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5901 - 5950 of 10000+ citations for 7 Methyl 1 5 dioxo 1 2 3 5 tetrahydro indolizine 6 carbonitrile since 2019

• Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

  Stefan Harjes, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-HA (#3724S, 1:2500, Cell Signaling), and rabbit anti-Cas9 (#ab189380 ...
• Insulin-mediated endothelin signaling is antiviral during West Nile virus infection

  Chasity E. Trammell, et al., bioRxiv - Microbiology 2023

  Quote: ... anti-Akt (pan) (1:2,000) (Cell Signaling 4691), or anti-actin (1:10,000 ...
• PD1 is transcriptionally regulated by LEF1 in mature T cells

  Pin Zhao, Lanming Sun, Cong Zhao, Samiullah Malik, bioRxiv - Immunology 2023

  Quote: ... LEF1 (Dilution of 1:5000, C12A5, Cell Signaling); β-actin (Dilution of 1:2000 ...
• Oropouche virus glycoprotein topology and cellular requirements for virus assembly

  Natalia S. Barbosa, et al., bioRxiv - Microbiology 2022

  Quote: ... anti-HA (Cell Signaling Technology C29F4, 1:20,000), anti-actin (Sigma A3853 ...
• RHINO restricts MMEJ activity to mitosis

  Alessandra Brambati, et al., bioRxiv - Molecular Biology 2023

  Quote: ... HUS1 (D4J9H, Cell Signaling Technology; 1: 1000 dilution), Polθ (gift from Repare therapeutics ...
• Repurposing of the antibiotic nitroxoline for the treatment of mpox

  Denisa Bojkova, et al., bioRxiv - Microbiology 2022

  Quote: ... phospho-AKT S473 (Cell Signaling, #4060, 1:1000), c-Raf (Cell Signaling ...
• Repurposing of the antibiotic nitroxoline for the treatment of mpox

  Denisa Bojkova, et al., bioRxiv - Microbiology 2022

  Quote: ... phospho-AKT T308 (Cell Signaling, #2965, 1:1000), phospho-AKT S473 (Cell Signaling ...
• Early mitochondrial dysfunction proceeds neuroinflammation, synaptic alteration, and autophagy impairment in hippocampus of App knock-in Alzheimer mouse models

  Luana Naia, et al., bioRxiv - Neuroscience 2023

  Quote: ... ULK1 (1:500) (Cell signaling, Cat. no. 8054), pSer555-ULK1 (1:500 ...
• Long-read sequencing and profiling of RNA-binding proteins reveals the pathogenic mechanism of aberrant splicing of an SCN1A poison exon in epilepsy

  Hannah C Happ, et al., bioRxiv - Genetics 2023

  Quote: ... Beta-actin (1:1000, Cell Signaling Technologies #3700S) was also used as additional sample loading control ...
• SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

  Brianna R. Daley, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-pAKT Ser473 (Cell Signaling 4060; 1:1000), anti-AKT (Cell Signaling 2920 ...
• SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis

  Patricia L. Theard, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and E-Cadherin (Cell Signaling 14472; 1:1000) primary antibodies ...
• FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1

  Suna Jung, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-MBNL1 (Cell signaling technology, 94633, 1:1,000), anti-MBNL2 (Cell signaling technology ...
• FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1

  Suna Jung, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-PTBP2 (Cell signaling technology, 59753, 1:1,000), anti-hnRNPF (Novusbio ...
• FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1

  Suna Jung, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-PTBP1 (Cell signaling technology, 57246, 1:1,000), anti-PTBP2 (Cell signaling technology ...
• ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion

  Demis Menolfi, et al., bioRxiv - Genetics 2023

  Quote: ... pCHK1 Ser245 (1:1000, 133D3 Cell Signaling, #2348), CHK1 (1:1000 ...
• ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion

  Demis Menolfi, et al., bioRxiv - Genetics 2023

  Quote: ... KAP1 (1:1000, TIF1β, C42G12 Cell Signaling, #4124), pCHK1 Ser245 (1:1000 ...
• Border-forming wound repair astrocytes

  Timothy M. O’Shea, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-Id3 (1:500; 9837; Cell Signaling); rabbit anti-Kcnj10 (Kir4.1 ...
• Aberrant activation of the innate immune sensor PKR by self dsRNA is prevented by direct interaction with ADAR1

  Ketty Sinigaglia, et al., bioRxiv - Immunology 2023

  Quote: ... p-eIF2α (Ser51) 1:1,000 (Cell Signaling, #3398), eIF2α 1:1,000 (Cell signaling ...
• The G protein-coupled receptor TBXA2R activates ERMs to promote motility, invasion, and metastasis of triple-negative breast cancer cells

  Kévin Leguay, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-Radixin (1:1000, Cell Signaling #2636), rabbit anti-Moesin (1:1000 ...
• The mitochondrial Ca²⁺ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation

  Emily Fernández García, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-MCU (D2z3B) (1:5,000, Cell signaling, 14997s), anti-Pyruvate Dehydrogenase E1-alpha subunit (1:5,000 ...
• NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma

  Eslam Katab, et al., bioRxiv - Cancer Biology 2023

  Quote: ... IkBa (1:1,000, mouse, Cell Signaling Technology #4814), Lamin B2 (1:1,000 ...
• NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma

  Eslam Katab, et al., bioRxiv - Cancer Biology 2023

  Quote: ... MyD88 (1:1,000, mouse, Cell Signaling Technology #50010), OTUD4 (1:1,000 ...
• NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma

  Eslam Katab, et al., bioRxiv - Cancer Biology 2023

  Quote: ... HA (1:1,000, rabbit, Cell Signaling Technology #3724), IkBa (1:1,000 ...
• ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease

  Tomoki Yanagi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-ACC (1:1,000, #3676, Cell Signaling Technology), anti-phospho-ACC (pSer79 ...
• ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease

  Tomoki Yanagi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-ULK1 (1:1,000, #8054, Cell Signaling Technology), anti-phospho-ULK1 (pSer555 ...
• Tissue-specific vulnerability to apoptosis in Machado-Joseph disease

  Ana F. Ferreira, et al., bioRxiv - Neuroscience 2023

  Quote: ... mouse anti-p53 (1:1000; #2524, Cell Signaling), mouse anti-GAPDH (1:10000 ...
• SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndrome

  Vera Stamenkovic, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-Fyn (1:1000, Cell Signaling, 4023), rabbit anti-alpha FMR1 (c-terminal ...
• FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1

  Suna Jung, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-MBNL2 (Cell signaling technology, 93182, 1:1000), anti-PTBP1 (Cell signaling technology ...
• Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

  Anastasia Knyazeva, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-ATG7 (1:1000, #8558, Cell Signaling Technology), anti-ATG16L1 (1:1000 ...
• Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

  Anastasia Knyazeva, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-ATG16L1 (1:1000, #8089, Cell Signaling Technology), anti-FIP200 (1:1000 ...
• Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

  Anastasia Knyazeva, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-LC3B (1:1000, #2775, Cell Signaling Technology), anti-ATG7 (1:1000 ...
• Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

  Anastasia Knyazeva, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-vimentin (1:1000, #5741, Cell Signaling Technology), anti-β-tubulin (1:1000 ...
• Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma

  Priyanka Gupta, et al., bioRxiv - Cancer Biology 2023

  Quote: ... GFP (Cell Signaling Technology 2956; RRID:AB_1196615; 1:2000), P-T202 LARP6 (Bibb Lab ...
• BMP7 promotes cardiomyocyte regeneration

  Chiara Bongiovanni, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti- phospho-AKT (1:1000, 9271, Cell Signaling), anti-GAPDH (1:1000 ...
• NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression

  Ken Takashima, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-Geminin (#52508, Cell Signaling Technology, 1:1000), anti-Thymidine Kinase 1(TK1 ...
• Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

  Jinhai Deng, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and Lamin A (1:1000, Cell Signaling Technology) were used for incubation overnight at 4 °C.
• NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression

  Ken Takashima, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-HSP90 (#4874, Cell Signaling Technology, 1:1000), anti-Geminin (#52508 ...
• Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4

  Evangelia Chavdoula, et al., bioRxiv - Cancer Biology 2023

  Quote: ... ATF4 1:100 (Cell Signaling Technology, Cat 11815), c-MYC 1:100 (Cell Signaling Technology ...
• Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4

  Evangelia Chavdoula, et al., bioRxiv - Cancer Biology 2023

  Quote: ... H2AK119ub 1:100 (Cell Signaling Technology, Cat 8240), H3K27ac (Cell Signaling Technology ...
• Late-life Rapamycin Treatment Enhances Cardiomyocyte Relaxation Kinetics and Reduces Myocardial Stiffness

  Akash D. Chakraborty, et al., bioRxiv - Physiology 2023

  Quote: ... TnI-pS23/24 (1:1000, Cell signaling technology), Total TnI (1:1000 ...
• Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors

  Lampros Mavrommatis, et al., bioRxiv - Bioengineering 2023

  Quote: ... anti-M-Cadherin (Cell Signaling Technology, 1:200) anti-SOX2 (ThermoFisher Scientific ...
• Lineage-specific intolerance to oncogenic drivers restricts histological transformation

  Eric E. Gardner, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti- EGFRL858R-PE (Cell Signaling #64716; 1:500), anti-EpCam-A488 (Abcam # ab237384 ...
• Immortalization and transformation of primary cells mediated by engineered ecDNAs

  Davide Pradella, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-c-MYC (1:1,000; Cell SIgnaling, #D84C12), anti-MDM2 (1:1000 ...
• Immortalization and transformation of primary cells mediated by engineered ecDNAs

  Davide Pradella, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-alpha-tubulin (1:5000, Cell Signaling, #3873), anti-p53 (1:1000 ...
• Weak neuronal glycolysis sustains cognition and organismal fitness

  Daniel Jimenez-Blasco, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-acetylated Lysine (1/1,000) (#9441; Cell Signaling), anti-Beclin (1/1,000 ...
• Regulation of Oocyte Meiotic Maturation: Unraveling the Interplay between PKA Inhibition and Cdk1 Activation

  Martina Santoni, et al., bioRxiv - Cell Biology 2023

  Quote: ... pY15-Cdk1 (1:1000, rabbit, Cell Signaling 9111), Cdk1 (1:5000 ...
• Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

  Anastasia Knyazeva, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-FIP200 (1:1000, #12436, Cell Signaling Technology), anti-ATG9A (1:1000 ...
• Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

  Anastasia Knyazeva, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-EGFR (1:100, #4267, Cell Signaling Technology), anti-GFP (1:500 ...
• GTPase activating protein DLC1 spatio-temporally regulates Rho signaling

  Max Heydasch, et al., bioRxiv - Cell Biology 2023

  Quote: ... 1:50 for pMLC (Cell Signaling Antibody #3671). Secondary antibody incubation (1:1000 ...
• An uncanonical CDK6 activity inhibits cilia function by suppressing axoneme polyglutamylation

  Kai He, et al., bioRxiv - Cell Biology 2023

  Quote: ... Flag (8146, Cell Signaling Technology, dilution 1:2000), RAB11A (71-5300 ...