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501 - 550 of 7988 citations for 3 Methyl 1 6 naphthyridine 2 carboximidamide hydrochloride since 2020

• An extra-glycolytic function for hexokinase 2 as an RNA-binding protein regulating SOX10 mRNA translation in melanoma

  Ana Luisa Dian, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-ACOT1/2 (Santa Cruz Biotechnology ...
• pVHL regulates protein stability of TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradation

  Caixia Wang, et al., bioRxiv - Cell Biology 2021

  Quote: ... mouse anti-Myc (1:1,000 for western blotting and 2 μg for co-IP assays; sc-40; Santa Cruz Biotechnology), and mouse anti-Flag (1:1,000 for western blotting and 2 μg for co-IP assays ...
• Subcellular dynamics and functional activity of the cleaved Na⁺ channel β1 subunit intracellular domain

  Alexander S. Haworth, et al., bioRxiv - Cell Biology 2021

  Quote: ... N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester (DAPT) (1 μM, 24 h, Santa Cruz Biotech) and L-685,458 (1 - 10 μM ...
• Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells

  Jaka Kragelj, et al., bioRxiv - Biophysics 2023

  Quote: ... Cells were then incubated for 2 h with primary antibody anti-α-Syn sc-69977 (Santa Cruz, 1:100 dilution) in blocking buffer ...
• Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in C. elegans

  Qian Zhao, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Antibodies for IP (NRBP1/2 rabbit, 21549-1-AP –ptg) and mock IP (IgG rabbit, Santa Cruz Biotech, sc-2027) were then added into the supernatant ...
• P4HA2 is associated with prognosis, promotes proliferation, invasion, migration and EMT in glioma

  Jing Lin, et al., bioRxiv - Cancer Biology 2020

  Quote: ... glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (sc-47724) from Santa Cruz Biotechnology (Dallas ...
• Keap1-resistant ΔN-Nrf2 isoform does not translocate to the nucleus upon electrophilic stress

  Sara Mikac, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-lamin A (C-3, sc-518013; Santa Cruz Biotechnology), anti-Keap1 (cat ...
• African Swine Fever Virus CD2v protein promotes β-Interferon expression and apoptosis in swine cells

  Sabal Chaulagain, et al., bioRxiv - Microbiology 2020

  Quote: ... or glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (sc-25778; Santa Cruz). The blots were developed with appropriate HRP-conjugated secondary antibodies and chemiluminescent reagents (Thermo Scientific) ...
• Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure

  Yijun Zhang, Joachim Seemann, bioRxiv - Cell Biology 2020

  Quote: ... Golgin-45 (E-3, Santa Cruz Biotechnology, cat.# sc-515193), Golgin-97 (CDF4 ...
• Non-muscle myosin 2 filaments are processive in cells

  Eric A. Vitriol, et al., bioRxiv - Cell Biology 2023

  Quote: NMIIB (clone A-3, SC-3769-42, Santa Cruz Biotechnology) Mouse monoclonal antibody used at 1:2000
• Dopamine receptor D2 confers colonization resistance via gut microbial metabolites

  Samantha A. Scott, Jingjing Fu, Pamela V. Chang, bioRxiv - Microbiology 2023

  Quote: ... and indole-3-acrylate (IA) was purchased from Santa Cruz Biotechnology ...
• BCL6 is a context-dependent mediator of the glioblastoma response to irradiation therapy

  Anna K.W. Tribe, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 µg N-3 anti-BCL6 antibody (Santa Cruz, USA) was added to five of the tubes and 5 µg non-specific Invitrogen™ normal rabbit IgG antibody (Thermo Fisher Scientific ...
• SCF^FBXW11 complex targets interleukin-17 receptor A for ubiquitin-proteasome-mediated degradation

  Ben Jin, et al., bioRxiv - Biochemistry 2023

  Quote: ... 3 µg anti-HA antibody (Santa Cruz Biotechnology, #sc-7392) was used to pull down ubiquitin-conjugated IL-17RA ...
• Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

  Yvonne Baumer, et al., bioRxiv - Immunology 2023

  Quote: ... anti-Galectin-3-AF488 (clone B2C10, Santa Cruz Biotechnologies, USA), and galectin-8-AF790 (clone C-8 ...
• Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration

  Yingzhu He, et al., bioRxiv - Cell Biology 2023

  Quote: ... were injected intraperitoneally with 3 doses of tamoxifen (Santa Cruz biotechnology ...
• Vimentin cysteine 328 modifications finely tune network organization and influence actin remodeling under oxidative and electrophilic stress

  Patricia González-Jiménez, et al., bioRxiv - Cell Biology 2023

  Quote: ... (+)-Biotin-(PEO)3-iodoacetamide (biotinylated iodoacetamide) was from Santa Cruz Biotechnology ...
• An efficient induction method for human spinal lower motor neurons and high-throughput image analysis at the single cell level

  Selena Setsu, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 3 μM dorsomorphin (Santa Cruz, Dallas, TX, United States) (Fujimori et al. ...
• Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

  Chong Zhang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and caspase-3 (SC-7148) were obtained from Santa Cruz Biotechnology (Dallas ...
• CD24 regulates extracellular vesicle release via an aSMase/PI3K/mTORC2/ROCK/actin pathway in B lymphocytes

  Hong-Dien Phan, et al., bioRxiv - Cell Biology 2024

  Quote: ... PI 3-kinase p110δ siRNA (Santa Cruz Biotechnology, SC-39132), and Rock-1 siRNA (Santa Cruz Biotechnology ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: GAPDH Antibody (A-3) (Santa Cruz Biotechnology, cat. no. 137179)
• Cutaneous human papillomavirus E6 impairs the cGAS-STING pathway

  Emily Tolbert, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and C23 (MS-3) HRP (sc-8031; Santa Cruz Biotechnology). After exposure to the matching appropriate horseradish peroxidase-conjugated secondary antibody ...
• Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation

  Nathaniel J. Hogrebe, et al., bioRxiv - Cell Biology 2024

  Quote: ... mouse anti-OCT-3/4 (sc-5279, Santa Cruz Biotechnology), goat anti-NANOG (AF1997 ...
• Dynamic Effects of Ventral Hippocampal NRG3/ERBB4 Signaling on Nicotine Withdrawal-Induced Responses

  Miranda L. Fisher, et al., bioRxiv - Neuroscience 2023

  Quote: ... for 1 h at room temperature before reacting overnight at 4°C with primary antibodies: Neuregulin-3 (NRG3) (1:500, sc-67002, N-terminal extracellular domain, Santa Cruz Biotechnology, Santa Cruz, CA), ERBB4 (1:500 ...
• Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjögren’s syndrome

  Jimin Yoon, et al., bioRxiv - Molecular Biology 2022

  Quote: ... cells were pretreated with 20 µM of 2-C′-methyladenosine (2-CM) (Santa Cruz Biotechnology) 24 h prior to poly I:C transfection.
• Bmf Facilitates Protein Degradation and Reduces Beclin1 Ubiquitination to Inhibit Autophagy Independent of mTOR

  Monica Delgado-Vergas, et al., bioRxiv - Cell Biology 2020

  Quote: ... We immunoprecipitated proteins with mouse anti Bcl-2 (C-2) (sc-7382 from Santa Cruz), rabbit anti Beclin1 (ab55878 from Abcam ...
• Cargo modulates the conformation of the nuclear pore in living cells

  Joan Pulupa, et al., bioRxiv - Cell Biology 2020

  Quote: ... Antibodies used: monoclonal rat-α-karyopherin α1/6 (2D9, Santa Cruz, Santa Cruz, CA, RRID:AB_2133549) at 1:500 ...
• Highly efficient, all-organic bioluminescence-photosensitizer conjugate eradicates early-stage tumors and prevents metastasis in mice

  Hao Yan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... with chlorin e6 mono 6-amino hexanoic acid amide (Ce6-HA) molecules (Santa Cruz Biotechnology) using the standard N-(3-dimethyl aminopropyl)-N-ethyl-carbodiimide hydrochloride (EDC)/N-hydroxysulfosuccinimide (Sulfo-NHS)-activated condensation reaction ...
• Cargo modulates the conformation of the nuclear pore in living cells

  Joan Pulupa, et al., bioRxiv - Cell Biology 2020

  Quote: ... Antibodies used: monoclonal rat-α-karyopherin α1/6 (2D9, Santa Cruz, Santa Cruz, CA, RRID:AB_2133549) at 1:500 ...
• Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

  Jie Fu, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Supernatants were immunoprecipitated with an anti-NRDC antibody (A-6) (sc-137199; Santa Cruz Biotechnology). The immunoprecipitated NRDC proteins were analyzed using a sodium dodecyl sulfate-polyacrylamide gel electrophoresis (8% ...
• MYPT1 is a non-canonical AKAP that tethers PKA to the MLCP signaling node

  Jawad S Khalil, et al., bioRxiv - Cell Biology 2023

  Quote: ... from Cell Signaling Technology (Leiden, The Netherlands), MYPT1 (mouse IgG1 mAb clone C-6, sc-514261) from Santa Cruz Biotechnology (Heidelberg ...
• The combined influence of viscoelasticity and adhesive cues on fibroblast spreading and focal adhesion formation

  Erica Hui, et al., bioRxiv - Bioengineering 2021

  Quote: ... Primary antibodies used in this work included paxillin (mouse monoclonal anti-paxillin B-2, Santa Cruz Biotechnology, sc-365379, 1:500) to visualize FA formation and α-smooth muscle actin (α-SMA ...
• Hypothalamic estrogen receptor alpha mediates key side effects of tamoxifen therapy in mice

  Z Zhang, et al., bioRxiv - Neuroscience 2020

  Quote: ... Sections were then blocked for 1 h in 10% BSA and 2% normal goat serum (NGS) and incubated overnight at 4 °C with primary antibody (ERα, 1:250, sc-8002, Santa Cruz). Following 3 × 10 min washing in PBS ...
• Ankylosis homologue mediates cellular efflux of ATP, not pyrophosphate

  Flora Szeri, et al., bioRxiv - Biochemistry 2021

  Quote: ... and using α-tubulin as a loading control (mouse anti-α-tubulin B-5-1-2, Santa Cruz Biotechnology, Dallas, TX).
• Identification of plant exclusive lipid transfer SMP proteins at membrane contact sites in Arabidopsis and Tomato

  Carolina Huercano, et al., bioRxiv - Plant Biology 2022

  Quote: ... The following primary antibodies were used for detection of epitope-tagged proteins: mouse monoclonal anti-GFP clone B-2 (1:1,000, catalog no. sc-9996, Santa Cruz Biotechnology) and anti-RFP antibody (1/2000 ...
• Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

  Sofie J. Desmet, et al., bioRxiv - Molecular Biology 2024

  Quote: ... cell lysates were prepared using SDS sample buffer followed by Western Blotting and antibody probing procedures according to the guidelines of the company for the respective antibodies (anti-PPARα: H-2, sc-398394, 1:1000, Santa Cruz Biotechnology ...
• Flotillin-2 regulates EGFR activation, degradation, and cancer growth

  David J. Wisniewski, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-Cbl-b (G-1, sc-8006), anti-ERK2 (D-2, sc-1647) and anti-HSC70 (sc-7298) antibodies were purchased from Santa Cruz Biotechnology (Dallas ...
• VEXAS anemia is a mosaic erythroblastopenia

  François Rodrigues, et al., bioRxiv - Cell Biology 2024

  Quote: ... Lysates were cleared by centrifugation at 13000rpm for 15min at 4°C and extracts of equal amount of total protein were used to immunoprecipitated p53 using 2 μg of antibody (DO-1, Santa Cruz) and 20 μL of protein A magnetic beads (prewashed with lysis buffer ...
• Sequential ATR and PARP Inhibition Overcomes Acquired DNA Damaging Agent Resistance in Pancreatic Ductal Adenocarcinoma

  Katharine J. Herbert, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Coverslips were blocked with 2% goat serum before overnight incubation with primary antibody at 4°C [anti-Rad51 (1:500, Santa Cruz), anti-53BP1 (1:1000 ...
• miR-126 modulates neural progenitor cell development

  Jeroen Bastiaans, et al., bioRxiv - Cell Biology 2024

  Quote: ... NPC were infected at 80% confluency by adding virus stocks at a final dilution of 1:2 together with 4 µg/mL Polybrene (Santa Cruz), followed by spinning down of virus onto the NPC at 2300 rpm for 1 hour at 30°C ...
• Quantification of extracellular vesicles with unaltered surface membranes using an internalized oligonucleotide tracer and droplet digital PCR applied to modeling of in vivo kinetics

  Thomas De Luca, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti α-actinin (clone H-2, 2 μg/mL, cat. no. sc-17829, Santa Cruz Biotechnology), anti-eIF2C (Argonaute1-4 ...
• Quantification of extracellular vesicles with unaltered surface membranes using an internalized oligonucleotide tracer and droplet digital PCR applied to modeling of in vivo kinetics

  Thomas De Luca, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-tsg 101 (clone C-2, 2 μg/mL, cat. no. sc-7964, Santa Cruz Biotechnology), anti-Alix (clone 3A9 ...
• Matrix Stiffness Regulates Liver Sinusoidal Endothelial Cell Function Mimicking Responses in Fatty Liver Disease

  Vaishaali Natarajan, et al., bioRxiv - Bioengineering 2020

  Quote: ... anti-stabilin-2 (Santa Cruz, CA) or anti-GAPDH (Millipore ...
• State-dependent protein-protein interactions mediating 4-1BB CAR Signaling

  Samuel A. Ritmeester-Loy, et al., bioRxiv - Immunology 2022

  Quote: ... anti-TRAF2 (F-2, Santa Cruz), anti-ZAP70 (D9H10 ...
• Single-cell transcriptomic analysis of antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts

  Fabian Pott, et al., bioRxiv - Microbiology 2021

  Quote: ... MX1/2 (Santa Cruz sc-47197), and IFITM3 (Abgent AP1153a ...
• SCF^FBXW11 complex targets interleukin-17 receptor A for ubiquitin-proteasome-mediated degradation

  Ben Jin, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-p-ERK1/2 (Santa Cruz Biotechnology ...
• MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

  Célia Guérin, et al., bioRxiv - Cancer Biology 2023

  Quote: ... ERK1/2 (Santa Cruz #Sc-154), ERK1/2-Phospho (Cell Signaling #9101) ...
• Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice

  André A. Weber, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... AMPKα1/2 (Santa Cruz, sc-25792), CYP7A1 (Abcam ...
• Capture of Human Neuromesodermal and Posterior Neural Tube Axial Stem Cells

  Dolunay Kelle, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and 2 µM IWP2 (Santa Cruz). The cells were split using 1X TrypLE Express at a ratio of 1:20-1:40.
• A common druggable signature of oncogenic CMYC, mutant KRAS and mutant p53 reveals functional redundancy and competition of the oncogenes in cancer

  Maria Grześ, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Gli-2 (Santa Cruz sc-271786); c-Jun (Santa Cruz sc-74543) ...
• GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage

  Terezia Vcelkova, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 2 μg GSE1 (515046, Santa Cruz), 30 μl of monoclonal HDAC1 (clone 10E2 ...