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451 - 500 of 989 citations for 1 Benzyl 4 5 benzyloxy 6 methoxy 1 indanone 2 ylidenyl methylpiperidine since 2020

• Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

  Kota Nagasaka, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 mM Trolox (Cayman Chemical; 10011659)) and 5 mM ATP (Jena Biosciences ...
• Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

  Rosana-Bristena Ionescu, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM, Cayman Chemicals) and hLIF (10 ng/ml ...
• Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

  Rosana-Bristena Ionescu, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM, Cayman Chemicals) and hLIF (10 ng/ml ...
• Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

  Rosana-Bristena Ionescu, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM, Cayman Chemicals) and hLIF (10 ng/ml ...
• Integrative single-cell analysis of neural stem/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis

  Bongsoo Park, et al., bioRxiv - Neuroscience 2024

  Quote: ... SB-431542 (2 µM) (Cayman Chemical), and hLIF (10 ng/ml ...
• A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects

  Taylor N. Takla, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2 µM XAV939 (Cayman Chemical, 13596), and 10 µM SB431542 (Cayman Chemical ...
• Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

  Dasmanthie De Silva, et al., bioRxiv - Molecular Biology 2021

  Quote: ... cells were incubated with AKT inhibitor AZD5363 at 1 μM (Cayman Chemical), mTOR inhibitor Torin1 250 nM (Cayman Chemical ...
• Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle

  Yao-Chang Tsan, et al., bioRxiv - Cell Biology 2021

  Quote: ... and we additionally included retinol inhibitor (BMS 453, Cayman Chemical, 1 µM) for days 3-6 to minimize atrial lineage differentiation.35 hPSC-CMs were maintained in CDM3 until purification by metabolic selection in CDM3-lactate using glucose-deprived ...
• 2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice

  Amanda Morgan, et al., bioRxiv - Neuroscience 2022

  Quote: The MAGL inhibitor JZL184 (10 mg/kg-1, Cayman Chemical, MI, USA), CB1R inverse agonist Rimonabant (3 mg kg-1 APIChem ...
• Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

  Amanda R. Dicks, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 1 µM ML329 (cat. num. 22481; Cayman Chemical, Ann Arbor, MI) at 5 x 105 cells/mL ...
• Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters

  Lucas J. D’Souza, et al., bioRxiv - Immunology 2021

  Quote: ... 1×106 5TGM1 cells were cultured with 20μg/mL 2NBDG (Cayman Chemical) in complete media for 1 hour at 37°C followed by antibody staining ...
• AURKB/Ipl1 restarts replication forks to recover from replication stress

  Erin Moran, et al., bioRxiv - Cell Biology 2021

  Quote: ... The ATP analogue 1-naphthyl-pyrazolo[3,4-d]pyrimidine (NAPP, Cayman Chemicals) was added to YPD at 75 μM ...
• LRH-1/NR5A2 Activation Rewires Immunometabolism Blunting Inflammatory Immune Cell Progression in Individuals with Type 1 Diabetes and Enhances Human Islet Function in Mice

  N Cobo-Vuilleumier, et al., bioRxiv - Cell Biology 2024

  Quote: ... and Prostaglandin E2 (PGE2, 1 μM, Cayman Chemical, Ann Arbor, MI, USA) to obtain mature DCs (mDCs) ...
• RudLOV—a new optically synchronized cargo transport method reveals unexpected effect of dynasore

  Tatsuya Tago, et al., bioRxiv - Cell Biology 2023

  Quote: ... After 1 h of incubation with 100 μM of dynasore (Cayman Chemical), the cells were fixed in 0.1 M cacodylate buffer (pH 7.4 ...
• Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons

  Breanna Q. Shen, et al., bioRxiv - Neuroscience 2022

  Quote: ... The DP1 antibody (101640, dilution 1:200) was obtained from Cayman Chemicals and the SOX10 antibody (ab216020 ...
• Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma

  Nicole M. Marsh, et al., bioRxiv - Cell Biology 2024

  Quote: ... before and after injection of 1 μM CCCP (Cayman Chemical Company, 25458) in KCl buffer ...
• Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

  Peiyuan Chai, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 1 µL 30 mM aldehyde reactive probe (Cayman Chemicals, ARP/aminooxy biotin) is added first ...
• Nascent transcript O-MAP reveals the molecular architecture of a single-locus subnuclear compartment built by RBM20 and the TTN RNA

  Evan E. Kania, et al., bioRxiv - Genomics 2024

  Quote: ... Cells were then treated with 1 μM CHIR-99021 (Cayman Chemical; 13122). On day 0 ...
• Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics

  Yun Qiu, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and STY-BODIPY were from Cayman Chemical Company (Ann Arbour ...
• Transient proliferation by reversible YAP and mitogen-control of the cyclin D1/p27 ratio

  Katherine R. Ferrick, et al., bioRxiv - Cell Biology 2024

  Quote: ... 100 nM Torin2 (Cayman Chemical Cat#14185, CAS#1223001-51-1, mTORi), 100 nM PD0325901 (Selleck Chemicals Cat#S1036 ...
• CD300e as a Driver of Immunosuppressive Tumor Microenvironment in Colorectal Cancer

  Annica Barizza, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 1 mM N-acetyl-L-cysteine (Cayman Chemical, Ann Arbor, Michigan, USA), 50 ng/mL EGF (Corning) ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-7-hexadecenoic acid (cis-7-C16:1, Cayman Chemical, Cat# 10007290), cis-8-octadecenoic acid (cis-8-C18:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 14(Z)-eicosenoic acid (cis-14-C20:1, Cayman Chemical, Cat# 10009375), cis-vaccenic acid (cis-11-C18:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 10(Z)-pentadecenoic acid (cis-10-C15:1, Cayman Chemical, Cat# 22362), 10(E)-pentadecenoic acid (trans-10-C15:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and trans-vaccenic acid (trans-11-C18:1, Cayman Chemical, Cat# 15301).
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 10(E)-pentadecenoic acid (trans-10-C15:1, Cayman Chemical, Cat# 22467), cis-11-eicosenoic acid/11(Z ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-10-heptadecenoic acid (cis-10-C17:1, Cayman Chemical, Cat# 19748), trans-10-heptadecenoic acid (trans-10-C17:1 ...
• Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems

  Vivian S. Park, et al., bioRxiv - Cancer Biology 2024

  Quote: ... cis-8-octadecenoic acid (cis-8-C18:1, Cayman Chemical, Cat# 27447), cis-10-heptadecenoic acid (cis-10-C17:1 ...
• ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury

  Aaron I. Weiner, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 0.025mg/g (E/Z)-4-hydroxytamoxifen (17308, Cayman Chemical) of a 100mg/mL stock in DMSO was sonicated into 30uL PBS at 4°C using an S220 Focused-Ultrasonicator (Covaris ...
• Near-anoxia induces immobilisation and sustains viability of sperm in ant queens: Novel insights into mechanisms of prolonged sperm storage

  Ayako Gotoh, Mika Takeshima, Ken-ichi Mizutani, bioRxiv - Zoology 2022

  Quote: ... and carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP) (Cayman chemical) in PBS as inhibitors of the mitochondrial respiratory pathway ...
• Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

  Fangfang Song, et al., bioRxiv - Physiology 2023

  Quote: ... Metformin hydrochloride (4 mg/mL, Cayman Chemical, No. 13118) and Dox (1mg/mL ...
• Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease mice

  Jennifer M. Hafycz, et al., bioRxiv - Neuroscience 2023

  Quote: Sodium 4-phenylbutyrate (PBA) (Cayman Chemical, Ann Arbor, MI) was administered as previously described (Hafycz et al. ...
• Protective variant in PLCγ2 mitigates Alzheimer’s disease-associated pathologies via enhancing beneficial microglia functions

  Mari Takalo, et al., bioRxiv - Neuroscience 2024

  Quote: ... carbonyl cyanide-4 (trifluoromethoxy) phenylhydrazone (FCCP) (#15218, Cayman Chemical) and a mixture of rotenone (#13995 ...
• CDK-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity

  Juan A. Cantres-Velez, et al., bioRxiv - Biochemistry 2020

  Quote: ... Cells were seeded in 10 cm2 dishes and treated with 6 μM R03306 (15149, Cayman Chemicals) for 16 h ...
• Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

  Sobhika Agarwala, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Runx1+23:mCherry+ zebrafish larvae were treated with 250 and 300uM of 6-OHDA (Cayman Chemical) for 24 hours ...
• The RNA-binding protein Puf5 buffers mRNA levels against chromatin-mediated changes in nascent transcription

  David Z. Kochan, et al., bioRxiv - Molecular Biology 2020

  Quote: ... 5-FOA was bought from Cayman Chemical (17318). Ampure XP beads were from Beckman Coulter (A63881) ...
• De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

  Thomas Laval, et al., bioRxiv - Immunology 2021

  Quote: ... LTB4-d4 and 5-HETE-d8 (Cayman Chemicals), and centrifuged at 5000rpm for 15min at 4°C ...
• Structure-Functional-Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward Discovery of Biased D1 Agonists

  Haoxi Li, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... coelenterazine h (Cayman Chemicals, 5 μM final concentration), was added per well ...
• Methylation of Q105 on histone H2A is part of a dynamic regulatory mechanism integrating metabolism with ribosome biogenesis through recruitment of Nhp2

  Julia S.P. Mawer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 5-FOA was bought from Cayman Chemicals (17318). Protein-G coupled Dynabeads™ (10004D ...
• Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT

  Tomasz H. Benedyk, et al., bioRxiv - Microbiology 2022

  Quote: ... supplemented with 5 μM clickable sphingosine (Cayman Chemical) for 5 min (pulse) ...
• Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

  Alissandra L. Hillis, et al., bioRxiv - Cancer Biology 2024

  Quote: ... or 5 µg/mL GGPP (Cayman Chemicals, 63330). At the endpoint ...
• An expanded 2-pyridinecarboxaldehyde (2PCA)-based chemoproteomics toolbox for probing protease specificity

  Haley N. Bridge, Clara L. Frazier, Amy M. Weeks, bioRxiv - Biochemistry 2023

  Quote: ... Biotin azide (5) was purchased from Cayman Chemical. Azide-SS-biotin (6 ...
• Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

  Niklas J. Lang, et al., bioRxiv - Cell Biology 2023

  Quote: ... and lysophosphatidic acid (LPA) (5 µM, Cayman chemical) as described before20 ...
• SARS-CoV-2 Envelope-mediated Golgi pH dysregulation interferes with ERAAP retention in cells

  Valerie Vargas-Zapata, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 10 uM nigericin (Cayman Chemical, 11437-5). Cells co-transfected with pHluorin and viral proteins were resuspended in Na-Ringer buffer ...
• Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability

  Adam J. Sugarman, et al., bioRxiv - Cancer Biology 2023

  Quote: ... folic acid and 5-methyl-THF (Cayman Chemical).
• Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism

  Nicholas L. Arp, et al., bioRxiv - Biochemistry 2023

  Quote: ... 0.2 mM alpha-ketoisocaproate (Cayman Chemical, 21052-5), and 5 µM rotenone (VWR ...
• Reorganization of innate immune cell lipid profiles by bioinspired meroterpenoids to limit inflammation

  Lorenz Waltl, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: Human recombinant 5-LOX (Cayman Chemical, 10 U) was pretreated with vehicle (DMSO ...
• Mesoscale regulation of MTOCs by the E3 ligase TRIM37

  Zhong Y. Yeow, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and 5 μg/mL cytochalasin B (Cayman Chemical) for 1 h 15 min to depolymerize microtubule and actin networks ...
• A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis

  Genta Ishikawa, et al., bioRxiv - Cell Biology 2024

  Quote: ... and 5 μM lysophosphatidic acid (Cayman Chemical, 62215). PCLS were then treated in the absence or presence of 10 µM terazosin (U.S ...
• Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud

  Min Shi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... supplemented with 5 μM CHIR99021 (CHIR, Cayman Chemical), 50 ng ml−1 of Activin A (PeproTech) ...