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201 - 250 of 2015 citations for 2 Chloro 3 4 cyanobenzoyl pyridine since 2020

• Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

  D Lara-Astiaso, et al., bioRxiv - Genomics 2022

  Quote: ... and CD55 (PE-conjugated; clone RIKO-3; Biolegend). Percent Gran-like (CD11b-high/Gr-1+ ...
• Rewiring of the TCR signalosome in natural intestinal Intraepithelial T lymphocytes drives non-deletional tolerance

  Harriet J. Watt, et al., bioRxiv - Immunology 2023

  Quote: ... LAG-3-PE-Cy7 (1:200) (all Biolegend) and TCRβ-BV786 (1:200 ...
• TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene

  Evelyn Kabirova, et al., bioRxiv - Genetics 2022

  Quote: ... and mrIL-3 (10 ng/ml) (Biolegend, 575502). Mast cells were also stained by toluidine blue (Biovitrum ...
• Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

  Niels Asger Jakobsen, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and propidium iodide (final concentration 3 μM; Biolegend) was used for dead cell exclusion ...
• Rapid activation of IL-2 receptor signaling by CD301b⁺ DC-derived IL-2 dictates the outcome of helper T cell differentiation

  Naoya Tatsumi, et al., bioRxiv - Immunology 2023

  Quote: ... and GATA-3 (16E10A23) were purchased from BioLegend. Anti-pSTAT5 (Tyr694 ...
• NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

  Michael S. Dahabieh, et al., bioRxiv - Immunology 2024

  Quote: ... TIM-3 BV711 (#119727, Clone RMT3-23, Biolegend), PD-1 BUV737 (#749306 ...
• PD-1 blockade enhances HIV-1 vaccine-induced CD8⁺ T-cell responses in PWH early ART-treated

  Miguel Marin, et al., bioRxiv - Immunology 2024

  Quote: ... and TIM-3 (PE, clone F38-2E2, Biolegend) antibodies for 25 minutes ...
• HIV-1 controllers possess a unique CD8+ T-cell activation phenotype and loss of control is associated with increased expression of exhaustion markers

  Amber D Jones, et al., bioRxiv - Immunology 2024

  Quote: ... and/or anti-Tim-3 (CD366) antibody (BioLegend, UltraLEAF purified anti-human ...
• Increasing Signal Intensity of Fluorescent Oligo-Labeled Antibodies to Enable Combination Multiplexing

  Madeline E. McCarthy, et al., bioRxiv - Molecular Biology 2024

  Quote: ... (3) CD4 (clone RPA-T4; Biolegend Cat: 300502) labeled with Atto488/647 int ...
• Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment

  Jacob Gadwa, et al., bioRxiv - Immunology 2024

  Quote: ... GATA-3: Alexa Fluor 647 (Clone: 16E10A23, Biolegend). Samples were analyzed on a Cytek Aurora spectral cytometer (Cytek Biosciences) ...
• Enhancing and inhibitory motifs have coevolved to regulate CD4 activity

  Mark S. Lee, et al., bioRxiv - Immunology 2021

  Quote: ... were coated overnight at 4°C with 8µg of biotinylated anti-CD4 antibody (clone RM4-4, BioLegend). Prior to immunoprecipitation (IP) ...
• Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4⁺ regulatory T cells

  Mark Mensink, et al., bioRxiv - Immunology 2022

  Quote: ... Cell surface expression of CTLA-4 was measured by adding anti-CTLA-4-PE-Dazzle594 mAb (BioLegend) in culture during restimulation for 24 h ...
• The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

  Mark S. Lee, et al., bioRxiv - Immunology 2023

  Quote: ... were coated overnight at 4°C with 8μg of biotinylated anti-CD4 antibody (clone RM4-4, BioLegend). Prior to immunoprecipitation (IP) ...
• Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine

  Suhas Sureshchandra, et al., bioRxiv - Immunology 2021

  Quote: ... IgD (IA6-2, BioLegend), CD27 (M-T271 ...
• Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

  Dehao Huang, et al., bioRxiv - Immunology 2021

  Quote: ... TRAIL (Biolegend, RIK-2), FasL (Biolegend ...
• The NK receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells

  Sumit Sen Santara, et al., bioRxiv - Immunology 2021

  Quote: ... 2 μM monensin (BioLegend) and 3 μM brefeldin A (BD ...
• The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation

  Danielle Minns, et al., bioRxiv - Immunology 2020

  Quote: ... IL-2 (Biolegend, #431004) and IL-22 (Biolegend ...
• Systemic and mucosal mobilization of granulocyte subsets during lentivirus infection

  Rhianna Jones, et al., bioRxiv - Immunology 2021

  Quote: ... CD32 (FUN-2; BioLegend), CD95 (DX2 ...
• Regeneration of humoral immunity from pluripotent stem cells by defined transcription factors

  Qi Zhang, et al., bioRxiv - Immunology 2021

  Quote: ... CD138(281-2, BioLegend), CD38(90 ...
• Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection

  Suhas Sureshchandra, et al., bioRxiv - Immunology 2021

  Quote: ... IgD (IA6-2, BioLegend), CD27 (M-T271 ...
• Circulating mast cell progenitors migrate to atopic dermatitis-like skin then adapt locally

  Yuki Honda Keith, et al., bioRxiv - Immunology 2022

  Quote: ... integrinβ2 (M18/2; BioLegend), IgE (R35-72 ...
• Integration of Avidity and Differentiation is enabled by CD8⁺ T-cell sensing of IFN-γ

  Lion F.K. Uhl, et al., bioRxiv - Immunology 2023

  Quote: ... IL-2 (Biolegend, #575404), IL-1β (Biolegend ...
• Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

  Lucy Cooper, et al., bioRxiv - Immunology 2023

  Quote: ... or 2 (Biolegend #155863) for 20 minutes at 4°C ...
• Novel Fas-TNFR chimeras that prevents Fas ligand-mediated kill and signals synergistically to enhance CAR T-cell efficacy

  Callum McKenzie, et al., bioRxiv - Synthetic Biology 2023

  Quote: ... IL-2 (Biolegend; 431804), CCL1 (R&D Systems ...
• Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-T_SCM cells using qCART, the Quantum pBac-based CAR-T system

  Peter S. Chang, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and IL-2 (BioLegend) were quantified by ELISA according to manufacturer’s instructions.
• Acquired resistance to PD-L1 inhibition is associated with an enhanced type I IFN-stimulated secretory program in tumor cells

  Yuhao Shi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... CD8b.2 (Biolegend, 140416), Granzyme B (Biolegend ...
• Lung Microbiome Intervention Attenuates Herpesvirus-Induced Post-HCT Pulmonary Fibrosis Through PD-L1 Upregulation on Dendritic Cells

  Joshua B. Perkins, et al., bioRxiv - Immunology 2024

  Quote: ... CD8a (Ly-2, BioLegend), and CCR6 (29-2L17 ...
• Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation

  Hrishikesh S. Kulkarni, et al., bioRxiv - Immunology 2024

  Quote: ... CD138 (281-2; Biolegend) CD38 (S21016F ...
• Macrophage-Based iNos Reporter Reveals Polarization and Reprogramming in the Context of Breast Cancer

  Javier A. Mas-Rosario, et al., bioRxiv - Immunology 2022

  Quote: ... culture media was removed and replaced with media containing either 50 ng/mL interleukin 4 (IL-4) (BioLegend) for 48 hr to generate M2 macrophages or 50 ng/mL interferon-gamma (IFN-γ ...
• Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunity

  Paul T. Kennedy, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and supplemented with sCTLA-4 conditioned media or murine CTLA-4-Fc fusion protein (10 µg/mL, BioLegend). After 4 days ...
• Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

  Ameen A. Salahudeen, et al., bioRxiv - Cell Biology 2020

  Quote: ... Mouse anti-TNFRSF12A (clone ITEM-4, Biolegend) was utilized for (Fig ...
• Synergistic activity of Nanog, Pou5f3, and Sox19b establishes chromatin accessibility and developmental competence in a context-dependent manner

  Liyun Miao, et al., bioRxiv - Developmental Biology 2020

  Quote: ... 4 µg of anti-RNA polymerase II CTD repeat YSPTSPS antibody [8WG16] from Abcam (ab817) and 4 µg from BioLegend (664912) were used for each sample ...
• Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells

  Ofer Guttman, et al., bioRxiv - Cell Biology 2021

  Quote: ... and 10 ng/ml IL-4 (Biolegend) for 9 days ...
• Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection

  Matheswaran Kandasamy, et al., bioRxiv - Microbiology 2020

  Quote: ... anti-CD4 (2µg/ml, RM4-4; Biolegend), anti-CD3 (2µg/ml ...
• High Frequencies of PD-1⁺TIM3⁺TIGIT⁺CTLA4⁺ Functionally Exhausted SARS-CoV-2-Specific CD4⁺ and CD8⁺ T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

  Pierre-Gregoire Coulon, et al., bioRxiv - Immunology 2022

  Quote: ... anti-CTLA-4 (APC, clone BNI3 – BioLegend), anti-CD138 (APC-Cy-7 ...
• Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial Infection

  Ellyse M. Cipolla, et al., bioRxiv - Immunology 2022

  Quote: ... Cd11a (M17/4,BioLegend, San Diego, CA), Cd127 (SB/199,Invitrogen-ThermoFisher Scientific ...
• Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells

  Deli Huang, et al., bioRxiv - Immunology 2020

  Quote: ... IL-4 at 50ng/ml(Biolegend, #574306), anti-CD40 at 5 μg/ml (Thermo ...
• Programming the lymph node immune response with Amphiphile-CpG induces potent cellular and humoral immunity following COVID-19 subunit vaccination in mice and non-human primates

  Lochana M. Seenappa, et al., bioRxiv - Immunology 2022

  Quote: ... IL-4 (PE, clone: 8D4-8, BioLegend), TNFα (BV605 ...
• Differential Nr4a1 and Nr4a3 expression discriminates tonic from activated TCR signalling events in vivo

  Emma Jennings, et al., bioRxiv - Immunology 2020

  Quote: ... TCRVβ5.1/5.2 APC (Clone MR9-4, BioLegend), B220 PerCPcy5.5 (Clone RA3-6B2 ...
• Coordinated changes in glycosylation regulate the germinal centre through CD22

  Jhon R. Enterina, et al., bioRxiv - Immunology 2021

  Quote: ... Mouse IL-4 (1 ng/mL; BioLegend) was added to primary co-culture for 4 days ...
• Acute lymph node slices are a functional model system to study immunity ex vivo

  Maura C. Belanger, et al., bioRxiv - Immunology 2020

  Quote: ... ELISA MAX detection anti-IL-4 (Biolegend), or detection TNFα (R&D Systems ...
• Antigen and Checkpoint Receptor Recalibration of T Cell Receptor Signal Strength

  Thomas A.E. Elliot, et al., bioRxiv - Immunology 2021

  Quote: ... CTLA-4 PE (clone UC10-4B9, BioLegend), OX40 APC (clone OX-86 ...
• The PD-1 checkpoint receptor maintains tolerance of self-reactive CD8 T cell in skin

  Martina Damo, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (clone GK1.5 or RM4-4, BioLegend), CD44 (clone IM7 ...
• The dietary fiber guar gum ameliorates experimental autoimmune encephalomyelitis via attenuated Th1 activation and differentiation

  Naomi M Fettig, et al., bioRxiv - Immunology 2022

  Quote: ... and 4 ng/mL TGF-β (Biolegend) for mixed Th1/Th17 skewing conditions ...
• MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

  Em P Harrington, et al., bioRxiv - Neuroscience 2022

  Quote: ... 20 ug/mL anti-IL-4 (BioLegend), 20 ug/mL anti-IFN-γ (BioLegend) ...
• Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy

  Raphael S. Peres, et al., bioRxiv - Immunology 2022

  Quote: ... CTLA-4 BV605 (clone UC10-4B9, BioLegend). Dead cells were excluded using efluor-780 fixable-viability dye (eBioscience) ...
• STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria

  Yulin Wang, et al., bioRxiv - Immunology 2022

  Quote: ... and 4 μg/ml CD49b PeCy7 (BioLegend) in 30 μl PBS for 30 minutes at 37°C ...
• Multi-omic QTL mapping in early developmental tissues reveals phenotypic and temporal complexity of regulatory variants underlying GWAS loci

  Timothy D. Arthur, et al., bioRxiv - Genomics 2024

  Quote: ... and SSEA-4 (PE anti-human, Biolegend). Pluripotency was also examined using PluriTest-RNAseq47.
• A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster Model

  Swayam Prakash, et al., bioRxiv - Immunology 2024

  Quote: ... anti-CTLA-4 (APC, clone BNI3 – BioLegend), anti-CD137 (APC-Cy-7 ...
• Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

  E. Nicholas Petersen, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4 ug/mL apolipoprotein E3 (BioLegend, USA) was mixed with fresh 10% FBS and applied to the cells for 1hr prior to shear and or fixing.