ... antibodies to TrCP1 (C-6) (Cat# sc-390629) (1:1000) and STUB1 (Cat# sc- 133066) (1:1000) were from Santa Cruz; antibodies to V5 (Cat# MCA1360GA ...
• Rab40 GTPases regulate AMBRA1-mediated transcription and cell migration

  Revathi Sampath, et al., bioRxiv - Molecular Biology 2024

  Quote: ... H-8), cul-5 (WB 1:500, H-300), and mouse anti-AMBAR1(G-6, 1:500) were purchased from Santa Cruz Biotechnology ...
• Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophils with activation across biological systems

  Rupsa Datta, et al., bioRxiv - Immunology 2024

  Quote: ... a 30 min pre-incubation with 1 µM pentafluorobenzenesulfonyl fluorescein (Santa Cruz, CAS 728912-45-6) by immersion was included ...
• Elevated soluble Galectin-3 as a marker of chemotherapy efficacy in Breast cancer patients; a prospective study

  Arooj Shafiq, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Gal-3 and Ki67 expression was detected by IHC using mouse polyclonal anti-Gal-3 (Santa Cruz, CA, USA, SC-14364, 1:500) and rabbit polyclonal anti-Ki67 (abcam ...
• Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins

  Susanna Cogo, et al., bioRxiv - Cell Biology 2022

  Quote: ... The antibodies and dyes used for ICC are as follows: mouse α-pan 14-3-3 (sc-1657, Santa Cruz Biotechnology, 1:100), mouse α-Flag® M2 (F1804 ...
• The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating mitophagy through caveolin-3

  JY Beak, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Caveolin-3 (sc-5310, 1:1000), Parkin (sc-32282, 1:1000), and Bnip3 (sc-56167, 1:1000) were from Santa Cruz Biotechnology (Dallas ...
• Analysis of alternative mRNA splicing in vemurafenib-resistant melanoma cells

  Honey Bokharaie, Walter Kolch, Aleksandar Krstic, bioRxiv - Cancer Biology 2022

  Quote: ... SF3B1 / SAP 155 (B-3) (1/1000 dilution, #sc-514655, Santa Cruz, Mouse), HSP90 (c45g5 ...
• Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

  Piyali Saha, et al., bioRxiv - Biochemistry 2020

  Quote: ... Ezetimibe and lysophosphatidylcholine (1-palmitoyl-sn-glycero-3-phosphocholine) were from Santa Cruz Biotechnology (Santa Cruz ...
• Inhibition of OCT4 Binding at the MYCN Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

  Kazuma Nakatani, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-caspase 3 (1:1000 dilution; sc-7148, Santa Cruz Biotechnology, Dallas, TX), and anti-actin (1:1000 dilution ...
• Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function

  Apurva T. Prabhakar, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) 1:10,000 (Santa Cruz; catalog no. sc-47724).
• RSV protects bystander cells against IAV infection by triggering secretion of type I and type III interferons

  Maciej Czerkies, et al., bioRxiv - Immunology 2022

  Quote: ... anti-OAS1 Antibody (F-3) (Santa Cruz Biotechnology, cat. sc-374656, 1:1000), anti-Influenza A Virus Nucleoprotein antibody [C43] (Abcam ...
• Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

  Erik B. Faber, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... and anti-SYCP-3 monoclonal antibody (sc-74569, Santa Cruz Biotechnology, 1:100) overnight at 4 °C ...
• Engram cell connectivity as a mechanism for information encoding and memory function

  Clara Ortega-de San Luis, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4-hydroxytamoxifen (4-OHT, Santa Cruz) was freshly prepared in oil (mix of sunflower seed oil ...
• The actin nucleator Spir-1 is a virus restriction factor that promotes IRF3 activation

  Alice Abreu Torres, et al., bioRxiv - Microbiology 2021

  Quote: ... Rb anti-14-3-3 (Santa Cruz, sc-629), Ms anti -Spir-1 (Santa Cruz ...
• PEAK3 pseudokinase represents a pro-migratory and -invasive signalling scaffold

  Jianmei Hou, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 14-3-3 (Santa Cruz Biotechnology, cat. sc-1657), PTPN12 (Abcam ...
• Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

  Hudson W. Coates, et al., bioRxiv - Molecular Biology 2022

  Quote: ... mouse monoclonal anti-pan-14-3-3 (Santa Cruz Biotechnology sc-1657 ...
• REPTOR/CREBRF encode key regulators of muscle energy metabolism

  Pedro Saavedra, et al., bioRxiv - Physiology 2021

  Quote: ... adenovirus was added to the medium for 3 hours on day 4 of differentiation at 250 MOI in the presence of 5 μg/ml polybrene (Santa Cruz Biotechnology). Experiments were performed 3 days later ...
• Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

  Flora Magnotti, et al., bioRxiv - Immunology 2021

  Quote: ... cells were stained using anti-ASC (Santa Cruz, sc22514R, 4 μg.mL-1), Alexa594-goat anti rabbit antibodies (Invitrogen ...
• Protein kinase Cε activation induces EHD-dependent degradation and downregulation of K_ATP channels: Implications for glucose stimulated insulin secretion

  Christopher J Cockcroft, et al., bioRxiv - Cell Biology 2020

  Quote: ... or mouse anti-Rme-1-4 (Santa Cruz Biotechnology, EHD (E-5), 0.8 μg/ml ...
• Role of ERK activation in H. pylori-induced disruption of cell-cell tight junctions

  Amita Sekar, Bow Ho, bioRxiv - Microbiology 2020

  Quote: ... and rabbit polyclonal anti-claudin-4 (1:1000, Santa Cruz Biotechnology, USA) were used in immunofluorescence and immunoblotting experiments respectively ...