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1901 - 1950 of 7271 citations since 2020

• A Shape Sensing Mechanism driven by Arp2/3 and cPLA₂ licenses Dendritic Cells for Migration to Lymph Nodes in Homeostasis

  Zahraa Alraies, et al., bioRxiv - Cell Biology 2023

  Quote: ... CK666 (selective Arp2/3 inhibitor, Tocris #3950), BI605906 (selective IKKβ inhibitor #53001).
• A Shape Sensing Mechanism driven by Arp2/3 and cPLA₂ licenses Dendritic Cells for Migration to Lymph Nodes in Homeostasis

  Zahraa Alraies, et al., bioRxiv - Cell Biology 2023

  Quote: ... For drug treatments: AACOCF3 (selective phospholipase A2 inhibitor, Tocris #1462-5), CK666 (selective Arp2/3 inhibitor ...
• Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

  Robbin A. Nameki, et al., bioRxiv - Cancer Biology 2023

  Quote: ... JQ1 (Tocris) or dimethyl sulfoxide as a vehicle control ...
• Primary Ciliary Dyskinesia patient specific hiPSC-derived airway epithelium in Air Liquid Interface culture recapitulates disease specific phenotypes in vitro

  Laura von Schledorn, et al., bioRxiv - Bioengineering 2023

  Quote: ... media was exchanged to basal media supplemented with 2 μM IWP2 (Tocris), 10 μM SB431542 and 3 μM Dorsomorphin (only for WT and NME5mut ...
• Transcriptional changes consistent with altered neuronal differentiation, angiogenesis, and tumor plasticity induced in human subpallial telencephalic organoid-glioblastoma chimeras

  Simone Chiola, et al., bioRxiv - Cancer Biology 2023

  Quote: ... The N2/B27 medium was supplemented with 4 µM Dorsomorphin (Tocris, Cat # 3039) and 10 µM SB431542 (Tocris ...
• A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects

  Taylor N. Takla, et al., bioRxiv - Neuroscience 2023

  Quote: ... the medium was then changed to 3N (50:50 DMEM/F12:neurobasal with N2 and B27 supplements) without vitamin A with 2 µM DMH1 (Tocris, 4126), 2 µM XAV939 (Cayman Chemical ...
• Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance

  Kurt M. Fraser, et al., bioRxiv - Neuroscience 2023

  Quote: The general dopamine receptor antagonist flupenthixol dihydrochloride (Tocris) was prepared at a concentration of 100 μM in sterile 0.9% saline and frozen in aliquots that were thawed fresh immediately prior to use ...
• Medial Prefrontal Cortex Serotonin Input Regulates Cognitive Flexibility in Mice

  Ashlea A. Morgan, et al., bioRxiv - Neuroscience 2023

  Quote: ... and WAY100635 (30 nM; Tocris) that was used to block 5-HT1A receptors.
• NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma

  Eslam Katab, et al., bioRxiv - Cancer Biology 2023

  Quote: ... MG132 (TOCRIS, 1748), cycloheximide (Sigma-Aldrich ...
• α-Melanocyte-Stimulating Hormone Regulates Pathological Cardiac Remodeling by Activating Melanocortin 5 Receptor in Cardiomyocytes

  Anni Suominen, et al., bioRxiv - Physiology 2023

  Quote: ... injections of either vehicle (PBS) or the α-MSH analogue melanotan-II (0.3 mg/kg/day, Tocris, # 2566).16 Sham-operated mice received vehicle according to the same treatment scheme ...
• The astrocyte α1-adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex

  Jérôme Wahis, et al., bioRxiv - Neuroscience 2023

  Quote: ... the chamber was perfused with recording ACSF containing 20 µM noradrenaline bitartrate (Tocris Bioscience) for 60 s ...
• Proteostasis and lysosomal quality control deficits in Alzheimer’s disease neurons

  Ching-Chieh Chou, et al., bioRxiv - Cell Biology 2023

  Quote: ... 2 µM Dorsomorphin (TOCRIS) and 2 µM XAV939 (Stemgent) ...
• Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development

  Juliane Tschuck, et al., bioRxiv - Cell Biology 2023

  Quote: ... SB431542 (#1614, Tocris) and XAV939 (#3748 ...
• Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development

  Juliane Tschuck, et al., bioRxiv - Cell Biology 2023

  Quote: ... and XAV-939 (#3748, Tocris). XAV-939 was removed from day 4 till day 18 ...
• Focal adhesions are controlled by microtubules through local contractility regulation

  J. Aureille, et al., bioRxiv - Cell Biology 2023

  Quote: ... Batimastat (Tocris Cat. No. 2961), Tubacin (Cat ...
• Monitoring GPCR Conformation with GFP-Inspired Dyes

  Anatoliy Belousov, et al., bioRxiv - Biophysics 2023

  Quote: ... SCH58261 (Tocris), Adenosine (Tocris) ...
• Monitoring GPCR Conformation with GFP-Inspired Dyes

  Anatoliy Belousov, et al., bioRxiv - Biophysics 2023

  Quote: ... Adenosine (Tocris), HMA (Merck ...
• Monitoring GPCR Conformation with GFP-Inspired Dyes

  Anatoliy Belousov, et al., bioRxiv - Biophysics 2023

  Quote: ... or NECA (Tocris)) were dissolved in DMSO to make 100 mM stock solutions ...
• An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCC

  Maroussia M.P. Ganpat, et al., bioRxiv - Cancer Biology 2023

  Quote: ... A83-01 (5 µM, Tocris Bioscience) and Next Generation Surrogate (NGS ...
• Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice

  Allen L. Pan, et al., bioRxiv - Neuroscience 2023

  Quote: ... and XAV939 (1 μM, Tocris) for 10 days of differentiation ...
• Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice

  Allen L. Pan, et al., bioRxiv - Neuroscience 2023

  Quote: ... DAPT (10 μM, Tocris) and PD0325901 (10 μM ...
• APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia

  Michael S. Haney, et al., bioRxiv - Neuroscience 2023

  Quote: ... Dissociated hiPSCs were then pelleted and resuspended in embryoid body media (10µM SB431542 (1614, Tocris) and 0.25µM LDN (04-0074 ...
• APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia

  Michael S. Haney, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 0.25µM LDN (04-0074, Stemgent) in N2B27) with 10µM ROCK inhibitor (1254, Tocris), followed by growth in suspension in a T-75 flask (12-565-349 ...
• APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia

  Michael S. Haney, et al., bioRxiv - Neuroscience 2023

  Quote: ... in N2B27 with 10nM DAPT (2634, Tocris). Next ...
• Exploratory rearing is governed by hypothalamic MCH cells according to the locus coeruleus

  Cristina Concetti, et al., bioRxiv - Neuroscience 2023

  Quote: The MCH receptor antagonist SNAP-94847 hydrochloride (Tocris Bioscience, 3347) was administered IP at a dose of 20 mg/kg ...
• Competition between stochastic neuropeptide signals calibrates the rate of satiation

  Stephen X. Zhang, et al., bioRxiv - Neuroscience 2023

  Quote: ... each slice was imaged for 15 minutes (15.5 frames per second) and 200 nM NPY (Tocris, 1153) was applied via perfusion starting at 4 minutes into the recording ...
• In Vitro Modulator Responsiveness of 655 CFTR Variants Found in People With CF

  Hermann Bihler, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... and 20 μM GlyH101 (5485, Tocris Bioscience, USA). Reagents were added at 20 ± 5 minutes intervals and the change in conductance (ΔGt ...
• Internalized β2-Adrenergic Receptors Inhibit Subcellular Phospholipase C-Dependent Cardiac Hypertrophic Signaling

  Wenhui Wei, Alan V. Smrcka, bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... ICI 118,551 (Tocris, Cat#0821), butanedione-monoxime (BDM ...
• Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation

  Zsuzsa Radvanyi, et al., bioRxiv - Physiology 2023

  Quote: ... AVP (Tocris Cat. #2935) and ddAVP (Tocris Cat ...
• Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation

  Zsuzsa Radvanyi, et al., bioRxiv - Physiology 2023

  Quote: ... the cell medium was replaced with the experimental medium (2 ml/well) consisting of DMEM containing 1 nM of 1,25-dihydroxyvitamin D3 (Tocris; Cat. #2551), as described previously58 ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... substance P (Tocris); ATP (Merck) ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... a Kv7 channel opener (Tocris); XE991 ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... a Kv7 channel blocker (Tocris); forskolin ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... a CaSR PAM agonist (Tocris Bioscience, Abingdon, UK); NPS-2143 ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... a CaSR NAM (Tocris); retigabine ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... an [Ca2+]i chelator (Tocris); NiCl2 hexahydrate ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... 3 μM CHIR-99021 (Tocris), 200 μM L-ascorbic acid (Merck) ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... 2 μM PD0332991 (Tocris), 10 ng/ml human BDNF (Miltenyi Biotec) ...
• Extracellular lactate as an alternative energy source for retinal bipolar cells

  Victor Calbiague Garcia, et al., bioRxiv - Physiology 2023

  Quote: ... the retinal slices were incubated for 15 min with 0.1 µM SR-13800 (Tocris, Cat. No. 5431), 2 µM AR-C155858 (Tocris ...
• Extracellular lactate as an alternative energy source for retinal bipolar cells

  Victor Calbiague Garcia, et al., bioRxiv - Physiology 2023

  Quote: ... AR-C155858 (AR-C; Tocris, Cat. No. 4960) for MCT1 and MCT2 ...
• Extracellular lactate as an alternative energy source for retinal bipolar cells

  Victor Calbiague Garcia, et al., bioRxiv - Physiology 2023

  Quote: ... we used three potent and specific inhibitors to isolate MCT isoforms: SR-13800 for MCT1 (SR; Tocris, Cat. No. 5431), AR-C155858 (AR-C ...
• Macrophage Migration Inhibitory Factor on Apoptotic Extracellular Vesicles Regulates Compensatory Proliferation

  Safia A. Essien, et al., bioRxiv - Cell Biology 2023

  Quote: ... 4-IPP (Tocris, 3429), and Brefeldin A (Millipore-Sigma ...
• Histone H1.2 Dependent Translocation of Poly (ADP-ribose) Initiates Parthanatos

  Jing Fan, et al., bioRxiv - Cell Biology 2023

  Quote: ... 20 µM NPLA (Tocris, 1200), 30 µM DPQ (Enzo ...
• Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer

  Michael UJ Oliphant, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Organoids are pelleted and gently resuspended in BTOM-ER containing 5% Matrigel and ROCK-inhibitor (10 μM Y267632, Tocris), and then plated on top of a solidified Matrigel-coated well ...
• PARG inhibition induces nuclear aggregation of PARylated PARP1

  Sateja Paradkar, et al., bioRxiv - Cancer Biology 2023

  Quote: ... PDD 00017273 (PARGi, Tocris), olaparib (MedChem Express) ...
• The cGAS-STING pathway regulates microglial chemotaxis in genome instability

  Emily J. Talbot, et al., bioRxiv - Cell Biology 2023

  Quote: ... then treated for an additional 24 h in the presence (synchronised in G2 cell cycle phase) or absence (asynchronised) of 9 μM CDK1 inhibitor RO-3306 (CDK1i; Tocris Bioscience) prior to collection.
• Estrogen regulates myogenic tone in hippocampal arterioles by enhanced basal release of nitric oxide and endothelial SK_Ca channel activity

  Danielle A. Jeffrey, et al., bioRxiv - Neuroscience 2023

  Quote: ... were discarded from the study. NS309 (Cat no. 3895) and Paxilline (Cat no. 2006) was purchased from Tocris Bioscience (USA) ...
• Mu-opioid receptor-dependent changes in social reward across adolescence in mice

  Zofia Harda, et al., bioRxiv - Neuroscience 2023

  Quote: ... injection of cyprodime hydrochloride 1 hour before the posttest (TOCRIS, cat ...
• Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus

  Katharina Klinger, et al., bioRxiv - Neuroscience 2023

  Quote: ... Either the selective Y1-R antagonist BIBP3226 (1 μM; Cat.-No. 2707; Tocris, Bristol, UK) or NPY (1 μM ...
• Dopaminoceptive D1 and D2 neurons in ventral hippocampus arbitrate approach and avoidance in anxiety

  Arthur Godino, et al., bioRxiv - Neuroscience 2023

  Quote: ... and (-)-Quinpirole hydrochloride (Tocris, #1061) were diluted in ACSF (see below ...