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3651 - 3700 of 10000+ citations for 6 Methyl 1 2 4 triazolo 4 3 b pyridazine since 2019

• Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

  Emmanouela Kallergi, et al., bioRxiv - Neuroscience 2020

  Quote: ... FIP200 (1:1000, Cell Signaling, #12436), Atg101 (1:1000 ...
• Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

  Emmanouela Kallergi, et al., bioRxiv - Neuroscience 2020

  Quote: ... Atg101 (1:1000, Cell Signaling, #13492), ULK1 (1:1000 ...
• Docosahexaenoic Acid has stem cell-specific effects in the SVZ and restores olfactory neurogenesis and function in the aging brain

  JE Le Belle, et al., bioRxiv - Neuroscience 2020

  Quote: ... EGFR (Cell Signaling Technology, 1:100), ID1 (Biocheck ...
• MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

  Dario Zimmerli, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pSTAT1 (1:1000, Cell Signaling, # 8826) and beta-Actin (1:10.000 ...
• Endogenous neural stem cells modulate microglia and protect from demyelination

  Béatrice Brousse, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-EGFR (1/50; Cell Signaling), rat anti-CD68 (1/200 AbCam).
• Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration

  Abigail H. Cleveland, et al., bioRxiv - Neuroscience 2021

  Quote: ... SOX2 1:200 (Cell Signaling, #4900S), SOX9 1:200 (R&D Systems ...
• Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration

  Abigail H. Cleveland, et al., bioRxiv - Neuroscience 2021

  Quote: ... NESTIN 1:500 (Cell Signaling, #4760), IBA1 1:2000 (Wako Chemicals ...
• Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content related to inflammation and recovery processes

  Annika Bub, et al., bioRxiv - Neuroscience 2021

  Quote: ... CD81 (1:1,000; #10037; Cell Signaling), Flotilin-1 (1:1,000 ...
• THE DYNAMIC INTERPLAY BETWEEN HOMEODOMAIN TRANSCRIPTION FACTORS AND CHROMATIN ENVIRONMENT REGULATES PRONEURAL FACTOR OUTCOMES

  Cheen Euong Ang, et al., bioRxiv - Genomics 2020

  Quote: ... rabbit-HSP90 (1:2500, Cell Signaling), rabbit-FLAG (1:500 ...
• Wilms Tumorigenesis in Human Kidney Organoids

  Verena Waehle, et al., bioRxiv - Cancer Biology 2021

  Quote: ... SIX1 (Cell Signaling #12891; 1:200), SIX2 (Proteintech #11562-1-AP ...
• The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma

  Muzhou Wu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... MITF (Cell Signaling, 12590s, 1:1000), AXL (Cell Signaling ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... CTSB (1:1000; Cell Signaling, 31718), CTSD (1:1000 ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... AKT1 (1:1000; Cell Signaling, 9272), phospho(Ser473)-AKT1 (1:2000 ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... CTSD (1:1000; Cell Signaling, 2284), VCP (1:400 ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... RPS6 (1:1000; Cell Signaling, 2317), phosphor(Ser240/244)-RPS6 (1:1000 ...
• Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

  Nina Meyer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... ATG7 (1:500; Cell Signaling, 8558), RB1CC1 (1:1000 ...
• Mapping the Cellular Origin and Early Evolution of Leukemia in Down Syndrome

  Elvin Wagenblast, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-STAG2 (Cell Signaling, 1:50) and anti-GAPDH (Cell Signaling ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... PERK (Cell signaling #3192; 1/1000), phospho-PERK (Cell signaling #3179 ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... eIF2α (Cell Signaling #2103, 1/1000), phospho-eIF2α (Cell Signaling #3398 ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... Calnexin (Cell signaling #2679; 1/1000), α-Tubulin (Santa Cruz #sc-32293 ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... ATF4 (Cell Signaling #11815, 1/1000), CHOP (Cell Signaling #5554 ...
• The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

  Lea Jabbour, et al., bioRxiv - Cell Biology 2021

  Quote: ... CHOP (Cell Signaling #5554, 1/1000), Bcl-xL (Cell Signaling #2764 ...
• Fructose 1,6-bisphosphate sensing by pyruvate kinase isozymes M2 (PKM2) controls MyoD stability and myogenic differentiation

  Minchul Kim, Yao Zhang, Carmen Birchmeier, bioRxiv - Cell Biology 2020

  Quote: ... β-Tubulin (Cell Signaling 2128, 1:2000), Huwe1 (Abcam ab70161 ...
• Fructose 1,6-bisphosphate sensing by pyruvate kinase isozymes M2 (PKM2) controls MyoD stability and myogenic differentiation

  Minchul Kim, Yao Zhang, Carmen Birchmeier, bioRxiv - Cell Biology 2020

  Quote: ... AMPKα (Cell Signaling 2532, 1:1000), phospho-AMPKα (Cell Signaling 2531 ...
• Fructose 1,6-bisphosphate sensing by pyruvate kinase isozymes M2 (PKM2) controls MyoD stability and myogenic differentiation

  Minchul Kim, Yao Zhang, Carmen Birchmeier, bioRxiv - Cell Biology 2020

  Quote: ... S6K (Cell Signaling 2708, 1:1000), phospho-S6K (Cell Signaling 97596 ...
• Transcriptional Control of Brain Tumour Stem Cells by a Carbohydrate Binding Protein

  Ahmad Sharanek, et al., bioRxiv - Cancer Biology 2021

  Quote: ... STAT3 (1:1000, Cell Signaling, #9139), phospho-STAT3 (Tyr705 ...
• Matriptase generates a tissue damage response via promoting Gq signalling, leading to RSK and DUOX activation

  MA Jiajia, et al., bioRxiv - Cell Biology 2021

  Quote: ... 1:100 (#4370, Cell Signaling Technology), Rabbit anti-p44/42 MAPK (Erk1/2) ...
• Counteracting Genome Instability by p53-dependent Mintosis

  Jianqing Liang, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-γH2AX (1:200; Cell Signaling; #9718 for IF ...
• Cell-to-cell heterogeneities during extrinsic apoptosis arise from cell cycle progression and transmitotic apoptosis resistance

  Nadine Pollak, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-Mcl-1 (Cell Signaling), mouse anti-PARP (BD Biosciences) ...
• ERK signaling licenses SKN-1A/NRF1 for proteasome production and proteasomal stress resistance

  Peng Zhang, et al., bioRxiv - Cell Biology 2021

  Quote: ... CAS3 (Cell Signaling Technology; 1:1,000), Actin (1:1,000) ...
• Molecular mechanisms underlying attenuation of live attenuated Japanese encephalitis virus vaccine SA14-14-2

  Pooja Hoovina Venkatesh, et al., bioRxiv - Cell Biology 2021

  Quote: ... Beclin-1 (Cell Signaling Technology #3738), IRE-1α (Novus Biologicals #NB100-2323) ...
• Wilms Tumorigenesis in Human Kidney Organoids

  Verena Waehle, et al., bioRxiv - Cancer Biology 2021

  Quote: ... LIN28B (Cell Signaling #4196, 1:250); NPHS1 (R&D Systems #AF4269 ...
• Wilms Tumorigenesis in Human Kidney Organoids

  Verena Waehle, et al., bioRxiv - Cancer Biology 2021

  Quote: ... LIN28A (Cell Signaling #3978, 1:600); LIN28B (Cell Signaling #4196 ...
• Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity

  Irene Riera-Tur, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-beclin-1 (3495, Cell Signaling), anti-HPRT (ab10479 ...
• Sex-Specific Role of Myostatin Signaling in Neonatal Muscle Growth, Denervation Atrophy, and Neuromuscular Contractures

  Marianne E Emmert, et al., bioRxiv - Developmental Biology 2022

  Quote: ... GAPDH (1:5000; Cell Signaling #2118) served as a control for sample loading ...
• History of previous midlife estradiol treatment permanently alters interactions of brain insulin-like growth factor-1 signaling and hippocampal estrogen synthesis to enhance cognitive aging in a rat model of menopause

  Nina E. Baumgartner, et al., bioRxiv - Neuroscience 2022

  Quote: ... total Akt (1:1000, Cell Signaling), total ERα (1:1000 ...
• In vivo reprogramming leads to premature death due to hepatic and intestinal failure

  Alberto Parras, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Asp175 (1:200, Cell Signaling, 9661).
• Genetic control of neuronal activity enhances axonal growth only on permissive substrates

  Francina Mesquida-Veny, et al., bioRxiv - Neuroscience 2022

  Quote: ... c-Fos (1:200, Cell Signaling), ChR2 (1:500 ...
• Ethanol exposure alters Alzheimer’s-related pathology, behavior, and metabolism in APP/PS1 mice

  Stephen C. Gironda, et al., bioRxiv - Neuroscience 2022

  Quote: ... BACE1 (Cell Signaling; 5606S; 1:1000), ADAM10 (Millipore ...
• Sex-Specific Role of Myostatin Signaling in Neonatal Muscle Growth, Denervation Atrophy, and Neuromuscular Contractures

  Marianne E Emmert, et al., bioRxiv - Developmental Biology 2022

  Quote: ... GAPDH (1:5000; Cell Signaling #2118) served as a control for sample loading ...
• Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

  Joanna L. Fiddler, et al., bioRxiv - Biochemistry 2022

  Quote: ... and GAPDH (Cell Signaling, 1:2000) were used ...
• Ethanol exposure alters Alzheimer’s-related pathology, behavior, and metabolism in APP/PS1 mice

  Stephen C. Gironda, et al., bioRxiv - Neuroscience 2022

  Quote: ... GluN2B (Cell Signaling; 4212; 1:1000), GABAAR α5 (Santa Cruz ...
• Ethanol exposure alters Alzheimer’s-related pathology, behavior, and metabolism in APP/PS1 mice

  Stephen C. Gironda, et al., bioRxiv - Neuroscience 2022

  Quote: ... GluN2A (Cell Signaling; 4025; 1:1000), GluN2B (Cell Signaling ...
• Spt6 directly interacts with Cdc73 and is required for Paf1C recruitment to active genes

  Mitchell A. Ellison, et al., bioRxiv - Molecular Biology 2022

  Quote: ... H2BK123ub (Cell Signaling 5546, 1:1,000), HA tag (Roche 11666606001 ...
• Single-Cell Multi-Omic Roadmap of Human Fetal Pancreatic Development

  de la O Sean, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Glucagon (1:200, Cell Signaling, 2760S), Insulin (1:200 ...
• Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Hutchinson-Gilford Progeria Syndrome

  Xiaojing Mao, et al., bioRxiv - Developmental Biology 2022

  Quote: ... K18 (1:1000, Cell Signaling #4548), total β-Catenin (1:1000 ...
• Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Hutchinson-Gilford Progeria Syndrome

  Xiaojing Mao, et al., bioRxiv - Developmental Biology 2022

  Quote: ... RCC1 (1:1000, Cell Signaling #3589), S6 Ribosomal Protein (1:1000 ...
• Neuronal hemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein

  Santulli Chiara, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-MYC 1:100 (Cell Signaling) and anti-Hemoglobin 1:1000 (MP Biomedicals) ...
• Plasticity in airway smooth muscle differentiation during mouse lung development

  Katharine Goodwin, et al., bioRxiv - Developmental Biology 2022

  Quote: ... pMLC2 (Cell Signaling 3671, 1:200), RFP (Abcam ab62341 ...
• Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease

  Josef Leibold, et al., bioRxiv - Cancer Biology 2022

  Quote: ... MSH2 (1:200, Cell Signaling, D24B5), MYC (1:100 ...