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3501 - 3550 of 10000+ citations for 6 Methyl 1 2 4 triazolo 4 3 b pyridazine since 2019

• ASO-based PKM Splice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth

  Wai Kit Ma, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rb-Slug (1:1,000; Cell Signaling), rb-E-cadherin (1:1,000 ...
• Haploinsufficient tumour suppressor PRP4K is negatively regulated during epithelial-to-mesenchymal transition

  Livia E. Clarke, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-Zeb-1 (Cell Signaling, 3396) (1:1000) ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... PUMA (1:1000, Cell Signaling Technology), RPL5 (1:1000 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... S6K (1:1000, Cell Signaling Technology), phospho-S6 (S235/236 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... S6 (1:1000, Cell Signaling Technology), phospho-4E-BP1 (Thr37/46 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... eEF2 (1:1000 Cell Signaling Technology), eEF2K (1:1000 Cell Signaling Technology) ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... eEF2K (1:1000 Cell Signaling Technology), followed by incubation with horseradish peroxidase-conjugated secondary antibodies (1:5000 ...
• CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer

  Ning Zhao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... AR (515S3, Cell Signaling, 1:1000), and B-Actin (A5441 ...
• CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer

  Ning Zhao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... PSMA (12815S, Cell Signaling, 1:1000), AR (515S3 ...
• Caveolin-1 temporal modulation enhances trastuzumab and trastuzumab-drug conjugate efficacy in heterogeneous gastric cancer

  Patrícia M. R. Pereira, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 1:1,000 (Cell Signaling Technology, 9541S), rabbit anti-pHER2 ...
• Caveolin-1 temporal modulation enhances trastuzumab and trastuzumab-drug conjugate efficacy in heterogeneous gastric cancer

  Patrícia M. R. Pereira, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 1:2,000 (Cell Signaling Technology, 4060S), rabbit anti-cleaved PARP ...
• Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

  Anna L Koessinger, et al., bioRxiv - Cancer Biology 2021

  Quote: ... β-tubulin (Cell Signaling #2146, 1:5000), HSP60 (Cell Signaling #4870 ...
• Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

  Anna L Koessinger, et al., bioRxiv - Cancer Biology 2021

  Quote: ... HSP60 (Cell Signaling #4870, 1:1000), or actin (Sigma #A4700 ...
• Deregulation of the histone H3K9 di-methylation landscape suppresses canonical Wnt signaling in embryonal rhabdomyosarcoma

  Ananya Pal, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-G9a (Cell Signaling, 1:50) and anti-Sp1(1:50 Santa Cruz ...
• Aryl Hydrocarbon Receptor Blocks Aging-Induced Senescence in the Liver and Fibroblast Cells

  Ana Nacarino-Palma, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-p53 (Cell signaling 1:1000) and anti-β-Actin (Sigma 1:1000 ...
• Parkin coordinates mitochondrial lipid remodeling to execute mitophagy

  Chao-Chieh Lin, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-lipin-1 (Cell Signaling 5195), anti-PLD2 (Scbt sc-515744) ...
• Modeling Human Peripheral Myelin Fully from Pluripotent Stem Cells and Immune-mediated Neuropathy In Vitro using ZIKA Virus

  Fahimeh Mirakhori, Cheng-Feng Qin, Zhiheng Xu, bioRxiv - Cell Biology 2020

  Quote: ... and GAPDH (Cell Signaling, 1:5,000) followed by horseradish-peroxidase-conjugated secondary antibodies (Cell Signaling) ...
• Activation of FAM111A Protease Induces Defects in Nuclear Function that Likely Underlie its Roles in Disease and Viral Restriction

  Minghua Nie, et al., bioRxiv - Cell Biology 2020

  Quote: ... PARP (Cell Signaling, 9542 (1:1000)) ...
• Exon Junction Complex dependent mRNA localization is linked to centrosome organization during ciliogenesis

  Oh Sung Kwon, et al., bioRxiv - Cell Biology 2020

  Quote: ... α-PCM1(Cell signaling, Rabbit 1:600), α-9G8 (described previously98 ...
• Endothelial mTOR maintains hematopoiesis during aging

  Pradeep Ramalingam, et al., bioRxiv - Cell Biology 2020

  Quote: ... phospho 4EBP-1 (Cell Signaling 2855), 4EBP-1 (Cell Signaling 9644 ...
• Endothelial mTOR maintains hematopoiesis during aging

  Pradeep Ramalingam, et al., bioRxiv - Cell Biology 2020

  Quote: ... phospho 4EBP-1 (Cell Signaling 2855), 4EBP-1 (Cell Signaling 9644) ...
• A simple and highly efficient method for multi-allelic CRISPR-Cas9 editing in primary cell cultures

  Pia Hoellerbauer, et al., bioRxiv - Cell Biology 2020

  Quote: ... Pten (Cell Signaling #9559S, 1:1,000), Nf1 (Santa Cruz #sc-67 ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... Rab11 (#5589S, 1:50, Cell Signaling), and LAMP1 (#ab25245 ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... ETS1 (#14069S, 1:1000, Cell Signaling), β-Actin (#sc-47778 ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... MET (#8198S, 1:1000, Cell Signaling), p-Akt S473 (#4060L ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... STAT3 (#9139S, 1:1000, Cell Signaling), p-c-Jun S63 (#9261S ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... EGFR (#4267S, 1:1000, Cell Signaling), p-MET Y1234/1235 (#3077S ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... Akt (#9272S, 1:1000, Cell Signaling), p-ERK1/2 T202/Y204 (#4370S ...
• Akt/Foxo pathway activation switches apoptosis to senescence in short telomere zebrafish

  Mounir El-Maï, et al., bioRxiv - Cell Biology 2020

  Quote: ... Ser473 (1:1000, Cell Signaling, #4060); anti-total-Akt (1:1000 Cell Signaling ...
• Akt/Foxo pathway activation switches apoptosis to senescence in short telomere zebrafish

  Mounir El-Maï, et al., bioRxiv - Cell Biology 2020

  Quote: ... Ser256 (1:100, Cell Signaling, #9461); anti-Tubulin (1:5000 ...
• Myosin-1b interacts with UNC45A and controls intestinal epithelial morphogenesis

  Céline Revenu, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti GAPDH (1:1000, Cell Signaling).
• SLX4IP-mediated telomere maintenance is essential for androgen receptor-independent castration-resistant prostate cancer

  Tawna L. Mangosh, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p21 (1:500, Cell Signaling, 2947), Ki-67 (1:1 000 ...
• Ubiquitin specific protease 1 expression and function in T cell immunity

  Kyla D Omilusik, et al., bioRxiv - Immunology 2021

  Quote: ... Usp1 (1:1000; D37B4, Cell Signaling), Wdr48 (1:1000 ...
• Cylindromatosis Drives Synapse Pruning and Weakening by Promoting Macroautophagy through Akt-mTOR Signaling

  Alexis S. Zajicek, et al., bioRxiv - Neuroscience 2021

  Quote: ... CYLD (1:1000; Cell Signaling, 8462), mTOR (1:1000 ...
• Cylindromatosis Drives Synapse Pruning and Weakening by Promoting Macroautophagy through Akt-mTOR Signaling

  Alexis S. Zajicek, et al., bioRxiv - Neuroscience 2021

  Quote: ... GluA1 (1:1000, Cell Signaling, 13185), GluA2 (1:1000 ...
• Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival

  C. N. Byrne-Hoffman, et al., bioRxiv - Cancer Biology 2019

  Quote: ... pAkt (1:1000, Cell Signaling Technology), and β-actin (1:1000 ...
• Enhancer and super-enhancer landscape in polycystic kidney disease

  Ronak Lakhia, et al., bioRxiv - Molecular Biology 2021

  Quote: ... CREB (Cell Signaling 9197S; 1:1000), STAT1 (Cell Signaling 14994S ...
• Enhancer and super-enhancer landscape in polycystic kidney disease

  Ronak Lakhia, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Fos (Cell Signaling 2250S; 1:1000), Jun (Cell Signaling 9165 ...
• Enhancer and super-enhancer landscape in polycystic kidney disease

  Ronak Lakhia, et al., bioRxiv - Molecular Biology 2021

  Quote: ... STAT1 (Cell Signaling 14994S; 1:1000), PC1(7e12 ...
• Enhancer and super-enhancer landscape in polycystic kidney disease

  Ronak Lakhia, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Jun (Cell Signaling 9165; 1:1000), CREB (Cell Signaling 9197S ...
• Fragmentation of Small-cell Lung Cancer Regulatory States in Heterotypic Microenvironments

  Dylan L. Schaff, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Rps6 (Cell Signaling #2317, 1:50), ubiquitin (Santa Cruz #sc-8017 ...
• Fragmentation of Small-cell Lung Cancer Regulatory States in Heterotypic Microenvironments

  Dylan L. Schaff, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Mavs (Cell Signaling #4983, 1:50), Hif1a (R&D Systems #NB100-134 ...
• Increased FOXL2 Expression Alters Uterine Structures and Functions

  Rong Li, et al., bioRxiv - Developmental Biology 2020

  Quote: ... FOXA2 (1:400, 8186, Cell signaling), P63 (1:800 ...
• Increased FOXL2 Expression Alters Uterine Structures and Functions

  Rong Li, et al., bioRxiv - Developmental Biology 2020

  Quote: ... PGR (1:400, 8257, Cell signaling), FOXA2 (1:400 ...
• Increased FOXL2 Expression Alters Uterine Structures and Functions

  Rong Li, et al., bioRxiv - Developmental Biology 2020

  Quote: ... P63 (1:800, 39692 Cell signaling), KI67(1:1000 ab15580 Abcam).
• Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut

  Erez Cohen, Donald T. Fox, bioRxiv - Developmental Biology 2020

  Quote: ... DCP1 (Cell Signaling, Asp261, 1:500), Phospho-Histone H3 (Cell Signaling ...
• LCK Regulates Homologous Recombination DNA Repair Identifying a New Target for Sensitizing PARP Inhibitors in HR Proficient Ovarian Cancer

  Goutam Dey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... γH2AX (1:1000 Cell Signaling Technology), GAPDH (1:5000 Proteintech) ...
• Age-dependent Effect Imposed by Rotenone Exposure

  Madeleine C. Moseley, et al., bioRxiv - Neuroscience 2021

  Quote: ... Ki67 (Cell Signaling, #9449S, 1:200), Tuj1 (Millipore #MAB1637 ...
• Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain

  Uri Nimrod Ramírez-Jarquín, et al., bioRxiv - Neuroscience 2021

  Quote: ... GFP (1:5000, Cell Signaling, #2956), mCherry (1:5000 ...
• Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain

  Uri Nimrod Ramírez-Jarquín, et al., bioRxiv - Neuroscience 2021

  Quote: ... Flotillin (1:1000, Cell Signaling, # 18634) and secondary antibodies conjugated to HRP (1:10000 ...