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101 - 150 of 2015 citations for 2 Chloro 3 4 cyanobenzoyl pyridine since 2020

• Depletion of CD206⁺ Tumour Macrophages via a Peptide-Targeted Star-Shaped Polyglutamate Inhibits Tumourigenesis and Metastatic Dissemination in Breast Cancer Models

  Anni Lepland, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 50 μL of interleukin-4 (IL-4, 50 ng/mL, BioLegend, cat. 574002) and M-CSF (100 ng/mL ...
• BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity

  Taylor L. Hickman, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and TIM-3 (F38-2E2) (Biolegend) were used to evaluate T cell phenotype ...
• Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease

  Scott A. Scarneo, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... 3:20,000 anti-CD28 (BioLegend 302913), and 1:10,000 (30 IU/mL ...
• Probiotic-guided CAR-T cells for universal solid tumor targeting

  Rosa L. Vincent, et al., bioRxiv - Bioengineering 2021

  Quote: ... LAG-3 BV421 (Biolegend clone 11C3C65), PD-1 PE-Cy7 (Biolegend clone EH12.2H7).
• A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses

  Huan Du, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-Galectin-3 (BioLegend, 126702), goat anti-Galectin-3 (R&D Systems ...
• Role of T cells in intrauterine administration of activated peripheral blood mononuclear cells in recurrent implantation failure

  Guillaume Ricaud, et al., bioRxiv - Immunology 2021

  Quote: ... anti-GATA-3/BV421 (Biolegend, USA), anti-IL-4/BV510 (Biolegend ...
• Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

  Tomokazu S. Sumida, et al., bioRxiv - Immunology 2020

  Quote: ... anti-Tim-3 (F38-2E2, Biolegend), anti-IFN-γ (4S.B3 ...
• Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation

  Scott McComb, et al., bioRxiv - Immunology 2021

  Quote: ... OKT-3 stock (BioLegend Inc, USA) was diluted to 50mg/ul ...
• Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

  Robert Parker, et al., bioRxiv - Immunology 2020

  Quote: ... and CD11c (S-HCL-3, Biolegend) for 20 minutes at room temperature ...
• Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche

  Aidan E. Gilchrist, Brendan A.C. Harley, bioRxiv - Bioengineering 2020

  Quote: ... recombinant murine MMP-3 (#552704, BioLegend), recombinant murine c-RP (#50409-M08H ...
• Cell-Intrinsic and Extrinsic Effects of Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia

  Fei Fei, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Galectin-3 (Biolegend, San Diego, USA), phospho-ERK1/2 ...
• Machine learning analysis of the T cell receptor repertoire identifies sequence features that predict self-reactivity

  Johannes Textor, et al., bioRxiv - Immunology 2023

  Quote: ... 20 ng/mL IL-3 (Biolegend), 50 ng/mL IL-6 (Biolegend) ...
• The OSUMMER lines: a series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6

  Brandon M. Murphy, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Lag-3 (Biolegend #C9B7W; 1:250), CD3 (BD Biosciences #145-2C11 ...
• Emergence and suppressive function of Tr1 cells in glomerulonephritis

  Shiwa Soukou-Wargalla, et al., bioRxiv - Immunology 2023

  Quote: ... CD366 (TIM-3) (BV 421, BioLegend, clone RMT3-23 ...
• Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice

  Tuancheng Feng, Huan Du, Fenghua Hu, bioRxiv - Neuroscience 2023

  Quote: ... mouse anti-Galectin-3 (BioLegend, 126702), rabbit anti-TFE3 (Sigma ...
• The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate lysosomal stress responses

  Tomoya Eguchi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-galectin-3 [M3/38] (BioLegend), anti-α-tubulin [DM1A] (Sigma) ...
• Tumor suppressor p53 deficiency increases tumor immunogenicity through promoting IL33-mediated anti-tumor immune responses

  Yang Li, et al., bioRxiv - Immunology 2022

  Quote: ... Tim-3 (BioLegend, 119721, RMT3-23), LAG-3 (BioLegend ...
• Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

  Yaeko Nakajima-Takagi, et al., bioRxiv - Immunology 2022

  Quote: ... recombinant mouse IL-3 (575506; Biolegend), and recombinant murine GM-CSF (315-03 ...
• Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa

  Maria E. Mercau, et al., bioRxiv - Immunology 2022

  Quote: ... Galectin-3 (BioLegend clone M3/38), CD11c (BioLegend clone N418) ...
• Modulating the proliferative and cytotoxic properties of human TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

  Sharon Yunger, et al., bioRxiv - Immunology 2022

  Quote: ... FITC-LAG-3 (clone 11C3C65, BioLegend) APC-CD25 (clone BC96 ...
• Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy

  Raphael S. Peres, et al., bioRxiv - Immunology 2022

  Quote: ... LAG-3-PE (clone C9B7W, Biolegend), RORgT-BV421 (clone Q31-378 ...
• Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy

  Raphael S. Peres, et al., bioRxiv - Immunology 2022

  Quote: ... GATA-3-AF647 (clone 16E10A23, BioLegend), RORgT-PE (clone AFKJS-9 ...
• Tregs constrain CD8⁺ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

  Joseph R. Palmeri, et al., bioRxiv - Immunology 2023

  Quote: ... αTIM-3-BV785 (RMT3-23, Biolegend), αTCF1/TCF7-AF488 (C63D9 ...
• Dendritic cell targeting in lymph nodes with engineered modular adapters improves HAdV5 and HC-HAdV5 tumor vaccination by co-secretion of IL-2v and IL-21

  Fabian Weiss, et al., bioRxiv - Biochemistry 2024

  Quote: ... anti-muCD40 (BioLegend clone 3/23), anti-muDEC205 (BioLegend clone NLDC-145) ...
• Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors

  Eunkyu Sung, et al., bioRxiv - Cell Biology 2024

  Quote: ... 25 ng/ml IL-3 (BioLegend), 25 ng/ml IL-6 (BioLegend) ...
• Profound Treg perturbations correlate with COVID-19 severity

  Silvia Galván-Peña, et al., bioRxiv - Immunology 2020

  Quote: ... 10mM HEPES),and stained at 4°C for 25 minutes using the following cell surface antibodies: CD14 Pacific Blue (clone M5E2, BioLegend cat# 301815, 2:100 dilution); CD19 Pacific Blue (clone H1B19 ...
• Macrophages in the uterus are functionally specialised and continually replenished from the circulation

  Nicholas A. Scott, et al., bioRxiv - Immunology 2021

  Quote: ... Recombinant murine IL-4 (Biolegend) was combined with rat IgG1 mAb to IL-4 ...
• Protein-based RBD-C-tag COVID-19 Vaccination Candidate Elicits Protection Activity against SARS-COV-2 Variant Infection

  Jaganathan Subramani, et al., bioRxiv - Microbiology 2021

  Quote: ... IL-4 APC (Biolegend, #504106), IL-17 PECy7 (Biolegend ...
• Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

  Christopher A. Cottrell, et al., bioRxiv - Immunology 2020

  Quote: ... CD4 ([clone OKT-4] BioLegend), CD3 ([clone SP34-2] BD) ...
• Public and private human T cell clones respond differentially to HCMV antigen when boosted by CD3 co-potentiation

  Laura R.E. Becher, et al., bioRxiv - Immunology 2020

  Quote: ... anti-Vβ5 (BioLegend, MR9-4), and anti-Nur77 (Invitrogen ...
• Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease

  AM Schonhoff, et al., bioRxiv - Neuroscience 2022

  Quote: ... IL-4 (clone 11B11, BioLegend), IL-17a (clone eBiol7B7 ...
• The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

  Iosifina P. Foskolou, et al., bioRxiv - Immunology 2022

  Quote: ... CTLA-4 (UC10-4B9, Biolegend); FcR Block (120-000-826 ...
• Remodeling of Il4-Il13-Il5 locus underlies selective gene expression

  Hiroyuki Nagashima, et al., bioRxiv - Immunology 2022

  Quote: ... AF488-IL-4 (11B11, Biolegend), PerCP-eFluor710-IL-13 (eBio13A ...
• Tregs constrain CD8⁺ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

  Joseph R. Palmeri, et al., bioRxiv - Immunology 2023

  Quote: ... α4-1BB-APC (17B5, Biolegend), αCD107a-APC-Cy7 (1D4B ...
• MAIT cells have a negative impact on GBM

  Seketoulie Keretsu, et al., bioRxiv - Immunology 2024

  Quote: ... IL-4 (Biolegend cat #: 500818), and IL-17A (Biolegend cat # ...
• The EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8⁺ T-cell revitalization

  Andrea Gramatica, et al., bioRxiv - Immunology 2024

  Quote: ... CD137 (BV650, 4-1BB, Biolegend), CD8 (BV605 ...
• Adjuvant conditioning shapes the adaptive immune response and promotes trained immunotolerance via NLRP3/IL-1

  Thais Boccia, et al., bioRxiv - Immunology 2024

  Quote: ... IL-4 (clone: 11B11; BioLegend), IL-17A (clone ...
• Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

  Gabriela Pessenda, et al., bioRxiv - Immunology 2024

  Quote: ... TIM-4 (RMT4-54, Biolegend) 1:200 ...
• Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunity

  Liliane Khoryati, et al., bioRxiv - Immunology 2020

  Quote: ... IL-2 immune complex (IL-2ic; mouse recombinant IL-2 + anti-IL-2 (JES6-1A12, BioLegend); molar ratio 2:1 ...
• LRRK2-dependent Rab GTPase phosphorylation in response to endolysosomal damage depends on macrophage differentiation

  Susanne Herbst, Maximiliano G. Gutierrez, bioRxiv - Cell Biology 2020

  Quote: ... anti-Galectin-3-AF647 (125408) from BioLegend and anti-CHMP4B (13683-1-AP ...
• The RAG1 Ubiquitin Ligase Domain Enhances the Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity

  Thomas N. Burn, et al., bioRxiv - Immunology 2022

  Quote: ... and 3 μg/ml anti-CD28 (Biolegend) in RPMI with 10% FBS ...
• The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

  Katie J Smith, et al., bioRxiv - Immunology 2022

  Quote: ... and rTGFβ (3 ng/ml; Biolegend, #580706), with or without 2.5μM mCRAMP ...
• The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation

  Danielle Minns, et al., bioRxiv - Immunology 2020

  Quote: ... and rTGFβ (3 ng/ml; Biolegend, #580706), with or without 2.5 μM mCRAMP for 1 to 3 days ...
• Disruption of augmin-mediated microtubule nucleation in neural stem cells causes p53-dependent apoptosis and aborts brain development

  Ricardo Viais, et al., bioRxiv - Cell Biology 2020

  Quote: ... β3-tubulin (Biolegend #801201, dilution 1:1000), cleaved caspase-3 (Novus Biologicals #MAB835 ...
• Opposing roles of Granzymes A and B in the immune response to intestinal infection

  Maud Vandereyken, et al., bioRxiv - Immunology 2021

  Quote: ... [clone 1D4B (BioLegend)] and CD107b (Mac-3) [clone M384 (BioLegend)].
• Novel populations of Tr1 cells contribute to the resolution of acute influenza A virus infection

  Caitlin A Abbott, et al., bioRxiv - Immunology 2022

  Quote: ... and anti-mouse LAG-3 (C9B7W, Biolegend), which were stained for 60 min at 37°C as previously described (Gagliani et al. ...
• Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

  Isaac Dean, et al., bioRxiv - Immunology 2023

  Quote: ... IgG2b BV605 or R718 (R12-3, BioLegend), IL-7Rα BV605 or BV421 (AFR34 ...
• Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations

  Aisha Souquette, et al., bioRxiv - Immunology 2023

  Quote: ... Panel 3) CD3-AF700 (Biolegend Cat. 300323), CD4-APC Fire750 (Biolegend Cat ...
• Modulating the proliferative and cytotoxic properties of human TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

  Sharon Yunger, et al., bioRxiv - Immunology 2022

  Quote: ... FITC-TIM-3 (clone F38-2E2, BioLegend), FITC-LAG-3 (clone 11C3C65 ...
• The transcription factor IRF-5 is essential for the metabolic rewiring of CD8 T cells during chronic infection

  Linh Thuy Mai, et al., bioRxiv - Immunology 2024

  Quote: ... anti TIM-3-BV605 (RMT3-23, Biolegend), anti CD44-PE-Cy7 (IM7 ...