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8451 - 8500 of 10000+ citations for 7 CHLORO 1 METHYL 1H PYRAZOLO 4 3 B PYRIDINE since 2019

• Epac1 regulates cellular SUMOylation by promoting the formation of SUMO-activating nuclear condensates

  Wenli Yang, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-SUMO1 (1:100; Cell Signaling Technology, Cat. # SC-4930), anti-SUMO2/3 (1:200 ...
• IntAct: a non-disruptive internal tagging strategy to study actin isoform organization and function

  M.C. van Zwam, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-profilin (#3246, Cell Signaling, 1:1000 for western blot), anti-cofilin (#5175P ...
• IntAct: a non-disruptive internal tagging strategy to study actin isoform organization and function

  M.C. van Zwam, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-cofilin (#5175P, Cell Signaling, 1:1000 for western blot). Secondary antibodies conjugated to Alexa647 ...
• HIF-1α induces glycolytic reprogramming in tissue-resident alveolar macrophages to promote survival during acute lung injury

  Parker S. Woods, et al., bioRxiv - Cell Biology 2022

  Quote: ... mouse anti-IL1β (Cell signaling, catalog number 12242 1:1000), rabbit anti-Lamin B1 (Proteintech ...
• HIF-1α induces glycolytic reprogramming in tissue-resident alveolar macrophages to promote survival during acute lung injury

  Parker S. Woods, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-LDHA (Cell signaling, catalog number 20125, 1:1000), rabbit anti-PHD2/Egln1 (Cell Signaling ...
• Aspirin Synergizes with Regorafenib to Reduce Growth of Colorectal Cancer

  Chang Su, et al., bioRxiv - Cancer Biology 2022

  Quote: ... supplemented with 1 mM phenylmethanesulfonyl fluoride (Cell Signaling Cat# 8553), 1% Protease Inhibitor Cocktail (Cell Signaling Cat# 5871 ...
• DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Confers Chemoresistance via Activation of YAP Signaling

  Yabing Nan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-p-LATS1 (S909) (9157, Cell Signaling Technology, 1:1000), anti-H3K4me1 (5326 ...
• DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Confers Chemoresistance via Activation of YAP Signaling

  Yabing Nan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-YAP (14074, Cell Signaling Technology, MA, USA, 1:1000), anti-p-YAP (S127 ...
• DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Confers Chemoresistance via Activation of YAP Signaling

  Yabing Nan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-p-YAP (S127) (4911, Cell Signaling Technology, 1:1000), anti-LATS1 (3477 ...
• Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode

  Lu Hu, et al., bioRxiv - Biochemistry 2022

  Quote: ... Secondary antibody was anti-rabbit (1:5000, 7074S, Cell Signaling).
• Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode

  Lu Hu, et al., bioRxiv - Biochemistry 2022

  Quote: ... Secondary antibody was anti-rabbit (1:5000, 7074S, Cell Signaling).
• Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode

  Lu Hu, et al., bioRxiv - Biochemistry 2022

  Quote: ... and secondary anti-mouse antibodies (1:5000, 7076S, Cell Signaling). The band intensities were quantified with ImageJ ...
• Sex-Specific Role of Myostatin Signaling in Neonatal Muscle Growth, Denervation Atrophy, and Neuromuscular Contractures

  Marianne E Emmert, et al., bioRxiv - Developmental Biology 2022

  Quote: ... or K48-linkage-specific-polyubiquitin (1:1000, Cell Signaling #8081). GAPDH (1:5000 ...
• Structural insights into p300 regulation and acetylation-dependent genome organisation

  Ziad Ibrahim, et al., bioRxiv - Biochemistry 2022

  Quote: ... or anti-HDAC1 antibody (1:100 dilution, Cell Signaling Technology) in 1% dry milk ...
• RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma

  Silke Lambing, et al., bioRxiv - Immunology 2022

  Quote: ... Alexa-488 anti-Calreticulin (Cell Signaling Technology, diluted 1:100).
• Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

  Lilija Wehling, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and anti-AKT (1:50, Cell Signaling Technology, #9272, RRID:AB_329827) were used ...
• Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

  Lilija Wehling, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and pLATS1/2 (1:500, Cell Signaling Technology, #8654, RRID:AB_10971635) and Cytochrome P450 2E1 (1:500 ...
• Targeted deletion of uterine glandular Foxa2 induces embryonic diapause in mice

  Mitsunori Matsuo, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Anti-E-Cad antibody (1:100, 3195s, Cell Signaling Technology) was used to stain the luminal epithelium ...
• 4-aminopyridine promotes accelerated skin wound healing via neurogenic-mediator expression

  Mashanipalya G. Jagadeeshaprasad, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit TGF-β antibody (Cell Signaling Technology, #3711S, 1:500), mouse anti-SOX10 antibody (Santa Cruz Biotechnology ...
• A retinal circuit that vetoes optokinetic responses to fast visual motion

  Adam Mani, et al., bioRxiv - Neuroscience 2022

  Quote: ... Rabbit anti-HA tag (1: 200, Cell Signaling Technology #3724) was used to stain the HA-tagged hM4Di receptor in the VGluT3 x DREADD mouse.
• Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

  Yian Guan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-pERK1/2 (1:5000, Cat#9101, Cell Signaling Technology), anti-PTPN12 (1:500 ...
• Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

  Yian Guan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-ERK1/2 (1:3000, Cat#4695, Cell Signaling Technology), anti-pERK1/2 (1:5000 ...
• Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

  Laura Virtanen, et al., bioRxiv - Molecular Biology 2022

  Quote: ... rabbit monoclonal pAKT T303 (1:1000, D6F8, Cell Signaling Technologies), rabbit polyclonal ERK1 (1:500 ...
• Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

  Laura Virtanen, et al., bioRxiv - Molecular Biology 2022

  Quote: ... rabbit monoclonal pERK1/2 (1:1000, D13.14.4E, Cell Signaling Technologies), rabbit monoclonal cleaved PARP-1 (1:1000 ...
• Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

  Laura Virtanen, et al., bioRxiv - Molecular Biology 2022

  Quote: ... rabbit polyclonal AKT (pan) (1:1000, C67E7, Cell Signaling Technologies), rabbit monoclonal pAKT T303 (1:1000 ...
• Hexosamine pathway activation improves memory but does not extend lifespan in mice

  Kira Allmeroth, et al., bioRxiv - Physiology 2022

  Quote: ... β-actin (mouse, Cell Signaling Technologies, 8H10D10, 1:25.000 in milk). After incubation with HRP-conjugated secondary antibody (Invitrogen ...
• A Protective Inter-Organ Communication Response Against Life-Threatening Malarial Anemia

  Qian Wu, et al., bioRxiv - Pathology 2022

  Quote: ... Phalloidin-Alexa Fluor® 647 (1:100; Cell Signaling, #8940) and goat anti-rabbit Alexa Fluor® 568 (1:500 ...
• Iron Deficiency Induces Heart Failure with Ectopic Cardiac Calcification in Mice with Metabolic Syndrome

  Yoshiro Naito, et al., bioRxiv - Pathology 2022

  Quote: ... and anti-GAPDH (#2118, Cell Signaling Technology; dilution 1:1000) antibodies were used.
• Disentangling the molecular mechanisms underlying the retrieval and extinction of morphine withdrawal-associated memories in the basolateral amygdala and dentate gyrus

  Aurelio Franco-García, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... and rabbit anti mTOR (1:1000; #2983, Cell Signaling Technology). After three washings with TBST (tris buffer saline tween ...
• GCNA is a histone binding protein required for spermatogonial stem cell maintenance

  Jonathan Ribeiro, Gerry P. Crossan, bioRxiv - Physiology 2022

  Quote: ... anti-FLAG (1:1000, catalog no. 2368, Cell Signaling Technology); anti-GFP (1:1000 ...
• GCNA is a histone binding protein required for spermatogonial stem cell maintenance

  Jonathan Ribeiro, Gerry P. Crossan, bioRxiv - Physiology 2022

  Quote: ... anti-γH2AX (1:200, catalog no. 2577, Cell Signaling Technology). Slides were washed three times for 5 min with TBS + 0.1% Tween 20 and then incubated for 1h at RT with the following secondary antibodies diluted in blocking buffer ...
• GCNA is a histone binding protein required for spermatogonial stem cell maintenance

  Jonathan Ribeiro, Gerry P. Crossan, bioRxiv - Physiology 2022

  Quote: ... anti-PCNA (1:400, catalog no. 13110, Cell Signaling Technology); anti-Cleaved Caspase 3 (1:300 ...
• GCNA is a histone binding protein required for spermatogonial stem cell maintenance

  Jonathan Ribeiro, Gerry P. Crossan, bioRxiv - Physiology 2022

  Quote: ... anti-FLAG (1:200, catalog no. 2368, Cell Signaling Technology); anti-LAMIN B1 (1:500 ...
• GCNA is a histone binding protein required for spermatogonial stem cell maintenance

  Jonathan Ribeiro, Gerry P. Crossan, bioRxiv - Physiology 2022

  Quote: ... anti-RPA2 (1:400, catalog no. 2208, Cell Signaling Technology). Cells were then washed with PBS-S-T and incubated for 1h at 37°C with the following secondary antibodies diluted in blocking buffer ...
• The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway

  Alberto Carreño, Jens Lykke-Andersen, bioRxiv - Molecular Biology 2022

  Quote: ... mouse monoclonal anti-GAPDH (Cell Signaling Technology, 97166, 1:1,000), rabbit polyclonal anti-EDC4 ((42) ...
• Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

  Hyosung Kim, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-pSTAT3(y705) (1:300 dilution, 9145S, Cell Signaling), goat anti-Serpina3n (1:200 dilution ...
• Mural norrin/β-catenin signaling regulates Lama2 expression to promote neurovascular unit assembly

  Saptarshi Biswas, et al., bioRxiv - Developmental Biology 2022

  Quote: ... FITC-conjugated rabbit anti-LEF1 (1:100; Cell Signaling Technology; Danvers ...
• Ex Vivo Validation of Six FDA-Approved Non-Receptor Tyrosine Kinase Inhibitors (NRTKIs) as Antivirals to Pandemic and Seasonal Influenza A Viruses

  Robert Meineke, et al., bioRxiv - Microbiology 2022

  Quote: ... phos-Stat3 (Tyr705) (D3A7) rabbit mAb (1:1000) (Cell Signaling), Influenza A virus NP Antibody (PA5-32242 ...
• Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes

  Judith Pineau, et al., bioRxiv - Cell Biology 2022

  Quote: ... HRP-linked Antibody (Cell signaling, #7077, 1/10000 for WB), Alexa Fluor 546 Phalloidin (Thermofisher ...
• Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes

  Judith Pineau, et al., bioRxiv - Cell Biology 2022

  Quote: ... HRP-linked Antibody (Cell signaling, #7074, 1/5000 for WB), Anti-Rat IgG ...
• Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Hutchinson-Gilford Progeria Syndrome

  Xiaojing Mao, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Non-phospho (Active) β-Catenin (1:1000, Cell Signaling #8814), RCC1 (1:1000 ...
• A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes

  Haiting Ma, et al., bioRxiv - Developmental Biology 2022

  Quote: ... a rabbit anti-ARID2 (Cell Signaling Technology 82342S 1:1000), or a mouse anti FLAG antibody (Sigma F1804 1:4000 ...
• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

  Jason J. Northey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-FAK (Y397) (Cell Signaling Technology, Cat. #: 8556, 1:200), phospho-FAK (Y397 ...
• An affinity-matured DLL4 ligand for broad-spectrum activation and inhibition of Notch signaling

  David Gonzalez-Perez, et al., bioRxiv - Bioengineering 2022

  Quote: ... and β-Actin (rabbit pAb, Cell Signaling Technology, 1:1,000). Secondary antibody anti-Rabbit IgG conjugated to HRP (Goat mAb ...
• An affinity-matured DLL4 ligand for broad-spectrum activation and inhibition of Notch signaling

  David Gonzalez-Perez, et al., bioRxiv - Bioengineering 2022

  Quote: ... anti-Notch2 (D76A6 rabbit mAb, Cell Signaling Technology, 1:1,000), and anti-β Actin (mouse mAb ...
• Adipose triglyceride lipase promotes prostaglandin-dependent actin remodeling by regulating substrate release from lipid droplets

  Michelle S. Giedt, et al., bioRxiv - Cell Biology 2022

  Quote: ... and mouse anti-α-Tubulin (1:5000, Cell Signaling Technologies). Membranes were washed 3 times in 1X PBS-0.1% Tween 20 (PBS-Tween) ...
• Transcriptome profiling of the ventral pallidum reveals a role for pallido-thalamic neurons in cocaine reward

  Michel Engeln, et al., bioRxiv - Neuroscience 2022

  Quote: ... and in rabbit anti-GFP (1:500; Cell Signaling #2555) overnight at 4°C as in 34 ...
• The cohesin modifier ESCO2 is stable during DNA replication

  Allison M. Jevitt, et al., bioRxiv - Cell Biology 2022

  Quote: Primary antibodies to P-Chk1 (Cell Signaling, rabbit, 1:1200), ß-tubulin (DSHB ...
• HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity

  Yabing Nan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and anti-c-Myc (1:50, Cell Signaling Technology, #9402). The following antibodies were used for PLA and IF assays ...
• 3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

  Jacqueline Salotti, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Ki67 (Cell Signaling Technology #12202, 1:200 for 30 min), and the Bond Polymer Refine Detection Kit (LeicaBiosystems #DS9800 ...