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• Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Causes Progressive Cerebellar Ataxia in Mice

  Mauricio Torres, et al., bioRxiv - Neuroscience 2024

  Quote: ... 0.3% Triton X-100 in PBS) for 1 hour at room temperature and with primary antibodies anti-Calbindin (Cell Signaling, 2173, 1:100), anti-KDEL (Novus Biologicals ...
• Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Causes Progressive Cerebellar Ataxia in Mice

  Mauricio Torres, et al., bioRxiv - Neuroscience 2024

  Quote: ... GFAP (Cell Signaling, 3670, 1:2,000), anti-ATF4 (Cell Signaling ...
• Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Causes Progressive Cerebellar Ataxia in Mice

  Mauricio Torres, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-ATF4 (Cell Signaling, 11815, 1:1,000), anti-CHOP (Cell Signaling ...
• Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Causes Progressive Cerebellar Ataxia in Mice

  Mauricio Torres, et al., bioRxiv - Neuroscience 2024

  Quote: ... and p-eIF2⍺ (Cell Signaling, 9721, 1:1,000). Membranes were washed with TBST and incubated with HRP conjugated secondary antibodies (Bio-Rad ...
• Purkinje Cell-specific Deficiency in SEL1L-HRD1 Endoplasmic Reticulum-Associated Degradation Causes Progressive Cerebellar Ataxia in Mice

  Mauricio Torres, et al., bioRxiv - Neuroscience 2024

  Quote: ... eIF2⍺ (Cell Signaling, 9722, 1:1,000), and p-eIF2⍺ (Cell Signaling ...
• Reduced SH3RF3 may protect against Alzheimer’s disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

  Ronak Patel, et al., bioRxiv - Neuroscience 2024

  Quote: ... phospho-p-50/p105 (1:1000; Cell Signaling Technologies), total p50/p105(1:1000 ...
• Reduced SH3RF3 may protect against Alzheimer’s disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

  Ronak Patel, et al., bioRxiv - Neuroscience 2024

  Quote: ... total p50/p105(1:1000; Cell Signaling Technology), phospho-Tau Ser422 (1:1000 ...
• Loss of AMPK potentiates inflammation by activating the inflammasome after traumatic brain injury in mice

  Mohammad Ejaz Ahmed, et al., bioRxiv - Neuroscience 2024

  Quote: ... pAMPKα (Thr183/Thr172; 2535S, Cell Signaling), and the NLRP3 (15101 ...
• Loss of AMPK potentiates inflammation by activating the inflammasome after traumatic brain injury in mice

  Mohammad Ejaz Ahmed, et al., bioRxiv - Neuroscience 2024

  Quote: ... and the NLRP3 (15101, Cell Signaling) overnight at 4°C ...
• Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia

  Meghraj S Baghel, et al., bioRxiv - Neuroscience 2024

  Quote: ... and cleaved caspase 3 (1:1000; 5A1E; Cell Signaling Technology). Immunoblots were developed using enhanced chemiluminescence method (Millipore Corp. ...
• Coordination of transcription-coupled repair and repair-independent release of stalled RNA polymerase II in response to transcription-blocking lesions

  Yongchang Zhu, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 1:1000 (Cell Signaling Technology, 86298); rabbit anti-CTD- Ser2-phosphorylated RPB1 polyclonal antibody ...
• Distinct Mechanisms of Type 3 Secretion System Recognition Control LTB₄ Synthesis in Neutrophils versus Macrophages

  Amanda Brady, et al., bioRxiv - Immunology 2024

  Quote: ... anti-p38 (Cell Signaling; Cat. No. 9228), anti-p-p44/42 (ERK1/2 ...
• Reduced ZMPSTE24 expression leads to prelamin accumulation and development of steatosis in MASLD patients

  Joseph D. Schinderle, Anqi Wu, Irina M. Bochkis, bioRxiv - Physiology 2024

  Quote: ... mouse antibody to LAMIN A/C (Cell Signaling mAb 4777, 1:2000), rabbit antibody to ZMPSTE24 (Invitrogen PA1-16965 ...
• Reduced ZMPSTE24 expression leads to prelamin accumulation and development of steatosis in MASLD patients

  Joseph D. Schinderle, Anqi Wu, Irina M. Bochkis, bioRxiv - Physiology 2024

  Quote: ... The primary antibodies used were rabbit antibody to histone H3 (Cell Signaling 4499, 1:4000), mouse antibody to LAMIN A/C (Cell Signaling mAb 4777 ...
• Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells

  Linda V. Sinclair, et al., bioRxiv - Immunology 2024

  Quote: ... or phospho ACC S79 (clone D7D11 cat no. 11818) prior to incubation with anti-rabbit Alexa 647 secondary (cat no. 4414; all Cell Signaling technology). Cells were washed and resupended in 0.5% FBS/PBS (v/v ...
• TRMT1L-catalyzed m²₂G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress

  Sseu-Pei Hwang, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Anti-SENP3 (5591, Cell Signaling), Anti-WDR18 (described in (34)) ...
• Super Enhancer-driven LncRNA UNC5B-AS1 Inhibits Inflammatory Phenotypic Transition in Smooth Muscle Cells via Lactylation Modification

  Xiangrui Zhu, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 5 μg of anti-H3K27ac antibody (Cell Signaling) was incubated overnight with the fragmented chromatin ...
• A phosphorylation code coordinating transcription condensate dynamics with DNA replication

  Carlos Origel Marmolejo, et al., bioRxiv - Molecular Biology 2024

  Quote: ... anti-phospho-ATR (1:500, Cell Signaling Technology, 2853S), anti-TRAP220/MED1 (1:1000 ...
• Multifunctional molecular hybrid for targeted colorectal cancer cells: Integrating doxorubicin, AS1411 aptamer, and T9/U4 ASO

  Kanpitcha Jiramitmongkon, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and Bax (1:1000; 20 kDa, Cell signaling). After incubation ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and anti-γH2AX (1:1000; Cell Signaling). Membranes were probed with HRP-conjugated secondary antibodies 1:30,000 diluted in TBS-T buffer (Jackson Immunoresearch) ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... VASP (1:1000, Cell Signaling), Cdc42 (1:1000 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... phospho-Ser-209-eIF4E (1:1000; Cell Signaling), phospho-Ser-51-eIF2α (1:1000 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... SLUG (1:1000, Cell Signaling), EFL1 (1:2500 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Cdc42 (1:1000, Cell Signaling), β-Catenin (1:1000 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Snail (1:1000; Cell Signaling). All phospho-specific antibodies were diluted in TBS-T with 1% milk and following antibodies were used ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... phospho-Ser-51-eIF2α (1:1000, Cell Signaling), SLUG (1:1000 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... SBDS (1: 1000, Cell Signaling), VASP (1:1000 ...
• Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression

  Poonam Roshan, et al., bioRxiv - Molecular Biology 2024

  Quote: ... phospho-Ser-10-Histone H3 (1:1000, Cell Signaling), and anti-γH2AX (1:1000 ...
• Inhibition of serine racemase prevents diabetic retinopathy

  Haiyan Jiang, et al., bioRxiv - Biochemistry 2024

  Quote: ... α-Tubulin (cat#2144s, RRID:AB_2210548)(Cell Signaling). Brain specific homeobox/POU domain protein(Brn3a ...
• Endogenously produced hydrogen cyanide serves as a novel mammalian gasotransmitter

  Karim Zuhra, et al., bioRxiv - Biochemistry 2024

  Quote: ... anti-myc tag (9B11) (Cell Signaling Technology, 2278, 1:1,000), anti-β-actin mouse monoclonal (AC-15 ...
• Endogenously produced hydrogen cyanide serves as a novel mammalian gasotransmitter

  Karim Zuhra, et al., bioRxiv - Biochemistry 2024

  Quote: ... HRP-linked antibody (Cell Signaling, 7076) diluted 1:3,000 in TBS-T/5% Milk ...
• Endogenously produced hydrogen cyanide serves as a novel mammalian gasotransmitter

  Karim Zuhra, et al., bioRxiv - Biochemistry 2024

  Quote: ... anti-myeloperoxidase rabbit monoclonal (E1E7I) (Cell Signaling Technology, 14569, 1:1,000), anti-catalase (D4P7B ...
• Endogenously produced hydrogen cyanide serves as a novel mammalian gasotransmitter

  Karim Zuhra, et al., bioRxiv - Biochemistry 2024

  Quote: ... anti-catalase (D4P7B) (Cell Signaling Technology, 12980, 1:1,000), anti-myc tag (9B11 ...
• eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

  Jacob A. Boyer, et al., bioRxiv - Cancer Biology 2024

  Quote: ... pAKT S473 (Cell Signaling Technology (CST) 4060) ...
• Human Organoid Tumor Transplantation Identifies Functional Glioblastoma - Microenvironmental Communication Mediated by PTPRZ1

  Weihong Ge, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-phospho-SRC (1:1000, Cell Signaling Tech 6943T). The membranes were incubated overnight at 4C ...
• Targeting the sphingolipid rheostat in IDH1^mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation

  Tyrone Dowdy, et al., bioRxiv - Cancer Biology 2024

  Quote: ... or CST (Cell Signaling Technology) as follows ...
• BMP signaling promotes heart regeneration via alleviation of replication stress

  Mohan Dalvoy Vasudevarao, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Senescence β-Galactosidase Staining Kit #9860 (Cell Signaling) was used as per manufactureŕs protocol ...
• Let-7 restrains an oncogenic epigenetic circuit in AT2 cells to prevent ectopic formation of fibrogenic transitional cell intermediates and pulmonary fibrosis

  Matthew J. Seasock, et al., bioRxiv - Cell Biology 2024

  Quote: ... Rabbit anti-H3K427me3 (Cell Signaling Technologies, 9733; 1:50 concentration), and Rabbit-antimouse IgG (Jackson ImmunoResearch ...
• Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1

  Fitzroy J. Byfield, et al., bioRxiv - Cell Biology 2024

  Quote: ... incubations were then made with lamin A/C (Cell Signaling Technologies, 4777S) and lamin B (ABCAM ...
• Cholesterol Restriction Primes RIG-I Antiviral Responses Through a Noncanonical Type I IFN Pathway

  Tasuku Nishimura, et al., bioRxiv - Immunology 2024

  Quote: ... according to the manufacturer’s instructions (Cell Signaling Technology number 9003). The cells were sonicated 15 times ...
• Viral Insulin/IGF-like Peptides Selectively Activate Host Insulin/IGF Signaling pathways during Grouper Iridovirus Infection

  Aurelien Chuard, et al., bioRxiv - Microbiology 2024

  Quote: ... p44/42 MAPK (Erk1/2) Antibody (Cell Signaling #9102); β-Actin (D6A8 ...
• Global mapping of the Chlamydia trachomatis conventional secreted effector – host interactome reveals CebN interacts with nucleoporins and Rae1 to impede STAT1 nuclear translocation

  Brianna Steiert, et al., bioRxiv - Microbiology 2024

  Quote: ... or anti-Phospho-GSK-3β (Cell Signaling) antibodies using the concentrations listed in Table S2 ...
• Global mapping of the Chlamydia trachomatis conventional secreted effector – host interactome reveals CebN interacts with nucleoporins and Rae1 to impede STAT1 nuclear translocation

  Brianna Steiert, et al., bioRxiv - Microbiology 2024

  Quote: ... anti-GSK-3β (Cell Signaling), or anti-Phospho-GSK-3β (Cell Signaling ...
• Global mapping of the Chlamydia trachomatis conventional secreted effector – host interactome reveals CebN interacts with nucleoporins and Rae1 to impede STAT1 nuclear translocation

  Brianna Steiert, et al., bioRxiv - Microbiology 2024

  Quote: ... Cells were fixed with 4% formaldehyde 18h post-transfection and stained with DAPI and anti-STAT1 (Cell Signaling) antibody ...
• PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

  Marwah Karim, et al., bioRxiv - Microbiology 2024

  Quote: ... LC3A/B (D3U4C) XP® Rabbit mAb (Cell Signaling Technology, #12741), and β-actin (Sigma-Aldrich ...
• Ca²⁺ Regulation of Myosin II and Myosin VI during Rupture of the Shigella-Containing Vacuole

  Mariette Bonnet, et al., bioRxiv - Microbiology 2024

  Quote: ... myosin VI (#13592) were from Cell Signaling. Secondary anti-rabbit IgG conjugated to Alexa Fluor R 488 (#111-545-003) ...
• Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions

  Xiaowei Jin, et al., bioRxiv - Biophysics 2024

  Quote: ... rabbit anti-RhoA (2117S; Cell Signaling Technology) or mouse anti-GAPDH (SC-32233 ...
• Proteome profiling identifies a link between the mitochondrial pathways and host-microbial sensor ELMO1 following Salmonella infection

  Sajan C Achi, et al., bioRxiv - Microbiology 2024

  Quote: ... and GAPDH (Cat No Cell 2118S, Cell Signaling Technology, Danvers, Massachusetts, USA). Anti-mouse IgG ...
• Proteome profiling identifies a link between the mitochondrial pathways and host-microbial sensor ELMO1 following Salmonella infection

  Sajan C Achi, et al., bioRxiv - Microbiology 2024

  Quote: ... HRP-linked Antibody (Cat No 7076S, Cell Signaling Technology, Danvers, Massachusetts, USA) and anti-rabbit IgG ...
• Engineered Ubiquitin Variants Mitigate Pathogenic Bacterial Ubiquitin Ligase Function

  Bradley E. Dubrule, et al., bioRxiv - Microbiology 2024

  Quote: ... mouse α-His (27E8; Cell Signaling Technology) 1 ...