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1451 - 1500 of 2743 citations for 2H Pyrazolo 4 3 c pyridine 3 chloro 4 5 6 7 tetrahydro since 2020

• Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

  Eswari Dodagatta-Marri, et al., bioRxiv - Cancer Biology 2020

  Quote: ... NKG2A/C/E APC (Biolegend 564383), Granzyme-B PE (eBioscience#12-8898-82) ...
• Low-Dose CDK4/6 Inhibitors Induce Presentation of Pathway Specific MHC ligands as Targets for Cancer Immunotherapy

  Angel Charles, et al., bioRxiv - Cancer Biology 2020

  Quote: ... C (clone W6/32) from Biolegend, FITC Anti-Human HLA-A2 from BD Biosciences ...
• Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart

  Panagiota Siatra, et al., bioRxiv - Cell Biology 2022

  Quote: ... c-Kit (Biolegend, Cat no. 105813), CD31 (Biolegend ...
• Promoter Choice: Who Should Drive the CAR in T Cells?

  Ali Hosseini Rad SM, et al., bioRxiv - Immunology 2020

  Quote: ... biotin anti-c-myc (Biolegend #908805). Mouse monoclonal β-actin primary antibody (Sigma-Aldrich #A2228 ...
• Hematopoietic stem cells are a reservoir for trained immunity in autoimmune disease

  Taylor S. Mills, et al., bioRxiv - Immunology 2022

  Quote: ... and c-Kit-APC/Cy7 (Biolegend), 50μg/mL Rat IgG (Sigma ...
• Simultaneous single cell measurements of intranuclear proteins and gene expression

  Hattie Chung, et al., bioRxiv - Genomics 2021

  Quote: ... c-Fos (BioLegend Poly6414, cat #641401), CD31 (eBioscience 390 ...
• Remodeling of Il4-Il13-Il5 locus underlies selective gene expression

  Hiroyuki Nagashima, et al., bioRxiv - Immunology 2022

  Quote: ... Biotin-Ly6G/C (RB6-8C5, Biolegend), Biotin-NK1.1 (PK136 ...
• A time and single-cell resolved model of hematopoiesis

  Iwo Kucinski, et al., bioRxiv - Cell Biology 2022

  Quote: ... c-Kit-APC/Cy7 (Biolegend 105826), Sca1-BV421 (Biolegend 108133 ...
• Dendritic cell-Natural Killer cell Crosstalk Modulates T cell activation in Response to Influenza A Viral Infection

  Abigail G. Harvey, et al., bioRxiv - Immunology 2022

  Quote: ... C (clone: W6/32; BioLegend®) antibodies ...
• Persister cancer cells are characterized by H4K20me3 heterochromatin that defines a low inflammatory profile

  Valentina Ramponi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... C antibody (1:100, Biolegend, #311404) for 40 minutes ...
• Genetic Mapping of Monocyte Fate Decisions Following Myocardial Infarction

  Andrew L Koenig, et al., bioRxiv - Immunology 2023

  Quote: ... c-Kit PerCP/Cy5.5 (BioLegend 135133), Il7ra PE/Cy7 (BioLegend 158209) ...
• Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

  Isaac Dean, et al., bioRxiv - Immunology 2023

  Quote: ... NKG2A/C/E BV421 (20d5, BioLegend), NKp46 BV650 or BV786 (29A1.4 ...
• Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

  Isaac Dean, et al., bioRxiv - Immunology 2023

  Quote: ... Granzyme C PE-Cy7 (SFC108, BioLegend), IFNγ BUV737 (XMG1.2 ...
• Eta-secretase-like processing of the amyloid precursor protein (APP) by RHBDL4

  Penalva Ylauna Christine Megane, et al., bioRxiv - Biochemistry 2023

  Quote: ... C1/6.1 (APP C-terminus, Biolegend) mouse-anti-myc (9B11 ...
• An “alert state” ribosome population acts as a master regulator of cytokine-mediated processes

  Anna Dopler, et al., bioRxiv - Immunology 2023

  Quote: ... C (clone W6/32, BioLegend 311432) and APC anti HLA-A2 (clone BB7.2 ...
• An “alert state” ribosome population acts as a master regulator of cytokine-mediated processes

  Anna Dopler, et al., bioRxiv - Immunology 2023

  Quote: ... C (clone W6/32, BioLegend 311432) and APC anti HLA-A2 (clone BB7.2 ...
• HIV-SEQ Reveals Global Host Gene Expression Differences Between HIV-Transcribing Cells from Viremic and Suppressed People with HIV

  Julie Frouard, et al., bioRxiv - Immunology 2024

  Quote: TotalSeq-C pooled antibody mix (Biolegend) was prepared so as to contain 0.4 μg of each antibody in a final volume of 100 μL/sample ...
• A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection

  Ningxin Kang, et al., bioRxiv - Immunology 2024

  Quote: ... TotalSeqTM-C oligonucleotide-conjugated antibodies (Biolegend) were also added at this step at 0.01mg/mL final concentration (one distinct antibody per sample) ...
• NF-kB c-Rel is dispensable for the development but is required for the cytotoxic function of NK cells

  Y Vicioso, et al., bioRxiv - Immunology 2021

  Quote: ... or from c-Relfl/fl and c-Relf/fNcr1Cre using MojoSort Magnetic Cell Separation (purchased from BioLegend). For anti-tumor cytotoxicity ...
• Resistance to vincristine in cancerous B-cells by disruption of p53-dependent mitotic surveillance

  Anne Bruun Rovsing, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and then washed and stained with PE-conjugated p53 antibody (Clone DO-7, BioLegend, Cat. 645805) 1:100 in 0.1% Triton X-100 0.5% BSA in PBS at room temperature for 30 min prior to a wash in 1% BSA in PBS ...
• Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits

  Gadisti Aisha Mohamed, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and PE/Cyanine 7 anti- mouse CD45 antibody (Biolegend, 103114, clone: 30-F11, 1:100 dilution) for 30 minutes on ice ...
• Integrated single cell analysis shows chronic alcohol drinking disrupts monocyte differentiation in the bone marrow niche

  Sloan A. Lewis, et al., bioRxiv - Immunology 2023

  Quote: ... and CD169 (Biolegend, 7-239. Stained cells were then fixed and permeabilized using Fixation buffer (BioLegend) and incubated overnight with a cocktail of intracellular antibodies – IL-6 (BD Biosciences ...
• Seminal plasma inhibits Chlamydia trachomatis infection in vitro, and may have consequences on mucosal immunity

  Louis Reot, et al., bioRxiv - Immunology 2023

  Quote: ... 24h and 48h using an apoptosis detection kit with PE-Annexin V and 7-AAD (Biolegend), according to the manufacturer instructions ...
• Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

  Sarah E Dremel, et al., bioRxiv - Microbiology 2023

  Quote: ... Cells were stained with Alexa Fluor 647 anti-mouse Thy-1.1 Antibody (BioLegend; clone OX-7) and enrichment was confirmed with CytoFlex S (Beckman Coulter) ...
• Spatio-temporal dynamics of the fibrotic niche in cardiac repair

  Andy Shing Fung Chan, et al., bioRxiv - Systems Biology 2024

  Quote: ... cells were washed with fresh medium with 0.1µg/mL recombinant human BMP-7 protein (Biolegend, 595601) or an equivalent amount of BSA ...
• Mapping the T cell repertoire to a complex gut bacterial community

  Kazuki Nagashima, et al., bioRxiv - Immunology 2022

  Quote: ... CD4 (RM4-5, BioLegend), CD3e (145-2C11 ...
• Disruption of Z-RNA–binding of ADAR1 induces Aicardi-Goutières syndrome–like encephalopathy in mice

  Taisuke Nakahama, et al., bioRxiv - Immunology 2020

  Quote: ... CD4 (RM4-5; BioLegend), CD8 (53-6.7 ...
• Metabolic regulation of ILC2 differentiation into ILC1-like cells during Mycobacterium tuberculosis infection

  Dan Corral, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (RM4-5, Biolegend), CD8a (53-6.7 ...
• 12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes

  Abhishek Kulkarni, et al., bioRxiv - Immunology 2021

  Quote: ... CD4 (RM4-5, Biolegend), CD80 (16-10A1 ...
• Phosphoproteomic analysis of the AKT signalling axis in cutaneous squamous carcinoma progression reveals novel therapeutic targets

  R Button, C Harwood, RFL O’Shaughnessy, bioRxiv - Cancer Biology 2022

  Quote: ... Keratin 5 (BioLegend Poly19055) (1:1,000 WB) ...
• Secreted Particle Information Transfer (SPIT) – A Cellular Platform for In Vivo Genetic Engineering

  Carsten T. Charlesworth, et al., bioRxiv - Synthetic Biology 2024

  Quote: ... CD4 (RM4-5; Biolegend), CD8 (54-6.7 ...
• IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling

  Holly Bachus, et al., bioRxiv - Immunology 2022

  Quote: ... IL-5 (TRFK5; BioLegend), IL-4 (11B11 ...
• Atheroprone shear stress stimulates noxious endothelial extracellular vesicle uptake by MCAM and PECAM-1 cell adhesion molecules

  Pierre-Michaël Coly, et al., bioRxiv - Cell Biology 2023

  Quote: ... α5 integrin (Biolegend, 921704), α6 integrin (Biolegend ...
• CD4 T cells and neutrophils contribute to epithelial-mesenchymal transition in breast cancer

  Amélien Sanlaville, et al., bioRxiv - Cancer Biology 2023

  Quote: ... CD4 (RM4-5; Biolegend), NKp46 (29A1.4 ...
• Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

  Jiang Li, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, Biolegend), CD206 (C068C2 ...
• Interferon-γ Elicits Pathological Hallmarks of ALS in Human Motor Neurons

  Changho Chun, et al., bioRxiv - Neuroscience 2023

  Quote: ... CD44 (C44Mab-5, BioLegend), and CD8 (SK1 ...
• A ketogenic diet reduces age-induced chronic neuroinflammation in mice

  Mitsunori Nomura, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, BioLegend), CD8 (53-6.7 ...
• Soquelitinib, A Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase (ITK), is Active in Several Murine Models of T Cell-Mediated Inflammatory Disease

  Lih-Yun Hsu, et al., bioRxiv - Immunology 2023

  Quote: ... CD4 (RM4-5, Biolegend), CD44 (IM7 ...
• Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity

  Maria Guillamot, et al., bioRxiv - Immunology 2024

  Quote: ... CD4 (Biolegend RM4/5), CD8 (Biolegend ...
• Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 responses

  Sonia Ndeupen, et al., bioRxiv - Immunology 2021

  Quote: ... PD-1 (29F.1A12) and Bcl-6 (K112-91) from BioLegend and BD Biosciences ...
• Autoimmunity increases susceptibility to and mortality from sepsis

  Isaac J. Jensen, et al., bioRxiv - Immunology 2021

  Quote: IL-6 and IL-10 ELISAs (ELISA MAX Deluxe Set, Biolegend) were performed according to the manufacturer’s instructions.
• Neuraminidase activity mediates IL-6 production through TLR4 and p38/ERK MAPK signaling in MRL/lpr mesangial cells

  Kamala P. Sundararaj, et al., bioRxiv - Cell Biology 2020

  Quote: ... ELISAs were used to measure IL-6 (Biolegend, San Diego, CA), GM-CSF (R&D systems ...
• Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells

  Nicholas J Maurice, et al., bioRxiv - Immunology 2021

  Quote: ... we used human RP10 media with combinations of rIL-6 (BioLegend), rIL-12 ...
• Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques

  Hyon-Xhi Tan, et al., bioRxiv - Immunology 2020

  Quote: ... and stained intracellularly with anti-BCL-6 Alexa647 (IG191E/A8; Biolegend). Non-human primate LN suspensions and PBMC were stained with the same protocol ...
• High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients

  Xiang Song, et al., bioRxiv - Immunology 2020

  Quote: ... interleukin (IL)-6 (10 ng/mL, Biolegend, San Diego, CA, USA), IL-1β (10 ng/mL ...
• A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic inflammation through 3D genome topology

  Aditi Chandra, et al., bioRxiv - Genomics 2022

  Quote: ... and 20 ng/mL of recombinant IL-6 (BioLegend, Cat# 575702) and 1 μg/mL of soluble anti-CD28 for 6 days at 37°C ...
• Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions

  Emanuele Lettera, et al., bioRxiv - Cell Biology 2023

  Quote: Mouse anti-human CD41/CD61-PC7 (Clone: A2A9/6; Biolegend, 359812), Verified Reactivity ...
• In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery

  Saijuan Xu, et al., bioRxiv - Bioengineering 2024

  Quote: ... was assessed utilizing the Mouse IL-6 ELISA Kit (BioLegend, 431307). IL1-β ...
• DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

  Jos Urbanus, et al., bioRxiv - Immunology 2022

  Quote: ... The c-kit+ fraction was stained with antibodies against CD117 (c-kit APC, clone 2B8, Biolegend, 1/100), Sca-1 (Pacific Blue ...
• Hierarchical chromatin regulation during blood formation uncovered by single-cell sortChIC

  Peter Zeller, et al., bioRxiv - Genomics 2021

  Quote: ... anti c-kit-APC (Biolegend, 1:800) and anti sca1-PeCy7 (Biolegend ...