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201 - 250 of 1849 citations for 6 Hydroxymethyl 4 methoxy 5 methyl nicotinic acid methyl ester since 2020

• Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease

  AM Schonhoff, et al., bioRxiv - Neuroscience 2022

  Quote: ... IL-4 (clone 11B11, BioLegend), IL-17a (clone eBiol7B7 ...
• The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

  Iosifina P. Foskolou, et al., bioRxiv - Immunology 2022

  Quote: ... CTLA-4 (UC10-4B9, Biolegend); FcR Block (120-000-826 ...
• Remodeling of Il4-Il13-Il5 locus underlies selective gene expression

  Hiroyuki Nagashima, et al., bioRxiv - Immunology 2022

  Quote: ... AF488-IL-4 (11B11, Biolegend), PerCP-eFluor710-IL-13 (eBio13A ...
• Tregs constrain CD8⁺ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

  Joseph R. Palmeri, et al., bioRxiv - Immunology 2023

  Quote: ... α4-1BB-APC (17B5, Biolegend), αCD107a-APC-Cy7 (1D4B ...
• MAIT cells have a negative impact on GBM

  Seketoulie Keretsu, et al., bioRxiv - Immunology 2024

  Quote: ... IL-4 (Biolegend cat #: 500818), and IL-17A (Biolegend cat # ...
• The EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8⁺ T-cell revitalization

  Andrea Gramatica, et al., bioRxiv - Immunology 2024

  Quote: ... CD137 (BV650, 4-1BB, Biolegend), CD8 (BV605 ...
• Adjuvant conditioning shapes the adaptive immune response and promotes trained immunotolerance via NLRP3/IL-1

  Thais Boccia, et al., bioRxiv - Immunology 2024

  Quote: ... IL-4 (clone: 11B11; BioLegend), IL-17A (clone ...
• Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

  Gabriela Pessenda, et al., bioRxiv - Immunology 2024

  Quote: ... TIM-4 (RMT4-54, Biolegend) 1:200 ...
• Mapping the T cell repertoire to a complex gut bacterial community

  Kazuki Nagashima, et al., bioRxiv - Immunology 2022

  Quote: ... CD4 (RM4-5, BioLegend), CD3e (145-2C11 ...
• Disruption of Z-RNA–binding of ADAR1 induces Aicardi-Goutières syndrome–like encephalopathy in mice

  Taisuke Nakahama, et al., bioRxiv - Immunology 2020

  Quote: ... CD4 (RM4-5; BioLegend), CD8 (53-6.7 ...
• Metabolic regulation of ILC2 differentiation into ILC1-like cells during Mycobacterium tuberculosis infection

  Dan Corral, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (RM4-5, Biolegend), CD8a (53-6.7 ...
• 12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes

  Abhishek Kulkarni, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (RM4-5, Biolegend), CD80 (16-10A1 ...
• IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling

  Holly Bachus, et al., bioRxiv - Immunology 2022

  Quote: ... IL-5 (TRFK5; BioLegend), IL-4 (11B11 ...
• Soquelitinib, A Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase (ITK), is Active in Several Murine Models of T Cell-Mediated Inflammatory Disease

  Lih-Yun Hsu, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, Biolegend), CD44 (IM7 ...
• Secreted Particle Information Transfer (SPIT) – A Cellular Platform for In Vivo Genetic Engineering

  Carsten T. Charlesworth, et al., bioRxiv - Synthetic Biology 2024

  Quote: ... CD4 (RM4-5; Biolegend), CD8 (54-6.7 ...
• A ketogenic diet reduces age-induced chronic neuroinflammation in mice

  Mitsunori Nomura, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, BioLegend), CD8 (53-6.7 ...
• Phosphoproteomic analysis of the AKT signalling axis in cutaneous squamous carcinoma progression reveals novel therapeutic targets

  R Button, C Harwood, RFL O’Shaughnessy, bioRxiv - Cancer Biology 2022

  Quote: ... Keratin 5 (BioLegend Poly19055) (1:1,000 WB) ...
• Atheroprone shear stress stimulates noxious endothelial extracellular vesicle uptake by MCAM and PECAM-1 cell adhesion molecules

  Pierre-Michaël Coly, et al., bioRxiv - Cell Biology 2023

  Quote: ... α5 integrin (Biolegend, 921704), α6 integrin (Biolegend ...
• CD4 T cells and neutrophils contribute to epithelial-mesenchymal transition in breast cancer

  Amélien Sanlaville, et al., bioRxiv - Cancer Biology 2023

  Quote: ... CD4 (RM4-5; Biolegend), NKp46 (29A1.4 ...
• Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

  Jiang Li, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, Biolegend), CD206 (C068C2 ...
• Interferon-γ Elicits Pathological Hallmarks of ALS in Human Motor Neurons

  Changho Chun, et al., bioRxiv - Neuroscience 2023

  Quote: ... CD44 (C44Mab-5, BioLegend), and CD8 (SK1 ...
• Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity

  Maria Guillamot, et al., bioRxiv - Immunology 2024

  Quote: ... CD4 (Biolegend RM4/5), CD8 (Biolegend ...
• Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract

  Alexander J. Nelson, et al., bioRxiv - Immunology 2024

  Quote: ... IL-4 neutralization was performed using anti-IL-4 (10 µg/mL, clone 11B11, BioLegend) or rat IgG1 isotype control (10 µg/mL ...
• Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 responses

  Sonia Ndeupen, et al., bioRxiv - Immunology 2021

  Quote: ... PD-1 (29F.1A12) and Bcl-6 (K112-91) from BioLegend and BD Biosciences ...
• Autoimmunity increases susceptibility to and mortality from sepsis

  Isaac J. Jensen, et al., bioRxiv - Immunology 2021

  Quote: IL-6 and IL-10 ELISAs (ELISA MAX Deluxe Set, Biolegend) were performed according to the manufacturer’s instructions.
• Neuraminidase activity mediates IL-6 production through TLR4 and p38/ERK MAPK signaling in MRL/lpr mesangial cells

  Kamala P. Sundararaj, et al., bioRxiv - Cell Biology 2020

  Quote: ... ELISAs were used to measure IL-6 (Biolegend, San Diego, CA), GM-CSF (R&D systems ...
• Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells

  Nicholas J Maurice, et al., bioRxiv - Immunology 2021

  Quote: ... we used human RP10 media with combinations of rIL-6 (BioLegend), rIL-12 ...
• Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques

  Hyon-Xhi Tan, et al., bioRxiv - Immunology 2020

  Quote: ... and stained intracellularly with anti-BCL-6 Alexa647 (IG191E/A8; Biolegend). Non-human primate LN suspensions and PBMC were stained with the same protocol ...
• High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients

  Xiang Song, et al., bioRxiv - Immunology 2020

  Quote: ... interleukin (IL)-6 (10 ng/mL, Biolegend, San Diego, CA, USA), IL-1β (10 ng/mL ...
• Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions

  Emanuele Lettera, et al., bioRxiv - Cell Biology 2023

  Quote: Mouse anti-human CD41/CD61-PC7 (Clone: A2A9/6; Biolegend, 359812), Verified Reactivity ...
• A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic inflammation through 3D genome topology

  Aditi Chandra, et al., bioRxiv - Genomics 2022

  Quote: ... and 20 ng/mL of recombinant IL-6 (BioLegend, Cat# 575702) and 1 μg/mL of soluble anti-CD28 for 6 days at 37°C ...
• In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery

  Saijuan Xu, et al., bioRxiv - Bioengineering 2024

  Quote: ... was assessed utilizing the Mouse IL-6 ELISA Kit (BioLegend, 431307). IL1-β ...
• Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy

  Nipun Verma, et al., bioRxiv - Genetics 2024

  Quote: Cell cycle analysis was performed using DAPI nucleic acid dye (Biolegend #422801). 1 day after passaging ...
• Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

  Luca Pagliaroli, et al., bioRxiv - Genomics 2021

  Quote: ... 4 µl of the respective antibodies were used: APC anti-human SSEA-4 antibody (Biolegend, #330417) and PE anti-human TRA-1-60-R antibody (Biolegend ...
• Characterizing the polarization continuum of macrophage subtypes M1, M2a and M2c

  TCL Oates, et al., bioRxiv - Immunology 2022

  Quote: ... with or without the inclusion of interleukin-4 at 20ng/mL (wt/vol, IL-4, BioLegend), interferon-g at 2.5ng/mL (wt/vol ...
• The PD-1 checkpoint receptor maintains tolerance of self-reactive CD8 T cell in skin

  Martina Damo, et al., bioRxiv - Immunology 2021

  Quote: ... CTLA-4 (clone UC10-4B9, BioLegend), EpCAM (clone G8.8 ...
• Phosphatidylserine binding regulates TIM-3 effects on T cell receptor signaling

  Courtney M. Smith, et al., bioRxiv - Biochemistry 2021

  Quote: ... anti-TIM-4 (BioLegend, catalog #354003), anti-PD-L1 (also labeled with Dazzle 594 ...
• Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4⁺ regulatory T cells

  Mark Mensink, et al., bioRxiv - Immunology 2022

  Quote: ... anti-CTLA-4-PE-Dazzle594 (BioLegend) and anti-NFATC2-AF488 (Cell Signaling Technology ...
• Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine

  Alexandra Atalis, et al., bioRxiv - Immunology 2022

  Quote: ... IL-4 (Biolegend, PE/Dazzle 594) and TNF-α (Biolegend ...
• Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy

  Raphael S. Peres, et al., bioRxiv - Immunology 2022

  Quote: ... CTLA-4-PE (clone BNI3, BioLegend), CD39-BV421 (clone A1 ...
• Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity

  Xian Zhou, et al., bioRxiv - Immunology 2020

  Quote: ... IL-4 (10 ng/mL; Biolegend), IL-2 (10 unit/mL ...
• Role of T cells in intrauterine administration of activated peripheral blood mononuclear cells in recurrent implantation failure

  Guillaume Ricaud, et al., bioRxiv - Immunology 2021

  Quote: ... anti-IL-4/BV510 (Biolegend, USA), anti-IL-17/BV711 (Biolegend ...
• Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

  Jacob W. Freimer, et al., bioRxiv - Genomics 2021

  Quote: ... or CTLA-4 (Biolegend, Cat #349908). Cells sorted for IL2RA underwent surface staining according to the manufacturer’s protocol ...
• Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

  Jacob W. Freimer, et al., bioRxiv - Genomics 2021

  Quote: ... or CTLA-4 (Biolegend, Cat #349908) and analyzed with an Attune NxT Flow Cytometer with a 96-well plate-reader.
• Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection

  J Zuo, et al., bioRxiv - Immunology 2020

  Quote: ... and anti-IL-4-PE (Biolegend). All antibodies were purchased from Biolegend ...
• Expression of Tim-3 drives naïve Treg to an effector-like state with enhanced suppressive activity

  Hridesh Banerjee, et al., bioRxiv - Immunology 2020

  Quote: ... CTLA-4 clone UC10-4B9 (BioLegend), CD103 clone M290 (BD) ...
• Acute lymph node slices are a functional model system to study immunity ex vivo

  Maura C. Belanger, et al., bioRxiv - Immunology 2020

  Quote: ... IL-4 (ELISA MAX standard, Biolegend) and TNFα (R&D Systems ...
• CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

  Xiaoyu Zhou, et al., bioRxiv - Immunology 2023

  Quote: ... or anti-CTLA-4 antibody (Biolegend) at 37°C for 1 hour ...
• Selective Inhibition of Interleukin-2 Inducible T Cell Kinase (ITK) Enhances Anti-Tumor Immunity in Association with Th1-skewing, Cytotoxic T cell Activation, and Reduced T Cell Exhaustion

  Lih-Yun Hsu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-human IL-4 (OA19A66, Biolegend) and anti-human IL-5 (TRFK5 ...
• Human cerebrospinal fluid single exosomes in Parkinson’s and Alzheimer’s diseases

  Koya Yakabi, et al., bioRxiv - Neuroscience 2023

  Quote: ... Aquaporin-4 (E5206) (BioLegend catalog #600352), CD11b (M1/70 ...