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401 - 450 of 1849 citations for 6 Hydroxymethyl 4 methoxy 5 methyl nicotinic acid methyl ester since 2020

• Microbial metabolite butyrate-prodrug polymeric micelles demonstrate therapeutic efficacy in pre-clinical models of food allergy and colitis

  Ruyi Wang, et al., bioRxiv - Bioengineering 2022

  Quote: ... CD4 BV605 (clone RM4-5, Biolegend), CD25 PE/Cy7 (clone PC61 ...
• Asymmetric cell division safeguards memory CD8 T cell development

  Fabienne Gräbnitz, et al., bioRxiv - Immunology 2022

  Quote: ... α-CD28 (5 µg/ml) (37.51, BioLegend) and human Fc-ICAM-1 (50 µg/ml ...
• Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa

  Maria E. Mercau, et al., bioRxiv - Immunology 2022

  Quote: ... CD64 (BioLegend clone X54-5/7.1), Ly6C (BioLegend clone HK1.4) ...
• Helicobacter chronic stage inflammation undergoes fluctuations that are altered in tlpA mutants

  Kevin S. Johnson, et al., bioRxiv - Microbiology 2022

  Quote: ... or CD4 (APC, RM4-5, BioLegend). Mouse Fc Block (CD16/CD32 ...
• Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy

  Raphael S. Peres, et al., bioRxiv - Immunology 2022

  Quote: ... CD4-BV711 (clone RMA4-5, BioLegend), CD45-AF700 (clone 30-F11 ...
• Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

  Jonathan D Teo, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-CD64 (X54-5/7.1, Biolegend), anti-CD45 (30-F11 ...
• PPAR-γ regulates the effector function of human T_H9 cells by promoting glycolysis

  Nicole L. Bertschi, et al., bioRxiv - Immunology 2022

  Quote: ... IL-12 (5 ng/ml) (BioLegend) for TH1 cells ...
• Microbiota colonization tunes the antigen threshold of microbiota-specific T cell activation in the gut

  Daniel Hoces, et al., bioRxiv - Immunology 2022

  Quote: ... CD4-PE/Cy7 (RM4-5, BioLegend), CD4-PerCP (RM4-5 ...
• Cellular sources and targets of type I interferons that drive susceptibility to tuberculosis

  Dmitri I. Kotov, et al., bioRxiv - Immunology 2022

  Quote: ... eF506-labeled CD4 (RM4-5, BioLegend), and AF647-labeled Ly6G (1A8 ...
• Early-life exposures to specific commensal microbes prevent type 1 diabetes

  Jamal Green, et al., bioRxiv - Immunology 2024

  Quote: ... FITC-CD4 (clone Rm4-5; Biolegend). Cells were washed twice with staining media and fixed overnight at 4°C using the eBioscience Fixation kit (cat# 005223-56 ...
• Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

  Megan R. Teh, et al., bioRxiv - Immunology 2024

  Quote: ... BFA (5 mg/mL) (Biolegend, 420601) and monensin (2 mM ...
• Primary nasal viral infection rewires the tissue-scale memory response

  Samuel W. Kazer, et al., bioRxiv - Immunology 2024

  Quote: ... anti-CD64 (X54-5/7.1, Biolegend), anti-CD69 (H1.2F3 ...
• Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation

  Janneke G.C. Peeters, et al., bioRxiv - Immunology 2024

  Quote: ... anti-mouse CD4 (RM4-5, BioLegend), anti-mouse CD8a (53-6.7 ...
• Functional impairment of “helpless” CD8⁺ memory T cells is transient and driven by prolonged but finite cognate antigen presentation

  Verena van der Heide, et al., bioRxiv - Immunology 2024

  Quote: ... brefeldin A (5 µg/mL; Biolegend), and monensin (2 µM ...
• A mass cytometry approach to track the evolution of T cell responses during infection and immunotherapy by paired T cell receptor repertoire and T cell differentiation state analysis

  Jesse Garcia Castillo, et al., bioRxiv - Immunology 2024

  Quote: ... anti-mouse CD4 (RM4-5, BioLegend), anti-mouse CD8a (53-6.7 ...
• Integration of Avidity and Differentiation is enabled by CD8⁺ T-cell sensing of IFN-γ

  Lion F.K. Uhl, et al., bioRxiv - Immunology 2023

  Quote: ... anti-CD4 (Biolegend, clone: RM4-5), anti-CD69 (Biolegend ...
• IL-15 promotes inflammatory T_h17 cells in the intestine

  Jonathan G. Golob, et al., bioRxiv - Immunology 2023

  Quote: ... IL-23 (5 ng/ml, BioLegend), anti-mouse IL-4 (10 ug/mL ...
• Sequential early-life viral infections modulate the microbiota and adaptive immune responses to systemic and mucosal vaccination

  Yuhao Li, et al., bioRxiv - Microbiology 2023

  Quote: ... CD4(Biolegend, RM4-5, 1:400), CD62L (Biolegend ...
• Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

  Lachlan P. Deimel, et al., bioRxiv - Immunology 2023

  Quote: ... 5 μg/mL brefeldin A (Biolegend) was added to all wells to suspend ER–Golgi trafficking and block cytokine secretion ...
• Monkeypox virus quadrivalent mRNA vaccine induces antibody responses and cellular immunity and protects mice against Vaccinia virus

  Ye Sang, et al., bioRxiv - Immunology 2022

  Quote: ... Brefeldin A (5 μg/ml; Biolegend) was incubated with cells for 4 h ...
• Lung influenza virus specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells

  Kerrie E Hargrave, et al., bioRxiv - Immunology 2023

  Quote: ... CD64-BV711 (BioLegend, X54-5/7.1), CD11c-eFluor780 (ThermoFisher ...
• Sexually dimorphic role of diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus

  Sanutha Shetty, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-CD64 (BioLegend, X54-5/7.1), anti-CD49b (BioLegend ...
• Germline-encoded specificities and the predictability of the B cell response

  Marcos C. Vieira, et al., bioRxiv - Immunology 2023

  Quote: ... anti-CD4 (clone RM4-5, Biolegend), anti-CD8 (clone 536.7 ...
• STING-Activating Polymer-Drug Conjugates for Cancer Immunotherapy

  Taylor L. Sheehy, et al., bioRxiv - Bioengineering 2024

  Quote: Antibodies: CD4 (RM4-5, BV605, Biolegend), CD44 (IM7 ...
• CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

  Benjamin H Gern, et al., bioRxiv - Immunology 2024

  Quote: ... CD4 BV510 (clone RM4-5; Biolegend), CD4 CF594 [conjugated in house] (clone RM4-5 ...
• Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage

  Benjamin M. Murter, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-CD4 (Biolegend: clone RM4-5), anti-CD11b (ThermoFisher ...
• Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies

  Xiuyuan Lu, et al., bioRxiv - Immunology 2024

  Quote: ... IL-7 (5 ng/ml, BioLegend) and IL-15 (5 ng/ml ...
• Remote force modulation of the T-cell receptor reveals an NFAT-threshold for CD4⁺ T cell activation

  Joseph Clarke, et al., bioRxiv - Immunology 2024

  Quote: ... CD4-AF700 (clone RM4-5, Biolegend) positive events ...
• Interleukin-1 receptor antagonist is a conserved driver of tuberculosis

  Dmitri I. Kotov, et al., bioRxiv - Immunology 2024

  Quote: ... eF506-labeled CD4 (RM4-5, BioLegend), and AF647-labeled Ly6G (1A8 ...
• Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses

  Sophia Navarre, et al., bioRxiv - Immunology 2024

  Quote: ... CD64 (clone X54-5/7.1, BioLegend); MerTK (clone 2B10C42 ...
• Intranasal immunization with CPAF combined with cyclic-di-AMP induces a memory CD4 T cell response and reduces bacterial burden following intravaginal infection with Chlamydia muridarum

  Taylor B. Poston, et al., bioRxiv - Immunology 2024

  Quote: ... anti-CD4 BV570 (RM4-5; BioLegend), anti-CD8 BUV395 (53-6.7 ...
• Pulmonary granuloma formation during latent Cryptococcus neoformans infection in C3HeB/FeJ mice involves progression through three immunological phases

  Jovany J. Betancourt, et al., bioRxiv - Microbiology 2024

  Quote: ... CD64 (X54-5/7.1, BV421, Biolegend), SiglecF (E50-2440 ...
• SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant transformation

  Hülya F. Taner, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-CD4 (clone RM4-5, BioLegend), anti-PD-1 (clone 29F1A12 ...
• Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

  Kerry L. Hilligan, et al., bioRxiv - Immunology 2021

  Quote: ... Anti-IL-6 (MP5-20F3) and anti-TNF-alpha (MP6-XT22) were from BioLegend.
• Loss of the adhesion protein Kindlin-1 stimulates tumor clearance via modulation of Tregs

  Emily R Webb, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and with or without anti-IL-6 antibody (20 μg/ml, Biolegend Cat#504512). Cells were then harvested from plates ...
• Loss of the adhesion protein Kindlin-1 stimulates tumor clearance via modulation of Tregs

  Emily R Webb, et al., bioRxiv - Cancer Biology 2022

  Quote: ... ELISA was conducted using the Mouse IL-6 ELISA Max™ Delux kit (Biolegend), following the manufacturer’s instructions ...
• Spiral ganglion neuron degeneration in deafened rats involves innate and adaptive immune responses not requiring complement

  Benjamin M. Gansemer, et al., bioRxiv - Neuroscience 2024

  Quote: ... and mouse IgG1-anti-rat MHCII (OX-6, 1:100, # 50-165-477 Biolegend) to label MHCII+ cells.
• Dnmt3a mutations limit normal and autoreactive Tfh differentiation

  Yunbing Shen, et al., bioRxiv - Immunology 2024

  Quote: IL-6 ELISA was performed according to the manufacturer’s instruction (Biolegend, Cat. No. 431301) with mouse serum diluted 1:50 ...
• Peptide aggregation-induced immunogenic cell death in a breast cancer spheroid model

  Gokhan Gunay, et al., bioRxiv - Bioengineering 2023

  Quote: ... and values were calculated based on the standard curve for IL-6 (BioLegend 431315), IL-1β (BioLegend 432615) ...
• Elevated CD153 Expression on Aged T Follicular Helper Cells is Vital for B cell Responses

  Alyssa L. Thomas, et al., bioRxiv - Immunology 2023

  Quote: ... in the presence or absence of 20ng/ml of recombinant mouse IL-6 (Biolegend) and/or 200ng/ml of nivalenol (Cayman Chemical ...
• Autosomal Dominant-Hyper-IgE Syndrome patients contain pre-Th17-cells that are activated by opportunistic pathogens to produce IL-10

  Giorgia Moschetti, et al., bioRxiv - Immunology 2024

  Quote: ... (iii) in the presence of 10 ng/ml of anti-IL-6 (Biolegend, U.S.A.), anti-IL-10 (Miltenyi Biotec ...
• Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9

  Chao Wang, et al., bioRxiv - Immunology 2024

  Quote: ... The trypsinized macrophages were stained with anti-Siglec-7 APC (BioLegend, clone 6-434) or anti-Siglec-9 APC (BioLegend ...
• Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

  Lucas H. Armitage, et al., bioRxiv - Immunology 2021

  Quote: ... Undifferentiated donor 2395 iPSC were stained with anti-SSEA-4-APC and anti-Oct-4-PE (BioLegend, San Diego, CA) using the Fixation/Permeabilization Solution kit from BD Biosciences (San Jose ...
• Adaptation to host cell environment during experimental evolution of Zika virus

  Vincent Grass, et al., bioRxiv - Microbiology 2021

  Quote: ... cell surface markers were detected by a 30 minute-incubation at 4°C with 4 µg/mL Pacific Blue-conjugated mouse anti-CD14 (clone 63D3, Biolegend), a 1:20 dilution of APC-conjugated mouse anti-CD163 (clone REA812 ...
• Single-cell chromatin and transcriptome dynamics of Synovial Fibroblasts transitioning from homeostasis to pathology in modelled TNF-driven arthritis

  Marietta Armaka, et al., bioRxiv - Cell Biology 2021

  Quote: ... for 10 min at 4°C and stained with fluorophore conjugated antibodies for 20 min at 4°C (anti-Pdpn PE-Cy7, Biolegend 127411 ...
• Constitutive expression of IκBζ promotes tumor growth and immunotherapy resistance in melanoma

  Antonia Kolb, et al., bioRxiv - Cancer Biology 2024

  Quote: ... for 10 minutes at 4°C and then surfaced-stained for 30 minutes at 4°C with the following antibodies obtained from BioLegend: anti-CD3-APC (Cat ...
• Directing an mRNA-LNP vaccine toward lymph nodes improves humoral and cellular immunity against SARS-CoV-2

  David M. Francis, et al., bioRxiv - Immunology 2021

  Quote: ... BV421 anti-mouse IL-4 (Cat: 504127 Biolegend), APC-Cy7 anti-mouse CD3 (Cat ...
• SIRPα sequesters SHP-2 to promote IL-4/13 signaling and alternative activation of macrophages

  Lei Shi, et al., bioRxiv - Immunology 2021

  Quote: IL-4 or IL-13 (Biolegend or PeproTech) was added into macrophage cultures at various concentrations to induce the M2/M2a phenotype in the presence or absence of a soluble CD47 extracellular domain (mCD47.ex or hCD47.ex) ...
• Oxaliplatin Resistance in Colorectal Cancer Enhances TRAIL Sensitivity Via Death Receptor 4 Upregulation and Lipid Raft Localization

  Joshua D. Greenlee, et al., bioRxiv - Cancer Biology 2021

  Quote: ... PE antihuman CD262 (DR5) (Biolegend, Clone DJR2-4), PE anti-human TRAILR3 (DcR1 ...
• STING suppresses cancer pain via immune and neuronal modulation

  Kaiyuan Wang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CD-4 APC (1:200, rat, Biolegend, 100411), FoxP3-PE (1:20 ...