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1751 - 1800 of 3059 citations for 6 Boc 1 oxa 6 azaspiro 3.3 heptan 3 one since 2019

• Resistance Exercise and Mechanical Overload Upregulate Vimentin for Skeletal Muscle Remodeling

  Joshua S. Godwin, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Sections were then blocked with 2.5% BSA/0.1% Triton-X for 1 hour and subsequently incubated with an antibody cocktail consisting of goat anti-mouse PDGFRα (1:100) (catalog #: AF1062; R&D Systems; Minneapolis, MN, USA), rabbit anti-vimentin (1:100) ...
• A developmental analysis of juxtavascular microglia dynamics and interactions with the vasculature

  Erica Mondo, et al., bioRxiv - Neuroscience 2020

  Quote: ... 3-6 consecutive sections were prepared from each sample and immunostained with anti-Iba1 antibody (Wako; Richmond, VA; 1:3000) and anti-CD31 antibody (R&D Systems; Minneapolis, MN; 1:200). Images of the ventricular and subventricular zones at the level of the frontal cortex were acquired on Leica SP8 confocal microscope using a 40X (1.3NA ...
• Local autocrine signaling of IGF1 synthesized and released by CA1 pyramidal neurons regulates plasticity of dendritic spines

  Xun Tu, Anant Jain, Helena Decker, Ryohei Yasuda, bioRxiv - Neuroscience 2021

  Quote: ... the IGF-1 concentration in the medium was measured using the Mouse/Rat IGF-I/IGF-1 Quantikine ELISA Kit (R&D Systems, Inc., Minneapolis, MN, USA)
• Membrane-type 1 matrix metalloproteinase (MMP-14) modulates tissue homeostasis by a non-proteolytic mechanism

  Mukundan Attur, et al., bioRxiv - Cell Biology 2019

  Quote: Paraffin-embedded specimens of brown adipose tissue (BAT) were cut and immunostained with antibody to uncoupling protein-1 UCP-1 (R&D Systems, cat. # MAB6158, Minneapolis, MN) at a concentration of 10 µg/mL by personnel of the Experimental Pathology Core of NYU School of Medicine ...
• Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines

  Anne Huber, et al., bioRxiv - Cancer Biology 2024

  Quote: 6–8-week-old mice were subcutaneously injected with 900 mechanically disrupted KPT GC organoids in 1:1 PBS and RGF BME (R&D Systems, Cat#3533-005-02) vehicle (equivalent of approximately 100,000 cells ...
• Suppression of endothelial miR-22-3p mediates non-small cell lung cancer cell-induced angiogenesis

  Yuan Gu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and then supplemented with 1 µg/mL VEGF (R&D Systems), 1 µg/mL bFGF (R&D Systems ...
• The role of icIL-1RA type 1 in oral keratinocyte senescence and the development of the senescence associated secretory phenotype

  Sven E Niklander, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-p21Waf1/Cip1 (1: 1000, MAB1047, R&D Systems, Minneapolis, USA), anti-phosphorylated p65 (1 ...
• B cell-intrinsic requirement for WNK1 kinase in T cell-dependent antibody responses

  Darryl Hayward, et al., bioRxiv - Immunology 2021

  Quote: ... 1 µg/ml recombinant murine CD40L (CD40L, R&D Systems; Biotechne) or 10 µg/ml LPS from Salmonella minnesota R595 (LPS ...
• Single-cell transcriptomic analysis unveils spinal motor neuron subtype diversity underpinning the water-to-land transition in vertebrates

  Ee Shan Liau, et al., bioRxiv - Developmental Biology 2021

  Quote: ... goat anti-Foxp1(1:100 R&D systems Cat# AF4534, RRID:AB_2107102); rabbit anti-Hoxc8 (1:5000 Sigma-Aldrich Cat# HPA028911 ...
• CD117/c-kit Defines a Prostate CSC-Like Subpopulation Driving Progression and TKI Resistance

  Koran S. Harris, et al., bioRxiv - Cancer Biology 2020

  Quote: ... goat polyclonal anti-SOX2 (1:20; R&D Systems; RRID: AB_355110), rabbit polyclonal anti-OCT4 (1:100 ...
• RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development

  Renaud Mevel, et al., bioRxiv - Developmental Biology 2020

  Quote: ... 500 ng/mL R-spondin 1 (R&D Systems, #4645-RS), 100 ng/mL Noggin (R&D Systems ...
• Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis

  Fatemeh Mirzapour-shafiyi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and anti-VEGF164 (R&D Systems, AF-493-NA, 1:100) in 1:1 BB/PBS) ...
• A TgfβRI/Snai1-dependent developmental module at the core of vertebrate axial elongation

  André Dias, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Primary antibodies (1:200): goat anti-Brachyury (R&D Systems, AF2085), rabbit anti-Sox2 (Abcam ...
• Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery

  Vincent Soubannier, et al., bioRxiv - Neuroscience 2019

  Quote: ... goat anti-SOX2 (1/500; R&D Systems, Cat. No. AF2018); rabbit anti-PAX6 (1/500 ...
• Plasmin-mediated cleavage of EphA4 at central amygdala inhibitory synapses controls anxiety

  Mariusz Mucha, et al., bioRxiv - Neuroscience 2021

  Quote: ... goat anti-EphA4 N-terminus (R&D Systems, UK; 1:500), goat anti-EphB2 ...
• An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

  Lindsay Broadbent, et al., bioRxiv - Immunology 2021

  Quote: ... 1 or 100 ng/mL human IFNλ3 (R&D systems, Biotechne) for 24 h ...
• AXL is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

  Wenting Du, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and stained for intracellular markers Arginase-1 (R&D Systems, IC5868P) and iNOS (Thermo Fisher ...
• The Initiation Knot is a Signaling Center Required for Molar Tooth Development

  Isabel Mogollón, et al., bioRxiv - Cell Biology 2020

  Quote: ... or goat polyclonal sonic hedgehog antibody (1:100, R&D Systems) and detected with Alexa Fluor-488 ...
• Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation

  Takeo Tsutsumi, et al., bioRxiv - Physiology 2019

  Quote: ... anti-CD31 monoclonal antibody (1:2,000; bba7, R&D Systems, MN), anti-fibronectin monoclonal antibody (1:2,000 ...
• Bone marrow transplantation rescues monocyte recruitment defect and improves cystic fibrosis in mice

  Zhichao Fan, et al., bioRxiv - Immunology 2019

  Quote: ... ICAM-1-Fc and CCL2 were purchased from R&D Systems. Casein blocking buffer and Penicillin-Streptomycin solution were purchased from Thermo Fisher Scientific ...
• High-resolution 3D imaging and topological mapping of the lymph node conduit system

  Inken D. Kelch, et al., bioRxiv - Immunology 2019

  Quote: ... These include antibodies against LYVE-1 (R&D Systems, clone 223322), collagen I (Abcam) ...
• Extracellular CIRP as a Novel Endogenous TREM-1 Ligand to Fuel Inflammation

  Naomi-Liza Denning, et al., bioRxiv - Immunology 2019

  Quote: ... goat anti-mouse TREM-1 Ab (Catalog AF1187; R&D Systems), goat anti-CD11b Ab (Catalog MBS420973MyBioSource ...
• Transient Receptor Potential Ankyrin 1 Mediates Afferent Signals in the Inflammatory Reflex

  Harold A. Silverman, et al., bioRxiv - Physiology 2019

  Quote: ... goat anti-IL1R1 (polyclonal, 1:40; R&D Systems, Minneapolis, MN); and mouse anti-NeuN (monoclonal ...
• Transient Receptor Potential Ankyrin 1 Mediates Afferent Signals in the Inflammatory Reflex

  Harold A. Silverman, et al., bioRxiv - Physiology 2019

  Quote: ... and goat anti-IL R1 (polyclonal, 1:40; R&D Systems). After incubation with primary antibodies ...
• Therapeutic potential of inhibition of the neuroinflammation induced cathepsin X: in vivo evidence

  Anja Pišlar, et al., bioRxiv - Molecular Biology 2019

  Quote: ... goat polyclonal anti-cathepsin X antibody (1:500, R&D Systems), rabbit polyclonal anti-iNOS (1:500 ...
• Alterations of redox and iron metabolism accompany development of HIV latency.

  Iart Luca Shytaj, et al., bioRxiv - Molecular Biology 2019

  Quote: ... IF for Nrf2 (mab3925, 1:250; R&D systems, Minneapolis, MN) or PML (sc/966x ...
• Enhancing mitochondrial activity in neurons protects against neurodegeneration in CNS inflammation

  Sina C. Rosenkranz, et al., bioRxiv - Neuroscience 2020

  Quote: ... phosphorylated PGC-1αS570 (rabbit 1:1000; R&D Systems; RRID: AB_10890391) and β-actin (rabbit 1:1000 ...
• Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells

  Yanshan Zhu, et al., bioRxiv - Microbiology 2021

  Quote: ... goat polyclonal ACE2 (1:500 dilution, Cat#AF933, R&D Systems), rabbit anti-TMPRSS2 antibody (1:1000 dilution ...
• An N-terminal Fusion Allele to Study Melanin Concentrating Hormone Receptor 1

  Kalene R. Jasso, et al., bioRxiv - Neuroscience 2021

  Quote: ... and anti-tyrosine hydroxylase (mouse, R&D Systems MAB7566 1:500). Fluorescent-conjugated secondary antibodies (ThermoFisher Scientific ...
• Integrative molecular roadmap for direct conversion of fibroblasts into myocytes and myogenic progenitor cells

  Inseon Kim, et al., bioRxiv - Cell Biology 2021

  Quote: ... Anti-Mouse Myosin Heavy Chain (1:1000, R&D Systems, MAB4470) and Anti-Ki-67 (SP6 ...
• C9ORF72 dipeptide repeat proteins disrupt formation of GEM bodies and induce aberrant accumulation of survival of motor neuron protein

  Yuma Kato, et al., bioRxiv - Neuroscience 2021

  Quote: ... 10 ng/mL recombinant human IGF-1 (R&D Systems, USA), and 200 ng/mL L-ascorbic acid (Sigma-Aldrich ...
• The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling

  Sheng Zhang, et al., bioRxiv - Neuroscience 2020

  Quote: ... Primary antibodies included Sox10 (1:100, RRID:AB_442208, #AF2864, R&D Systems), Sox10 (1:100 ...
• SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

  Wei Qiao, et al., bioRxiv - Microbiology 2021

  Quote: ... 1 ng/mL recombinant murine IL-1b (R&D system, USA) was supplemented in the medium ...
• Periaxonal and nodal plasticity modulate action potential conduction in the adult mouse brain

  Carlie L Cullen, et al., bioRxiv - Neuroscience 2020

  Quote: ... Primary antibodies included goat anti-PDGFRα (1:200; R&D Systems), rabbit anti-OLIG2 (1:400 Millipore) ...
• Oxidized LDL but not angiotensin II induces the interaction between LOX-1 and AT1 receptors

  Li Lin, et al., bioRxiv - Cell Biology 2020

  Quote: ... LOX-1 neutralizing antibody (0.6 mg/kg/day, R&D Systems) and Enalapril (ACEI ...
• Exosomal melanotransferrin as a potential biomarker for metastatic melanoma

  Anne Bonhoure, et al., bioRxiv - Cell Biology 2020

  Quote: Mouse monoclonal anti-MTf (R&D Systems, MAB81751, dilution 1/50) antibodies were used for flow cytometry and immunofluorescence using anti-mouse IgG conjugated with Alexa Fluor 488 (Invitrogen ...
• Quantitative proteomics identifies secreted diagnostic biomarkers as well as tumor-dependent prognostic targets for clear cell Renal Cell Carcinoma

  Aydanur Senturk, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and anti-PLOD2 mouse at 1:250 (MAB4445, R&D Systems). The UltraView Detection kit (760-500 ...
• Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype

  T.M. O’Shea, et al., bioRxiv - Neuroscience 2022

  Quote: ... goat anti-Lipocalin-2 (Lcn2) (1:200, R&D systems, AF1857), goat anti-Clusterin (Clu ...
• Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

  Hyosung Kim, et al., bioRxiv - Neuroscience 2022

  Quote: ... goat anti-VE-cadherin (1:300 dilution, AF938, R&D Systems). The following day ...
• FTY720 requires vitamin B₁₂-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis

  Deepa Jonnalagadda, et al., bioRxiv - Neuroscience 2022

  Quote: ... goat anti-Lcn2 (1:500 dilution, R&D systems, cat # AF1857), rabbit anti-Hmox1 (1:500 dilution ...
• Polar protein Wag31 both activates and inhibits cell wall metabolism at the poles and septum

  Neda Habibi Arejan, et al., bioRxiv - Microbiology 2022

  Quote: Cultures were stained with 1 μg/mL HADA (R&D systems) for 15 minutes with rolling and incubation at 37°C ...
• Peritoneal M2 macrophage-derived extracellular vesicles as natural multi-target nanotherapeutics to attenuate cytokine storm after severe infections

  Yizhuo Wang, et al., bioRxiv - Immunology 2022

  Quote: ... anti-mouse KIM-1 (AF1817, R&D Systems, Minneapolis, MN, USA), anti-mouse CD68 (ab201340 ...
• Cdh5-lineage independent origin of dermal lymphatic vessels revealed by temporally restricted lineage tracing

  Yan Zhang, et al., bioRxiv - Developmental Biology 2022

  Quote: ... goat anti-mouse NRP2 (R&D Systems, cat AF567, 1:200), rabbit anti-PROX1 (generated against human PROX1 C-terminus (567-737aa ...
• SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis

  Vanessa Goyon, et al., bioRxiv - Cell Biology 2022

  Quote: ... Fgf21 by goat polyclonal antibodies (AF3057, 1:500, R&D systems), CHOP by rabbit polyclonal antibodies (5554 ...
• Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling

  Bhavana Palakurthi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and anti-CXCL16 (dilution 1:500, R&D Systems MAB503-100).
• Vascular-Derived SPARC and SerpinE1 Regulate Interneuron Tangential Migration and Accelerate Functional Maturation of Human Stem Cell-Derived Interneurons

  Matthieu Genestine, et al., bioRxiv - Neuroscience 2020

  Quote: ... Western blot antibodies: Goat-anti-SPARC (1:1000; R&D Systems) and Rabbit-anti-SerpinE1 (1:1,000 ...
• Met/HGFR triggers detrimental reactive microglia in TBI

  Rida Rehman, et al., bioRxiv - Neuroscience 2021

  Quote: ... Rabbit anti-pMet/HGFR (1:200, Cell Signaling/R&D systems), Rabbit anti-pBTK (1:200 ...
• Adaptive tail-length evolution in deer mice is associated with differential Hoxd13 expression in early development

  Evan P. Kingsley, et al., bioRxiv - Genetics 2021

  Quote: ... then immunostained with anti-Sox2 (R&D Systems MAB2018; 1:500), anti-Brachyury/T (R&D Systems AF2085 ...
• Physiological activation of the nephron central command drives endogenous kidney tissue regeneration

  Georgina Gyarmati, et al., bioRxiv - Physiology 2021

  Quote: ... anti-renin antibody (1:100, AF4277, R&D Systems, Minneapolis, MN), anti-alpha smooth muscle actin antibody (αSMA ...
• Heterogeneity in the size of the apical surface of cortical progenitors

  Caroline Badouel, Christophe Audouard, Alice Davy, bioRxiv - Developmental Biology 2022

  Quote: Goat α-Ephrin B1 (R&D Systems AF-473, 1/50); Rabbit α-Phospho-Histone 3 (Cell Signaling 9701 ...