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1551 - 1600 of 2743 citations for 2H Pyrazolo 4 3 c pyridine 3 chloro 4 5 6 7 tetrahydro since 2020

• RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection

  Marissa Lindman, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (Biolegend, clone RM4-5), CD45.2 (Biolegend ...
• A role for BCL6 in maintaining CX3CR1⁺ CD4⁺ T cells during helminth infection

  Denis G. Loredan, et al., bioRxiv - Immunology 2023

  Quote: ... IL-5 APC (TRFK5, BioLegend), GATA3 PerCP-Cyanine5.5 (16E10A23 ...
• Oncostatin M is a Master Regulator of an Inflammatory Network in Dnmt3a-Mutant Hematopoietic Stem Cells

  Logan S. Schwartz, et al., bioRxiv - Cell Biology 2023

  Quote: ... CD4 (BioLegend clone RM4-5), CD5 (BioLegend clone 53-7.3) ...
• Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

  Jonathan D Teo, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-CD4 (RM4-5, Biolegend), anti-P2RY12 (S16007D ...
• Remodeling of Il4-Il13-Il5 locus underlies selective gene expression

  Hiroyuki Nagashima, et al., bioRxiv - Immunology 2022

  Quote: ... PE-IL-5 (TRFK5, Biolegend), PE-CF594-KLRG1 (2F1 ...
• Microbiota colonization tunes the antigen threshold of microbiota-specific T cell activation in the gut

  Daniel Hoces, et al., bioRxiv - Immunology 2022

  Quote: ... CD4-PerCP (RM4-5, BioLegend), CD62L-FITC (MEL-14 ...
• Electrostatic-driven Interactions Enhance Intratumoral Retention and Antitumor Efficacy of Immune Checkpoint Blockade Antibodies

  Rashmi P Mohanty, et al., bioRxiv - Bioengineering 2023

  Quote: ... CD4 (RM4-5, #100511, BioLegend), CD8 (53-6.7 ...
• Dose range-finding toxicity study in rats with recombinant human lactoferrin produced in Komagataella phaffii

  Ross Peterson, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... CD11b (clone WT.5) (Biolegend), CD25 (clone OX-39 ...
• Dynamic fibroblast-immune interactions shape wound healing after brain injury

  Nathan A. Ewing-Crystal, et al., bioRxiv - Immunology 2024

  Quote: ... anti-CD4 (RM4-5, Biolegend 100557 ...
• Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitis

  Marisol Alvarez-Martinez, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, BV785, Biolegend), TCR-β (H57-597 ...
• Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitis

  Marisol Alvarez-Martinez, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, BV785, Biolegend), TCR-β (H57-597 ...
• Influenza infection recruits distinct waves of regulatory T cells to the lung that limit lung resident IgA+ B cells

  Louisa E. Sjaastad, et al., bioRxiv - Immunology 2022

  Quote: ... CD4 (RM4-5, Biolegend 100559), CD8 (53-6.7 ...
• Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

  Jiang Li, et al., bioRxiv - Immunology 2023

  Quote: ... CD64 (X54-5/7.1, Biolegend), RELMα (DS8RELM ...
• Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis

  Julia Sbierski-Kind, et al., bioRxiv - Immunology 2023

  Quote: ... anti-CD4 (RM4-5, Biolegend), anti-CD8 (53-6.7 Biolegend) ...
• Attenuated Mycobacterium tuberculosis Vaccine Protection in a Low Dose Murine Challenge Model

  Samuel J. Vidal, et al., bioRxiv - Microbiology 2023

  Quote: ... CD4 (clone RM4-5, BioLegend), CD8a (clone 53-6.7 ...
• Lung Microbiome Intervention Attenuates Herpesvirus-Induced Post-HCT Pulmonary Fibrosis Through PD-L1 Upregulation on Dendritic Cells

  Joshua B. Perkins, et al., bioRxiv - Immunology 2024

  Quote: ... CD64 (X54-5/7.1, BioLegend), CD24 (M1/69 ...
• Polyphosphate mobilization influences the ability of Cryptococcus neoformans to cause disease in a murine model of cryptococcosis

  Kabir Bhalla, et al., bioRxiv - Microbiology 2024

  Quote: ... CD4 (RM4-5) from BioLegend; NK1.1 (PK136) ...
• Astrocytic RIPK3 exerts protective anti-inflammatory activity during viral encephalitis via induction of serpin protease inhibitors

  Marissa Lindman, et al., bioRxiv - Immunology 2024

  Quote: ... CD4 (Biolegend, clone RM4–5), CD45.2 (Biolegend ...
• Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19

  Candice N. Baker, et al., bioRxiv - Immunology 2024

  Quote: ... CD64 (X54-5/7.1) (Biolegend); CD335 (29A1.4) ...
• Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

  Gabriela Pessenda, et al., bioRxiv - Immunology 2024

  Quote: ... CD64 (X54-5/7.1, Biolegend) 1:200 ...
• 4-week GLP immunotoxicity assessment of lactoferrin alpha produced by Komagataella phaffii in Sprague Dawley rats

  Ross Peterson, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... CD11b (clone WT.5) (Biolegend), CD25 (clone OX-39 ...
• Crosstalk between the RNA-binding proteins Regnase-1 and -3 shapes mast cell survival and cytokine expression

  Marian Bataclan, et al., bioRxiv - Immunology 2024

  Quote: ... were isolated ex vivo from mouse peritoneal cavity by intraperitoneal lavage followed by magnetic bead-based enrichment for c-Kit+ cells using anti-CD117 (c-Kit)-APC antibody (Biolegend) and APC microbeads (Miltenyi Biotec) ...
• Mouse Memory CD8 T cell subsets defined by Tissue Resident Memory (T_RM) Integrin Expression Exhibit Distinct Metabolic Profiles

  Mike Sportiello, et al., bioRxiv - Immunology 2023

  Quote: ... and plated in TRM-like culture media with 10 ng/mL mouse IL-7 (Biolegend Catalog No. 577804) and 10 ng/mL human TGFβ1 (Fisher Scientific PHG9214 ...
• TESOGENASE, An Engineered Nuclease Editor for Enhanced Targeted Genome Integration

  Hangu Nam, et al., bioRxiv - Bioengineering 2023

  Quote: ... resuspended in fluorescence-activated cell sorting (FACS) buffer (2% BSA in PBS) and stained with 7-AAD (BioLegend) as a dye for cell viability assay ...
• A Gallium-68-Labeled Peptide Radiotracer For CD38-Targeted Imaging In Multiple Myeloma With PET

  Ajay Kumar Sharma, et al., bioRxiv - Cancer Biology 2023

  Quote: ... cells (1x106) were stained with PE-labelled anti-human CD38 monoclonal antibody (clone HB-7, BioLegend Cat # 356604) in FACS buffer (0.5% FBS with 2 mM EDTA ...
• Circular single-stranded DNA is a superior homology-directed repair donor template for efficient genome engineering

  Keqiang Xie, et al., bioRxiv - Bioengineering 2022

  Quote: ... resuspended in fluorescence-activated cell sorting (FACS) buffer (2% FBS in PBS) and stained with 7-AAD (BioLegend), and the indicated cell-surface marker ...
• Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein

  Darko Bosnakovski, et al., bioRxiv - Molecular Biology 2023

  Quote: Cells were trypsinized and stained with Annexin V and 7-AAD using APC Annexin V staining kit (BioLegend) according to the manufacturer’s instructions ...
• ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma

  Yuting Lu, et al., bioRxiv - Cancer Biology 2024

  Quote: ... This was centrifuged again (300xg for 7 minutes) and resuspended in 1X red blood cell lysis buffer (BioLegend) in deionized water ...
• Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia

  Shellaina J. V. Gordon, et al., bioRxiv - Cancer Biology 2024

  Quote: ... After 7-days treatment cells were stained with anti-CD11b antibody (Clone M1/70, Biolegend, Cat. 101212, RRID:AB_312794) and DAPI before analysis by flow cytometry ...
• Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling

  Bhavana Palakurthi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and BV510 anti-mouse c-KIT (BioLegend,105839); T cell specific markers used were BV 421 PD-1 (BioLegend,135217) ...
• Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins

  Fengwen Zhang, et al., bioRxiv - Microbiology 2022

  Quote: ... C antibody conjugated to AF647 (W6/32, Biolegend). In some experiments ...
• The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression

  Katharina Hutter, et al., bioRxiv - Immunology 2022

  Quote: ... anti-c-Kit-APC (BioLegend; 135108, 1 : 300), anti-CD1d-PE (Thermo Fisher Scientific ...
• Transient delivery of A-C/EBP protein perturbs differentiation of 3T3-L1 cells and induces preadipocyte marker genes

  Nishtha Sharma, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Anti-C/EBPβ antibody (Biolegend, Cat. no. 606202) was used at 1:2000 dilution for overnight at 4°C ...
• Proteomic and functional analyses of the periodic membrane skeleton in neurons

  Ruobo Zhou, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-Myh10 (C-terminus) antibody (Biolegend, 909901), rabbit anti-GFP antibody (Thermo Fisher Scientific ...
• Effects of Post-Myocardial Infarction Heart Failure on the Bone Vascular Niche

  Jedrzej Hoffmann, et al., bioRxiv - Cell Biology 2020

  Quote: ... BV421- conjugated c-kit (105827, Biolegend, clone 2B8), PE-Cy7-conjugated Ly-6A (122513 ...
• Immunoprofiling reveals novel mast cell receptors and a continuous nature of human lung mast cell heterogeneity

  Elin Rönnberg, et al., bioRxiv - Immunology 2021

  Quote: ... CD66a/c/e-A488 (clone ASL-32, Biolegend), CD326-BV650 (Clone 9C4 ...
• EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

  Tanner J. DuCote, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and HLA-A,B,C-APC (BioLegend, #311410). Antibodies used for mouse studies ...
• Innate extracellular Hsp70 inflammatory properties are mediated by the interaction of Siglec-E and LOX-1 receptors

  Thiago J. Borges, et al., bioRxiv - Immunology 2023

  Quote: ... and mouse anti-c-Myc (clone 9E10, Biolegend) were used as 1:300 ...
• Interleukin-1α and Leukemia Inhibitory Factor Promote Extramedullary Hematopoiesis

  Derek A.G. Barisas, et al., bioRxiv - Immunology 2022

  Quote: ... and anti-c-Kit FITC (Biolegend, clone 2B8). Cells were then washed into holding buffer (0.04% BSA in PBS) ...
• Complement C5a receptor 1 blockade reverses cognitive deficits following cranial radiation therapy for brain cancer

  Robert P. Krattli, et al., bioRxiv - Neuroscience 2024

  Quote: ... PE anti-mouse Ly6-C (Biolegend, Cat. 128008), and APC anti-mouse CD88 (Biolegend ...
• Engineered 3D Hydrogel Matrices to Modulate Trophoblast Stem Cell-Derived Placental Organoid Phenotype

  Emily M. Slaby, et al., bioRxiv - Bioengineering 2024

  Quote: ... C antibody (BioLegend catalog #311404, clone W6/32), and APC anti-human EGFR antibody (BioLegend catalog #352906 ...
• Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4⁺ T-cells

  Alberto Herrera, et al., bioRxiv - Immunology 2024

  Quote: ... and HLA-A-B- C (W6/32, Biolegend) along with a fixable live/dead stain (Thermofisher ...
• Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane

  Einollah Sarikhani, et al., bioRxiv - Bioengineering 2024

  Quote: ... Mouse anti-Lamin A/C (1:400, Biolegend), and Rabbit anti-CHMP4B (1:100 ...
• SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant transformation

  Hülya F. Taner, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-Gr1 (Ly6g/c) (clone RB6-8C5, BioLegend), anti-Glut1 (clone EPR3915 ...
• Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism

  Hugo A. Penny, et al., bioRxiv - Immunology 2021

  Quote: ... with IL-6 (10ng/ml) (Peptrotech, USA) and BAFF (200ng/ml) (Biolegend, UK), supplemented with differing concentrations of leucine ...
• Metal-Organic Framework Encapsulated Whole-Cell Vaccines Enhance Humoral Immunity against Bacterial Infection

  Michael A. Luzuriaga, et al., bioRxiv - Immunology 2021

  Quote: ... The LEGENDplex™ Mouse Immunoglobulin Isotyping Panel (6-plex) was bought from BioLegend. Ultrapure water was obtained from an ELGA PURELAB flex 2 system with resistivity measured to at least 18.2 MΩ -cm.
• FACT subunit SUPT16H associates with BRD4 and contributes to silencing of antiviral interferon signaling

  Dawei Zhou, et al., bioRxiv - Molecular Biology 2021

  Quote: ... PE anti-human IFNγ and anti-IL-6 antibodies were purchased from BioLegend. Anti-flavivirus group antigen antibody that probes ZIKV E protein and anti-SARS-CoV-1/2 NP 1C7C7 antibody was purchased from Sigma-Aldrich ...
• Single cell analysis of endometriosis reveals a coordinated transcriptional program driving immunotolerance and angiogenesis across eutopic and ectopic tissues

  Yuliana Tan, et al., bioRxiv - Genomics 2021

  Quote: ... for hashing with TotalSeq-A anti-human Hashtag reagents (Supplementary Table 6, Biolegend) for 30 min at 4°C and following previously published protocol68 ...
• SIRPα sequesters SHP-2 to promote IL-4/13 signaling and alternative activation of macrophages

  Lei Shi, et al., bioRxiv - Immunology 2021

  Quote: ... rat anti-mouse IL-6 or rat anti-mouse Ly6G (all from Biolegend), followed by fluorescence-conjugated secondary antibodies ...
• Pathogen and human NDPK-proteins promote AML cell survival via monocyte NLRP3-inflammasome activation

  Sandro Trova, et al., bioRxiv - Microbiology 2023

  Quote: ... IL-1β and IL-6 were analyzed by ELISA MAX Deluxe Sets (Biolegend) according to manufacturer’s instruction.