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401 - 450 of 989 citations for 1 Benzyl 4 5 benzyloxy 6 methoxy 1 indanone 2 ylidenyl methylpiperidine since 2020

• Cholesterol accumulation-induced impairment of AKT signaling in LPS-stimulated macrophages play a dispensable role in suppressing HIF-1α-dependent glycolysis

  Kenneth K.Y. Ting, Myron I. Cybulsky, bioRxiv - Immunology 2024

  Quote: ... 2-NBDG (Cayman Chemicals #11046) (100 μg/mL ...
• Gz Enhanced Signal Transduction assaY (G_ZESTY) for GPCR deorphanization

  Luca Franchini, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... 2-arachidonoyl glycerol (Cayman Chemicals), N-Formyl-Met-Leu-Phe (R&D systems) ...
• Glucagon-like peptide-1 receptor differentially controls mossy cell activity across the dentate gyrus longitudinal axis

  Alex Steiner, et al., bioRxiv - Neuroscience 2022

  Quote: Exendin-4 acetate was purchased from Cayman Chemical Company (Ann Arbor ...
• Effects of repeated developmental GLP-1R agonist exposure on adult behavior and hippocampal structure in mice

  Catherine Cerroni, et al., bioRxiv - Neuroscience 2023

  Quote: Exendin-4 acetate was purchased from Cayman Chemical Company (catalogue no ...
• NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

  Fakhar H. Waqas, et al., bioRxiv - Microbiology 2023

  Quote: ... 4-octyl itaconate (4OI) from (Biomol (Cayman chemical) Hamburg ...
• Theft of Host Transferrin Receptor-1 by Toxoplasma gondii is required for infection

  Stephen L. Denton, et al., bioRxiv - Microbiology 2023

  Quote: ... (Z)-4-hydroxy Tamoxifen (Cayman Chemical Company #14854) was dissolved in DMSO at 2.5mM and added to cultures to a final concentration of 2.5µM at the indicated timepoints ...
• APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size

  Ian A. Windham, et al., bioRxiv - Cell Biology 2023

  Quote: ... 4 µg/mL hydrocortisone (Cayman Chemical Cat# 20739), 5 µg/mL bovine insulin (Sigma-Aldrich Cat# I6634) ...
• The mitochondrial unfolded protein response promotes senescence in human microglia by increasing S-adenosylmethionine availability for polyamine synthesis

  Maria Jose Perez J., et al., bioRxiv - Neuroscience 2024

  Quote: ... MitoQ (CAS number 845959-50-4; Cayman Chemical), and etoposide (CAS number 33419-42-0 ...
• PRMT5-mediated histone methylation regulates alternative splicing via MECP2-PTBP1 to promote EMT in breast cancer hypoxia

  Srinivas Abhishek Mutnuru, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 100 [M 4SU (4-thiouridine, Cayman Chemical, T4509) was added in the culture medium 14 hrs prior to crosslinking ...
• Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity

  U. Rand, et al., bioRxiv - Microbiology 2021

  Quote: ... we additionally added 0.8 μM ruxolitinib (Cayman Chemical, Cat. #Cay11609-1) to these wells ...
• Dynamics of replication origin over-activation

  Haiqing Fu, et al., bioRxiv - Genomics 2020

  Quote: ... MLN4924 and SKP2 inhibitors were purchased from Cayman Chemicals (15217-1) and Millipore (506305) ...
• Apolipoprotein E isoform-specific phase transitions in the retinal pigment epithelium drive disease phenotypes in age-related macular degeneration

  Nilsa La Cunza, et al., bioRxiv - Neuroscience 2020

  Quote: ... the LXRα agonist T0901317 (1 µM for 16 h, Cayman Chemicals) and the lipophilic statin Simvastatin (5 µM for 16 h ...
• α-Synuclein aggregation intermediates form fibril polymorphs with distinct prion-like properties

  Surabhi Mehra, et al., bioRxiv - Neuroscience 2020

  Quote: ... cells were incubated with 1 μM FlAsH dye (Cayman Chemicals, USA) and 10 mM EDT prepared in Opti-MEM (Invitrogen ...
• Macrophage-produced peroxynitrite induces antibiotic tolerance and supersedes intrinsic mechanisms of persister formation

  Jenna E. Beam, et al., bioRxiv - Microbiology 2021

  Quote: ... with goat anti-mouse IgG-HRP secondary (1:10000; Cayman Chemical). Western blot was analyzed and quantified by densitometry using FIJI.
• Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

  Andrew M. Tidball, et al., bioRxiv - Neuroscience 2022

  Quote: ... Daily 75% media changes with 1 µM cyclopamine (Cayman Chemical, 11321) added began on day 1 ...
• Baculovirus bv/odv-e26 is required for host behavioral manipulation by optimizing viral virulence to lepidopteran hosts

  Hiroyuki Hikida, Susumu Katsuma, bioRxiv - Microbiology 2022

  Quote: ... and 1% sodium deoxycholate] with 30 μg/ml E64 (Cayman Chemical), a cysteine protease inhibitor ...
• DNA methylation in the upstream CpG island of the GPER locus and its relationship with GPER expression in colon cancer cell lines

  Uttariya Pal, Sujasha Ghosh, Anil Mukund Limaye, bioRxiv - Cancer Biology 2020

  Quote: ... was purchased from Cayman Chemical (Cat. No. CAS 881639-98-1) (MI ...
• DNA damage response signaling to mitochondria drives senescence

  Shota Yamauchi, et al., bioRxiv - Cell Biology 2022

  Quote: ... and incubated with 1 μM BODIPY 493/503 (Cayman Chemical, 25892) and DAPI (1:2000 ...
• A microbiota-derived metabolite instructs peripheral efferocytosis

  Pedro H. V. Saavedra, et al., bioRxiv - Immunology 2022

  Quote: ... Antibiotic cocktail consisted of 1 g/L ampicillin (Cayman Chemical, 14417); 1 g/L kanamycin (K4000) ...
• Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed myelinating oligodendrocytes in PLP1 mutant mice

  Tassnim Abdelwahab, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-citrullinated MBP (1:300, catalog no. 26742; Cayman Chemical); For indirect detection ...
• Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

  Dong Liu, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-OPTN C-terminus 1:1000 (Cayman Chemical, No. 100000), rabbit anti-OPTN polyclonal 1:1000 (Cayman Chemical ...
• Chronically low NMNAT2 expression causes sub-lethal SARM1 activation and altered response to nicotinamide riboside in axons

  Christina Antoniou, et al., bioRxiv - Neuroscience 2024

  Quote: ... mouse anti-NAMPT monoclonal antibody (1 in 2000, Cayman Chemical 10813), mouse anti-NMNAT2 monoclonal antibody (1 in 250 ...
• Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature

  Kalev Freeman, et al., bioRxiv - Neuroscience 2023

  Quote: Endothelial viability was tested using 1 µM NS309 (Cayman Chemical, USA) and a dilatory response > 85 % was considered “intact.” Experimental interventions were then carried out using T-peptide (20 minutes ...
• Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells

  Yijun Yang, et al., bioRxiv - Cancer Biology 2024

  Quote: T3 (#16028) or 1-850 (#17248) was purchased from Cayman Chemical Company ...
• Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

  Alexandria P Eiken, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and JQ-1 were purchased from Cayman Chemical (Ann Arbor, MI). TPCA-1 was purchased from Sigma-Aldrich (Saint Louis ...
• Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

  Caterina Ivaldo, et al., bioRxiv - Cell Biology 2022

  Quote: ... A431 cells were exposed to 1 μM staurosporine (Cayman chemical, USA) or 5 μM ionomycin (Cayman chemical) ...
• Phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid-liquid phase separation at double-strand breaks

  Qilin Long, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 100μM 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) (Cayman Chemical, 10010302) for 2h ...
• The cGAS-STING pathway regulates microglial chemotaxis in genome instability

  Emily J. Talbot, et al., bioRxiv - Cell Biology 2023

  Quote: ... cells were treated with 1 µM camptothecin (CPT; Cayman Chemical Company) for 1 h ...
• SCF^{cyclin F} - EXO1 axis controls cell cycle dependent execution of double strand break repair

  Hongbin Yang, et al., bioRxiv - Cell Biology 2023

  Quote: ... and 1 µM okadaic acid (Cayman Chemical, 10011490-50 ug-CAY). After lysing on ice for 10 minutes ...
• Multi-spectral Fluorescent Reporter Influenza A Viruses Allow for in vivo Studies of Innate Immune Function in Zebrafish

  Brandy-Lee Soos, et al., bioRxiv - Immunology 2023

  Quote: ... or DMSO-solubilized MDIVI-1 (Cayman Chemical Company, Ann Arbor, MI) by adding these solutions into the embryo water at 24 hpi ...
• MicroRNA-27a-5p downregulates the expression of proinflammatory cytokines in lipopolysaccharide-stimulated human dental pulp cells via NF-κB signaling pathway

  Shihan Wang, et al., bioRxiv - Pathology 2024

  Quote: ... 1 µM BAY 11-7085 (Cayman Chemical, Ann Arbor, MI, USA) was employed.
• Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

  Bryan J. Song, et al., bioRxiv - Neuroscience 2024

  Quote: ... D2R antagonist (eticlopride hydrochloride, Cayman Chemical #29112; 0.5 mg kg−1). Drugs were dissolved in sterile saline at appropriate concentrations and were injected at 0.1 ml solution per 10 g of mouse ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-vaccenic acid (cis-11-C18:1, Cayman Chemical, Cat# 20023), trans-petroselinic acid (trans-6-C18:1 ...
• Structure and Mechanism of Hedgehog Acyl Transferase

  Claire E. Coupland, et al., bioRxiv - Biophysics 2021

  Quote: ... and 5 mM valproic acid (Cayman Chemical). For biotinylated proteins ...
• Droplet array-based platform for parallel optical analysis of dynamic extracellular vesicle secretion from single cells

  Kazuki Hattori, et al., bioRxiv - Bioengineering 2022

  Quote: 5 μM manumycin A (#10010497, Cayman Chemical) was used as a pretreatment for 1 hour (37 °C in culture medium) ...
• On the Origin of Ultraslow Spontaneous Na⁺ Fluctuations in Neurons of the Neonatal Forebrain

  Carlos Perez, et al., bioRxiv - Neuroscience 2020

  Quote: ... (2R)-amino-5-phosphonopentanoate) from Cayman Chemical
• Characterising replisome disassembly in human cells

  Rebecca M. Jones, et al., bioRxiv - Cell Biology 2022

  Quote: ... 5 µM Wee1i (MK-1775, Cayman Chemicals, 21266 ...
• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  Yueyang Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... 10 μM BMS-5 (Cayman Chemical, #21072) or 2 μM ML-7 (Cayman Chemical ...
• Ca²⁺-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress

  Wei Chen, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 μM Ionomycin (No. 10004974, Cayman Chemical); 250 μM CPZ (No ...
• The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1α-dependent recruitment and differentiation of pro-tumor ICOS^hiGITR^hi Blimp-1⁺ effector regulatory T cells in breast tumors

  Marie Boutet, et al., bioRxiv - Immunology 2024

  Quote: ... 5 μM Y-27632 (Cayman Chemical, #10005583) and 5% Matrigel (Corning ...
• Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

  Katjana Schwab, et al., bioRxiv - Genomics 2022

  Quote: ... 5-FU (25 μg/ml, Cayman Chemicals), or Doxorubicin (0.2 µg/ml ...
• Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids

  Jinlun Bai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 5 µM SU5402 (Cayman Chemical, #13182). Starting at d28 ...
• Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects

  Margaret S. Collins, et al., bioRxiv - Cell Biology 2023

  Quote: ... NEI (CAS#1448314-31-5, Cayman Chemical), SIV (CAS# 201677-61-4 ...
• Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

  Elliot Ensink, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 μM CB-839 (22038, Cayman Chemical), 300 μM BSO (14484 ...
• PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

  David J. Sherman, et al., bioRxiv - Cell Biology 2024

  Quote: ... 5 µM Triacsin C (Cayman Chemical, #10007448) dissolved in dimethyl sulfoxide (DMSO ...
• Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

  Deborah Y. Moss, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Metformin (Cayman Chemicals, #13118, 3-5 mM), IACS-10759 (Selleckchem ...
• Sex-specific differences in rotarod performance and type 1 cannabinoid receptor levels in a rat model of traumatic brain injury treated with Δ⁹-tetrahydrocannabinol

  Tallan Black, et al., bioRxiv - Neuroscience 2022

  Quote: ... for 1 h before being incubated overnight at 4°C with primary antibodies directed against the N-terminal extracellular region of the CB1R (1:500, rabbit polyclonal antibody, Cayman Chemical Company, Cat# 101500, Lot# 0580081-1) and βactin (1:10,000 ...
• Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2

  Yi-Hsuan Wu, et al., bioRxiv - Microbiology 2020

  Quote: TEPP-46 (ML-265) and 2-deoxy-D-Glucose (2-DG) were ordered from Cayman Chemical. DASA-58 was purchased from SelleckChem ...
• LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation

  Ahmed M. Fahmy, et al., bioRxiv - Immunology 2023

  Quote: ... 2’’3’’-cGAMP ELISA was done using the 2’’3’’-cGAMP ELISA Kit (Cayman Chemical Co.) according to the manufacturer’s instructions.
• Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

  Andrew M. Tidball, et al., bioRxiv - Neuroscience 2022

  Quote: ... 2 µM XAV939 (Cayman Chemical, 13596), and 10 µM SB431542 (Cayman Chemical ...