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801 - 850 of 946 citations for 3 Hydrazino 5 methyl 4H 1 2 4 triazol 4 ylamine hydrochloride since 2020

• Phosphatidylinositol 3-kinase-independent synthesis of PtdIns(3,4)P₂ by a phosphotransferase

  Glenn F. W. Walpole, et al., bioRxiv - Cell Biology 2021

  Quote: ... 16:0-18:1 PS (POPS, Avanti Polar Lipids Inc. 840034; 18:1 Liss Rhod PE (Avanti Polar Lipids Inc. 810150); and DSPE-PEG(2000 ...
• Contrasting effects of reduced phosphatidylcholine synthesis in absence of seipin: embryonic lethality goes down while lipid droplets get even larger

  Jinglin Zhu, et al., bioRxiv - Developmental Biology 2022

  Quote: ... DAGs were quantified using d5-DAG16:0/16:0 and d5-DAG18:1/18:1 as internal standards (Avanti Polar Lipids). To facilitate comparison between samples ...
• Allergic inflammation triggers dyslipidemia via IgG signalling

  Nieves Fernández-Gallego, et al., bioRxiv - Immunology 2023

  Quote: ... 800 µl of a previously prepared mixture consisting of MeOH:MTBE:Chloroform (1.33:1:1, v/v/v) and 25 µl light Splash Lipidomics (Mass Spec Standard, 330707, Avanti Polar Lipids, Inc.) used as the internal standard were added to each sample at RT for deproteinization and lipid extraction ...
• Ral GTPases promote metastasis by controlling biogenesis and organ colonization of exosomes

  S Ghoroghi, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Synthetics internals lipid standards (PA 14:1/17:0, PC 17:0/14:1 and PS 17:0/17:0) from Avanti Polar Lipids was added ...
• Small mitochondrial protein NERCLIN regulates cardiolipin homeostasis and mitochondrial ultrastructure

  Svetlana Konovalova, et al., bioRxiv - Cell Biology 2021

  Quote: ... 400 μL of the lipid extract was spiked with CL 14:0/14:0/14:0/14:0 and PG 20:1/20:1 (Avanti Polar Lipids) internal standards ...
• Fatty sweet symphony: Decoding distinct ganglioside patterns of native and differentiated mesenchymal stem cells by a novel glycolipidomics profiling strategy

  Katharina Hohenwallner, et al., bioRxiv - Biochemistry 2022

  Quote: ... Deuterated GM3 18:0/18:1;O2-d5 and GM1 18:0/18:1;O2-d5 standards were purchased from Avanti Polar Lipids, Inc ...
• Lipid accumulation promotes scission of caveolae

  Madlen Hubert, et al., bioRxiv - Biochemistry 2020

  Quote: ... D-lactosyl-ß-1,1’ N-palmitoyl-D-erythro-sphingosine [LacCer(d18:1/16:0)] and Lyso-Lactosylceramide (Lyso-LacCer) were purchased from Avanti Polar Lipids Inc ...
• The Ebola virus VP40 matrix undergoes endosomal disassembly essential for membrane fusion

  Sophie L. Winter, et al., bioRxiv - Microbiology 2022

  Quote: ... (d18:1 with N-acylated 14:0, 19:0, 27:0, semi-synthesized or GlcCer d18:1/17:0, Avanti Polar Lipids), 5 pmol lactosylceramide (Hex2Cer ...
• The Mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs

  Sara Cioccolo, et al., bioRxiv - Biophysics 2024

  Quote: ... #791639), Phosphatidylglycerol (15:0-18:1-d7-PG, #791640) and Sphingomyelin (18:1-d9 SM, #791649) were purchased from Avanti Polar Lipids, Inc and were added to a final concentration of 10 μg/mL ...
• Urinary multi-omics reveal non-invasive diagnostic biomarkers in clear cell renal cell carcinoma

  Gustav Jonsson, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Internal standard mix (PE 34:0, 830456P; PS 34:0, 840028P; LPC 17:1, 855677C; SM d35:1, 860585; purchased form Avanti Polar Lipids, USA ...
• Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8⁺ T cells

  Elisa Matas-Rico, et al., bioRxiv - Cancer Biology 2021

  Quote: ... LPA(1-oleoyl) was obtained from Avanti Polar Lipids. Human ATX was produced in HEK293 Flip-in cells and purified as previously described (Salgado-Polo et al. ...
• Phosphatidylinositol 3-kinase-independent synthesis of PtdIns(3,4)P₂ by a phosphotransferase

  Glenn F. W. Walpole, et al., bioRxiv - Cell Biology 2021

  Quote: ... 16:0-18:1 PS (POPS, Avanti Polar Lipids Inc ...
• Next-generation intranasal Covid-19 vaccine: a polymersome-based protein subunit formulation that provides robust protection against multiple variants of concern and early reduction in viral load of the upper airway in the golden Syrian hamster model

  Jian Hang Lam, et al., bioRxiv - Immunology 2022

  Quote: ... using a 1 ml mini-extruder (Avanti Polar Lipids) to get monodispersed ACM-antigen vesicles ...
• The glycolipid GlcCer is recruited into the viral envelope to promote phenuivirus binding to host cells

  Zina M. Uckeley, et al., bioRxiv - Microbiology 2022

  Quote: ... or GlcCer (d18:1/17:0, Avanti Polar Lipids)) ...
• Oncogenic memory underlying minimal residual disease in breast cancer

  Ksenija Radic Shechter, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 10 pmol lyso-phosphatidylcholine (17:1, Avanti Polar Lipids), 50 pmol cardiolipin (14:1/14:1/14:1/15:1 ...
• Structure of an open K_ATP channel reveals tandem PIP₂ binding sites mediating the Kir6.2 and SUR1 regulatory interface

  Camden M. Driggers, et al., bioRxiv - Biochemistry 2024

  Quote: ... and 1 mg/mL brain PIP2 (Avanti Polar Lipids), and incubated at 4°C for 30 minutes before increasing the volume 10x in the same buffer without added lipids but including the detergent digitonin at a final concentration of 0.5% ...
• White matter lipidome alterations in the schizophrenia brain

  Dmitry Senko, et al., bioRxiv - Neuroscience 2023

  Quote: ... lysophosphatidylcholine (LPC 18:1-d7, Avanti Polar Lipids, 791643C), phosphatidylglycerol (PG 15:0/18:1-d7 ...
• Linking medicinal cannabis to autotaxin-lysophosphatic acid signaling

  Mathias C. Eymery, et al., bioRxiv - Biochemistry 2022

  Quote: ... and LPA 18:1 (#857130C) from Avanti Polar Lipids. Choline quantification kits (#40007 ...
• Vesicle-mediated mitochondrial clearance underlies an actionable metabolic vulnerability in triple-negative breast cancer

  Jody Vykoukal, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Sphingomyelin(18:1/18:1-d9) and C11 TopFluor Sphingomyelin (N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosylphosphorylcholine) (Avanti Polar Lipids 791649 and 810265P). Azithromycin (MedChemExpress ...
• A genome-wide genetic screen identified targets for destabilizing the parasitophorous vacuole of Chlamydia trachomatis

  Mohammed Rizwan Babu Sait, et al., bioRxiv - Microbiology 2024

  Quote: ... 17:0 glucosyl(β) ceramide (d18:1/17:0) and 17:0 lactosyl(β) ceramide (d18:1/17:0) (all from Avanti Polar Lipids) 77 ...
• Structure and reconstitution of a MCU-EMRE mitochondrial Ca²⁺ uniporter complex

  Chongyuan Wang, et al., bioRxiv - Biochemistry 2020

  Quote: ... and 0.01 mg/mL 18:1 cardiolipin (Avanti Polar Lipids)) ...
• Phospholipid isotope tracing reveals β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma

  Chad VanSant-Webb, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 1% Splash Lipidomix Mass Spec Standard (Avanti Polar Lipids, 330707), and 1% Deuterated Ceramide Lipidomix Mass Spec Standard (Avanti Polar Lipids ...
• Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity

  Le Zheng, et al., bioRxiv - Biochemistry 2023

  Quote: ... using D-erythrosphingosine (d18:1) (Cat# 860490P, Avanti Polar Lipids) as the standard ...
• A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function

  Jesse D. Gelles, et al., bioRxiv - Cell Biology 2024

  Quote: ... and cardiolipin (18:1) (Cat. No. 710335C, Avanti Polar Lipids) were combined at a ratio of 48:28:10:10:4 (5 mg total) ...
• Modeling compound lipid homeostasis using stable isotope tracing

  Karl Wessendorf-Rodriguez, et al., bioRxiv - Cell Biology 2024

  Quote: ... SPB 18:1;O2 [D7] (Avanti Polar Lipids, Cat# 860657), and GM3-d3 18:1;O2/18:0 [D3] (Cayman Chemicals ...
• Modeling compound lipid homeostasis using stable isotope tracing

  Karl Wessendorf-Rodriguez, et al., bioRxiv - Cell Biology 2024

  Quote: ... SPB 18:1;O2 [D7] (Avanti Polar Lipids, Cat# 860657), and GM3 18:1;O2/18:0 [D3] (Cayman Chemicals ...
• Acyl-CoA thioesterase-2 facilitates β-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner

  Carmen Bekeova, et al., bioRxiv - Biochemistry 2023

  Quote: ... The tissue was added to low retention Eppendorf tube prepared with 0.6 mL 80% methanol (MeOH) and 20 µL SPLASH® LIPIDOMIX (diluted 1:1 with methanol from original #330707 Avanti solution) (Avanti Polar Lipids, Alablaster, AL) and kept in dry ice ...
• Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6)

  Charline Ogier, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 20 µL of lipidomics internal standard mix (1:1, SPLASH® LIPIDOMIX #330707: Ceramide/Sphingoid Internal Standard Mixture I #LM6002, both from Avanti Polar Lipids, Alablaster, AL) and kept in dry ice ...
• Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALS

  Delfina Larrea, et al., bioRxiv - Molecular Biology 2022

  Quote: ... in conjunction with referencing of appropriate internal standards: ceramide d18:1/17:0 and sphingomyelin d18:1/12:0 (Avanti Polar Lipids, Alabaster, AL, USA). Values were represented as mole fraction with respect to total lipid (% molarity) ...
• Designing Biological Micro-Sensors with Chiral Nematic Liquid Crystal Droplets

  Lawrence W. Honaker, et al., bioRxiv - Bioengineering 2021

  Quote: ... 25 mg·ml-1 in chloroform) were sourced from Avanti Polar Lipids. Kdo2-Lipid A (di[3-deoxy-D-manno-octulosonyl]-lipid A (ammonium salt) ...
• Phosphatidylinositol 3-kinase-independent synthesis of PtdIns(3,4)P₂ by a phosphotransferase

  Glenn F. W. Walpole, et al., bioRxiv - Cell Biology 2021

  Quote: ... 16:0-18:1 PC (POPC, Avanti Polar Lipids Inc. 850457C); 16:0-18:1 PS (POPS ...
• Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1

  Stijn van Dorp, et al., bioRxiv - Biophysics 2021

  Quote: ... biotinylated lipids (18:1 Biotinyl Cap PE, Avanti Polar Lipids #870273C) were mixed with egg-PC lipids (Avanti Polar Lipids #840051C ...
• The composition and function of Enterococcus faecalis membrane vesicles

  Irina Afonina, et al., bioRxiv - Microbiology 2021

  Quote: ... monoglucosyl-diacylglycerol (MGDAG 34:1) (Avanti polar lipids, Alabaster, AL, USA) and were run alongside the samples (Table S2).
• Nanoscale Organization of FasL on DNA Origami as a Versatile Platform to Tune Apoptosis Signaling in Cells

  Ricarda M. L. Berger, et al., bioRxiv - Biophysics 2020

  Quote: 18:1 (Δ9-cis) DOPC was purchased from Avanti Polar Lipids, Alabaster ...
• Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

  Ruilin Tian, et al., bioRxiv - Genomics 2021

  Quote: ... and PI(15:0/18:1□d7) (EquiSPLASH, Avanti Polar Lipids), and finally 4 mL MTBE ...
• Tracer-based lipidomics identifies novel disease-specific biomarkers in mitochondrial β-oxidation disorders

  Marit Schwantje, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 50 μM D9-C18:1 (Avanti Polar Lipids, Cat. No 861809O) and 25 μmol/L L-carnitine (Sigma-Aldrich ...
• Selective endocytic uptake of targeted liposomes occurs within a narrow range of liposome diameter

  Grant Ashby, et al., bioRxiv - Bioengineering 2023

  Quote: ... or 20 mol% 18:1 Biotinyl Cap PE (Avanti Polar Lipids) were added to the wells at a 1 μM total lipid concentration ...
• White matter lipidome alterations in the schizophrenia brain

  Dmitry Senko, et al., bioRxiv - Neuroscience 2023

  Quote: ... phosphatidylcholine (PC 15:0/18:1-d7, Avanti Polar Lipids, 791637C), and phosphatidylethanolamine (PE 15:0/18:1-d7 ...
• VISION — an open-source software for automated multi-dimensional image analysis of cellular biophysics

  Florian Weber, et al., bioRxiv - Biophysics 2024

  Quote: ... and DGS-NTA(Ni) (18:1, Avanti Polar Lipids, cat# 790404C). For normal GUVs ...
• Phospholipid isotope tracing reveals β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma

  Chad VanSant-Webb, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 1% Splash Lipidomix Mass Spec Standard (Avanti Polar Lipids 330707) was added to the homogenized tissue.
• White matter lipidome alterations in the schizophrenia brain

  Dmitry Senko, et al., bioRxiv - Neuroscience 2023

  Quote: ... diacylglycerol (DAG 15:0/18:1-d7, Avanti Polar Lipids, 791647C), ceramide (Cer d18:1-d7/15:0 ...
• White matter lipidome alterations in the schizophrenia brain

  Dmitry Senko, et al., bioRxiv - Neuroscience 2023

  Quote: ... phosphatidylglycerol (PG 15:0/18:1-d7, Avanti Polar Lipids, 791640C), phosphatidylcholine (PC 15:0/18:1-d7 ...
• Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2

  Lea C. Neelsen, et al., bioRxiv - Biophysics 2023

  Quote: ... and oleoyl-CoA (LC-CoA 18:1) (Avanti Polar Lipids, USA) were prepared as stocks (1 - 100 mM ...
• A practical guide to time-resolved fluorescence microscopy and spectroscopy

  Benjamin S. Clark, et al., bioRxiv - Biophysics 2024

  Quote: ... A solution of 1% biotinyl cap-phosphoethanolamine (Avanti Polar Lipids, 870277P) in Egg PC (Avanti Polar Lipids ...
• White matter lipidome alterations in the schizophrenia brain

  Dmitry Senko, et al., bioRxiv - Neuroscience 2023

  Quote: ... ceramide (Cer d18:1-d7/15:0, Avanti Polar Lipids, 860681), lysophosphatidylcholine (LPC 18:1-d7 ...
• Synthetic control of actin polymerization and symmetry breaking in active protocells

  Shiva Razavi, et al., bioRxiv - Synthetic Biology 2023

  Quote: ... All lipids (Supplementary Table 1) were purchased from Avanti Polar Lipids. Hexadecane (H6703 ...
• Single-Cell Epitope-Transcriptomics Reveal Lung Stromal and Immune Cell Response Kinetics to Nanoparticle-delivered RIG-I and TLR4 Agonists

  M. Cole Keenum, et al., bioRxiv - Bioengineering 2022

  Quote: ... MPLA PHAD® (1 μg/mg PLGA, Avanti Polar Lipids, #699800P) was dissolved in DCM prior to emulsification ...
• Glutathione supports lipid abundance in vivo

  Gloria Asantewaa, et al., bioRxiv - Biochemistry 2023

  Quote: ... and SPLASH LIPIDOMIX (1:1000, Avanti Polar Lipids Inc., Cat# 330707). After sonicating (1400 rpm ...
• Structural basis of membrane targeting and coatomer assembly by human GBP1

  Tanja Kuhm, et al., bioRxiv - Biophysics 2023

  Quote: 1 mg of brain polar lipid extract (BPLE, Avanti Polar Lipids) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC ...
• CryoEM Structure of the human THIK-1 K2P K⁺ Channel Reveals a Lower ‘Y-gate’ Regulated by Lipids and Anaesthetics

  Karin EJ Rödström, et al., bioRxiv - Biophysics 2024

  Quote: ... and oleoyl-CoA (LC-CoA 18:1) (Avanti Polar Lipids, USA) were prepared as stocks (1 - 100 mM ...