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8251 - 8300 of 10000+ citations for 7 CHLORO 1 METHYL 1H PYRAZOLO 4 3 B PYRIDINE since 2019

• Extensive and diverse patterns of cell death sculpt neural networks in insects

  Sinziana Pop, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-cleaved Drosophila Dcp1 (1:100; Asp216, Cell Signaling), guinea pig anti-Syncrip (1:100 ...
• Arap1 Loss Causes RPE Phagocytic Dysfunction and Subsequent Photoreceptor Death

  Andy Shao, et al., bioRxiv - Molecular Biology 2021

  Quote: ... and rabbit anti-Beta-actin IgG (1:4000, Cell Signaling) overnight at 4°C ...
• The hallucinogenic serotonin_2A receptor agonist, DOI, promotes CREB-dependent gene expression of specific plasticity-associated genes in the rodent neocortex

  Lynette A. Desouza, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-pCREB (1:1000; Cell Signaling Technology, MA, USA) or goat anti-5-HT2A receptor (1:500 ...
• Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

  Polina Kosillo, et al., bioRxiv - Neuroscience 2021

  Quote: ... and phospho-S6 (Ser240/244) (1:1000, Cell Signaling: 5364S). The following secondary antibodies were used ...
• TrkB agonists prevent post-ischemic BDNF-TrkB mediated emergence of refractory neonatal seizures in CD-1 pups

  P.A. Kipnis, et al., bioRxiv - Neuroscience 2019

  Quote: ... rabbit α Erk1/2 (1:1000, Cell Signaling Technology; #4695), rabbit α phospho-Erk1/2 (1:1000 ...
• Nuclear Export of Drosophila PERIOD contributes to temperature compensation of the circadian clock

  Astrid Giesecke, et al., bioRxiv - Neuroscience 2021

  Quote: ... 1:2000 for mouse anti HA-tag (6E2 Cell signaling), and 1:2000 for anti-CLK (3) ...
• The chromatin remodeler Ino80 mediates alternative RNAPII pausing site determination

  Youngseo Cheon, et al., bioRxiv - Molecular Biology 2021

  Quote: ... and anti-tubulin (Cell Signaling, 2144S; used at 1:4000).
• End-of-life targeted auxin-mediated degradation of DAF-2 Insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

  Richard Venz, et al., bioRxiv - Molecular Biology 2021

  Quote: ... HRP-conjugated goat anti-mouse (Cell Signaling #7076, 1:2000) secondary antibodies were used to detect the proteins by enhanced chemiluminescence (Bio-Rad #1705061) ...
• Tendon Cell Deletion of IKKβ/NF-κB Drives Functionally Deficient Tendon Healing and Altered Cell Survival Signaling In Vivo

  Katherine T. Best, et al., bioRxiv - Molecular Biology 2020

  Quote: ... phospho-S6K1 (1:1000, Cat#: 9234, Cell Signaling, Danvers, MA), total S6K1 (1:1000 ...
• Tendon Cell Deletion of IKKβ/NF-κB Drives Functionally Deficient Tendon Healing and Altered Cell Survival Signaling In Vivo

  Katherine T. Best, et al., bioRxiv - Molecular Biology 2020

  Quote: ... total AKT (1:1000, Cat#: 9272, Cell Signaling, Danvers, MA), β-catenin (1:1000 ...
• Tendon Cell Deletion of IKKβ/NF-κB Drives Functionally Deficient Tendon Healing and Altered Cell Survival Signaling In Vivo

  Katherine T. Best, et al., bioRxiv - Molecular Biology 2020

  Quote: ... phospho-p38 (1:1000, Cat#: 9216, Cell Signaling, Danvers, MA), total p38 (1:1000 ...
• Tendon Cell Deletion of IKKβ/NF-κB Drives Functionally Deficient Tendon Healing and Altered Cell Survival Signaling In Vivo

  Katherine T. Best, et al., bioRxiv - Molecular Biology 2020

  Quote: ... phospho-JNK (1:1000, Cat#: 4668, Cell Signaling, Danvers, MA), total JNK (1:1000 ...
• Tendon Cell Deletion of IKKβ/NF-κB Drives Functionally Deficient Tendon Healing and Altered Cell Survival Signaling In Vivo

  Katherine T. Best, et al., bioRxiv - Molecular Biology 2020

  Quote: ... phospho-AKT (1:1000, Cat#: 4060, Cell Signaling, Danvers, MA), total AKT (1:1000 ...
• Tendon Cell Deletion of IKKβ/NF-κB Drives Functionally Deficient Tendon Healing and Altered Cell Survival Signaling In Vivo

  Katherine T. Best, et al., bioRxiv - Molecular Biology 2020

  Quote: ... and GAPDH (1:1000, Cat#: 2118, Cell Signaling, Danvers, MA). Full length gels provided in supplemental figures 1 and 2 ...
• Tendon Cell Deletion of IKKβ/NF-κB Drives Functionally Deficient Tendon Healing and Altered Cell Survival Signaling In Vivo

  Katherine T. Best, et al., bioRxiv - Molecular Biology 2020

  Quote: ... total p38 (1:1000, Cat#: 9212, Cell Signaling, Danvers, MA), phospho-S6K1 (1:1000 ...
• Tumor elimination by clustered microRNAs miR-306 and miR-79 via non-canonical activation of JNK signaling

  Zhaowei Wang, Xiaoling Xia, Tatsushi Igaki, bioRxiv - Cell Biology 2022

  Quote: ... HRP-linked antibody (Cell Signaling Technology, Cat #7074, 1:5000) or anti-guinea pig IgG ...
• Mechanisms of A-type lamin targeting to nuclear ruptures are disrupted in LMNA- and BANF1-associated progerias

  Rhiannon M. Sears, Kyle J. Roux, bioRxiv - Cell Biology 2022

  Quote: ... and rabbit anti-Ankle2 (1:1000; ab225905; Cell Signaling Technology). Mouse monoclonal anti-tubulin (1:5000 ...
• Separate to operate: the centriole-free inner core of the centrosome regulates the assembly of the intranuclear spindle in Toxoplasma gondii

  Ramiro Tomasina, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-HA at 1:200 (Cell Signaling, Cat #: 3724S), mouse anti-IMC-1(16) ...
• Link between aging and atheroprotection in Mif-deficient atherosclerotic mice

  Christine Krammer, et al., bioRxiv - Immunology 2021

  Quote: ... and rabbit anti-mouse Ki67 (1:200, #9129T, Cell Signaling). Afterwards ...
• Regulation of eIF6 through multisite and sequential phosphorylation by GSK3β

  Courtney F. Jungers, et al., bioRxiv - Molecular Biology 2019

  Quote: ... and anti-GSK3β monoclonal antibody (1:1000) (Cell Signaling Technology) diluted in Tris-buffered saline with 0.1% Tween-20 (TBS-T).
• Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism

  Sophie Trefely, et al., bioRxiv - Biochemistry 2019

  Quote: ... catalase (Cell Signaling Technologies, cat. #14097, clone D5N7V, lot 1).
• Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

  Chunmei Li, et al., bioRxiv - Developmental Biology 2019

  Quote: ... Phospho-Histone H3 (Ser10) (Cell Signaling Technology 9701, 1:500), Anti-GFP rabbit IgG ...
• Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation

  Takeo Tsutsumi, et al., bioRxiv - Physiology 2019

  Quote: ... anti-AKT polyclonal antibody (1:2,000; #9272, Cell Signaling Technology), anti-phospho-AKT (Ser473 ...
• Low-dose IFN-γ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer

  Mengjia Song, et al., bioRxiv - Cancer Biology 2019

  Quote: ... anti-Akt (Cell Signaling Technology, Boston, MA, USA, 1:1000), anti-phospho-Akt (Cell Signaling Technology ...
• Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn-independent effect of tau on glutamate-induced Ca²⁺ response

  Guanghao Liu, et al., bioRxiv - Neuroscience 2019

  Quote: ... Src (36D10, 1:250, rabbit polyclonal, Cell Signaling, Cat #2109), phospho-Src (1:250 ...
• Estrogen-related receptor beta activation and isoform shifting by cdc2-like kinase inhibition restricts migration and intracranial tumor growth in glioblastoma

  DM Tiek, et al., bioRxiv - Cancer Biology 2019

  Quote: ... phosphorylated histone H3 Serine 10 (1:1000, Cell Signaling, #3377S), and total histone H3 (1:1000 ...
• Distinct Vegfa isoforms control endothelial cell proliferation through PI3 kinase signalling mediated regulation of cdkn1a/p21

  Martin Lange, et al., bioRxiv - Developmental Biology 2020

  Quote: ... anti-p44/42 MAPK antibody (1:2000; #9102, Cell Signaling) and anti-αActin antibody (1:5000 ...
• Genetic interactions of histone acetyl-transferase enzymes encoding genes Gcn5 and Mof with hsrω lncRNA gene

  Deo Prakash Chaturvedi, bioRxiv - Genetics 2019

  Quote: ... rabbit anti-H3K9Ac (1:100 dilution, Cell Signaling Technology, USA) and mouse anti-Megator BX34 (1:20 dilution ...
• Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

  Nathalie Tisch, et al., bioRxiv - Developmental Biology 2019

  Quote: ... p-ERK p44/42 (1:1000, ref.9106, Cell Signaling), ERK (1:1000 ...
• Cholangiocarcinoma presents a distinct myeloid-derived suppressor cell signature compared to other hepatobiliary cancers

  Defne Bayik, et al., bioRxiv - Pathology 2019

  Quote: ... antibody diluted 1:100 using SignalStain Diluent (Cell Signaling Technology) and incubated for 40 minutes at 37°C ...
• IPSC-derived neuronal cultures expressing the Alzheimer’s disease associated rare TREM2 R47H variant enables the construction of an Aβ-induced gene regulatory network

  Soraia Martins, et al., bioRxiv - Neuroscience 2019

  Quote: ... mouse anti βIII-tubulin (1:1000, Cell Signaling #TU-20). After washing the blots three times with PBS/ 0,05%Tween20 they were incubated with the appropriate secondary antibody ...
• IPSC-derived neuronal cultures expressing the Alzheimer’s disease associated rare TREM2 R47H variant enables the construction of an Aβ-induced gene regulatory network

  Soraia Martins, et al., bioRxiv - Neuroscience 2019

  Quote: ... mouse anti-βIII-tubulin (1:200, Cell Signaling #TU-20), rabbit anti-MAP2 (1:1000 ...
• HMGB1 orchestrates uterine macrophage trafficking to safeguard embryo implantation

  Shizu Aikawa, et al., bioRxiv - Developmental Biology 2019

  Quote: ... Anti-E-Cad antibody (1:100, 3195s, Cell Signaling Technology) and anti-F4/80 (1:1000 ...
• Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals

  Christopher B. Mulholland, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and monoclonal rabbit anti-UHRF1 (1:250; D6G8E, Cell Signaling). Following secondary antibodies were used ...
• Krüppel-like factor 2- induced microRNAs: implications for treatment of pulmonary hypertension

  Hebah Sindi, et al., bioRxiv - Cell Biology 2019

  Quote: ... and human/mouse pSer536-p65 (1:1000, Cell Signaling, 3033) were used (Pradere ...
• SLC19A1 is an importer of the immunotransmitter cGAMP

  Anthony F. Cordova, et al., bioRxiv - Biochemistry 2019

  Quote: ... and cGAS (1:1000) were purchased from Cell Signaling Technology. Mouse monoclonal anti-α-tubulin (1:1000 ...
• Altered immunity of laboratory mice in the natural environment is associated with fungal colonization

  Frank Yeung, et al., bioRxiv - Immunology 2019

  Quote: ... clone D4W2Z (Cell Signaling Cat# 98941 Lot# 1 RRID: unassigned) raised against synthetic peptide corresponding to residues surrounding Asp42 of mouse CD8α protein (5 ...
• Cancer gene therapy by NF-κB-activated cancer cell-specific expression of CRISPR/Cas9 targeting to telomere

  Wei Dai, Jian Wu, Danyang Wang, Jinke Wang, bioRxiv - Cancer Biology 2019

  Quote: ... or TBP Rabbit mAb (Cell Signaling Technology, diluted 1:1000). After washing three times with 1 M TBS (pH 7.6 ...
• Schwann cell demyelination is triggered by a transient mitochondrial calcium release through Voltage Dependent Anion Channel 1

  Nicolas Tricaud, et al., bioRxiv - Neuroscience 2019

  Quote: ... total non-phosphorylated JNK (1/1000, Cell Signaling, Ref. 9252) were from rabbit ...
• Schwann cell demyelination is triggered by a transient mitochondrial calcium release through Voltage Dependent Anion Channel 1

  Nicolas Tricaud, et al., bioRxiv - Neuroscience 2019

  Quote: ... phospho-Thr180/Tyr182-p38 (1/1000, Cell Signaling, Ref. 9211), Cleaved Caspase-3 (1/1000 ...
• Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo

  K. A. Staats, et al., bioRxiv - Neuroscience 2019

  Quote: ... anti-mouse HRP (Cell Signaling, cat. no. 7076S, 1:5,000), and anti-rabbit HRP (Cell Signaling ...
• Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo

  K. A. Staats, et al., bioRxiv - Neuroscience 2019

  Quote: ... mouse anti-p53 (Cell Signaling, cat. no. 2524S, 1:1,000), mouse anti-Synaptophysin (Sigma ...
• Anterior Cleft Palate due to Cbfb deficiency and its rescue by folic acid

  Safiye E. Sarper, et al., bioRxiv - Developmental Biology 2019

  Quote: ... monoclonal rabbit anti-Stat3 (1:200, #9139, Cell Signaling Technology) overnight at 4°C ...
• Linking endoplasmic reticulum stress to polyploidy in ovarian cancer cells

  Lucile Yart, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-PERK antibodies (CS56833, 1:1000 dilution from Cell Signaling), mouse anti-CHOP antibodies (MA1-250 ...
• Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues

  Ivana Gasic, et al., bioRxiv - Cell Biology 2019

  Quote: ... 1:1’000 rabbit anti-β-actin (Cell Signaling, USA, #4970), 1:15’000 Hoechst 3342 (Thermo Fisher Scientific ...
• Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

  Jakob Morgenstern, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Beta-actin (1:2500 dilution; 4967S; rabbit; Cell Signaling Technology) in 2% dry milk containing PBS and 0.05% Tween20 (PBS-T) ...
• Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

  Jakob Morgenstern, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Histone H3 (1:2500 dilution; 4499S; rabbit; Cell Signaling Technology), Gapdh (1:2500 dilution ...
• Effects of altering histone post-translational modifications on mitotic chromosome structure and mechanics

  Ronald Biggs, et al., bioRxiv - Cell Biology 2019

  Quote: ... with a 1:1600 rabbit anti-H3K27me3 (Cell Signaling 9733) primary and a 1:500 of 488-nm anti-mouse IgG (Invitrogen A11001 ...
• Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

  Alberto Granzotto, et al., bioRxiv - Neuroscience 2019

  Quote: ... rabbit p-ERK5 and rabbit ERK5 1:1000 (Cell Signaling). As secondary antibodies ...
• Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

  Alberto Granzotto, et al., bioRxiv - Neuroscience 2019

  Quote: ... rabbit p-P38 and rabbit P38 1:1000 (Cell Signaling); rabbit P53 1:1000 (Cell Signaling) ...