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Citations for Tocris :
701 - 750 of 873 citations for 5 Benzyloxy pyrimidine 2 carbonitrile since 2020
Citations are collected from bioRxiv only, the total number of publications could be much larger.
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bioRxiv - Neuroscience 2021Quote: ... AM 251 (N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide) from Tocris and ...
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bioRxiv - Genetics 2021Quote: ... Cells were then incubated in RPMI/B27 (-Insulin) for 24 hours before changing media to 5 μM IWP2 (Tocris) in RPMI/B27(-Insulin) ...
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bioRxiv - Molecular Biology 2021Quote: ... Calu-3 cells were preincubated for 1 h with medium (50 μl/well) containing either increasing concentrations of Camostat (0.5, 5 or 50 μM; Tocris) or dimethyl sulfoxide (solvent control ...
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bioRxiv - Cancer Biology 2023Quote: ... Organoids are pelleted and gently resuspended in BTOM-ER containing 5% Matrigel and ROCK-inhibitor (10 μM Y267632, Tocris), and then plated on top of a solidified Matrigel-coated well ...
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bioRxiv - Cell Biology 2023Quote: For inhibition of P2X4R cells were pre-incubated for 30 min with 10 μM of 5-BDBD (Tocris Bioscience). Blockage of αvβ3/αvβ5 integrins was achieved by the pre-incubation with 10 μM of cilengitide for 2 hours (Sigma-Aldrich).
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bioRxiv - Pharmacology and Toxicology 2024Quote: ... the α4-selective nAChR antagonist dihydro-β-erythroidine hydrobromide (DHβE; 5 mg/kg in sterile saline; Tocris, Bristol, UK), or the α7-selective nAChR antagonist methyllycaconitine citrate (MLA ...
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bioRxiv - Neuroscience 2024Quote: ... CACNA1A+/− networks on MEA at DIV51 were treated with 20 µM 4-aminopyridine (4-AP; Tocris, #504-24-5) and recorded for 30 minutes after the compound was added ...
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bioRxiv - Neuroscience 2024Quote: ... Immunoblot was obtained by first blocking membranes for 1 h at room temperature with a solution of 0.1% Tween 20 and 5% Bovine Serum Albumin (BSA) (#5217, Tocris) in 1× PBS (pH 7.4 ...
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bioRxiv - Neuroscience 2023Quote: ... 5 mM QX314 was added into the intracellular pipette solution while GABAA receptor antagonist picrotoxin (PTX, 50 μM, Tocris), GABAB receptor antagonist CGP55845 (3 μM ...
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bioRxiv - Neuroscience 2023Quote: ... slices were incubated in recording ACSF supplemented with 5 μM 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX, Tocris, 1045) and 100 μM D-(−)-2-Amino-5-phosphonopentanoic acid (D-APV ...
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bioRxiv - Neuroscience 2023Quote: ... anisomycin and N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM-251) were purchased from Tocris Bioscience ...
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bioRxiv - Bioengineering 2024Quote: ... cells were either directly imaged or washed 1x and incubated for 5 min with Hoechst 33342 (Tocris, 5117/50) to a final concentration 1 ng/µL prior to imaging ...
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bioRxiv - Cell Biology 2024Quote: ... transgenic embryos were treated in 6-well plates at the indicated time points with 5 μM Ro5-3335 (Tocris) or DMSO (Sigma ...
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bioRxiv - Developmental Biology 2024Quote: ... Monolayers followed the same timing but were cultured in 6-well plates in 3.5 ml of medium and 5 µM XAV939 (Tocris) was included between day 3 and 6.
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bioRxiv - Cell Biology 2024Quote: ... the porcine/human EPSCs were resuspended and seeded in pEPSCs supplemented with 5 μm Y27632 (Tocris, cat. no. 1254). The addition of 5% FBS (Gibco ...
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bioRxiv - Cell Biology 2022Quote: ... Apoptosis was induced in non-primed macrophages using the Bcl-2 inhibitor venetoclax (ABT-199, Tocris 6960) at 25 μM for 16 h ...
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bioRxiv - Neuroscience 2021Quote: ... IP3 receptors were blocked by bath application of 2-APB (100 µM, Tocris, Germany, micro-perfusion pump), 2-APB was applied at least 15 min prior t-LTP induction and was present throughout the recordings ...
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bioRxiv - Cell Biology 2021Quote: 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride (NE-100 hydrochloride) was purchased from Tocris (3133). Stock and work solutions were prepared using 100% dimethyl sulfoxide sterile-filtered (DMSO ...
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bioRxiv - Genomics 2022Quote: ... Media was then changed to CM Media supplemented with 2 μM Wnt-C59 (Tocris Biosciences, Bristol, UK) for 2 days prior to switching to CM Media without any supplements ...
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bioRxiv - Developmental Biology 2021Quote: ... early somite (1 day; 2 µM SB505124, 4 µM dorsomorphin, 500 nM PD173074 [cat. num. 3044; Tocris Bioscience ...
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Prelimbic proBDNF facilitates memory destabilization by regulation of neuronal function in juvenilesbioRxiv - Neuroscience 2022Quote: ... 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP; 32 ng/μL; Cat#01773, Tocris Bioscience), NVP-AAM077 (0.8 ng/μL ...
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bioRxiv - Neuroscience 2023Quote: ... in the presence of the mGluR5 antagonist 2-methyl-6 (phenylethynyl)-pyridine (MPEP, 25 μM; Tocris Bioscience) in ACSF at 31-33°C as previously (18) ...
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bioRxiv - Synthetic Biology 2022Quote: (5Z)-5[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2-methyl-3-(2,2,2-trifluoroethyl)-4H-imidazol-4-one (DFHBI-1T) was purchased from Tocris Bio-techne ...
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bioRxiv - Neuroscience 2022Quote: ... (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl-cyclopropanecarboxylate-dihydrochloride (NNC550396 or nnc) was purchased from TOCRIS and initially dissolved at 25 mM in water ...
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Serotonin, Etonogestrel and breathing activity in murine Congenital Central Hypoventilation SyndromebioRxiv - Physiology 2022Quote: ... LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride) was purchased from Tocris Bioscience (Bristol ...
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bioRxiv - Neuroscience 2024Quote: ... neurofibrillary tangles and related AD pathological structures were additionally stained using 1 µM 4,4’-[(2-methoxy-1,4-phenylene) di-(1E)-2,1-ethenediyl] bisphenol (MX-04) (Tocris) for 15 minutes at room temperature ...
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bioRxiv - Cancer Biology 2024Quote: From day 2-7 cells were cultured in SRM media supplemented with 0.1 µM LDN193189 (Tocris Biosciences), 10 µM SB431452(Tocris Biosciences) ...
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bioRxiv - Developmental Biology 2021Quote: ... a combined medium was prepared by collecting 1mL of medium from the wells and mixing with same volume of fresh RPMI+B27 without insulin medium and supplemented with 5 µM IWP2 (Tocris). The medium was changed to 2mL RPMI+B27 without insulin at d5 ...
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bioRxiv - Neuroscience 2020Quote: ... In this method dual SMAD inhibition was performed using KOSR media supplemented with 10 μM ROCKi and SMAD inhibitors: 5 μM dorsomorphin (Tocris) and 10 μM SB431542 (Tocris ...
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bioRxiv - Neuroscience 2020Quote: ... placed in an aCSF-filled borosilicate glass pipette (3-5 MΩ) in the presence of 6,7-Dinitroquinoxaline-2,3-dione (DNQX; 10 μM; Tocris #14A/166549).
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bioRxiv - Pharmacology and Toxicology 2020Quote: ... Alzet minipumps (model 1004) delivering either the high-affinity 5-HT2B antagonist SB204741 (Tocris Biosciences; 1 mg kg-1d-1) or vehicle (50% dimethyl sulfoxide [Sigma-Aldrich] and polyethylene glycol-400 [Fisher Chemical] ...
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bioRxiv - Cell Biology 2021Quote: ... MEFs WT and GPS2-KO cells were treated in the presence or absence of homoharringtonine (HHT) (5 μM, Tocris Bioscience) for 10 min to prevent new translation initiation ...
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bioRxiv - Neuroscience 2020Quote: ... Sections were washed with 1x PBS for three times and incubated with either 5 µM of Methoxy X04 (Tocris Bioscience) for 20 min at RT or 300 nM of DAPI for 10 minutes at RT ...
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bioRxiv - Cell Biology 2021Quote: ... flow cytometer, and the fractions of stained cells were quantified using FloJo 10.6, with Staurosporine (4 h, 5 μM) (Tocris, 1285) used as a positive control for cell death and to help establish gating of the sorted cells.
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bioRxiv - Neuroscience 2022Quote: ... animals were treated with the selective positive allosteric modulator (PAM) of mGluR5 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB; Tocris, UK) that was diluted in saline solution containing 5-10% final concentration of DMSO and polyethylene glycol 400 (DMSO ...
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bioRxiv - Neuroscience 2020Quote: Larvae were raised on small-batch Drosophila cornmeal dextrose medium (126) prepared with 5 μM L685,458 (Tocris Bioscience, Minneapolis, MN) and processed as above ...
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bioRxiv - Neuroscience 2020Quote: ... 1 mL/kg) or CNO (3.0 mg/kg i.p. in 95% saline, 5% DMSO, 1 mL/kg) (Tocris, Bristol, UK) in counterbalanced order ...
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bioRxiv - Synthetic Biology 2020Quote: Cells expressing stably integrated or transiently transfected rTetR-effectors were assayed by flow cytometry during and after 5 days of 1 μg/mL doxycycline (Tocris) treatment ...
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bioRxiv - Developmental Biology 2020Quote: Embryos were incubated at 28°C from the one cell stage to 75% epiboly (8 hpf) in E3 medium containing 5 μM of the Yap1 antagonist verteporfin (5305, Tocris) dissolved in DMSO or the same volume of DMSO as control.
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bioRxiv - Neuroscience 2021Quote: ... 10 μM NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline) and 50 μM AP-5 (Tocris Bioscience, UK) were applied in the bath to block excitatory synaptic responses.
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bioRxiv - Cell Biology 2023Quote: ... (Optopharma Ltd.) and 20 nM for 1-Oleoyl lysophosphatidic acid sodium salt (LPA) (5 mM stock dissolved in water) (Tocris). As controls ...
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bioRxiv - Biophysics 2023Quote: ... The Piezo1 channel activator Yoda1 (5, 10, 20 or 30 μM, dissolved in 10 mM DMSOt, Tocris Bioscience, Bristol, UK) and the Transient Receptor Potential Vanilloid (TRPV4 ...
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bioRxiv - Cell Biology 2022Quote: Taxol microtubules were prepared as described above, however were labeled with 16% biotin and 5% Alexa555 tubulin and stored in BRB80T (BRB80, 10 μM Taxol (Tocris)) ...
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bioRxiv - Developmental Biology 2024Quote: ... before changing medium on day 3 to RPMI 1640 with 1x B27 minus insulin and 5 mM IWP2 (Tocris 3533). On day 5 ...
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bioRxiv - Bioengineering 2024Quote: ... using a stepwise protocol (Fig. S1a): induction from hESCs to primitive streak by treatment with 5 μM CHIR99021 (#4423, Tocris); induction from primitive streak to paraxial mesoderm by treatments with 5 μM CHIR99021 ...
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bioRxiv - Neuroscience 2024Quote: ... D1-like and D2-like receptors were blocked by applying SFK 83566 hydrobromide for 5 minutes in the bath at 10 µM (1586, Tocris) and sulpiride at 10 µM (S8010 ...
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bioRxiv - Cell Biology 2024Quote: ... and P2Y1 antagonist 1-(2- (2- tert-butylphenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea (BPTU; BMS- 646786, #870544-59-5) were obtained from Tocris Bioscience (Bristol ...
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bioRxiv - Cell Biology 2024Quote: ... The drugs used were 10 µM para-Nitroblebbistatin (motorPharma, #DR-N-111) or 5 µM Y-27632 (Tocris Bioscience, #1254). As a control we used dimethyl sulfoxide (DMSO ...
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bioRxiv - Developmental Biology 2024Quote: RUES2-GLR hESCs grown routinely in NutriStem® hPSC XF were first plated as single cells at a density of 5.2-6.7 x 103 cells/cm2 with 5 µM Y-27632 (Tocris Biosciences, 1254) for the first 24h after plating ...
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bioRxiv - Neuroscience 2021Quote: Bilateral mosaic tadpoles expressing GCaMP6s at stage 48 were immobilized in 2 mM pancuronium dibromide (Cedarlane/Tocris 0693) and embedded in 1% low melting point agarose in a petri dish filled with 0.1X MBSH ...