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51 - 100 of 361 citations for 3 3 Bromomethyl phenyl thiophene since 2020

• LRRK2-dependent Rab GTPase phosphorylation in response to endolysosomal damage depends on macrophage differentiation

  Susanne Herbst, Maximiliano G. Gutierrez, bioRxiv - Cell Biology 2020

  Quote: ... anti-Galectin-3-AF647 (125408) from BioLegend and anti-CHMP4B (13683-1-AP ...
• The RAG1 Ubiquitin Ligase Domain Enhances the Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity

  Thomas N. Burn, et al., bioRxiv - Immunology 2022

  Quote: ... and 3 μg/ml anti-CD28 (Biolegend) in RPMI with 10% FBS ...
• The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

  Katie J Smith, et al., bioRxiv - Immunology 2022

  Quote: ... and rTGFβ (3 ng/ml; Biolegend, #580706), with or without 2.5μM mCRAMP ...
• The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation

  Danielle Minns, et al., bioRxiv - Immunology 2020

  Quote: ... and rTGFβ (3 ng/ml; Biolegend, #580706), with or without 2.5 μM mCRAMP for 1 to 3 days ...
• Disruption of augmin-mediated microtubule nucleation in neural stem cells causes p53-dependent apoptosis and aborts brain development

  Ricardo Viais, et al., bioRxiv - Cell Biology 2020

  Quote: ... β3-tubulin (Biolegend #801201, dilution 1:1000), cleaved caspase-3 (Novus Biologicals #MAB835 ...
• Opposing roles of Granzymes A and B in the immune response to intestinal infection

  Maud Vandereyken, et al., bioRxiv - Immunology 2021

  Quote: ... [clone 1D4B (BioLegend)] and CD107b (Mac-3) [clone M384 (BioLegend)].
• Novel populations of Tr1 cells contribute to the resolution of acute influenza A virus infection

  Caitlin A Abbott, et al., bioRxiv - Immunology 2022

  Quote: ... and anti-mouse LAG-3 (C9B7W, Biolegend), which were stained for 60 min at 37°C as previously described (Gagliani et al. ...
• Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

  Isaac Dean, et al., bioRxiv - Immunology 2023

  Quote: ... IgG2b BV605 or R718 (R12-3, BioLegend), IL-7Rα BV605 or BV421 (AFR34 ...
• Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations

  Aisha Souquette, et al., bioRxiv - Immunology 2023

  Quote: ... Panel 3) CD3-AF700 (Biolegend Cat. 300323), CD4-APC Fire750 (Biolegend Cat ...
• Modulating the proliferative and cytotoxic properties of human TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

  Sharon Yunger, et al., bioRxiv - Immunology 2022

  Quote: ... FITC-TIM-3 (clone F38-2E2, BioLegend), FITC-LAG-3 (clone 11C3C65 ...
• The transcription factor IRF-5 is essential for the metabolic rewiring of CD8 T cells during chronic infection

  Linh Thuy Mai, et al., bioRxiv - Immunology 2024

  Quote: ... anti TIM-3-BV605 (RMT3-23, Biolegend), anti CD44-PE-Cy7 (IM7 ...
• Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

  D Lara-Astiaso, et al., bioRxiv - Genomics 2022

  Quote: ... CD55 (PE-conjugated; clone RIKO-3; Biolegend), CD41 (APC-conjugated ...
• Proteostasis and lysosomal quality control deficits in Alzheimer’s disease neurons

  Ching-Chieh Chou, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-Galectin-3 (1:1000; Biolegend, 125401), anti-γ-H2AX (1:200 ...
• Novel inhibitors of acute, axonal DLK palmitoylation are neuroprotective and avoid the deleterious side effects of cell-wide DLK inhibition

  Xiaotian Zhang, et al., bioRxiv - Neuroscience 2024

  Quote: ... β3 tubulin (mouse, BioLegend, TUJ1, #MMS-435P), myc (rabbit ...
• Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

  Yijuan Zhang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... PE anti-mouse CD366 (Tim-3) (Biolegend), PE/Cy7 anti-mouse CD279 (PD-1 ...
• SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant transformation

  Hülya F. Taner, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-Tim-3 (clone RMT3-23, BioLegend), anti-TCRγ/δ (clone GL3 ...
• Enhanced anti-tumor activity by Zinc Finger Repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs

  Marion David, et al., bioRxiv - Cancer Biology 2024

  Quote: ... LAG-3 and TGFBR2 (Biolegend, Amsterdam, Netherlands). For TILs characterization ...
• Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

  Or-Yam Revach, et al., bioRxiv - Cancer Biology 2024

  Quote: ... T cells were activated for 3 days using 3 μg anti-human CD3 and CD28 antibodies (Biolegend, 300438, 377604) and 50 ng/mL of IL-2 (Peprotech ...
• Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

  Julia Kazmierski, et al., bioRxiv - Immunology 2022

  Quote: ... and anti-TIM-3/CD366-FITC (#345022; Biolegend). To determine ACE2 cell surface expression ...
• Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

  Yunlong Cao, et al., bioRxiv - Immunology 2021

  Quote: ... 3 μL PE/Cyanine7 anti-IgM(Biolegend, 314532), and fluorophore-labelled Receptor-Binding Domain (RBD ...
• Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

  Yunlong Cao, et al., bioRxiv - Immunology 2021

  Quote: ... 3 μL FITC anti-CD20 Antibody (Biolegend, 302304), 3.5 μL Brilliant Violet 421 anti-CD27 Antibody (Biolegend ...
• Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

  Yunlong Cao, et al., bioRxiv - Immunology 2021

  Quote: ... 3 μL FITC anti-CD19 Antibody (Biolegend, 392508), 3 μL FITC anti-CD20 Antibody (Biolegend ...
• In vivo analysis of Trypanosoma cruzi persistence foci at single cell resolution

  Alexander I. Ward, et al., bioRxiv - Microbiology 2020

  Quote: ... Antibodies against β-tubulin-3 (Biolegend, Cat#802001), CD45 (Tonbo Biosciences ...
• A P2rx7 passenger mutation affects the vitality and function of immune cells in P2X4ko and other transgenic mice

  Marco Er-Lukowiak, et al., bioRxiv - Immunology 2020

  Quote: ... and recombinant IL-3 (10 ng/ml, Biolegend). BMMCs were transferred into a new petri dish with new BMMC medium every 3-4 days ...
• Overcoming microenvironment-mediated chemoprotection through stromal galectin-3 inhibition in acute lymphoblastic leukemia

  Somayeh S. Tarighat, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and galectin-3 (#125402, Biolegend, San Diego, CA), were diluted 1:1000 or 1:2000 in 5% BSA and incubated for 1hour at room temperature ...
• Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

  D Lara-Astiaso, et al., bioRxiv - Genomics 2022

  Quote: ... and CD55 (PE-conjugated; clone RIKO-3; Biolegend). Percent Gran-like (CD11b-high/Gr-1+ ...
• Rewiring of the TCR signalosome in natural intestinal Intraepithelial T lymphocytes drives non-deletional tolerance

  Harriet J. Watt, et al., bioRxiv - Immunology 2023

  Quote: ... LAG-3-PE-Cy7 (1:200) (all Biolegend) and TCRβ-BV786 (1:200 ...
• Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity

  Julia Prigann, et al., bioRxiv - Microbiology 2023

  Quote: ... and anti-TIM-3/CD366-FITC (#345022; Biolegend). For intracellular immunostaining ...
• Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

  Niels Asger Jakobsen, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and propidium iodide (final concentration 3 μM; Biolegend) was used for dead cell exclusion ...
• Rapid activation of IL-2 receptor signaling by CD301b⁺ DC-derived IL-2 dictates the outcome of helper T cell differentiation

  Naoya Tatsumi, et al., bioRxiv - Immunology 2023

  Quote: ... and GATA-3 (16E10A23) were purchased from BioLegend. Anti-pSTAT5 (Tyr694 ...
• Therapy-induced senescence upregulates antigen presentation machinery and triggers anti-tumor immunity in Acute Myeloid Leukemia

  Diego Gilioli, et al., bioRxiv - Cancer Biology 2022

  Quote: ... CD223 (LAG-3) BV605 (cat#369324 from BioLegend), CD3 BUV737 (cat#565466 from BD) ...
• Therapy-induced senescence upregulates antigen presentation machinery and triggers anti-tumor immunity in Acute Myeloid Leukemia

  Diego Gilioli, et al., bioRxiv - Cancer Biology 2022

  Quote: ... CD366 (TIM-3) BV421 (cat#345008 from BioLegend), CD223 (LAG-3 ...
• TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene

  Evelyn Kabirova, et al., bioRxiv - Genetics 2022

  Quote: ... and mrIL-3 (10 ng/ml) (Biolegend, 575502). Mast cells were also stained by toluidine blue (Biovitrum ...
• NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

  Michael S. Dahabieh, et al., bioRxiv - Immunology 2024

  Quote: ... TIM-3 BV711 (#119727, Clone RMT3-23, Biolegend), PD-1 BUV737 (#749306 ...
• Increasing Signal Intensity of Fluorescent Oligo-Labeled Antibodies to Enable Combination Multiplexing

  Madeline E. McCarthy, et al., bioRxiv - Molecular Biology 2024

  Quote: ... (3) CD4 (clone RPA-T4; Biolegend Cat: 300502) labeled with Atto488/647 int ...
• HIV-1 controllers possess a unique CD8+ T-cell activation phenotype and loss of control is associated with increased expression of exhaustion markers

  Amber D Jones, et al., bioRxiv - Immunology 2024

  Quote: ... and/or anti-Tim-3 (CD366) antibody (BioLegend, UltraLEAF purified anti-human ...
• PD-1 blockade enhances HIV-1 vaccine-induced CD8⁺ T-cell responses in PWH early ART-treated

  Miguel Marin, et al., bioRxiv - Immunology 2024

  Quote: ... and TIM-3 (PE, clone F38-2E2, Biolegend) antibodies for 25 minutes ...
• Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment

  Jacob Gadwa, et al., bioRxiv - Immunology 2024

  Quote: ... GATA-3: Alexa Fluor 647 (Clone: 16E10A23, Biolegend). Samples were analyzed on a Cytek Aurora spectral cytometer (Cytek Biosciences) ...
• Dietary Protection Against the Visual and Motor Deficits Induced by Experimental Autoimmune Encephalomyelitis

  Katarzyna Zyla-Jackson, et al., bioRxiv - Immunology 2023

  Quote: ... we incubated sequential de-paraffinized sections with anti-2’,3’-cyclic-nucleotide 3’-phosphodiesterase (CNPase) (mouse CNPase: 1:200 dilution; Biolegend, Inc.), anti-CD3 (rabbit ...
• Natural killer-like B cells promote Th17 cell differentiation and exacerbate rheumatoid arthritis

  Ping Wang, et al., bioRxiv - Immunology 2021

  Quote: ... anti-CD28 and anti-CD40 (3 μg/mL, Biolegend) in a round-bottom 96-well plate ...
• High Frequencies of PD-1⁺TIM3⁺TIGIT⁺CTLA4⁺ Functionally Exhausted SARS-CoV-2-Specific CD4⁺ and CD8⁺ T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

  Pierre-Gregoire Coulon, et al., bioRxiv - Immunology 2022

  Quote: ... anti-TIM-3 (BV 711, clone F38-2E2 – BioLegend), anti-PD1 (PE-Cy7 ...
• Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

  Eugenia Zah, et al., bioRxiv - Bioengineering 2020

  Quote: ... LAG-3 (eBioscience #17-2239-42 or BioLegend #369314), CD8 (Miltenyi #130-113-164) ...
• SARS-CoV-2-associated ssRNAs activate inflammation and immunity via TLR7/8

  Valentina Salvi, et al., bioRxiv - Immunology 2021

  Quote: ... FITC-conjugated anti-mouse CD40 (clone HM40-3, Biolegend) and APC-CY7-conjugated anti-mouse CD86 (clone GL-1 ...
• Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular Damage

  Heather Branscome, et al., bioRxiv - Cell Biology 2021

  Quote: ... α-Tubulin β 3 (Tuj1; Biolegend MMS-435P; 1:200). The appropriate secondary antibody (Alexa Fluor 594 goat anti-rabbit ...
• Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

  Ning Yang, et al., bioRxiv - Microbiology 2021

  Quote: ... and stained with antibodies against CD40 (3/23, Biolegend) and CD86 (GL-1 ...
• STING suppresses cancer pain via immune and neuronal modulation

  Kaiyuan Wang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CD-3 APC/cy7 (1:200, rat, Biolegend, 100221), CD-4 APC (1:200 ...
• Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in lung adenocarcinoma

  Chun-Chun Cheng, et al., bioRxiv - Cancer Biology 2020

  Quote: ... with 3 μl of Annexin-V-APC (640941, BioLegend) and DAPI (200 ng/ml) ...
• Circulating levels of epirubicin cause endothelial senescence while compromising metabolic activity and vascular function

  Amanda J Eakin, et al., bioRxiv - Cell Biology 2020

  Quote: ... rat anti-mouse Mac-2 (Galectin-3, 125402, Biolegend) for myeloid cells (Ho and Springer 1982) ...
• Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

  Adriaan van der Graaf, et al., bioRxiv - Genetics 2020

  Quote: ... or IL-21 (3 ng/ml, Biolegend, cat 571204) (n=8 samples per condition ...
• MiR-324-5p regulates the structure of dendritic spines and is essential for hippocampal long-term potentiation

  Emma V Parkins, et al., bioRxiv - Neuroscience 2023

  Quote: ... Beta 3 tubulin rabbit polyclonal (BioLegend Cat# 802001, RRID:AB_2564645), Anti-PSD-95 MAGUK scaffold protein mouse monoclonal (Antibodies Incorporated Cat# 75-348 ...