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1701 - 1750 of 9012 citations for 6H Pyrazolo 3 4 b pyridin 6 one 3 cyclobutyl 1 2 4 5 tetrahydro 4 methyl 9CI since 2019

• Programming the lymph node immune response with Amphiphile-CpG induces potent cellular and humoral immunity following COVID-19 subunit vaccination in mice and non-human primates

  Lochana M. Seenappa, et al., bioRxiv - Immunology 2022

  Quote: ... and further stained with anti-human Bcl-6 (PE, clone: 7D1, BioLegend) and anti-human Ki-67 (BV421 ...
• Deletion of the AMPylase mFICD alters cytokine secretion and affects cognitive plasticity in vivo

  Nicholas McCaul, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Il-6 and IL-1β levels were quantified by ELISA (Biolegend kits).
• IL-27R signaling serves as immunological checkpoint for NK cells to promote hepatocellular carcinoma

  Turan Aghayev, et al., bioRxiv - Immunology 2020

  Quote: ... H-2Kb/H-2Db-APC/Fire 750 (28-8-6; BioLegend, 114617), Streptavidin-APC/Cy7 (BioLegend ...
• Tumor-educated Gr1⁺CD11b⁺ cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6–JAK signaling

  Sanam Peyvandi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... recombinant mouse Oncostatin M and IL-6 (Biolegend, Cat #: 762802 & 575702 respectively).
• Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations

  Jessica Brown, et al., bioRxiv - Neuroscience 2023

  Quote: ... Four μg of Tau12 (N-terminal [epitope = amino acids 6-18], BioLegend), HT7 (mid-region [epitope = amino acids 159-163] ...
• Setdb1-loss induces type-I interferons and immune clearance of melanoma

  Meaghan K. McGeary, et al., bioRxiv - Cancer Biology 2023

  Quote: ... stained with antibodies to MHC-I (H2dB/H2kB; 28-8-6; Biolegend) and/or ab573(Evans et al. ...
• Co-engagement of TIGIT⁺ immune cells to PD-L1⁺ tumours by a bispecific antibody potentiates T-cell response and tumour control

  Xiaopei Cui, et al., bioRxiv - Immunology 2023

  Quote: ... then washed 6 times followed by incubating with TMB substrate (Biolegend/421101) and stop solution ...
• Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis in rabbit

  Nobuyuki Oguri, et al., bioRxiv - Pathology 2023

  Quote: ... and CD66b (mouse monoclonal, clone 6/40c; BioLegend, San Diego, CA, USA). Next ...
• Neutrophil subsets play dual roles in tuberculosis by producing inflammasome dependent-IL-1β or suppressing T-cells via PD-L1

  Emilie Doz-Deblauwe, et al., bioRxiv - Immunology 2023

  Quote: ... C57BL/6 mice received 200 μg anti-Ly6G antibody (clone 1A8, Biolegend) via the i.p ...
• Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

  Jiaqing Hao, et al., bioRxiv - Cancer Biology 2024

  Quote: ... The intracellular cytokines staining with anti-mouse IL-6 (Cat. #504508, Biolegend) and anti-mouse TNFα (Cat ...
• γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

  Natasja L. de Vries, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Granzyme B and perforin were detected intracellularly using Fixation Buffer and Intracellular Staining Permeabilization Wash Buffer (BioLegend). Compensation was carried out with CompBeads (BD Biosciences ...
• Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2

  Takahiro Kageyama, et al., bioRxiv - Immunology 2021

  Quote: PBMCs were first stained with either Zombie Green (for T cell and B cell staining panel) (Biolegend) or Zombie NIR (for monocyte staining panel ...
• DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells

  Yale S. Michaels, et al., bioRxiv - Bioengineering 2021

  Quote: ... Cells were stained with 0.1ug TotalSeq-B anti-human Hashtag antibody (Biolegend, 394633, 394635, 394637 or 394639) per sample diluted in 100uL HF buffer for 30 minutes on ice ...
• SILAC phosphoproteomics reveals unique signaling circuits in CAR-T cells and the inhibition of B cell-activating phosphorylation in target cells

  Alijah A. Griffith, et al., bioRxiv - Cell Biology 2021

  Quote: ... Raji B cells were stained for CD19 with PE anti-human CD19 antibody (Biolegend, #392506, clone 4G7) and the top 3% highest CD19-expressing cells (Raji B cells ...
• Transcription factor TFII-I fine tunes innate properties of B lymphocytes

  Amit Singh, et al., bioRxiv - Immunology 2022

  Quote: ... B cells were stained with anti CD21-FITC and anti CD23-PE antibodies (Biolegend, San Diego, CA) and sorted at the BD FACS-Aria Fusion ...
• AhR-mediated activation of innate lymphocytes restrains tissue-resident memory-like CD8+ T cell responses during contact hypersensitivity

  S. Romero-Suárez, et al., bioRxiv - Immunology 2022

  Quote: ... and then incubated with a mixture of fluorophore-conjugated and TotalSeq™-B oligo-conjugated antibodies (Biolegend). After washing ...
• Mild/Asymptomatic Maternal SARS-CoV-2 Infection Leads to Immune Paralysis in Fetal Circulation and Immune Dysregulation in Fetal-Placental Tissues

  Brianna M. Doratt, et al., bioRxiv - Immunology 2023

  Quote: ... Samples were then washed twice and incubated with individual TotalSeq B antibodies (HTO) (BioLegend, San Diego, California) per manufacturer’s instructions ...
• ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion

  Demis Menolfi, et al., bioRxiv - Genetics 2023

  Quote: ... splenic B cells were collected and stained with FITC anti-mouse/human GL7 (Biolegend, Cat. No. 144604) and PE hamster anti-mouse CD95 (BD ...
• Fibroblast activation protein regulates natural killer cell migration, extravasation and tumor infiltration

  Allison A. Fitzgerald, et al., bioRxiv - Immunology 2023

  Quote: ... B cells and monocytes were isolated from PBMCs (AllCells) using Mojosort magnetic cell separation system from Biolegend via CD3 positivity (Biolegend ...
• Tissue environment, not ontogeny, defines intestinal intraepithelial T lymphocytes

  Alejandro Brenes, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 [clone RM4-5 (BioLegend)] ...
• A third vaccination with a single T cell epitope protects against SARS-CoV-2 infection in the absence of neutralizing antibodies

  Iris N. Pardieck, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (clone RM4-5, BioLegend), CD8 (clone 53-6.7 ...
• IL-27 receptor signaling regulated stress myelopoiesis drives Abdominal Aortic Aneurysm development

  Iulia Peshkova, et al., bioRxiv - Immunology 2019

  Quote: ... CD4-Cy5PE (RM4-5; Biolegend), CD8a-Cy5PE (53-6.7 ...
• Comprehensive proteomics analyses identify PIM kinases as key regulators of IL-15 driven activation of intestinal intraepithelial lymphocytes

  Olivia J. James, et al., bioRxiv - Immunology 2020

  Quote: ... CD4 [clone RM4-5 (BioLegend)] ...
• Compartmentalization of intestinal bacteria by hepatic ILC3s prevents infections after surgery

  Manuel O. Jakob, et al., bioRxiv - Immunology 2019

  Quote: ... CD4-BV785 (RM4-5, Biolegend), CD62L BV510 (MEL-14) ...
• NLRP1B and NLRP3 control the host response following colonization with the commensal protist Tritrichomonas musculis

  Pailin Chiaranunt, et al., bioRxiv - Immunology 2021

  Quote: ... CD64 (X54-5/7.1; BioLegend), and MHCII (I-A/I-E ...
• Opposing roles of Granzymes A and B in the immune response to intestinal infection

  Maud Vandereyken, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 [clone RM4-5 (BioLegend)] ...
• IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

  Dennis Das Gupta, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-CD2 (RM2-5, Biolegend), anti-CXCR4 (L276F12 ...
• IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

  Dennis Das Gupta, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-CD43 (RM2-5, Biolegend), anti-CD24 (M1/69 ...
• Single-cell transcriptomic profile reveals macrophage heterogeneity in medulloblastoma and their treatment-dependent recruitment

  Mai T. Dang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... CD11b (BioLegend, clone CBRM1/5), Ly6C (BioLegend ...
• Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

  Valentina Stolz, et al., bioRxiv - Immunology 2022

  Quote: ... CD4 (clone: RM4-5, Biolegend), CD44 (clone ...
• Streptococcus pneumoniae rapidly translocates from the nasopharynx through the cribriform plate to invade and inflame the dura

  Teerawit Audshasai, et al., bioRxiv - Microbiology 2021

  Quote: ... CD4 (clone RM4-5, Biolegend), CD11b (clone M1/70 ...
• TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

  Benjamin H Gern, et al., bioRxiv - Immunology 2019

  Quote: ... CD4 (clone RM4-5; BioLegend), CD8a (clone 53-6.7 ...
• Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Immunity

  John P. Murad, et al., bioRxiv - Immunology 2020

  Quote: ... mCD4 (Biolegend, Clone: RM4-5), mCD137 (ThermoFisher ...
• IL-4-induced hysteresis in naïve T cell activation

  Alexandre P. Meli, et al., bioRxiv - Immunology 2020

  Quote: ... CD4 (clone RM4-5, Biolegend), CD4 (clone GK1.5 ...
• Protection induced by anti-PD-1 and anti-PD-L1 treatment in Leishmania amazonensis-infected BALB/c mice

  Alessandra M. da Fonseca-Martins, et al., bioRxiv - Immunology 2019

  Quote: ... Brefeldin (5 mg/ml, Biolegend) and PMA (phorbol 12-myristate 13-acetate ...
• IL-4-induced hysteresis in naïve T cell activation

  Alexandre P. Meli, et al., bioRxiv - Immunology 2020

  Quote: ... CD4 (clone RM4-5, Biolegend), B220 (clone RA3-6B2 ...
• KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance

  Anastasia-Maria Zavitsanou, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CD64 (X54-5/7.1, Biolegend), CD80 (16-10A1 ...
• Expression of Tim-3 drives naïve Treg to an effector-like state with enhanced suppressive activity

  Hridesh Banerjee, et al., bioRxiv - Immunology 2020

  Quote: ... GARP clone F011-5 (BioLegend). CellTrace Violet was from Invitrogen.
• Bifurcated monocyte states are predictive of mortality in severe COVID-19

  Anthony R. Cillo, et al., bioRxiv - Immunology 2021

  Quote: ... CD36::FITC (Biolegend, 5-271), CD3::Spark Blue 550 (Biolegend ...
• Influenza infection recruits distinct waves of regulatory T cells to the lung that limit lung resident IgA+ B cells

  Louisa E. Sjaastad, et al., bioRxiv - Immunology 2022

  Quote: ... CD4 (RM4-5, Biolegend 100559), CD8 (53-6.7 ...
• Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

  Jonathan D Teo, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-CD4 (RM4-5, Biolegend), anti-P2RY12 (S16007D ...
• Remodeling of Il4-Il13-Il5 locus underlies selective gene expression

  Hiroyuki Nagashima, et al., bioRxiv - Immunology 2022

  Quote: ... PE-IL-5 (TRFK5, Biolegend), PE-CF594-KLRG1 (2F1 ...
• Microbiota colonization tunes the antigen threshold of microbiota-specific T cell activation in the gut

  Daniel Hoces, et al., bioRxiv - Immunology 2022

  Quote: ... CD4-PerCP (RM4-5, BioLegend), CD62L-FITC (MEL-14 ...
• Dose range-finding toxicity study in rats with recombinant human lactoferrin produced in Komagataella phaffii

  Ross Peterson, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... CD11b (clone WT.5) (Biolegend), CD25 (clone OX-39 ...
• Dynamic fibroblast-immune interactions shape wound healing after brain injury

  Nathan A. Ewing-Crystal, et al., bioRxiv - Immunology 2024

  Quote: ... anti-CD4 (RM4-5, Biolegend 100557 ...
• Electrostatic-driven Interactions Enhance Intratumoral Retention and Antitumor Efficacy of Immune Checkpoint Blockade Antibodies

  Rashmi P Mohanty, et al., bioRxiv - Bioengineering 2023

  Quote: ... CD4 (RM4-5, #100511, BioLegend), CD8 (53-6.7 ...
• Type I IFN signaling mediates NET release to promote Mycobacterium tuberculosis replication and granuloma caseation

  Chanchal Sur Chowdhury, et al., bioRxiv - Microbiology 2022

  Quote: ... CD4 (clone RM4-5; BioLegend), TCRβ (clone H57-567 ...
• RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection

  Marissa Lindman, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (Biolegend, clone RM4-5), CD45.2 (Biolegend ...
• A role for BCL6 in maintaining CX3CR1⁺ CD4⁺ T cells during helminth infection

  Denis G. Loredan, et al., bioRxiv - Immunology 2023

  Quote: ... IL-5 APC (TRFK5, BioLegend), GATA3 PerCP-Cyanine5.5 (16E10A23 ...
• An exosome-based gene delivery platform for cell-specific CRISPR/Cas9 genome editing

  Sunil Dubey, et al., bioRxiv - Molecular Biology 2023

  Quote: ... CD4 (BV605, RM4-5, BioLegend), NK-1.1 (Brilliant Violet 650 ...