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651 - 700 of 1183 citations for 2 Pyridinesulfonic acid methyl ester since 2020

• Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

  Ling Zhou, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... ERK1/2 (4696S) were obtained from Cell Signaling Technology (Boston, MA, USA), against NFE2 (11089-1-AP) ...
• A combination of the geroprotectors trametinib and rapamycin is more effective than either drug alone

  Lisonia Gkioni, et al., bioRxiv - Physiology 2024

  Quote: ... and total ERK1/2 (1:1000, anti-rabbit, Cell Signaling Technology, 4695) in 5% fatty-acid free BSA in TBS-T at 4°C overnight ...
• Rigosertib Reverses Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome

  Levi Legler, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and anti-phospho-ERK 1/2 (Thr202/Tyr204) (#9101) (Cell Signaling Technology). Visualization of the primary antibody binding was performed using the Li-Cor anti-rabbit 680 IRDye system in conjunction with the Li-Cor Odyssey FC ...
• Cocaine, via ΔFosB, remodels gene expression and excitability in ventral hippocampus

  Andrew L. Eagle, et al., bioRxiv - Neuroscience 2024

  Quote: ... or 2 μg of rabbit polyclonal IgG isotype (3900S, Cell Signaling Technology). Antibody-bound chromatin fragments were isolated with protein G plus/protein A agarose beads (MilliporeSigma) ...
• Improved protein binder design using beta-pairing targeted RFdiffusion

  Isaac Sappington, et al., bioRxiv - Biochemistry 2024

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, #9101) 1:10,000 dilution ...
• Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase

  Erin Skeens, et al., bioRxiv - Biochemistry 2024

  Quote: ... and ERK1/2 using anti-phospho-p38 MAPK (Cell Signaling Cat# 9215), anti-phospho-JNK1/2 (Cell Signaling cat#4668 ...
• Contractile forces direct the chiral swirling of minimal cell collectives

  Ghina Badih, et al., bioRxiv - Cell Biology 2024

  Quote: Rabbit Anti-Phospho-Myosin Light Chain 2 (Ser19) Antibody (Cell Signaling 3671) was used at 1/100 and secondary Goat anti-Rabbit IgG Alexa Fluor 546 antibody (Invitrogen A11035 ...
• The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cells

  Shadi Zahedi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-p44/42 MAP kinase (pERK1/2) (#9101S) (Cell Signaling, Danvers, MA); p44/42 MAP kinase (Erk1/2 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... or Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology)/Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... or Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology)/Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... or Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology)/Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences).
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... or Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology)/Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences).
• Iodoacetic acid disrupts mouse oocyte maturation by inducing oxidative stress and spindle abnormalities

  Xiaofei Jiao, et al., bioRxiv - Cell Biology 2020

  Quote: ... and anti-phospho-p44/42 MAPK (Erk1/2) (1:200, Cell Signaling Technologies). As for γ-H2AX or phospho-p44/42 MAPK (Erk1/2 ...
• MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis

  Carolyn Sangokoya, Robert Blelloch, bioRxiv - Developmental Biology 2020

  Quote: ... and p44/42 Erk1/2 at 1:1000 dilution (Cell Signaling Technology, 4696). Secondary infrared-dye antibodies were used at 1:10,000 ...
• MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis

  Carolyn Sangokoya, Robert Blelloch, bioRxiv - Developmental Biology 2020

  Quote: ... and p44/42 Erk1/2 at 1:700 dilution (Cell Signaling Technology, 4696) for 30 minutes at 4°C followed by incubation with species-specific secondary antibodies Alexa Fluor 568 or 594 goat anti-mouse IgG at 1:200 dilution (Invitrogen ...
• Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants

  Nastaran Daneshgar, et al., bioRxiv - Pathology 2021

  Quote: ... and phospho-p44/42 MAPK (ERK1/2) (Cell Signaling Technology, 4370, 1:500), anti-Catalase (R&D ...
• Engineering single pan-specific ubiquibodies for targeted degradation of all forms of endogenous ERK protein kinase

  Erin A. Stephens, et al., bioRxiv - Synthetic Biology 2021

  Quote: ... rabbit anti-p-p44/42 MAPK (ERK1/2) (Cell Signaling, cat # 9101 S) to detect pERK2 ...
• Immune elicitation by sensing the conserved signature from phytocytokines and microbes via the Arabidopsis MIK2 receptor

  Shuguo Hou, et al., bioRxiv - Plant Biology 2021

  Quote: ... which was then blotted using α-pERK1/2 antibodies (Cell Signaling, Cat # 9101) for the detection of phosphorylated MPK3 ...
• Silencing of oncogenic KRAS by mutant-selective small interfering RNA

  Bjoern Papke, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Rabbit polyclonal anti-p44/42 MAPK (ERK1/2) (Cell Signaling Technology Cat #9102), ß-Actin (Sigma-Aldrich Cat #5441).
• Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via PDH regulation

  Takeshi Ikizawa, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit polyclonal anti-p44/42 MAPK (Erk1/2) antibody (Cell Signaling, Cat#9102), rabbit polyclonal anti-phospho-acetyl-CoA-carboxylase (Ser79 ...
• Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

  Hiroki Yagi, et al., bioRxiv - Pathology 2022

  Quote: ... rabbit polyclonal anti-phosphorylated ERK1/2 (Thr202/Tyr204) antibody (Cell Signaling Technology, #9101), rabbit polyclonal anti-ERK1/2 antibody (Cell Signaling Technology ...
• The Chlamydia protein CpoS modulates the inclusion microenvironment and restricts the interferon response by acting on Rab35

  Karsten Meier, et al., bioRxiv - Microbiology 2022

  Quote: ... rabbit-anti-Rab35 (1:1000; Cell Signaling, 9690; or Proteintech, 11329-2-AP), mouse-anti-β-actin (1:2000 ...
• Polypyrimidine Tract-Binding Protein 1 (PTBP1) regulates CD4 T cell Activation independent of its role in proliferation

  Bitha Narayanan, et al., bioRxiv - Immunology 2022

  Quote: ... p38MAPK (cat. #9212) and ERK1/2 (cat. #9102) were purchased from Cell Signaling. Goat mAb against p65 (clone C-20 ...
• THE STABILIZATAION OF C-MYC BY THE NOVEL CELL CYCLE REGULATOR, SPY1, DECREASES EFFICACY OF BREAST CANCER TREATMENTS

  Rosa-Maria Ferraiuolo, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-p-ERK 1/2 [Thr 202/Tyr 204] (Cell Signaling; 1:1000), and anti-ERK1/2 (Santa Cruz Biotechnology ...
• Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome

  Fikri Birey, et al., bioRxiv - Neuroscience 2021

  Quote: ... and Phospho-Myosin Light Chain 2 (Ser19) (rabbit, Cell Signaling, 1:1,000, 3671S) antibodies for 72 h at 4 °C ...
• Activation of SGK1.1 up-regulates the M-current in the presence of epilepsy mutations

  Elva Martin-Batista, et al., bioRxiv - Neuroscience 2021

  Quote: ... Nedd4-2 was detected with a rabbit polyclonal antibody from Cell Signaling (4013S). GAPDH was detected with a mouse monoclonal antibody (Abcam ...
• Perineuronal net receptor PTPσ regulates retention of memories

  Angelina Lesnikova, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-phospho-p44/42 MAPK (Erk1/2) rabbit mAb (Cell Signaling Technology, #9101); anti-phospho-p70 S6 kinase rabbit polyclonal antibody (pAb ...
• Streptococcus suis induces expression of cyclooxygenase-2 in porcine lung tissue

  Muriel Dresen, et al., bioRxiv - Microbiology 2021

  Quote: ... 6 diamidino-2-phenylindole (DAPI, 0.5 μg/mL in PBS, Cell Signaling Technology). Stained sections were mounted with ProLong® Gold Antifade Reagent (Cell Signaling Technology ...
• Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets

  Laura Van Moortel, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... Rabbit anti-phosphoGR Ser211 was purchased from Cell Signaling Technology (4161S, lot 2). Mouse anti-Flag M2 and mouse anti-β-actin (AC-15 ...
• Intracellular Energy Controls Dynamics of Stress-induced Ribonucleoprotein Granules

  Tao Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... with or without 50 μM CP91149 or 2 μM oligomycin (Cell Signaling Technology). For the glutamine deprivation ...
• Microsecond pulse electrical stimulation modulates cell migration

  Xiao-Wei Xiang, et al., bioRxiv - Bioengineering 2022

  Quote: ... F(ab’)2 Fragment (Alexa Fluor® 488 Conjugate) (#4412S, Cell Signaling Technology). The cells were imaged with an inverted fluorescence microscope (Ti2-U ...
• Balancing competing effects of tissue growth and cytoskeletal regulation during Drosophila wing disc development

  Nilay Kumar, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Phospho-Myosin Light Chain 2 (Ser19) (1:50, Rabbit, Cell Signaling Technology #3671S), α-Rho1 (1:10 ...
• Nuclear SUN1 Stabilizes Endothelial Cell Junctions via Microtubules to Regulate Blood Vessel Formation

  Danielle B Buglak, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-phospho-myosin light chain 2 (Thr18/Ser19) (1:500, 3674S, Cell Signaling), anti-alpha-tubulin (1:500 ...
• V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis

  Miriam Formica, et al., bioRxiv - Genetics 2020

  Quote: ... rabbit anti-p-ERK 1/2 (Thr202/Tyr204) 1:1000 (4370, Cell Signaling), rabbit anti-ERK 1/2 1:1000 (4695 ...
• Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia

  L. Martin, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-phosphorylated Erk1-2 (Thr180/Tyr182) (Cell Signaling Technology, #4370; 1:100 dilution), anti-phosphorylated P38 (Abcam ...
• Palmitoylation targets the Calcineurin phosphatase to the Phosphatidylinositol 4-kinase complex at the plasma membrane

  Idil Ulengin-Talkish, et al., bioRxiv - Biochemistry 2021

  Quote: ... ERK using p44/42 Erk1/2 antibody (1:3,000; 3A7, Cell Signaling Technologies). Phosphorylation status of FAM126A in each treatment was quantified as pFAM126A S485 signal/FLAG signal and reported relative to that of in DMSO treated FAM126A WT sample ...
• The MKRN1-BRAF exon4-exon9 fusion is a targetable oncogenic driver

  Megan A. Girtman, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Total MEK1/2 (#4694S) all purchased from Cell Signaling Technology (CST, Davers, MA), Raf-B (Santa Cruz Biotechnology ...
• Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways

  F Quessy, et al., bioRxiv - Neuroscience 2021

  Quote: ... Phospho-p44/42 MAPK 1:250 (Erk1/2) (Thr202/Tyr204) (Cell Signaling, 9101), DAT 1:500 (Millipore ...
• Neuron-like function of the nephron central command

  Georgina Gyarmati, et al., bioRxiv - Physiology 2021

  Quote: ... anti-cyclooxygenase 2 (COX2) antibody (1:100, 12282S, Cell Signaling Technology, Danvers, MA,), anti-Na-K-2Cl cotransporter antibody (NKCC2 1:100 ...
• Cell Stiffening Contributes to Complement-mediated Injury of Choroidal Endothelial Cells in Early AMD

  Andrea P. Cabrera, et al., bioRxiv - Pathology 2021

  Quote: ... or monoclonal rabbit anti-Myosin Light Chain 2 (D18E2) antibody (Cell Signaling Technologies). GAPDH (Sigma ...
• Antitumor activity of a lectibody targeting cancer-associated high-mannose glycans

  Young Jun Oh, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and phospho-MAPK1 (ERK1/2) were purchased from Cell Signaling Technology (Danver, MA). EGF and IGF1 were purchased from Thermo Fisher Scientific (Waltham ...
• DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinoma

  Sk. Kayum Alam, et al., bioRxiv - Cancer Biology 2021

  Quote: ... total ERK1/2 (Cat no.: 4695; Dilution 1:1000) from Cell Signaling Technology. Monoclonal antibodies (200 μg/ml ...
• Fibroblasts close a void in free space by a purse-string mechanism

  Avelino Dos Santos Da Costa, et al., bioRxiv - Biophysics 2020

  Quote: ... and phosphor-myosin light chain 2 (Thr18/Ser19) antibody (3674, Cell Signaling Technology) in 1% BSA (1/200 dilution ...
• The Imprinted Igf2-Igf2r Axis is Critical for Matching Placental Microvasculature Expansion to Fetal Growth

  Ionel Sandovici, et al., bioRxiv - Developmental Biology 2021

  Quote: ... mouse anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling, 9106), rabbit anti-p44/42 MAPK (Erk1/2 ...
• Turnover Regulation of the Rho GTPase Cdc42 by Heat Shock Protein Chaperones and the MAPK Pathway Scaffold Bem4

  Beatriz González, Paul J. Cullen, bioRxiv - Cell Biology 2021

  Quote: ... Polyclonal rabbit phospho-p44/42 MAPK (Erk1/2, Cat#3102, Cell Signaling Technology) were used at 1:10,000 dilution ...
• ALK signaling drives tumorigenicity and chemoresistance of pancreatic ductal adenocarcinoma cells

  Beatriz Parejo-Alonso, et al., bioRxiv - Cancer Biology 2022

  Quote: ... ERK 1/2 (1:3000) (all from Cell Signaling Technology, Danvers, MA, USA), pERK 1/2 (T202-Y204 ...
• Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

  Hiroki Yagi, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... rabbit polyclonal anti-phosphorylated ERK1/2 (Thr202/Tyr204) antibody (Cell Signaling Technology, #9101), rabbit polyclonal anti-ERK1/2 antibody (Cell Signaling Technology ...
• Optogenetic Regulation of EphA1 RTK Activation and Signaling

  Anna I Wurz, Kevin Zheng, Robert M. Hughes, bioRxiv - Synthetic Biology 2024

  Quote: ... total ERK using p44/42 MAPK (ERK1/2) rabbit Ig (Cell Signaling Technologies). Blots were washed with TBST 3x for 5 min and incubated in corresponding secondary antibody for 1 hour room temperature ...
• RhoA activation promotes glucose uptake to elevate proliferation in MAPK inhibitor resistant melanoma cells

  Vasanth Siruvallur Murali, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Thr18/Ser19 Phospho-Myosin Light Chain 2 1:1000(Cell Signaling Technology, 3674), GLUT1 1:1000 (Cell Signaling Technology,12939S) ...
• ACE1 knockout in neurons selectively dysregulates the hippocampal renin angiotensin system and causes vascular loss

  Sohee Jeon, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-p-p44/42 MAPK (p-Erk1/2) (#CS9101, Cell Signaling Technology), rabbit anti-p44/42 (Erk1/2 ...