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4651 - 4700 of 6398 citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Preserved striatal innervation and motor function despite severe loss of nigral dopamine neurons following mitochondrial dysfunction induced by mtDNA mutations

  Thomas Paß, et al., bioRxiv - Neuroscience 2023

  Quote: ... polyclonal α-GAPDH (1:1,000; Merck Millipore, AB2302), and polyclonal α-Parkin (1:2,000 ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... rabbit polyclonal anti-CaSR (SAB4503369, 1:100, Merck); mouse monoclonal anti-MAP2 (M1406 ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... mouse monoclonal anti-MAP2 (M1406, 1:100, Merck); Alexa 488 goat anti-mouse IgG (H+L ...
• USP7/Maged1-Mediated H2A Monoubiquitination in the Paraventricular Thalamus: An Epigenetic Mechanism Involved in Cocaine Use Disorder

  Julian Cheron, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-H2A (1/1000, Merck, 07-146), and rabbit anti-mono-ubiquitylated H2A (1:1000 ...
• Balance of AKT isoforms in intestinal barrier function. Implications for inflammatory bowel disease therapy

  Teresa García-Prieto, et al., bioRxiv - Immunology 2023

  Quote: ... and further incubated with DAPI (Merck, 1:7500). Finally ...
• Regulation potential of transcribed simple repeated sequences in developing neurons

  Tek Hong Chung, et al., bioRxiv - Genomics 2023

  Quote: ... and 1 µg/ml laminin (Merck, cat# L2020). Dox was omitted from the medium beginning from day 3 and half-medium changes were carried out twice a week until day 14.
• A Dual Color Pax7 and Myf5 In Vivo Reporter to Investigate Muscle Stem Cell Heterogeneity in Regeneration and Aging

  Sara Ancel, et al., bioRxiv - Cell Biology 2023

  Quote: ... or anti-MyHC (Merck, #05-716, 1/200) and then with appropriate secondary antibodies (Thermo Fisher Scientific ...
• Balance of AKT isoforms in intestinal barrier function. Implications for inflammatory bowel disease therapy

  Teresa García-Prieto, et al., bioRxiv - Immunology 2023

  Quote: ... with the exception that DAPI (Merck, 1:5000) was used instead of Hoechst ...
• A pre-vertebrate endodermal origin of calcitonin-producing neuroendocrine cells

  Jenaid M. Rees, et al., bioRxiv - Developmental Biology 2024

  Quote: ... rabbit anti-tyrosine hydroxylase (Merck, AB152; 1:250), rabbit-anti calcitonin (BMA Biomedicals ...
• Distributional coding of associative learning within projection-defined populations of midbrain dopamine neurons

  Riccardo Avvisati, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-Aldh1a1 (1:500, HPA002123, Sigma Merck). Sections were washed in PBS and then incubated for > 4 h at room temperature in PBS-Triton and secondary antibodies ...
• Microglial colonisation of the developing brain is facilitated by clonal expansion of highly proliferative progenitors and follows an allometric scaling

  Liam Barry-Carroll, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-Caspase3 (Merck Millipore; PC679; 1:50) or rabbit anti-Ki67 (Abcam ...
• Ageing impairs the neuro-vascular interface in the heart

  Julian U. G. Wagner, et al., bioRxiv - Physiology 2022

  Quote: ... Gt anti-Choline Acetyltransferase (1:100, AB144P, Merck), Gt anti-calcitonin gene-related peptide (1:100 ...
• Shared and host-specific transcriptomic response of Pseudomonas donghuensis P482 to the exudates of tomato (Dicot) and maize (Monocot) shed light on the host-adaptive traits in the promiscuous root colonizing bacteria

  Dorota M. Krzyżanowska, et al., bioRxiv - Microbiology 2022

  Quote: ... rifampicin (50 µg mL-1) (Sigma-Aldrich/Merck), ampicillin (50 µg mL-1 ...
• Cohesin is involved in transcriptional repression of stage-specific genes in the human malaria parasite

  Catarina Rosa, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and 1 U/μL of Benzonase (Merck 71206). The lysates were cleared by centrifugation at 16,000 g for 10 min at 4°C ...
• Phenotypic switch and reduced the growth of melanoma spheroids in the presence of mast cell-conditioned medium: potential impact of nutrient starvation effects

  Mirjana Grujic, et al., bioRxiv - Immunology 2022

  Quote: ... 1% sodium pyruvate (cat. #S8636-100ml, Merck KGaA) 1% MEM (cat ...
• Zinc-finger protein 518 plays a crucial role in pericentromeric heterochromatin formation by linking satellite DNA to heterochromatin

  Shinya Ohta, et al., bioRxiv - Cell Biology 2022

  Quote: ... mouse anti-HP1γ (1:1,000, #MAB3450, Merck Millipore), and mouse anti-GAPDH (1:10,000 ...
• Zinc supplementation induced transcriptional changes in primary human retinal pigment epithelium: a single-cell RNA sequencing study to understand age-related macular degeneration

  Eszter Emri, et al., bioRxiv - Cell Biology 2022

  Quote: ... and RPE65 (Merck Millipore, Darmstadt, Germany, 1:50), diluted in PBST containing 1% goat sera ...
• RNA dicing regulates the expression of an oncogenic JAK1 isoform

  Yuval Malka, et al., bioRxiv - Molecular Biology 2024

  Quote: ... JAK1 JH2 domain (Merck 05-1154, 1:500), Phospho-JAK1 (Cell signaling 3331 ...
• MDM2 acts as a timer reporting the length of mitosis

  Luke J. Fulcher, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1:250 Protease Inhibitor Cocktail (Merck #P8340-5ML), 1:1000 Phosphatase Inhibitor cocktail 3 (Merck #P0044-5ML) ...
• MDM2 acts as a timer reporting the length of mitosis

  Luke J. Fulcher, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1:250 Protease Inhibitor Cocktail (Merck #P8340-5ML), 1:1000 Phosphatase Inhibitor cocktail 3 (Merck #P0044-5ML) ...
• A combinatory genetic strategy for targeting neurogliaform neurons in the mouse basolateral amygdala

  Attila Ozsvár, et al., bioRxiv - Neuroscience 2024

  Quote: ... or Mouse Anti-Reln (1:1000, MAB5364, Merck) diluted in a solution containing ...
• mTOR controls growth and internal architecture of human breast cancer spheroids

  Katharina Hötte, et al., bioRxiv - Cell Biology 2024

  Quote: ... before incubation with 1 µg/ml DAPI (Merck) and secondary antibodies (anti-mouse AF568 ...
• Roles of TYRO3 Family Receptors in Germ Cell Development During Mouse Testis Formation

  Zhenhua Ming, et al., bioRxiv - Developmental Biology 2024

  Quote: ... anti-Laminin rabbit polyclonal (L9393, Merck, 1:200), anti-phospho-Histone H3 (Ser10 ...
• DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection

  Mélanie Messmer, et al., bioRxiv - Microbiology 2024

  Quote: ... 1 tablet of commercial protease inhibitor cocktail (Merck)) ...
• Treatment with furosemide indirectly increases inhibitory transmission in the developing hippocampus

  C. Peerboom, T. Wijne, C.J. Wierenga, bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-KCC2 (07-432, Merck, 1:1000) and s940-pKCC2 (p1551-940 ...
• Treatment with furosemide indirectly increases inhibitory transmission in the developing hippocampus

  C. Peerboom, T. Wijne, C.J. Wierenga, bioRxiv - Neuroscience 2023

  Quote: ... guinea pig anti-NeuN (ABN90, Merck, 1:1000), chicken anti-VGAT (131 006 ...
• Sperm induction of somatic cell-cell fusion as a novel functional test

  Nicolas G. Brukman, et al., bioRxiv - Developmental Biology 2023

  Quote: ... clone Mab120 (1:500, Cat# MABT1357; Merck Millipore) followed by the secondary antibody Alexa Fluor 647 goat anti-rat (1:500 ...
• HuD (ELAVL4) gain-of-function impairs neuromuscular junctions and induces apoptosis in in vitro and in vivo models of amyotrophic lateral sclerosis

  Beatrice Silvestri, et al., bioRxiv - Neuroscience 2024

  Quote: ... Anti-TUJ1 (1:1000; T2200, Merck Life Sciences) was diluted in the same solution and incubated for 1 h at RT ...
• Non-canonical contribution of human Dicer helicase domain in antiviral innate immune response

  Morgane Baldaccini, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-GFP (1:1000, 11814460001 Merck, Sigma Aldrich), anti-GAPDH-HRP (1:10000 ...
• Clock driven waves of Tbx6 expression prefigure somite boundaries

  Olivier F. Venzin, et al., bioRxiv - Developmental Biology 2023

  Quote: ... anti-YFP (Merck Millipore, MABE1906, 1:25 dilution), H2A.Z (Active Motif ...
• Cockayne syndrome patient iPSC-derived brain organoids and neurospheres show early transcriptional dysregulation of biological processes associated with brain development and metabolism

  Leon-Phillip Szepanowski, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit Nestin (1:1000, Merck Sigma-Aldrich #N5413), mouse anti-MAP2 (Synaptic Systems ...
• Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model

  Behzad Yaghmaeian Salmani, et al., bioRxiv - Neuroscience 2023

  Quote: ... Nuclei were stained with DAPI (1:200, Merck) 5 min before sorting and preserved in 2% BSA until downstream procedures.
• Lowering mutant huntingtin by small molecules relieves Huntington’s disease symptoms and progression

  Anat Bahat, et al., bioRxiv - Molecular Biology 2023

  Quote: ... anti-PolyQ clone MW1 (1:1000; MABN2427, Merck) and anti-eIF4G1 for human samples (1:2000 ...
• Identification of SIRT4 as a novel paralog-specific interactor and candidate suppressor of C-RAF kinase in MAPK signaling

  Mehrnaz Mehrabipour, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-Vinculin (1:1000; #V9131, Merck, Darmstadt, Germany); anti-SIRT4 (1:1000 ...
• Deletion of FAT1 in hybrid EMT cells stimulates the migration of neighboring non-mutant cells through secretion of extracellular vesicles

  Juliana Geay, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-FAT1 (1:500, MABC612, mouse monoclonal, Merck). Secondary antibodies used were HRP donkey anti-rabbit and goat anti-mouse (both 1:1000 ...
• Leishmania Ribosomal Protein (RP) paralogous genes compensate each other’s expression maintaining protein native levels

  Francisca S. Borges, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and α -EF1α: (1:80,000, Merck 05-235). Both primary antibodies were diluted in solution of TBS-T with 2.5% powdered milk and incubated for 1 h at RT ...
• Reversal of pathologic changes in fibroblasts from Niemann-Pick type C disease patients by inhibition of bromodomain and extraterminal proteins

  Martina Parente, et al., bioRxiv - Cell Biology 2023

  Quote: ... and 1% penicillin-streptomycin (all Sigma-Aldrich/Merck) at 37°C and 5% CO2 ...
• Simulated digestion, uptake and colonic fermentation of Gorse (Ulex europeaus) suggests safe use as a source of protein concentrates and bioactives

  Ajay Iyer, et al., bioRxiv - Biochemistry 2023

  Quote: ... and pancreatin (0.08 g·mL−1; Merck, Darmstadt, Germany) were prepared using the stock salivary ...
• Development of a generalisable tryptophan-optimised quenchbody biosensor based on a synthetic nanobody library

  Jordan H. Cater, et al., bioRxiv - Bioengineering 2024

  Quote: ... and Perfluoro-1-Octanol (Sigma-Aldrich/Merck, #370533) was added to the tube in 1:1 ratio with the emulsion volume ...
• “Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory”

  Diana L. Bordin, et al., bioRxiv - Molecular Biology 2023

  Quote: ... γH2AX (Ser 139) (1:50, Merck 05-636); Ki67 (1:200 ...
• Nanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8;21)-positive Acute Myeloid Leukaemia

  Hasan Issa, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Rabbit polyclonal anti-RUNX1 (1:40, Merck Millipore), Rabbit monoclonal anti-RUNX1 (1:1000 ...
• SMDT1 variants impair EMRE-mediated mitochondrial calcium uptake in patients with muscle involvement

  Elianne P. Bulthuis, et al., bioRxiv - Genetics 2022

  Quote: ... anti-β-Actin/ACTB (#A5441, 1:100,000; Merck), anti-V5 (#R960-25 ...
• Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

  Daniyal J Jafree, et al., bioRxiv - Immunology 2022

  Quote: ... rabbit anti-PROX1 polyclonal (1:200, ABN278, Merck), goat anti-LYVE1 polyclonal (1:100 ...
• Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities

  Makrina Daniilidou, et al., bioRxiv - Neuroscience 2022

  Quote: ... TRX-1 (RAB1756, Sigma-Aldrich, Merck KGaA, Germany)] ...
• Delaying the GABA shift indirectly affects membrane properties in the developing hippocampus

  C. Peerboom, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-KCC2 (07-432, Merck, 1:1000) and s940-pKCC2 (p1551-940 ...
• Delaying the GABA shift indirectly affects membrane properties in the developing hippocampus

  C. Peerboom, et al., bioRxiv - Neuroscience 2023

  Quote: ... guinea pig anti-VGLUT (AB5905, Merck, 1:1000), mouse anti-NeuN (MAB377 ...
• Extracellular vesicles improve GABAergic transmission in Huntington’s disease iPSC-derived neurons

  Margarida Beatriz, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-GAD 65/67 (1:100, #ab1511, Merck), anti-DARPP32 (EP720Y ...
• Astrocyte-like subpopulation of NG2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells and is capable of forming neuron-like cells after ischemic injury

  Lucie Janeckova, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-NeuN mouse monoclonal antibody (1:200; Merck), anti-Pdgfrα rabbit polyclonal antibody (1:200 ...
• Astrocyte-like subpopulation of NG2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells and is capable of forming neuron-like cells after ischemic injury

  Lucie Janeckova, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-Mag mouse monoclonal antibody (1:800; Merck), anti-NeuN mouse monoclonal antibody (1:200 ...
• Platelet pannexin-1 channels modulate inflammation during abdominal aortic aneurysm formation

  Lisa Maria Metz, et al., bioRxiv - Cell Biology 2022

  Quote: ... respectively phospho Panx1 Tyr198 (#ABN1681, Merck, 1:1000) at 4°C overnight and with an appropriate HRP-conjugated secondary antibody (#7074S ...