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5501 - 5550 of 10000+ citations for 7 Amino 1 3 dimethyl 1H 8H pyrido 2 3 d pyrimidine 2 4 5 trione since 2020

• Stable iPSC-derived NKX2-1⁺ Lung Bud Tip Progenitor Organoids Give Rise to Airway and Alveolar Cell Types

  Renee F.C. Hein, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 100ng/mL NOGGIN (R&D Systems, Cat#6057), 10µM Y-27632 (APExBIO ...
• Stretchable mesh microelectronics for the biointegration and stimulation of neural organoids

  Thomas L. Li, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 20 ng/ml EGF (R&D Systems) for 19 days with daily medium change in the first 10 days ...
• Single-hit genome edition for expression of single-chain immunoglobulins by edited B cells

  Natsuko Ueda, et al., bioRxiv - Immunology 2022

  Quote: ... 250 U/ml IFN-α (R&D Systems), 20 ng/ml IL-6 (Peprotech ...
• High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing

  Alec S.T. Smith, et al., bioRxiv - Bioengineering 2022

  Quote: ... and 10 ng/ mL HGF (R&D Systems). On day 8 post induction ...
• Simulating the Tumor Microenvironment for Immune Cell Interactions via Deployable Extrusion Bioprinting

  Corrado Mazzaglia, et al., bioRxiv - Bioengineering 2022

  Quote: ... and Osteopontin (Goat IgG, R&D systems AF808) diluted in blocking buffer ...
• Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activity

  Erica R. Vander Mause, et al., bioRxiv - Bioengineering 2022

  Quote: ... and 0.25µM recombinant human CD229 (R&D Systems) in kinetics buffer ...
• Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

  Ashley Mello, et al., bioRxiv - Cancer Biology 2022

  Quote: ... or isotype control antibody (#AB108C, R&D Systems) for 72 hours ...
• SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating Hes5

  Eun-Bee Choi, et al., bioRxiv - Cell Biology 2022

  Quote: ... and FGF2 (12 ng/ml, R&D Systems). For in vitro differentiation of EpiSC-L cells ...
• SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating Hes5

  Eun-Bee Choi, et al., bioRxiv - Cell Biology 2022

  Quote: ... Activin A (20 ng/ml, R&D Systems), and FGF2 (12 ng/ml ...
• Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation

  Steven Swendeman, et al., bioRxiv - Biochemistry 2022

  Quote: ... Panel A (Cat No. ARY006; R&D Systems) following the manufacturer’s instructions ...
• Modifications of lipoic arm by reactive nitrogen species regulate α-ketoacid dehydrogenases

  Gretchen L. Seim, et al., bioRxiv - Biochemistry 2022

  Quote: ... and 30ng/mL IFN-γ (R&D Systems).
• Claudin5 protects the peripheral endothelial barrier in an organ and vessel type-specific manner

  M Richards, et al., bioRxiv - Cell Biology 2022

  Quote: ... goat anti-VE-Cadherin (R&D Systems, AF1002), chicken anti-GFP (Abcam ...
• Tumor-educated monocytes suppress T cells via adenosine and depletion of adenosine in the tumor microenvironment with adenosine deaminase enzyme promotes response to immunotherapy

  Omar S. Sarkar, et al., bioRxiv - Cell Biology 2022

  Quote: PGE2 was measured by ELISA (R&D Systems) in supernatants from murine LLC ...
• A Kalirin Missense Mutation Enhances Dendritic RhoA Signaling and Leads to Regression of Cortical Dendritic Arbors Across Development

  MJ Grubisha, et al., bioRxiv - Neuroscience 2021

  Quote: ... Commercially available recombinant mouse OMGp (R&D Systems) was reconstituted to 100 µg/mL in sterile PBS ...
• IFN-λ4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling

  Olusegun O. Onabajo, et al., bioRxiv - Cancer Biology 2020

  Quote: ... IFN-λ2 (60 ng/ml, R&D Systems), and custom IFN-λ3 (20 ng/ml ...
• ELAV proteins bind and stabilize C/EBP mRNA in the induction of long-term memory in Aplysia

  Anastasios A. Mirisis, et al., bioRxiv - Neuroscience 2020

  Quote: ... rhTGFβ-sRII (R&D Systems, #241-R2-025), SB203580 (Tocris ...
• Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs

  Vikramjeet Singh, et al., bioRxiv - Neuroscience 2020

  Quote: ... goat anti-mouse ACE (AF1513, R&D Systems), and rabbit anti-mouse actin (4967 ...
• Integrated role of microRNA-30e-5p through targeting negative regulators of innate immune pathways during HBV infection and SLE

  Richa Mishra, et al., bioRxiv - Immunology 2020

  Quote: ... rhIFNβ (bei resources) and rhTNFα (R&D Systems). All sh-clones ...
• SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4

  Fanny Onodi, et al., bioRxiv - Immunology 2021

  Quote: ... FITC anti-CCR7 (R&D System, clone 150503).
• Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration

  Juliane Obst, et al., bioRxiv - Neuroscience 2020

  Quote: ... and sheep polyclonal IgG (AF5195, R&D Systems) and 10 μL IL-34 stimulus (R&D systems ...
• A lineage-tracing tool to map the fate of hypoxic tumour cells

  Jenny A.F. Vermeer, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and goat anti-CD31 (AF3628, R&D Systems) or goat IgG (R&D Systems ...
• Ciliary IFT88 safeguards coordinated epiphyseal vascularisation, resorption and ossification from disruptive physiological mechanical forces

  C. R. Coveney, et al., bioRxiv - Physiology 2021

  Quote: ... Anti-CD31 (Goat IgG R&D systems, AF3628) Anti-Vegf (monoclonal Abcam ...
• GREM1 is epigenetically reprogrammed in muscle cells after exercise training and controls myogenesis and metabolism

  Odile Fabre, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2.5 ng/μl basic FGF (R&D Systems). Satellite cells were then purified using MACS cell separation system ...
• A versatile human intestinal organoid-derived epithelial monolayer model for the study of enteric pathogens

  Kourtney P. Nickerson, et al., bioRxiv - Microbiology 2020

  Quote: ... anti-human KLF4 APC-conjugated (R&D System) and anti-human SPIB (Invitrogen ...
• Transcriptomic profiling of human effector and regulatory T cell subsets identifies predictive population signatures

  Barbara Höllbacher, et al., bioRxiv - Immunology 2020

  Quote: ... PE-conjugated anti-CCR10 Ab (R&D Systems), PerCP/Cy5.5-conjugated anti-CCR4 Ab (BioLegend) ...
• Proteomic and functional analyses of the periodic membrane skeleton in neurons

  Ruobo Zhou, et al., bioRxiv - Neuroscience 2020

  Quote: ... goat anti-CHL1 antibody (R&D systems, AF2147), rabbit anti-NCAM1 antibody (EMD Millipore ...
• Proteomic and functional analyses of the periodic membrane skeleton in neurons

  Ruobo Zhou, et al., bioRxiv - Neuroscience 2020

  Quote: ... rat anti-L1CAM antibody (R&D Systems, MAB5674), rabbit anti-Myh10 (N-terminus ...
• CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signalling to promote expansion of cortical progenitors

  Roxane Van Heurck, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 100 ng/mL Noggin (R&D systems), and the medium was replenished every day ...
• CD39⁺PD-1⁺CD8⁺ T cells mediate metastatic dormancy in breast cancer

  Paulino Tallón de Lara, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 75 ng/ml mouse IFNγ (R&D Systems) plus 5 ng/ml mouse TNFα (PeproTech ...
• Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

  BI Reinfeld, et al., bioRxiv - Cancer Biology 2020

  Quote: ... CA9 AF647 (303123, R&D Systems FAB2188R-100UG), Human Fc Block (BD 564220) ...
• Perineuronal net receptor PTPσ regulates retention of memories

  Angelina Lesnikova, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-TRKB goat pAb (R&D Systems, #AF1494); secondary goat anti-mouse horseradish peroxidase (HRP)-conjugated antibody (Bio-Rad ...
• Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly

  Jacopo A. Carpentieri, et al., bioRxiv - Neuroscience 2020

  Quote: ... Sheep anti TBR2/EOMES (R&D system AF6166), rabbit anti NEUN (Abcam ab177487) ...
• The Mammalian Target of Rapamycin (mTOR) Kinase Mediates Haloperidol-Induced Cataleptic Behavior

  Uri Nimrod Ramírez-Jarquín, et al., bioRxiv - Neuroscience 2020

  Quote: ... SKF 81297 hydrobromide was from R&D systems. Rapamycin was purchased from LC laboratories (R-5000) ...
• MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

  Dario Zimmerli, et al., bioRxiv - Cancer Biology 2021

  Quote: ... concentrations of CCL5 (R&D Systems, DY278-05) were measured using Enzyme-Linked Immuno Sorbent Assay (ELISA ...
• Subcellular mRNA localization and local translation of Arhgap11a in radial glial cells regulates cortical development

  Louis-Jan Pilaz, et al., bioRxiv - Neuroscience 2020

  Quote: ... mouse anti-Ror-Beta (R&D Systems, N7927), rabbit anti-Laminin (Millipore ...
• Development of a dual fluorescent reporter system in Clostridioides difficile reveals a division of labor between virulence and transmission gene expression

  M. Lauren Donnelly, et al., bioRxiv - Microbiology 2022

  Quote: ... gas-permeable ELISA plate sealers (R&D Systems). Plates were read in Epoch Plate Reader (BioTek ...
• Combined small molecule treatment accelerates timing of maturation in human pluripotent stem cell-derived neurons

  Emiliano Hergenreder, et al., bioRxiv - Neuroscience 2022

  Quote: ... 100 ng/mL Activin A (R&D systems), and 3 μM of CHIR99021 (Cayman Chemical ...
• Obesity promotes breast epithelium DNA damage in BRCA mutation carriers

  Priya Bhardwaj, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and IL-6 (R&D Systems, Minneapolis, MN) following the manufacturer’s protocols.
• The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency

  Paraskevi Athanasouli, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Primary goat anti-Gata6 (R&D systems, AF1700) (1:200 ...
• Aspartate reduces liver inflammation and fibrosis by suppressing the NLRP3 inflammasome pathway via upregulating NS3TP1 expression

  Li Zhou, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Human recombinant TGF-β1 from R&D Systems Inc ...
• Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

  Elien Grajchen, et al., bioRxiv - Immunology 2022

  Quote: ... and rmTGFβ (10 ng/ml; R&D Systems) in a 96-well U-bottom plate ...
• Mesenchymal Stromal Cells Donate Mitochondria to Articular Chondrocytes Exposed to Mitochondrial, Environmental, and Mechanical Stress

  Megan J. Fahey, et al., bioRxiv - Cell Biology 2022

  Quote: ... with 10% fetal bovine serum (R&D Systems), 1% MEM Amino Acids (gibco ...
• Single cell Transcriptome and T cell Repertoire Mapping of the Mechanistic Signatures and T cell Trajectories Contributing to Vascular and Dermal Manifestations of Behcet’s Disease

  Ling Chang, et al., bioRxiv - Immunology 2022

  Quote: ... rhIL2 and rhTGFβ (LS-G4063, R&D Systems). Th0 and Treg groups were also exposed to rhIL32γ to assess the impact of the cytokine on differentiation efficacy ...
• Modulation of glucose metabolism by 2-Deoxy-D-Glucose (2DG) promotes IL-17 producing human T cell subsets

  Xin Chen, et al., bioRxiv - Immunology 2022

  Quote: ... and IL- 23 (100ng/ml) (R&D Systems). Cells were expanded for 2 weeks in media replenished for 2DG and IL-2.
• Molecular Characterization of the Tumor Microenvironment in Renal Medullary Carcinoma

  David S. Tourigny, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and CD70 (Clone 301731, R&D Systems #MAB2738). SMARCB1/INI1 staining was scored as retained or lost when compared to internal positive control cells (endothelial/stromal cells and lymphocytes) ...
• Impact of glycoengineering and immunogenicity on the anti-cancer activity of a plant-made lectin-Fc fusion protein

  Matthew Dent, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Recombinant Fc receptors obtained from R&D Systems were captured by flowing them over the chip surface at 5 μg/mL for 60 seconds with a flow rate of 10 μL/min ...
• ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

  Asmi Chakraborty, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Primary antibodies included anti-ST6GAL1 (R&D systems) and anti-SOX9 (AbCam) ...
• TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development

  Jifan Feng, et al., bioRxiv - Developmental Biology 2022

  Quote: ... recombinant human TGFβ1 (7754-BH, R&D Systems) was used at 5 ng/ml for the TGFβ1 treatment group for 24 hours ...
• Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia

  Julen Goikolea, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-OPN goat (AF808-SP, R&D systems), anti-Iba-1 rabbit (#019-19741 ...
• ETV2 upregulation marks the specification of early cardiomyocytes and endothelial cells during co-differentiation

  Xu Cao, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and 50 ng/ml VEGF (R&D Systems). From day 6 onwards ...