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4151 - 4200 of 10000+ citations for 6 Methyl 1 2 4 triazolo 4 3 b pyridazine since 2019

• Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy

  Martin L. Read, et al., bioRxiv - Cancer Biology 2023

  Quote: ... PICALM (1:1000; Cell Signaling Technology) and β-actin (1:2000 ...
• Oxygen-independent, hormonal control of HIF-1α regulates the developmental and regenerative growth of cardiomyocytes

  Amarylis C.B.A. Wanschel, et al., bioRxiv - Developmental Biology 2023

  Quote: ... Cas9 (1:2000; 14697, Cell signaling), AMPKα (1:2000 ...
• Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin

  Stephanie L. Baringer, et al., bioRxiv - Neuroscience 2023

  Quote: ... IRP2 (Cell Signaling, 37135, 1:1000), FTH (Cell Signaling ...
• Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin

  Stephanie L. Baringer, et al., bioRxiv - Neuroscience 2023

  Quote: ... IRP1 (Cell Signaling, 20272, 1:1000), IRP2 (Cell Signaling ...
• Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin

  Stephanie L. Baringer, et al., bioRxiv - Neuroscience 2023

  Quote: ... FTH (Cell Signaling, 4393 1:1000), FTL (Abcam ...
• Epigenetic mechanisms to propagate histone acetylation by p300/CBP

  Masaki Kikuchi, et al., bioRxiv - Biochemistry 2023

  Quote: ... H2B (Cell Signaling, #12364, 1/1,000), H2BK12ac (Abcam ...
• Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

  Robbin A. Nameki, et al., bioRxiv - Cancer Biology 2023

  Quote: ... MECOM (Cell Signaling, 1:500, AB_2184098) primary antibodies were diluted in Antibody Dilution Buffer (AF1924 ...
• PRMT1 Inhibition Selectively Targets BNC1-Dependent Proliferation, but not Migration in Squamous Cell Carcinoma

  Rafik Boudra, et al., bioRxiv - Cancer Biology 2023

  Quote: ... IRF6 (Cell Signaling, 6948, 1:500), SPRR1B (Abcam ...
• PRMT1 Inhibition Selectively Targets BNC1-Dependent Proliferation, but not Migration in Squamous Cell Carcinoma

  Rafik Boudra, et al., bioRxiv - Cancer Biology 2023

  Quote: ... GAPDH (Cell Signaling, 2118, 1:5000)
• PRMT1 Inhibition Selectively Targets BNC1-Dependent Proliferation, but not Migration in Squamous Cell Carcinoma

  Rafik Boudra, et al., bioRxiv - Cancer Biology 2023

  Quote: ... p130 (Cell Signaling, 13383, 1:1000), p-FAK (Y397 ...
• Early embryogenesis in CHDFIDD mouse model reveals facial clefts and altered craniofacial neurogenesis

  M Hampl, et al., bioRxiv - Developmental Biology 2023

  Quote: ... SOX2 (1:100, 2748s, Cell Signaling), SOX9 (1:100 ...
• Development of an Accelerated Cellular Model for Alzheimer’s Disease

  Huijing Xue, et al., bioRxiv - Cell Biology 2023

  Quote: ... GFAP antibody (Cell Signaling, 1:1000); Lamin A/C antibody ...
• The human acetylcholinesterase c-terminal T30 peptide activates neural growth through an alpha 7 nicotinic acetylcholine receptor mTOR pathway

  Alexandru Graur, Nadine Kabbani, bioRxiv - Neuroscience 2023

  Quote: ... LC3B (1:1000 Cell Signaling 2775), p-eIF4E (1:1000 Cell Signaling 9741) ...
• PRMT1 Inhibition Selectively Targets BNC1-Dependent Proliferation, but not Migration in Squamous Cell Carcinoma

  Rafik Boudra, et al., bioRxiv - Cancer Biology 2023

  Quote: ... IRF6 (Cell Signaling, 6948, 1:100), Ki67 (NCL-Ki67p ...
• Age-related increases in IGFBP2 increase melanoma cell invasion and lipid synthesis

  Gretchen M. Alicea, et al., bioRxiv - Cancer Biology 2023

  Quote: ... HSP90 (1:10,000, Cell Signaling 4877S), IGFBP2 (1:1,000) ...
• The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance

  Ling Zhang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Survivin (1:1,000, Cell Signaling, 2808). Following incubation with the appropriate secondary horseradish peroxidase-conjugated antibodies ...
• Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway

  Iqbal Dulloo, et al., bioRxiv - Cell Biology 2022

  Quote: ... DDR1 (Cell Signaling, #5583T ; 1:1000), DDX3X (Cell Signaling ...
• Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway

  Iqbal Dulloo, et al., bioRxiv - Cell Biology 2022

  Quote: ... DDX3X (Cell Signaling, #3189S; 1:1000), ADAM17 (AbCam ...
• Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease mice

  Jennifer M. Hafycz, et al., bioRxiv - Neuroscience 2023

  Quote: ... CREB (1:200, Cell Signaling 86B10); pPERK (Thr980 ...
• Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease mice

  Jennifer M. Hafycz, et al., bioRxiv - Neuroscience 2023

  Quote: ... Akt (1:500, Cell Signaling 9272); BDNF (1:500 ...
• Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease mice

  Jennifer M. Hafycz, et al., bioRxiv - Neuroscience 2023

  Quote: ... pAKT (1:500, Cell Signaling 9271); Akt (1:500 ...
• Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease mice

  Jennifer M. Hafycz, et al., bioRxiv - Neuroscience 2023

  Quote: ... peIF2α (1:100, Cell Signaling 3597S); BiP/anti-KDEL (1:1000 ...
• TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages

  Xuezhen Chen, et al., bioRxiv - Neuroscience 2023

  Quote: ... Trem2 (1:400, Cell Signaling Technology), and CD31 (1:800 ...
• Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

  Ling He, et al., bioRxiv - Neuroscience 2023

  Quote: ... β-actin (#3700S, 1:1000, Cell Signaling) in 1X TBST containing 5% BSA overnight at 4°C with gentle rocking ...
• Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR

  Dali Zong, et al., bioRxiv - Cancer Biology 2023

  Quote: ... pCHK2 (T68, 1:1000, Cell Signaling), CHK2 (1:1000 ...
• Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR

  Dali Zong, et al., bioRxiv - Cancer Biology 2023

  Quote: ... pCHK1 (S345, 1:500, Cell Signaling), pCHK1 (S317 ...
• Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy

  Lei Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... VHL (68547,Cell Signaling, 1:1000), β-actin (13E5 ...
• Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy

  Lei Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... β-actin (13E5, Cell Signaling, 1:5,000), β-tubulin (9F3 ...
• Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

  Alice Laschuk Herlinger, et al., bioRxiv - Cancer Biology 2023

  Quote: ... EGFR (1:1,000; Cell Signaling, #4267), pERK1/2 (1:1,000 ...
• Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

  Alice Laschuk Herlinger, et al., bioRxiv - Cancer Biology 2023

  Quote: ... AKT (1:1,000; Cell Signaling, #9272), p21 (1:1,000 ...
• Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

  Alice Laschuk Herlinger, et al., bioRxiv - Cancer Biology 2023

  Quote: ... HDAC2 (1:1,000; Cell Signaling, #2540), histone H3K9ac (1:500 ...
• Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome

  Maiko Matsui, et al., bioRxiv - Physiology 2023

  Quote: ... Pan-Akt (1:1000, Cell Signaling), pAkt (S437 ...
• Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome

  Maiko Matsui, et al., bioRxiv - Physiology 2023

  Quote: ... pAkt (S437) (1:1000, Cell Signaling), AMPK (1:1000 ...
• Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzyme

  Chatrawee Duangjan, et al., bioRxiv - Cell Biology 2023

  Quote: ... pAKT (Cell Signaling Technology, 1:1000), AKT2 (Cell Signaling Technology ...
• DTX3L and USP28 fine-tune DNA double strand repair through mutual regulation of their protein levels

  Yashwanth Ashok, et al., bioRxiv - Biochemistry 2023

  Quote: ... p53 (#48818; 1:1000; Cell signaling), DTX3L (#HPA010570 ...
• Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzyme

  Chatrawee Duangjan, et al., bioRxiv - Cell Biology 2023

  Quote: ... pmTOR (Cell Signaling Technology, 1:1000), FoxO1 (Cell Signaling Technology ...
• Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin-degrading enzyme

  Chatrawee Duangjan, et al., bioRxiv - Cell Biology 2023

  Quote: ... MAPK (Cell Signaling Technology, 1:1000), pMAPK (Cell Signaling Technology ...
• The YARS Tyrosyl tRNA Synthetase Regulates Senescence Induction and Escape Through the Transcriptional Control of LIN9, a Member of the DREAM Complex

  Hugo Coquelet, et al., bioRxiv - Cancer Biology 2023

  Quote: ... LARS (1/1000, Cell signaling, 35509), WARS (1/1000 ...
• Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of Phosphodiesterase 2A

  Sébastien Delhaye, et al., bioRxiv - Animal Behavior and Cognition 2023

  Quote: ... anti-GluR1 (Cell Signaling, 1:1000) and anti-Ser845-GluR1 (Cell Signaling ...
• Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progression

  Sarah Y. Valles, et al., bioRxiv - Cell Biology 2023

  Quote: ... H3pS10 (1:1000; Cell Signaling: #53348). Secondary antibodies for Western blotting are IRDye 680RD Goat anti-Mouse (1:10000 or 1:20000 ...
• BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss

  Mario A. Shields, et al., bioRxiv - Pathology 2023

  Quote: ... Amylase (Cell Signaling #3796, 1:2000), Par3 (Millipore-Sigma #HPA030443 ...
• Autophagy regulates tumor growth and metastasis

  Lei Qiang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... LC3 (1:200 Cell Signaling Biotechnology), Twist1 (1:200 Abcam) ...
• Parkinson’s genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes

  Mai Nguyen, et al., bioRxiv - Cell Biology 2023

  Quote: ... cGAS (Cell signaling, 15102, 1:1000), GBA (R&D Systems ...
• Human pluripotent stem cell-derived respiratory airway progenitors generate alveolar epithelial cells and recapitulate features of idiopathic pulmonary fibrosis

  Mikael G. Pezet, et al., bioRxiv - Cell Biology 2023

  Quote: ... GAPDH (1:5000, Cell Signaling Technology). Species-specific secondary antibodies with HRP conjugates (Cell Signaling Technology ...
• Serine arginine-rich splicing factor (SRSF7) cooperates with the histone methyltransferase KMT5a to promote the type I interferon response via transcriptional activation of IRF7

  Haley M. Scott, et al., bioRxiv - Immunology 2023

  Quote: ... Y701 STAT1 (Cell Signaling, 1:1000), STAT1 (Cell Signaling ...
• Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

  Amy E.M. Beedle, et al., bioRxiv - Biophysics 2023

  Quote: ... or (1:300, 14074S, Cell Signaling). Integrin α5 ...
• Autophagy regulates tumor growth and metastasis

  Lei Qiang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... HA (1:200 Cell Signaling Biotechnology), Myc (1:200 Cell Signaling Biotechnology) ...
• Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis

  Leona A. Nease, et al., bioRxiv - Cancer Biology 2023

  Quote: ... GPX4 (52455S, Cell Signaling; 1:250), MSRB1 (A6737 ...
• Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression

  Gaoyang Liang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... STAT3 (Cell Signaling, 12640, 1:1000) and α-tubulin (Sigma ...
• Biphasic Npas4 expression promotes inhibitory plasticity and suppression of fear memory consolidation in mice

  David V.C. Brito, et al., bioRxiv - Neuroscience 2023

  Quote: ... Fos (1:1000, Cell Signaling, #2250), Npas4 (1:1000 ...