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5951 - 6000 of 10000+ citations for 7 Methyl 1 5 dioxo 1 2 3 5 tetrahydro indolizine 6 carbonitrile since 2019

• NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma

  Eslam Katab, et al., bioRxiv - Cancer Biology 2023

  Quote: ... HA (1:1,000, rabbit, Cell Signaling Technology #3724), IkBa (1:1,000 ...
• ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion

  Demis Menolfi, et al., bioRxiv - Genetics 2023

  Quote: ... KAP1 (1:1000, TIF1β, C42G12 Cell Signaling, #4124), pCHK1 Ser245 (1:1000 ...
• ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion

  Demis Menolfi, et al., bioRxiv - Genetics 2023

  Quote: ... pCHK1 Ser245 (1:1000, 133D3 Cell Signaling, #2348), CHK1 (1:1000 ...
• Border-forming wound repair astrocytes

  Timothy M. O’Shea, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-Id3 (1:500; 9837; Cell Signaling); rabbit anti-Kcnj10 (Kir4.1 ...
• Long-read sequencing and profiling of RNA-binding proteins reveals the pathogenic mechanism of aberrant splicing of an SCN1A poison exon in epilepsy

  Hannah C Happ, et al., bioRxiv - Genetics 2023

  Quote: ... Beta-actin (1:1000, Cell Signaling Technologies #3700S) was also used as additional sample loading control ...
• ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease

  Tomoki Yanagi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-ACC (1:1,000, #3676, Cell Signaling Technology), anti-phospho-ACC (pSer79 ...
• ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease

  Tomoki Yanagi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-ULK1 (1:1,000, #8054, Cell Signaling Technology), anti-phospho-ULK1 (pSer555 ...
• An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes

  Simone Caielli, et al., bioRxiv - Immunology 2023

  Quote: ... anti-cleaved (mature) Caspase 1 (Cell Signaling #4199S), anti-AIM2 (Cell Signaling #12948S) ...
• Aberrant activation of the innate immune sensor PKR by self dsRNA is prevented by direct interaction with ADAR1

  Ketty Sinigaglia, et al., bioRxiv - Immunology 2023

  Quote: ... p-eIF2α (Ser51) 1:1,000 (Cell Signaling, #3398), eIF2α 1:1,000 (Cell signaling ...
• ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease

  Tomoki Yanagi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-Raptor (1:1000, #2280, Cell Signaling Technology), anti-phospho-Raptor (Ser792 ...
• Tissue-specific vulnerability to apoptosis in Machado-Joseph disease

  Ana F. Ferreira, et al., bioRxiv - Neuroscience 2023

  Quote: ... mouse anti-p53 (1:1000; #2524, Cell Signaling), mouse anti-GAPDH (1:10000 ...
• SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndrome

  Vera Stamenkovic, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-Fyn (1:1000, Cell Signaling, 4023), rabbit anti-alpha FMR1 (c-terminal ...
• FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1

  Suna Jung, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-MBNL2 (Cell signaling technology, 93182, 1:1000), anti-PTBP1 (Cell signaling technology ...
• Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

  Anastasia Knyazeva, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-ATG7 (1:1000, #8558, Cell Signaling Technology), anti-ATG16L1 (1:1000 ...
• Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

  Anastasia Knyazeva, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-ATG16L1 (1:1000, #8089, Cell Signaling Technology), anti-FIP200 (1:1000 ...
• Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

  Anastasia Knyazeva, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-LC3B (1:1000, #2775, Cell Signaling Technology), anti-ATG7 (1:1000 ...
• Aberrant activation of the innate immune sensor PKR by self dsRNA is prevented by direct interaction with ADAR1

  Ketty Sinigaglia, et al., bioRxiv - Immunology 2023

  Quote: ... Rig-I 1:500 (Cell Signaling, [D14G6] #3743), Mda5 1:1000 (Cell Signaling [D74E4],#5321) ...
• Aberrant activation of the innate immune sensor PKR by self dsRNA is prevented by direct interaction with ADAR1

  Ketty Sinigaglia, et al., bioRxiv - Immunology 2023

  Quote: ... HA tag Rabbit 1:1000 (Cell signaling #3724), HA tag mouse 1:2000 (antibodies.com #A85278 ...
• DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity

  Coral K. Wille, et al., bioRxiv - Genetics 2023

  Quote: ... and α-TUBULIN (1:3000; Cell Signaling, 3873). Immunoblot images were captured with ECL on an ImageQuant LAS 4000 or with LI-COR Odyssey ...
• DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity

  Coral K. Wille, et al., bioRxiv - Genetics 2023

  Quote: ... total Histone H3 (1:3000; Cell Signaling, 3638S) and α-TUBULIN (1:3000 ...
• Proximity Analysis of Native Proteomes Reveals Interactomes Predictive of Phenotypic Modifiers of Autism and Related Neurodevelopmental Conditions

  Yudong Gao, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-Shank2 (Cell signaling #12218S, 1:1000), mouse anti-Ank3 (ThermoFisher #33-8800 ...
• Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4

  Evangelia Chavdoula, et al., bioRxiv - Cancer Biology 2023

  Quote: ... H3K27me3 1:50 (Cell Signaling Technology, Cat 9733), H2AK119ub 1:100 (Cell Signaling Technology ...
• Functional Organization of Glycolytic Metabolon on Mitochondria

  Haoming Wang, et al., bioRxiv - Cell Biology 2023

  Quote: ... or rabbit anti-HK1 (Cell Signaling, 1:250), goat anti-rabbit Alexa Fluor™ 647 (1:500) ...
• Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance

  Stewart W.C. Masson, et al., bioRxiv - Systems Biology 2023

  Quote: ... PRAS40 (Cell Signaling Technologies #2691; diluted 1:1000), phosphorylated AMPK (Cell Signaling Technologies ...
• Nucleoporin93 (Nup93) Limits Yap Activity to Prevent Endothelial Cell Senescence

  Tung D. Nguyen, et al., bioRxiv - Physiology 2023

  Quote: ... anti-LaminA/C (1:1000, Cell Signaling, 4777S); anti-α/β-Tubulin (1:1000 ...
• Acetylation-dependent coupling between G6PD activity and apoptotic signaling

  Fang Wu, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-Ubiquitin (Cell Signaling Technology, #3936; 1:1000), anti-ENO1 (Abcam ...
• Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation

  Kyle Brown, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-BMI1 antibody (1:500; Cell Signaling; 6964S); and anti-H3K27me3 antibody (1:4000 ...
• NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses

  Diones Bueno, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-COXIV 1:1000 (Cell Signaling, Danvers, USA), anti-b-tubulin 3 ...
• NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses

  Diones Bueno, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-VDAC 1:1000 (Cell Signaling, Danvers, USA), anti-COXIV 1:1000 (Cell Signaling ...
• Radiopaque Implantable Biomaterials for Nerve Repair

  Kendell M Pawelec, Jeremy ML Hix, Erik M Shapiro, bioRxiv - Bioengineering 2023

  Quote: ... c-Jun (1:1000, Cell Signaling Technology, 60A8), Sox10 (1:1000 ...
• Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1

  J. Paluncic, et al., bioRxiv - Cancer Biology 2023

  Quote: ... NDRG1 (1:800; D8G9 XP, Cell Signaling Technology), and SOX10 (1:1500 ...
• Oxygen-independent, hormonal control of HIF-1α regulates the developmental and regenerative growth of cardiomyocytes

  Amarylis C.B.A. Wanschel, et al., bioRxiv - Developmental Biology 2023

  Quote: ... Thr172-phospho-AMPKα (1:2000; 2535S, Cell signaling), Total OXPHOS WB Antibody Cocktail (ab110413 ...
• Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency

  Ross C. Bretherton, et al., bioRxiv - Cell Biology 2023

  Quote: ... total p38 MAPK (Cell Signaling 9212, 1:1000), and GAPDH (Fitzgerald 10R-2932 ...
• Combined KRAS^G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS^G12C-driven cancers by addressing intrinsic and acquired resistance

  Venu Thatikonda, et al., bioRxiv - Cancer Biology 2023

  Quote: ... pERK Thr202/Tyr204 (Cell Signaling #4376; 1:500), ERK (Cell Signaling #9102 ...
• Combined KRAS^G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS^G12C-driven cancers by addressing intrinsic and acquired resistance

  Venu Thatikonda, et al., bioRxiv - Cancer Biology 2023

  Quote: ... cleaved PARP (Asp214) (Cell Signaling #9541; 1:1000), Cyclin D1 (Biosite #ARB-Q4OL25-0,5 ...
• Elevated plasma and urinary erythritol is a biomarker of excess simple carbohydrate intake in mice

  Semira R. Ortiz, Martha S. Field, bioRxiv - Biochemistry 2022

  Quote: ... and alpha-tubulin (1:1,000, Cell Signaling Technology). Secondary anti-rabbit antibody (1:100,000 ...
• Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

  Joseph H. Garcia, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-GAPDH (Cell Signaling #5174, 1:50000) overnight at 4°C ...
• Structural basis for BIRC6 to balance apoptosis and autophagy

  Shuo-Shuo Liu, et al., bioRxiv - Cell Biology 2022

  Quote: ... Caspase-9 (1:1000, Cell Signaling Technology, #9508), Cleaved Caspase-3 (1:1000 ...
• The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions

  Zheng Fan, et al., bioRxiv - Cell Biology 2022

  Quote: ... and ERG antibody (#97249, Cell Signaling, 1:200) diluted in blocking buffer with 0.1% Triton X-100.
• Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis

  Victor M. Bii, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-AKT (1:1000, Cell Signaling, #9272), mouse anti-P-MAPK (1:2000 ...
• Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis

  Victor M. Bii, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-IKKβ (1:1000, Cell Signaling, #8943), rabbit anti-p-YAP (1:500 ...
• Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis

  Victor M. Bii, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-YAP (1:500, Cell Signaling, #4912), rabbit anti-LATS1/2 (1:1000 ...
• YAP-dependent autophagy is controlled by AMPK, SIRT1 and flow intensity in kidney epithelial cells

  Aurore Claude-Taupin, et al., bioRxiv - Cell Biology 2023

  Quote: ... Phospho-YAP_S61 (Cell Signaling Technology, #75784, 1:1000), TAZ (Sigma ...
• YAP-dependent autophagy is controlled by AMPK, SIRT1 and flow intensity in kidney epithelial cells

  Aurore Claude-Taupin, et al., bioRxiv - Cell Biology 2023

  Quote: ... Phospho-YAP_S127 (Cell Signaling Technology, #13008, 1:1000), Phospho-YAP_S61 (Cell Signaling Technology ...
• YAP-dependent autophagy is controlled by AMPK, SIRT1 and flow intensity in kidney epithelial cells

  Aurore Claude-Taupin, et al., bioRxiv - Cell Biology 2023

  Quote: ... Phospho-LATS1_T1079 (Cell Signaling Technology, #8654, 1:1000), H3K9ac (Sigma ...
• YAP-dependent autophagy is controlled by AMPK, SIRT1 and flow intensity in kidney epithelial cells

  Aurore Claude-Taupin, et al., bioRxiv - Cell Biology 2023

  Quote: ... Phospho-TAZ_S89 (Cell Signaling Technology, #59971, 1:1000), LATS1 (Cell Signaling Technology ...
• Cell migration CRISPRi screens in human neutrophils reveal regulators of context-dependent migration and differentiation state

  Nathan M. Belliveau, et al., bioRxiv - Cell Biology 2022

  Quote: ... p-Ser2448 mTOR (1:1000; Cell Signaling, #5536), Alexa Fluor 790 to GAPDH (1:1000 ...
• Peripheral extracellular vesicle-derived miR-150-3p exacerbates acute kidney injury following acute pancreatitis by promoting ferroptosis through FTH1 signaling

  Ji-tao Cui, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-GPX4 (1:1,000, C29H4, Cell Signaling Technology), anti-Cox-2 (1:1,000 ...
• Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis

  Chang-Soo Seong, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and rabbit anti-LKB1 (1:1000, Cell Signaling) in TBS-T (0.1% Tween 20 ...
• Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination

  Yi-Chang Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-Akt (1:1000; Cat# 9272, Cell Signaling), respectively ...