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1701 - 1750 of 7271 citations since 2020

• G protein-Coupled Receptor Associated Sorting Protein GASP1 mediated trafficking of the Glucagon Like Peptide-1 Receptor contributes to the development of tolerance to incretin drugs

  Anirudh Gaur, et al., bioRxiv - Cell Biology 2024

  Quote: ... high glucose (11mM) or high glucose + 100nM Ex-4 (Tocris, 1933). After an hour ...
• The evolutionary ancient MEIS transcription factors actuate lineage-specific transcription to establish cardiac fate

  Zoulfia Darieva, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Monolayers followed the same timing but were cultured in 6-well plates in 3.5 ml of medium and 5 µM XAV939 (Tocris) was included between day 3 and 6.
• Ciliary biology intersects autism and congenital heart disease

  Nia Teerikorpi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... then re-plated in mTESR Plus Medium with the addition of 10nM Y-27632 dihydrochloride ROCK inhibitor (Tocris; Cat. No. 125410) for 24 hr.
• A transgene-free, human peri-gastrulation embryo model with trilaminar embryonic disc-, amnion- and yolk sac-like structures

  Shiyu Sun, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Cells are then centrifuged and re-suspended in mTeSR1 containing 10 µM Y27632 (Tocris, cat #1254), at a concentration of 4 × 106 cells mL-1 ...
• Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection

  Liuliu Yang, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 200 nM TPPB (Tocris Bioscience) and 0.25 μM SANT-1 (Sigma Aldrich ...
• Hypoxia promotes airway differentiation in the human lung epithelium

  Ziqi Dong, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and 10 mM A83-01 (Tocris, 2939)] ...
• A maternally inherited Chromosomal Passenger Complex regulates germ plasm ribonucleoparticle aggregation in Zebrafish

  Cara E. Moravec, Francisco Pelegri, bioRxiv - Developmental Biology 2024

  Quote: ZM2 (ZM44739, Tocris Bioscience) was dissolved in DMSO at a concentration of 20 mM ...
• Axin1 and Axin2 regulate the WNT-signaling landscape to promote distinct mesoderm programs

  Rocío Hernández-Martínez, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Dorsomorphin and SB431542 were obtained from Tocris.
• Decidual natural killer cells promote extravillous trophoblast developmental pathways: evidence from trophoblast organoid co-cultures

  Morgan L. Zych, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 2.5uM prostaglandin E2 (Tocris 2296), 1.5uM CHIR99021 (Cell Signaling Technology #54290S) ...
• Decidual natural killer cells promote extravillous trophoblast developmental pathways: evidence from trophoblast organoid co-cultures

  Morgan L. Zych, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 500nM A83-01 (Tocris 2939), 2.5uM prostaglandin E2 (Tocris 2296) ...
• The exit of naïve pluripotency contains a lipid metabolism-induced checkpoint for genome integrity

  Roshni A. de Souza, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and PF06424439 for DGAT2 (Tocris, 6348) and cultured for a further 24 hours ...
• The exit of naïve pluripotency contains a lipid metabolism-induced checkpoint for genome integrity

  Roshni A. de Souza, et al., bioRxiv - Developmental Biology 2024

  Quote: ... cells were treated with specified inhibitors including UK5099 (20 μM; Tocris, 4186), BPTES (10 μM ...
• Reversal of vein of Galen aneurysmal malformation by stimulation of flow-mediated vessel fusion

  Edwige Martin-Valiente, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1µM Selumetinib (TOCRIS), 1µM YS-49 (MCE ...
• Defining Cellular Diversity at the Swine Maternal-Fetal Interface Using Spatial Transcriptomics and Organoids

  Cole R. McCutcheon, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 500 nM A83-01 (Tocris, 2939), 1.5 µM CHIR99021 (Tocris ...
• Defining Cellular Diversity at the Swine Maternal-Fetal Interface Using Spatial Transcriptomics and Organoids

  Cole R. McCutcheon, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1.5 µM CHIR99021 (Tocris, 4423), 50 ng/mL recombinant human EGF (Gibco ...
• Spatiotemporal map of the developing human reproductive tract at single-cell resolution

  Valentina Lorenzi, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 500nM A83-01 (Tocris, 2939), 50 ng/mL recombinant human EGF (Peprotech ...
• A mitochondrial redox switch licenses the onset of morphogenesis in animals

  Updip Kahlon, et al., bioRxiv - Developmental Biology 2024

  Quote: ... MitoPY1 (Tocris, #4428) at 1mM in 100% DMSO into His2Av-mRFP embryos ...
• Effect of the daily exposure of 1.7 GHz LTE electromagnetic field in early fetal brain development using a human brain organoid model of the cerebral cortex

  Gyu Yeon Park, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and 10 μM SB-431542(Tocris, UK #1614). Neurulation media supplemented with Dorsomorphin and SB-431542 was changed daily from day 1 to day 5 ...
• The transcription factor GABPA is a master regulator of naïve pluripotency

  Chengjie Zhou, Meng Wang, Chunxia Zhang, Yi Zhang, bioRxiv - Developmental Biology 2024

  Quote: ... and 3 μM CHIR99021 (Tocris, 4423).
• The transcription factor GABPA is a master regulator of naïve pluripotency

  Chengjie Zhou, Meng Wang, Chunxia Zhang, Yi Zhang, bioRxiv - Developmental Biology 2024

  Quote: ... 0.5 μM PD0325901 (Tocris, 4192) and 3 μM CHIR99021 (Tocris ...
• CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death

  Paul Chammas, et al., bioRxiv - Developmental Biology 2024

  Quote: ... culture media was changed and 8 µg/mL polybrene (7711, Tocris) was added to the media prior to the addition of 15 µl of concentrated virus ...
• Midfacial retrusion and loss of facial appendages caused by mutation of Pax9 in zebrafish

  Sandhya Paudel, et al., bioRxiv - Developmental Biology 2024

  Quote: ... embryos were treated with BIO (6-bromoindirubin-3’-oxime) (TOCRIS Bioscience), a small molecule inhibitor of glycogen synthase kinase-3 (Sato et al. ...
• Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells

  Robert Morey, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 500nM A83-01 (Tocris), 1.5µM CHIR99021 (Sigma-Aldrich) ...
• Epiboly in zebrafish requires reactive oxygen species produced by NADPH oxidases for the regulation of vesicular trafficking

  Arlen Ramírez-Corona, et al., bioRxiv - Developmental Biology 2024

  Quote: VAS2870 was obtained from different distributors (SML0273, Sigma-Aldrich; 19205, Cayman Chemical; 6654, Tocris; sc-471103 Santa Cruz), hydrogen peroxide (H1009 ...
• Modelling co-development between the somites and neural tube in human Trunk-like Structures (hTLS)

  Komal Makwana, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and single cells were seeded with medium supplemented with 10 µM Y- 27632 (ROCK inhibitor; Tocris Biosciences, 1254). Fresh medium was exchanged daily ...
• Modelling co-development between the somites and neural tube in human Trunk-like Structures (hTLS)

  Komal Makwana, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and 1 µM all trans-retinal (Tocris, 0695), unless otherwise stated ...
• Modelling co-development between the somites and neural tube in human Trunk-like Structures (hTLS)

  Komal Makwana, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and 10 µM SB431542 (Tocris Biosciences, 1614; TGFβ inhibitor) in NutriStem® hPSC XF for 24 hours ...
• Modelling co-development between the somites and neural tube in human Trunk-like Structures (hTLS)

  Komal Makwana, et al., bioRxiv - Developmental Biology 2024

  Quote: ... they were pretreated on the fourth day (96h) with 4 µM CHIR99021 (Chiron; Tocris Biosciences, 4423) and 10 µM SB431542 (Tocris Biosciences ...
• Modelling co-development between the somites and neural tube in human Trunk-like Structures (hTLS)

  Komal Makwana, et al., bioRxiv - Developmental Biology 2024

  Quote: RUES2-GLR hESCs grown routinely in NutriStem® hPSC XF were first plated as single cells at a density of 5.2-6.7 x 103 cells/cm2 with 5 µM Y-27632 (Tocris Biosciences, 1254) for the first 24h after plating ...
• Modelling co-development between the somites and neural tube in human Trunk-like Structures (hTLS)

  Komal Makwana, et al., bioRxiv - Developmental Biology 2024

  Quote: ... cultures were pre-treated in StemFit 02 with 20 ng/mL bFGF supplemented with CHIR99021 (Chiron; Tocris Biosciences, 4423). Alternatively ...
• Modelling co-development between the somites and neural tube in human Trunk-like Structures (hTLS)

  Komal Makwana, et al., bioRxiv - Developmental Biology 2024

  Quote: ... or treated with BMS493 (2.5 µM; Tocris 3509) at 72h during embedding ...
• Modelling co-development between the somites and neural tube in human Trunk-like Structures (hTLS)

  Komal Makwana, et al., bioRxiv - Developmental Biology 2024

  Quote: ... SAG (Tocris, 4366) was added to 20 µL of medium containing 10% growth factor- reduced Matrigel (v/v ...
• Integration of sexual dimorphism and left-right asymmetry in the development of the duck syrinx

  Darcy Mishkind, et al., bioRxiv - Developmental Biology 2024

  Quote: ... and treated with 100µl of 0.375mM or 0.5 mM LDN-193189 dihydrochloride (Tocris 6053) or the same volume of PBS ...
• Integration of sexual dimorphism and left-right asymmetry in the development of the duck syrinx

  Darcy Mishkind, et al., bioRxiv - Developmental Biology 2024

  Quote: ... WNT agonist CHIR 99021(Tocris, 4423) at 2µM ...
• Integration of sexual dimorphism and left-right asymmetry in the development of the duck syrinx

  Darcy Mishkind, et al., bioRxiv - Developmental Biology 2024

  Quote: ... females with 0.1µg/g MPP dihydrochloride (Tocris 1991) diluted in 400µl PBS ...
• Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation

  Magdalena A. Sutcliffe, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μM CHRI99021 (Tocris 4423), 2.5 μM IWP2 ...
• Protrudin acts at ER-endosome contacts to promote KIF5-mediated endosomal fission and endosome-to-Golgi transport

  Julia Kleniuk, et al., bioRxiv - Cell Biology 2024

  Quote: ... was added to iPSCs after thawing to improve recovery and ROCK inhibitor Y-27632 (10 µM, Tocris, 1254) was added occasionally after passaging to improve viability ...
• A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase

  LA Allan, et al., bioRxiv - Cell Biology 2024

  Quote: ... RO-3306 (10μM) from Tocris; the SiR-DNA far-red DNA probe (1:10000 ...
• Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

  Zheng Liao, et al., bioRxiv - Cell Biology 2024

  Quote: ... 0.3 μm WH-4-023 (Tocris, cat. no. 5413), 2 μm Minocycline hydrochloride (Santa Cruz Biotech-nology ...
• Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

  Zheng Liao, et al., bioRxiv - Cell Biology 2024

  Quote: ... or 2.0 μm IWR-1 (Tocris, cat. no. 3532), 65.0 μg ml−1 vitamin C (Sigma ...
• Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

  Zheng Liao, et al., bioRxiv - Cell Biology 2024

  Quote: ... the following small molecules and cytokines were added into 500 ml N2B27 basal media: 0.2 μm CHIR99021 (GSK3i; Tocris, cat. no. 4423), 0.3 μm WH-4-023 (Tocris ...
• Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

  Zheng Liao, et al., bioRxiv - Cell Biology 2024

  Quote: ... the porcine/human EPSCs were resuspended and seeded in pEPSCs supplemented with 5 μm Y27632 (Tocris, cat. no. 1254). The addition of 5% FBS (Gibco ...
• Orthogonal inducible control of Cas13 circuits enables programmable RNA regulation in mammalian cells

  Yage Ding, et al., bioRxiv - Synthetic Biology 2023

  Quote: ... 10000x stocks of Dano (10mM, MedChem Express HW-10238) and CHIR 90021 (GSK3 inhibitor) (10mM, Tocris Bio-Techne 4423) were prepared by dissolving in dimethyl sulfoxide (DMSO ...
• Circadian desynchronization attenuates information throughput of prefrontal cortex pyramidal neurons in mice

  Brandon L. Roberts, Ilia N. Karatsoreos, bioRxiv - Neuroscience 2023

  Quote: ... All compounds were obtained from Tocris Cookson ...
• Contribution of individual excitatory synapses on dendritic spines to electrical signalling

  Ju-Yun Weng, Cesar Ceballos, Dejan Zecevic, bioRxiv - Neuroscience 2023

  Quote: ... The pharmacological agents were obtained from Tocris. The somatic whole-cell recording data were not corrected for liquid junction potential ...
• A local translation program regulates centriole amplification in the airway epithelium

  Helu Liu, et al., bioRxiv - Cell Biology 2023

  Quote: ... 10uM Rock inhibitor Y27632 (Tocris, # 1254) was added to mTEC/Plus only once when the cells were plated ...
• 5-HT_1A and 5-HT_2B receptor interaction and co-clustering regulates serotonergic neuron excitability

  Amina Benhadda, et al., bioRxiv - Neuroscience 2023

  Quote: ... 5-HT1A-R agonist 8-OH-DPAT or antagonist NAN-190 (NAN) were from Tocris (UK). Competition was performed at concentration between 10−11 to 10−5 M ...
• Phosphorylation of pyruvate dehydrogenase marks the inhibition of in vivo neuronal activity

  Dong Yang, et al., bioRxiv - Neuroscience 2023

  Quote: ... Inhibitor cocktail containing 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; Tocris, 10 μM), (2R)-2-amino-5-phosphonopentanoic acid (AP5 ...
• A thin-film optogenetic visual prosthesis

  Eric B Knudsen, et al., bioRxiv - Neuroscience 2023

  Quote: ... resuspended in DMEM media with 10µM Y-27632 (ROCK inhibitor, Tocris), and plated ...
• RGS14 is neuroprotective against seizure-induced mitochondrial oxidative stress and pathology in hippocampus

  Nicholas H Harbin, et al., bioRxiv - Neuroscience 2023

  Quote: ... KA (3 mg/mL) was prepared on the day of experimentation by dissolving KA (Tocris, 0222) in a 0.9% bacteriostatic saline solution ...