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801 - 850 of 1183 citations for 2 Pyridinesulfonic acid methyl ester since 2020

• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: p44/42 MAPK (Erk1/2) (3A7) Mouse mAb (Cell Signaling Technology, cat. no. 9107)
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology, cat. no. 9154) c-Raf (D4B3J ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... /Phospho-p44/42 MAPK (Erk1/2) D13.14.4E XP®Rabbit mAb (Cell Signaling Technology) or Phospho-MEK1/2 (Ser217/221 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... /Phospho-p44/42 MAPK (Erk1/2) D13.14.4E XP®Rabbit mAb (Cell Signaling Technology) or Phospho-MEK1/2 (Ser217/221 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) D13.14.4E XP®Rabbit mAb (Cell Signaling Technology), Phospho-MEK1/2 (Ser217/221 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... Mouse mAb (Cell Signaling Technology)/Phospho-p44/42 MAPK (Erk1/2) D13.14.4E XP®Rabbit mAb (Cell Signaling Technology) were diluted in Intercept PBS Block Buffer (LicorBio ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... Mouse mAb (Cell Signaling Technology)/Phospho-p44/42 MAPK (Erk1/2) D13.14.4E XP®Rabbit mAb (Cell Signaling Technology) or Phospho-MEK1/2 (Ser217/221 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... Mouse mAb (Cell Signaling Technology)/Phospho-p44/42 MAPK (Erk1/2) D13.14.4E XP®Rabbit mAb (Cell Signaling Technology) or Phospho-MEK1/2 (Ser217/221 ...
• Suppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complex

  Zhe Ji, et al., bioRxiv - Cell Biology 2024

  Quote: ... cells were incubated with 2 ng/mL TGF-β3 (Cell signaling #8425 and #10858) or 20 ng/mL BMP-4 (Peprotech 120-05 ...
• Sustained experimental activation of FGF8/ERK in the developing chicken spinal cord reproducibly models early events in ERK-mediated tumorigenesis

  Axelle Wilmerding, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) 1:250 (Cell signaling #9101), rabbit anti-SOX2 1:500 (AB5603 Merck Millipore) ...
• MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis

  Carolyn Sangokoya, Robert Blelloch, bioRxiv - Developmental Biology 2020

  Quote: ... Phospho-p44/42 Erk1/2 Thr202/Tyr204 at 1:1000 dilution (Cell Signaling Technology, 4370), and p44/42 Erk1/2 at 1:1000 dilution (Cell Signaling Technology ...
• Surface-associated antigen induces B-cell permeabilization and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

  Fernando Y. Maeda, et al., bioRxiv - Cell Biology 2021

  Quote: ... and incubated with rabbit anti-phosphorylated myosin light chain 2 (pMLC2) antibodies (Cell Signaling Technology) to label activated NMII (Bresnick 1999) ...
• Reversal of β-amyloid induced microglial toxicity in vitro by activation of Fpr2/3

  Edward S. Wickstead, et al., bioRxiv - Neuroscience 2020

  Quote: ... or superoxide dismutase 2 (SOD2; rabbit monoclonal, 1:1000, Cell Signaling Technology, Leiden, The Netherlands) in Tris-buffer saline solution containing 0.1% Tween-20 and 5% (w/v ...
• Negative durotaxis: cell movement toward softer environments

  Aleksi Isomursu, et al., bioRxiv - Biophysics 2020

  Quote: ... rbt anti-p-ERK1/2 (T202/Y204) (Cell Signaling Technology, 4370, 1:1000 for WB), ms anti-YAP (Santa Cruz Biotechnology ...
• Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

  Weiyi Xu, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... Primary antibodies used are listed as below: anti-phosph-ERK1/2 (Cell Signaling Technologies, 9101S), anti-ERK1/2 (Cell Signaling Technologies ...
• Kir6.2-containing K_ATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer’s-related pathology

  John Grizzanti, et al., bioRxiv - Neuroscience 2022

  Quote: ... 2° antibody conjugated with HRP specific to either (1:3,000) goat anti-rabbit (Cell Signaling) or (1:3,000 ...
• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

  Jason J. Northey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-p44/42 MAPK (ERK1/2) (T202/Y204) (Cell Signaling Technology, Cat. #: 9101, 1:200), NFκB p65 (D14E12 ...
• Semaphorin3F Drives Dendritic Spine Pruning through Rho-GTPase Signaling

  Bryce W. Duncan, et al., bioRxiv - Neuroscience 2021

  Quote: ... For Cofilin we used rabbit monoclonal anti-Cofilin1/2 antibodies (Cell Signaling Technology# 5175, RRID:AB_10622000), and rabbit monoclonal anti-phospho-Cofilin Ser3 (Cell Signaling Technology# 3313 ...
• Purinergic receptor P2RY14 cAMP signaling regulates EGFR-driven Schwann cell precursor self-renewal and nerve tumor initiation in neurofibromatosis

  Jennifer Patritti-Cram, et al., bioRxiv - Neuroscience 2021

  Quote: ... P44/42 MAPK (Erk1/2) (137F5) rabbit mAB (1:1000, Cell Signaling Technologies, Cat#: 4695S).
• Loss of O-GlcNAcylation on MeCP2 Thr 203 Leads to Neurodevelopmental Disorders

  Juanxian Cheng, et al., bioRxiv - Neuroscience 2020

  Quote: ... and the rest was incubated with 2 μg anti-HA antibody (Cell Signaling Technology, 3724) or anti-GFP (Cell Signaling Technology ...
• Biphasic Response of Protein Kinase A to Cyclic Adenosine Monophosphate Triggers Distinct Epithelial Phenotypes

  João Pedro Fonseca, et al., bioRxiv - Systems Biology 2020

  Quote: ... F(ab’)2 Fragment (Alexa Fluor® 488 Conjugate) (Cell Signaling Technology #4412, 1:1000).
• Biphasic Response of Protein Kinase A to Cyclic Adenosine Monophosphate Triggers Distinct Epithelial Phenotypes

  João Pedro Fonseca, et al., bioRxiv - Systems Biology 2020

  Quote: ... anti-p44/42 MAPK (Erk1/2) (L34F12) Mouse mAb (Cell signaling technology ##4696, 1:2000), anti-Phospho-p38 MAPK (Thr180/Tyr182 ...
• Schizophrenia Risk Proteins ZNF804A and NT5C2 Interact at Synapses

  Afra Aabdien, et al., bioRxiv - Neuroscience 2021

  Quote: ... in PBS and blocked simultaneously in 2% normal goat serum (NGS – Cell Signaling Technology, 5425) in PBS for one hour with agitation ...
• MG132 induces progerin clearance and improves disease phenotypes in fibroblasts of patients affected with Hutchinson-Gilford Progeria-like syndromes

  Karim Harhouri, et al., bioRxiv - Genetics 2021

  Quote: ... 2/ Colorimetric detection of senescence-associated β galactosidase following the manufacturer’s protocol (Cell Signaling #9860). Cells were seeded in 4 chamber-wells slides (SPL Lifesciences ...
• Long-term non-invasive drug treatments for adult zebrafish

  Yuting Lu, E. Elizabeth Patton, bioRxiv - Cancer Biology 2021

  Quote: ... total p44/42 MAPK (ERK1/2) primary antibody (1:200, rabbit, Cell Signaling Technologies #9102), and Alexa-fluor 488 secondary antibody (1:1000 ...
• KRAS G12D can be targeted by potent salt-bridge forming inhibitors

  Zhongwei Mao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... slides were incubated with primary antibodies against pERK1/2 (1:200, Cell Signaling Technology, 4370), cleaved Caspase-3 (1:200 ...
• HOXB8 counteracts MAPK/ERK oncogenic signaling in a chicken embryo model of neoplasia

  Axelle Wilmerding, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit anti-Phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) Antibody #9101 (Cell Signaling Technology), rabbit anti-SOX2 1:500 (AB5603 Merck Millipore) ...
• Cell-intrinsic functions of the transcription factor Bhlhe40 in activated B cells and T follicular helper cells restrain the germinal center reaction and prevent lymphomagenesis

  René Rauschmeier, et al., bioRxiv - Immunology 2021

  Quote: ... Alexa Fluor 647–labeled anti–rabbit F(ab)2 fragment (both from Cell Signaling Technology) and the Cytofix/Cytoperm kit (BD ...
• Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

  Bowen Tan, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2% donkey serum) and then incubated with primary antibody (rabbit anti-c-fos, Cell Signaling, 1:500 for 100-μm sections ...
• Thrombospondin 2 is a key determinant of fibrogenesis in NAFLD

  Takefumi Kimura, et al., bioRxiv - Molecular Biology 2023

  Quote: ... small mothers against decapentaplegic (SMAD) 2/3 (D7/G7) (Cell Signaling Technology, #8685, 1:1,000), Phospho-Smad2 (Ser465/467)/Smad3 (Ser423/425 ...
• Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates that reduce surface AMPA receptor expression in primary neurons

  Jocelyn Widagdo, et al., bioRxiv - Neuroscience 2022

  Quote: ... total myc-GluA1/2 was labeled with rabbit anti-myc antibody (71D10, Cell Signaling Technology) at 4°C overnight ...
• Murine gammaherpesvirus 68 ORF45 stimulates B2 retrotransposon and pre-tRNA activation in a manner dependent on mitogen-activated protein kinase (MAPK) signaling

  Azra Lari, Britt A. Glaunsinger, bioRxiv - Microbiology 2022

  Quote: ... anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) antibody (Cell Signaling #9101, 1:1000), anti-Brf1polyclonal antibody (Bethyl ...
• Ca²⁺-driven cytoplasmic backflow secures spindle position in fertilized mouse eggs

  Takaya Totsuka, Miho Ohsugi, bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-phospho-myosin light chain 2 (Ser19) (pMLC) (1:100, Cell Signaling Technology #3671), for 2 hours ...
• Enhanced feature matching in single-cell proteomics characterizes response to IFN-γ and reveals co-existence of different cell states

  Karl K. Krull, Syed A. Ali, Jeroen Krijgsveld, bioRxiv - Systems Biology 2024

  Quote: ... U-2 OS cells underwent treatment with 50 ng/mL recombinant IFN-γ (Cell Signaling). The cytokine was diluted in 0.5% (w/v ...
• Endosomal LRBA regulates the endo-lysosomal pathway

  Viktória Szentgyörgyi, et al., bioRxiv - Immunology 2024

  Quote: ... mouse monoclonal anti p44/42 MAPK (Erk1/2) (L334F10) antibody (#4696, Cell Signaling, 1:2000), rabbit polyclonal anti phospho-p44/42 MAPK (Erk1/2 ...
• Endosomal LRBA regulates the endo-lysosomal pathway

  Viktória Szentgyörgyi, et al., bioRxiv - Immunology 2024

  Quote: ... mouse monoclonal anti p44/42 MAPK (Erk1/2) (L334F10) antibody (#4696, Cell Signaling, 1:2000), rabbit polyclonal anti phospho-p44/42 MAPK (Erk1/2 ...
• Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral and signaling plasticity in vivo

  Mohamed R. Ahmed, et al., bioRxiv - Neuroscience 2023

  Quote: ... blots were re-probed with a rabbit anti-ERK1/2 antibody (Cell Signaling, cat.# 9102) at 1:1,000 dilution to detect total ERK1/2 ...
• Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning

  George R. Bjorklund, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (RRID:AB_2315112, Cell Signaling Technologies 4370), rabbit anti-ERK2 (RRID:AB_732210 ...
• Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning

  George R. Bjorklund, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (RRID:AB_2315112, Cell Signaling Technologies 4370), rabbit anti-ERK2 (RRID:AB_732210 ...
• Influence of myosin regulatory light chain and myosin light chain kinase on hair cells of the inner ear

  Ryohei Oya, et al., bioRxiv - Biophysics 2023

  Quote: ... anti-phospho-myosin light chain 2 (3671; Cell Signaling Technology, Danvers, MA, USA; 1:50); Alexa Fluor 488-labeled secondary antibody (Thermo Fisher Scientific ...
• FGF9, a potent mitogen, is a new ligand for integrin αvβ3, and the FGF9 mutant defective in integrin binding acts as an antagonist

  Chih-Chieh Chang, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-phospho-p44/42 MAPK (p-ERK1/2) (Thr-202/Tyr204) (Cell Signaling Technology, USA), rabbit anti-FGFR1 (Cell Signaling Technology ...
• Differentiation signals from glia are fine-tuned to set neuronal numbers during development

  Anadika R. Prasad, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (1:100, Cell Signaling #9101), chicken anti-RFP (1:500 ...
• Discovery of E6AP AZUL binding to UBQLN1/2 in cells, phase-separated droplets, and an AlphaFold-NMR integrated structure

  Gwen R. Buel, et al., bioRxiv - Biophysics 2022

  Quote: ... 2 mg of protein was combined with 15 µL anti-UBQLN1 (Cell Signaling Technologies 14526) or anti-UBQLN2 (Cell Signaling Technologies 85509 ...
• HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

  Brian A. Davies, et al., bioRxiv - Cell Biology 2022

  Quote: ... total-p42/44 MAPK (ERK1/2) 3A7 mouse monoclonal antibody (1:2000, 9107, Cell Signaling), p-AKT-S473 D9E rabbit monoclonal antibody (1:1000 ...
• Atypical Chemokine Receptor 3 ‘Senses’ CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

  Christopher T. Schafer, et al., bioRxiv - Biochemistry 2023

  Quote: ... ERK1/2 phosphorylation was detected by probing with anti-phospho-p44/42 (4370, Cell Signaling) and anti-tubulin (T6074 ...
• Combined KRAS^G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS^G12C-driven cancers by addressing intrinsic and acquired resistance

  Venu Thatikonda, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (1:2000, Cell Signaling Technology #4370) was developed using Opal tyramide signal amplification (TSA ...
• Oncogenic Kras^G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8⁺ T cells dependent manner

  Krishnan K. Mahadevan, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (1:2000, Cell Signaling Technology #4370) was developed using Opal tyramide signal amplification (TSA ...
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... Erk1/2 phosphorylated at Thr202 and Tyr204 rabbit (Cell Signaling Technology, 4370, 1:200 dilution), phospho-Akt at Ser473 rabbit (Cell Signaling Technology ...
• Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis

  Thomas Kehrer, et al., bioRxiv - Microbiology 2022

  Quote: ... Antibodies used for immunostaining of histology slides are: SARS-CoV-2 spike (99423S, Cell Signaling) at a 1:400 dilution ...
• Alterations in the preneoplastic breast microenvironment of BRCA1/2 mutation carriers revealed by spatial transcriptomics

  Anthony Caputo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 1:200 phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, 9101S). Primary antibodies used for immunohistochemistry of FFPE tissues were 1:50 COL6 (Rockland ...