Labshake search

4351 - 4400 of 10000+ citations for 6 Methyl 1 2 4 triazolo 4 3 b pyridazine since 2019

• Impairment of the Hif-1α regulatory pathway in Foxn1-deficient (Foxn1^−/−) mice affects the skin wound healing process

  Sylwia Machcinska, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Immunofluorescence assays were performed with the following primary antibodies: anti-Trx-1 (1:50, Cat# 24295, Cell Signaling) and anti-eGFP (1:400 ...
• Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain

  Annemarie Dedek, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-non-phospho-STEP (1:1000) and anti-pY416-Src (or pY420-Fyn) (1:1000) from Cell Signaling; and anti-pY1472GluN2B (1:1000 ...
• The LUBAC participates in Lysophosphatidic Acid-induced NF-κB Activation

  Tiphaine Douanne, et al., bioRxiv - Immunology 2020

  Quote: ... Antibodies to phosphorylated IκBα (5A5, 1:5,000), and GEF-H1 (55B6, 1:1,000) were from Cell Signaling Technology. Antibodies against SHARPIN (A303-559A ...
• OXPHOS Promotes Apoptotic Resistance and Persistence in T_H17 cells

  Hanna S. Hong, et al., bioRxiv - Immunology 2021

  Quote: ... Anti-Bcl-xL (54H6; 1:800) and anti-Bim (C34C5; 1:400) were purchased from Cell Signaling Technology. Flow samples were acquired using a Fortessa analyzer (BD Biosciences) ...
• Reduced methionine synthase (Mtr) expression creates a functional vitamin B12 deficiency that leads to uracil accumulation in mouse mitochondrial DNA

  Katarina E. Heyden, et al., bioRxiv - Biochemistry 2022

  Quote: ... Membranes were then incubated for 1 hour with 1:2000 primary antibody (α-SHMT2 and GAPDH, Cell Signaling #33443S and #14C10 ...
• Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function

  Sajjad Khani, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-ADCY3 (#Ab14778, Abcam, dilution 1:500, and anti-phospho-PKA Substrate (#9624, Cell Signaling Technology, 1:1000). Membranes were washed three times for 10 min with TBS-T and incubated for 1 h at room temperature with 10 mL of the respective horseradish peroxidase (HRP)-coupled secondary antibody ...
• Transcriptomically unique endolysosomal and homeostatic microglia populations in Alzheimer’s disease and aged human brain

  Katherine E. Prater, et al., bioRxiv - Neuroscience 2022

  Quote: ... Nuclei were labeled with either anti-PU.1-PE (clone 9G7, 1:50, Cell Signaling Technology, Danvers, MA) or IgG-PE isotype control (clone DA1E ...
• Single neurons and networks in the claustrum integrate input from widespread cortical sources

  Andrew M. Shelton, et al., bioRxiv - Neuroscience 2024

  Quote: ... Merck NE1019, RRID:AB_604550; rat anti-MBP 1:500, Abcam ab7349, RRID:AB_305869; rabbit anti-FLAG 1:500, Cell Signaling Technology 14793 ...
• Nuclear reassembly defects after mitosis trigger apoptotic and p53-dependent safeguard mechanisms in Drosophila

  Jingjing Li, et al., bioRxiv - Cell Biology 2024

  Quote: ... Primary antibodies used were as follows: anti-cleaved Dcp-1 from rabbit (#9578, Cell signaling Technology. 1:500,), anti-Lamin from mouse (Developmental Studies Hybridoma Bank ADL84.12 deposited by P ...
• Cannabinoid type-1 (CB₁) receptors in glial cells promote neuromuscular junction repair following nerve injury

  Roberta Piovesana, et al., bioRxiv - Neuroscience 2024

  Quote: ... Membranes were incubated with the primary antibody (CB1R, 1:500 Abcam #23703; GAPDH, 1:5000, Cell signaling #21185) diluted in blocking buffer ...
• ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

  Songnan Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Primary antibody mouse anti-tubulin (1:2000) and rabbit anti-GFP (1:1000) were purchased from Cell Signaling and added overnight at 4°C ...
• Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery

  Natalie S. Wallace, et al., bioRxiv - Cell Biology 2023

  Quote: ... mouse anti-Myc-tag 1:8000 for immunofluorescence and 1:6000 for Western blots (2276; Cell Signaling Technology); HRP-conjugated anti-6X His tag 1:8000 for Western blots (ab184607 ...
• APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size

  Ian A. Windham, et al., bioRxiv - Cell Biology 2023

  Quote: ... mouse anti-HA-Tag mAb 6E2 (1:250 IF; 1:1000 WB; Cell Signaling Technology Cat# 2367, RRID:AB_10691311), mouse anti-DYKDDDDK Tag mAb 9A3 (1:200 IF ...
• Investigating the Role and Regulation of GPNMB in Progranulin-deficient Macrophages

  Drew A. Gillett, et al., bioRxiv - Immunology 2024

  Quote: ... Primary antibodies (PGRN R&D Systems af2557, 1: 400; GPNMB Abcam, ab188222 1:2500; MITF Cell Signaling Technologies 97800S ...
• Proteasomal control of anti-CRISPRs for the regulation of CRISPR/Cas9 activity using Cas9-ACROBAT

  Timothy D. Martin, et al., bioRxiv - Cell Biology 2024

  Quote: ... Phospho-Histone H2A.X Ser139 (1:1,000, cat. # 9718S), and FLAG-HRP (1:1,000, cat. # 2044S) from Cell Signaling, CDKN1A/p21 (1:1,000 ...
• Interferon-Gamma Signaling Promotes Melanoma Progression and Metastasis

  Bo Zhou, et al., bioRxiv - Cancer Biology 2021

  Quote: ... IRF1 (D5E4, 1:1,000; Cell Signaling Technology). The secondary antibodies used for detection were horseradish peroxidase (HRP)–conjugated goat anti-mouse and goat anti-rabbit IgG (1:5,000 ...
• Interferon-Gamma Signaling Promotes Melanoma Progression and Metastasis

  Bo Zhou, et al., bioRxiv - Cancer Biology 2021

  Quote: ... STAT3 (124H6, 1:1,000; Cell Signaling Technology), pSTAT3 (Y705 ...
• Inhibition of Metastatic Uveal Melanoma Cell Proliferation by the Histone Deacetylase 6 Inhibitor, Ricolinostat, is Linked to Altered Microphthalmia-associated Transcription Factor and Phospho-ERK Expression

  Husvinee Sundaramurthi, et al., bioRxiv - Cancer Biology 2021

  Quote: ... GAPDH (1:1000; #2118, Cell Signaling Technology) and β-actin (1:1000 ...
• ASO-based PKM Splice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth

  Wai Kit Ma, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rb-E-cadherin (1:1,000; Cell Signaling), rb-Vimentin (1:1,000 ...
• Haploinsufficient tumour suppressor PRP4K is negatively regulated during epithelial-to-mesenchymal transition

  Livia E. Clarke, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and anti-Zo-1 (Cell Signaling, 8193) (1:1000) ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 4E-BP1 (1:1000, Cell Signaling Technology), HIF-1α (1:1000 Novus Biologicals) ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Cleaved PARP (1:1000, Cell Signaling Technology), Caspase 3 (1:1000 ...
• A subset of CB002 xanthine analogues bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

  Liz J. Hernández Borrero, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pH3 (#3377) (1:1,000; Cell Signaling Technology) and β-actin (1:10000 ...
• Loss of the H4 lysine methyltransferase KMT5B drives tumorigenic phenotypes by depleting H3K27me3 at loci otherwise retained in H3K27M mutant DIPG cells

  Ketty Kessler, et al., bioRxiv - Cancer Biology 2021

  Quote: ... H3K27me3 at 1/500 (#9735, Cell Signaling), H3 at 1/2000 (#9715 ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p53 (Cell Signaling Technology, #2527, 1:1000), CDK4 (Cell Signaling Technology ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... RB (Cell Signaling Technology, #9313, 1:1000), p-CREB (Cell Signaling Technology ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CDK4 (Cell Signaling Technology, #12790, 1:1000), P-ERK (Cell Signaling Technology ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CREB (Cell Signaling Technology, #9104, 1:1000), tyrosinase (Abcam ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... AKT (Cell Signaling Technology, #9272, 1:1000) CHRM1 (Invitrogen ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... FoxM1 (Cell Signaling Technology, #5436, 1:1000). After incubation with the appropriate secondary antibody ...
• Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors

  Angela M. Carter, et al., bioRxiv - Cancer Biology 2021

  Quote: ... GFP (Cell Signaling Technology 2956; 1:2000), SSTR2 (Santa Cruz sc-365502 ...
• Dissection of N-, O- and glycosphingolipid glycosylation changes in PaTu-S pancreatic adenocarcinoma cells upon TGF-β challenge

  Jing Zhang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Slug 1:1000 (IB: 9585, Cell Signaling), SOX4 1:1000 (IB ...
• NMNAT promotes glioma growth through regulating post-translational modifications of p53 to inhibit apoptosis

  Jiaqi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-SIRT1 (1:1000, Cell Signaling, 2492), anti-acetyl-p53 (1:1000 ...
• Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma

  Marc A. Vittoria, et al., bioRxiv - Cancer Biology 2021

  Quote: ... secondary antibodies (1:5000, Cell Signaling Technology) for 1 h ...
• Chromatin reorganization during myoblast differentiation involves the caspase-dependent removal of SATB2

  Ryan A.V. Bell, et al., bioRxiv - Molecular Biology 2019

  Quote: ... rabbit Gapdh (1:400; #2118, Cell Signaling), rabbit desmin (1:400 ...
• Deregulation of the histone H3K9 di-methylation landscape suppresses canonical Wnt signaling in embryonal rhabdomyosarcoma

  Ananya Pal, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-H3K9me2 (#9753S, 1:1000, Cell Signaling), anti-ß-actin (#A2228 ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... β-actin (Cell Signaling Technology, 3700S, 1:2000), ERK1/2 (Cell Signaling Technology ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... BRAF (Cell Signaling Technology, 9433, 1:500), CRAF (Cell Signaling Technology ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CRAF (Cell Signaling Technology, 9422, 1:500), Akt1 (Abcam ...
• Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD⁺ signaling

  Mustafa N. Okur, et al., bioRxiv - Cell Biology 2020

  Quote: ... p-DRP-1 (S616, Cell signaling, #3455), Beclin-1 (Cell signaling ...
• Boron induces osteogenesis by stimulating NaBC1 in cooperation with BMPR1A

  Patricia Rico, et al., bioRxiv - Cell Biology 2020

  Quote: ... pMLC-intracellular tension (Cell Signaling, 1:200), integrin α5 (abcam ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... NGFR (1:1000) (Cell Signaling Technology, #8238), SOX10 (1:1000 ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... GAPDH (1:2000) (Cell Signaling Technology, #5174), ATF4 (1:200 ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... AXL (1:200) (Cell Signaling Technology, #8661), MITF (1:100 ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... ATF4 (1:200) (Cell Signaling Technology, #11815S), phospho-Rb S780 (1:1500 ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... γ-H2AX (1:400) (Cell Signaling Technology, #9718), and MCM2 (1:200 ...
• Gain-of-function mutations amplify cytotoxic FAM111 protease activity in human genetic disorders

  Saskia Hoffmann, et al., bioRxiv - Cell Biology 2020

  Quote: ... histone H2AX (2595, Cell Signaling (1:1,000)) ...
• Boron induces osteogenesis by stimulating NaBC1 in cooperation with BMPR1A

  Patricia Rico, et al., bioRxiv - Cell Biology 2020

  Quote: ... Smad1 and pSmad1 (Cell Signaling, 1:200), FAK and pFAK (Millipore ...
• Boron induces osteogenesis by stimulating NaBC1 in cooperation with BMPR1A

  Patricia Rico, et al., bioRxiv - Cell Biology 2020

  Quote: ... ERK and pERK (Cell Signaling, 1:200), Smad1 and pSmad1 (Cell Signaling ...
• Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance

  Clara Alcon, et al., bioRxiv - Cancer Biology 2020

  Quote: ... rabbit anti-MCL-1 (Cell Signaling, CST5453), rabbit anti-NOXA (Cell Signaling ...