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5001 - 5050 of 8862 citations for 6 1 4 dioxa 8 azaspiro 4.5 decan 8 yl 3 hydroxy 2 iminopyrimidin 4 amine since 2019

• Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

  Chun Wang, et al., bioRxiv - Cell Biology 2024

  Quote: ... or β-actin (1:2,000; Santa Cruz Biotechnology, TX) overnight at 4°C followed by incubation for 1 hour with secondary goat anti-mouse IRDye 800 (Thermo Fisher Scientific ...
• A predominately pulmonary activation of complement in a mouse model of severe COVID-19

  Peter J. Szachowicz, et al., bioRxiv - Immunology 2024

  Quote: ... anti-HopE1 (1:100, cat#sc-398703, Santa Cruz), anti-vWF (1:500 ...
• The mitochondrial stress-induced protein carboxyl-terminal alanine and threonine tailing (msiCAT-tailing) promotes glioblastoma tumorigenesis by modulating mitochondrial functions

  Ting Cai, et al., bioRxiv - Cancer Biology 2024

  Quote: ... mouse anti-TOMM20 (1:500, Santa Cruz, cat. 18023S), rabbit anti-MTCO2 (1:500 ...
• Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth

  Hitoshi Matakatsu, Richard G. Fehon, bioRxiv - Developmental Biology 2024

  Quote: ... Rabbit anti-HA (1:1,000; Y-11, Santa Cruz), iFluor 555 or iFluor 647 conjugated Mouse anti-V5 (1:100 ...
• Notch1 is required to maintain supporting cell identity and vestibular function during maturation of the mammalian balance organs

  Alison Heffer, et al., bioRxiv - Developmental Biology 2024

  Quote: ... anti-Spp1(OPN) (mouse, 1:300, Santa Cruz Biotechnology), anti-Calb2 (rabbit ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... mouse anti-EGFR (1:50, Santa Cruz sc-120), chicken anti-GFP (1:500 ...
• Homologous recombination promotes mitotic death to suppress the innate immune response

  Radoslaw Szmyd, et al., bioRxiv - Cell Biology 2024

  Quote: ... RAD52 (F-7, Santa Cruz, sc-365341, 1:500), POLθ (Thermo Fisher Scientific ...
• Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila

  Zhixin Ma, et al., bioRxiv - Developmental Biology 2024

  Quote: ... mouse anti-aPKC (1/50, Santa Cruz, Sc-17781).
• Collagen fibril formation at the plasma membrane occurs independently from collagen secretion

  Adam Pickard, et al., bioRxiv - Cell Biology 2024

  Quote: ... Syntaxin 5 (Santa Cruz, sc-365124, 1:500(WB)) PDI (Abcam ...
• Homologous recombination promotes mitotic death to suppress the innate immune response

  Radoslaw Szmyd, et al., bioRxiv - Cell Biology 2024

  Quote: ... WAPL (A-7, Santa Cruz, sc-365189, 1:1000), CHK1 (2G1D5 ...
• Telomeric lncRNA TERRA localizes to stress granules in human ALT cells

  Luca Larini, et al., bioRxiv - Molecular Biology 2024

  Quote: ... anti-NXF1 (1:150, sc-136095, Santa Cruz Biotechnology) and anti-actinin (1:1000 ...
• Bhlhe40 limits proliferation and prevents excessive angiogenesis in mouse embryoid bodies under hypoxia

  Barbara Acosta-Iborra, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 1:1000 mouse anti-CAS9 (Santa Cruz Biotechnology, SC517386), 1:5000 mouse anti-Tubulin (Sigma ...
• Localized K63 ubiquitin signaling is regulated by VCP/p97 during oxidative stress

  Austin O. Maduka, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-VCP (1:2,500, Santa Cruz Biotechnology, #sc-57492), anti-NPLOC4 (Proteintech ...
• The UFMylation pathway is impaired in Alzheimer’s disease

  Tingxiang Yan, et al., bioRxiv - Neuroscience 2024

  Quote: ... or 1 µM thapsigargin (Santa Cruz Biotechnology, sc-24017).
• Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice

  Alejandro Martín-Ávila, et al., bioRxiv - Neuroscience 2024

  Quote: ... and TRIM21 (Ro/SSA) (1:1000, Santa Cruz, mouse) in Superblock TM blocking buffer in TBS (Thermo Fisher Scientific ...
• Hematopoietic growth factors Regulate Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5

  Xuefang Ren, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-GCSFR (1:100, Santa Cruz Biotechnology, USA), rat anti-CD31 (1:200 ...
• Genetic ablation of the DNA demethylation pathway in retinal progenitor cells impairs photoreceptor development and function, leading to retinal dystrophy

  Galina Dvoriantchikova, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-Opn1sw (1:200, sc-14363, Santa Cruz Biotechnology), anti-Opn1mw (1:200 ...
• Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

  Nelson García-Vázquez, et al., bioRxiv - Biochemistry 2024

  Quote: ... cyclin E (1:1,000, Santa Cruz Biotechnology sc-247), Flag (1:2,000 ...
• Differential effects of diphenyl diselenide (PhSe)₂ on mitochondria-related pathways depending on the cellular energy status in Bovine Vascular Endothelial Cells

  Letícia Selinger Galant, et al., bioRxiv - Biochemistry 2024

  Quote: ... α-GCLC (1:1000; Santa Cruz Biotechnology, CA, USA), α-GCLM (1:1000 ...
• Cadherin 4 assembles a family of color-selective retinal circuits that respond to light offset

  Aline Giselle Rangel Olguin, et al., bioRxiv - Neuroscience 2024

  Quote: ... mouse anti-Cdh13 (1:500 Santa Cruz Biotechnology, RRID:AB_10612090); goat anti-VAChT (1:1500 ...
• Mechanosensitive FHL2 tunes endothelial function

  Shailaja Seetharaman, et al., bioRxiv - Cell Biology 2024

  Quote: ... VE-Cadherin (mouse, Santa Cruz, SC-9989, 1:2000) pMLC (rabbit ...
• Widespread impact of nucleosome remodelers on transcription at cis-regulatory elements

  Benjamin J. Patty, Sarah J. Hainer, bioRxiv - Systems Biology 2024

  Quote: ... NFYA (Santa Cruz SC-17753, lot D2522, 1:50) and IgG (Sigma-Aldrich ...
• Amyloid-β increases MBP and MOBP translation in oligodendrocytes through dysregulation of hnRNP A2 dependent RNA dynamics

  Adhara Gaminde-Blasco, et al., bioRxiv - Molecular Biology 2024

  Quote: ... hnRNP A2/B1 (sc-374053, 1:1000, Santa Cruz), MAG (SC-166849 ...
• Amyloid-β increases MBP and MOBP translation in oligodendrocytes through dysregulation of hnRNP A2 dependent RNA dynamics

  Adhara Gaminde-Blasco, et al., bioRxiv - Molecular Biology 2024

  Quote: ... hnRNP A2/B1 (sc-374053, 1:500, Santa Cruz), hnRNP F (sc-32310 ...
• ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis

  Junji Zhu, et al., bioRxiv - Microbiology 2024

  Quote: ... anti-ARIH1 (1:500, Cat# sc-390763; Santa Cruz), anti-Actin (1:2,000 ...
• Molecular differences between neonatal and adult stria vascularis from organotypic explants and transcriptomics

  Matsya Ruppari Thulasiram, et al., bioRxiv - Molecular Biology 2024

  Quote: ... rabbit anti Cldn11 (1:250; Santa Cruz sc-25711), rabbit anti Kir4.1 (1:250 ...
• DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects

  A Colomer-Boronat, et al., bioRxiv - Molecular Biology 2024

  Quote: ... anti-OCT4 (1:300, sc-8628, Santa Cruz Biotechnology) and anti-KLF4 (1:1000 ...
• The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis

  Miguel Marin-Rodero, et al., bioRxiv - Immunology 2024

  Quote: ... goat anti-doublecortin (1:500, Santa Cruz, sc-8066); CLR ...
• Ccrk-Mak/Ick kinase signaling axis is a ciliary transport regulator essential for retinal photoreceptor maintenance

  Taro Chaya, et al., bioRxiv - Developmental Biology 2024

  Quote: ... mouse anti-Cep164 (1:200, Santa Cruz, sc-515403), rabbit anti-Rhodopsin (1:2,500 ...
• Gαi2 Interaction with EB1 Controls Microtubule Dynamics and Rac1 Activity in Xenopus Neural Crest Cell Migration

  Soraya Villaseca, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti V5-probe (Santa Cruz, sv5-pk; 1:5000); anti acetylated tubulin (Sigma ...
• PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses

  Srivatsan Parthasarathy, et al., bioRxiv - Microbiology 2024

  Quote: ... anti-PARP14 (Santa Cruz Biotechnology SC-377150, 1:100), and anti-GAPDH (Millipore-Sigma G8795 ...
• Rbm24 maintains survival of cochlear outer hair cells by repressing Insm1

  Chao Li, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-Pou4f3 (mouse, 1:500, sc-81980, Santa Cruz). After removing the primary antibody by washing thrice (10 mins each ...
• Rbm24 maintains survival of cochlear outer hair cells by repressing Insm1

  Chao Li, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-Prestin (goat, 1:1000, sc-22692, Santa Cruz), anti-vGlut3 (rabbit ...
• BRWD1 orchestrates chromatin topology by converting static to dynamic cohesin complexes

  Malay Mandal, et al., bioRxiv - Immunology 2023

  Quote: Chromatin from flow-sorted small pre-B cells (2×106) from WT and Brwd1-/- mice were used for each ChIP experiment with anti-BRWD1 (E-15, Santa Cruz Biotechnology, sc-83517, lot J1508), anti-H3K4me1 (07-436 ...
• Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma

  Ashwin R. Iyer, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Transcription factor ChIP-Seq was performed as previously described11 with 2-5 ug of antibody was used per immunoprecipitation (POU2F2, sc-233X, Santa Cruz; POU2AF1, sc-955X, Santa Cruz; p300, A300-358A, Bethyl). ATAC-Seq was performed as previously described10 with nuclei isolated from 50,000 cells for each sample ...
• Human blood exposure to Clostridium perfringens epsilon toxin may shed light on erythrocyte fragility during active multiple sclerosis

  K. Rashid Rumah, et al., bioRxiv - Microbiology 2019

  Quote: ... Proteins were transferred to an Immobilon-P membrane (MilliporeSigma) and probed with either mouse-anti MAL 1:1000 (clone E-1, Santa Cruz Biotechnology, Inc.) or rabbit anti-ICln 1:1000 (PA5-13450 ...
• Evolutionarily conserved regulation of embryonic fast-twitch skeletal muscle differentiation by Pbx factors

  Gist H. Farr III, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Cryosections were blocked with 3% BSA/1% normal donkey serum in a humidified slide box and subsequently incubated with anti-Pbx2 (1:100, polyclonal rabbit, Santa Cruz, G-20) and anti-Myod1 (5.8A ...
• Increased TSH-producing cells in the pituitary gland of Pax6 haploinsufficient mice

  Kenji K. Johnson, James D. Lauderdale, bioRxiv - Developmental Biology 2020

  Quote: ... membranes were rinsed several times in 1xTBSTw and incubated with goat anti-rabbit HRP-conjugated secondary antibody (1:20,000; Bio-Rad, catalog 179-5046; or 1:10,000; Santa Cruz, catalog sc-2004) in 5% non-fat dried milk for 1 hour at room temperature with gentle agitation ...
• BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

  Batya Cohen, et al., bioRxiv - Developmental Biology 2019

  Quote: ... Membranes were probed with anti HA-tag monoclonal antibody (Covance, HA.11, 1:100) while β-Tubulin (Santa Cruz, H-235, 1: 500) was used as a loading control ...
• Oxidant-Resistant LRRC8A/C Anion Channels Support Superoxide Production by Nox1

  Hyehun Choi, et al., bioRxiv - Cell Biology 2021

  Quote: ... Cells were permeabilized with 0.5% Triton-X 100 and blocked with 1% BSAprior to incubation with primary and secondary antibody (1:100) (Nox1 (Santa Cruz, sc-5821), (LRRC8D (Santa Cruz ...
• Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in C. elegans

  Haikel Dridi, et al., bioRxiv - Cell Biology 2021

  Quote: ... PDE4 (kindly provided to us by Kenneth Miller, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma), PP1 (sc6104, 1:1000) or an anti-calstabin antibody (Santa Cruz 1: 2,500). To determine channel oxidation ...
• Alzheimer’s Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway

  Tomoya Sasahara, et al., bioRxiv - Biochemistry 2020

  Quote: ... These sections were incubated overnight at 4°C with primary antibody against NAKα3 (ANP-003, 1:200; Alomone Labs, Jerusalem, Israel) and von Willebrand factor glycoprotein (sc-365712, 1:50; Santa Cruz Biotechnology, Dallas, TX) in the presence of normal goat serum in PBS ...
• Maturation of lateral habenula and early-life experience-dependent alteration with behavioral disorders in adulthood

  Tomoya Nakamura, et al., bioRxiv - Neuroscience 2020

  Quote: ... an anti-Zif268/Egr1 rabbit antibody (1:1500 for DAB staining; 1:300 for fluorescence staining; C-19, Santa Cruz Biotechnology, Dallas, USA), and anti-mCherry animal antibody (1:1000 for fluorescence staining ...
• Importin α2 association with chromatin: Direct DNA binding via a novel DNA binding domain

  Kazuya Jibiki, et al., bioRxiv - Molecular Biology 2020

  Quote: ... The primary antibody for KPNA2 (importin α2) (rat monoclonal antibody, MBL, Japan: 1/400 dilution; or goat polyclonal, Santa Cruz: 1/200 dilution) and the secondary antibody (Alexa488 conjugated anti-rat or anti-rabbit IgG in 1/100 dilution ...
• Pro-apoptotic and anti-invasive properties underscore the tumor suppressing impact of myoglobin on subset of human breast cancer cells

  Mostafa A. Aboouf, et al., bioRxiv - Cancer Biology 2022

  Quote: ... membranes were incubated with HRP-conjugated secondary antibodies: donkey-anti-rabbit 1:5000 (Amersham, #NA934V) or goat-anti-mouse 1:5000 (Santa Cruz, #sc-2031), for 1 hour at room temp ...
• Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies

  David Choy Buentello, et al., bioRxiv - Developmental Biology 2021

  Quote: ... Abcam, cat.no. ab32454; mouse anti-GFAP, 1:500, Abcam, cat.no. ab212398; mouse anti-β3-tubulin, 1:500, Santa Cruz Biotechnology, cat.no. sc-80005) in blocking solution overnight at 4°C ...
• Attenuating the DNA damage response to double strand breaks restores function in models of CNS neurodegeneration

  Richard I. Tuxworth, et al., bioRxiv - Neuroscience 2019

  Quote: ... Primary antibodies used were: mouse anti-PDF C7-s (1:50; Developmental Studies Hybridoma Bank) and rabbit anti-Per1 (1:200; Santa Cruz, CA, USA). Secondary antibodies were ...
• Hyperconcentrated Mucus Unifies Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis

  Takafumi Kato, et al., bioRxiv - Pathology 2021

  Quote: ... we performed immunohistochemistry of MUC5B for human tracheal serial sections with the antiserum (M-25, 1:1000) and previously established commercial rabbit anti-MUC5B antibody (H-300, Santa Cruz, 1:1000). Staining with these antibody and antiserum appeared identical ...
• The developmental progression of eight opsin spectral signals recorded from the zebrafish retinal cone layer is altered by the timing and cell type expression of thyroxin receptor β2 (trβ2) gain-of-function transgenes

  Ralph F. Nelson, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-blue opsin (rabbit, 1:5,000, kindly provided by Jeremy Nathans) and anti-rod opsin (1D4, mouse, 1:100, Santa Cruz: sc-57432, RRID:AB_785511), the later raised against bovine rhodopsin but recognizing red-cone outer segments in zebrafish (Yin et al. ...
• Transcriptional circuitry of NKX2-1 and SOX1 defines an unrecognized lineage subtype of small cell lung cancer

  Ranran Kong, et al., bioRxiv - Molecular Biology 2022

  Quote: ... human primary SCLC tumor specimens and genetic engineered mouse model (GEMM) tumor specimens with anti-NKX2-1 (1:100; Santa Cruz, sc-53136), anti-SOX1 (R&D ...