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Citations for Tocris :
1051 - 1093 of 1093 citations for tert Butyl 2 chloro 5H pyrrolo 3 4 b pyridine 6 7H carboxylate since 2020
Citations are collected from bioRxiv only, the total number of publications could be much larger.
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bioRxiv - Pathology 2022Quote: About 0.1 to 0.2 MOI (Multiplicity of Infection) equivalent of VSV-G and pseudotype SARS-CoV-2 spike virus particles were treated with recombinant LL37 (Tocris) and niacinamide (vitamin B3 ...
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bioRxiv - Cell Biology 2022Quote: ... resuspended in DMEM-1%BSA and incubated in suspension for 30 min at 37°C in 10% CO2 and 2 μg/ml CT04 (#CT04-A, Cytoskeleton or 10 μM EHT1864 (#3872, Tocris). The vehicle control included the corresponding dilution of DMSO as needed ...
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bioRxiv - Microbiology 2024Quote: ... the cells were hybridized with V-EV71-C1 probe (Biotechne) at 40°C for 2 hours and then the signals were revealed using TSA Vivid 570 kit (Tocris). The slides were then incubated with blocking buffer and incubated with MAB979 (1:100 ...
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bioRxiv - Neuroscience 2024Quote: ... another group of animals received an ip injection of WIN55,212-2 (0.5 mg/kg) along with CB1 receptor antagonist SR141716A (0.5 mg/kg, ip) (Tocris Bioscience, Bristol, UK). Rats were randomly selected for each group ...
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bioRxiv - Neuroscience 2023Quote: Adherent human iPSCs were grown to near confluence before the differentiation to heterogenous spinal/hindbrain neurons was initiated by changing the media for two days to media d1-2 (200 nM LDN193189 [Tocris, 6053] ...
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bioRxiv - Neuroscience 2023Quote: Adherent human iPSCs were grown to near confluence before the differentiation to heterogenous spinal/hindbrain neurons was initiated by changing the media for two days to media d1-2 (200 nM LDN193189 [Tocris, 6053], 10 µM SB431542 [Tocris, 1614] ...
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bioRxiv - Cell Biology 2023Quote: ... Cells were cultured in an ad hoc defined generic medium (Supplementary Table 2) supplemented with Rho-kinase inhibitor (ROCKi; Tocris) and Primocin ...
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bioRxiv - Neuroscience 2023Quote: ... 1 MgCl2, and 2 CaCl2 (300-310 mOsm, pH adjusted to 7.4 with NaOH) supplemented by SC79 (5uM, Tocris 4635) or A769662 (1uM ...
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bioRxiv - Biochemistry 2023Quote: ... Washed membranes were incubated in the hypotonic buffer in the presence of 2 mg/ml iodoacetamide and 50 μm SSR149415 (Tocris) for 20 min ...
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bioRxiv - Pharmacology and Toxicology 2024Quote: ... The slow delayed rectifier potassium current (IKs) was isolated as the current sensitive to 2 µM JNJ303 (Tocris, Bristol, UK). 10 µM nifedipine 5 µM E4031 and 1 µM SEA0400 (all from Sigma-Aldrich ...
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bioRxiv - Neuroscience 2024Quote: ... and control mice (littermates lacking either the Cre or GqDREADD gene) were given an IP injection of CNO (3 mg/kg, Tocris, Cat. No. 6329, 0.5 mg/ml in saline) >30 minutes before the assessment ...
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bioRxiv - Neuroscience 2024Quote: ... and control mice (littermates lacking either the Cre or GqDREADD gene) were given an IP injection of CNO (3 mg/kg, Tocris, Cat. No. 6329, 0.5 mg/ml in saline) >30 minutes before the assessment but was otherwise identical to the previous 3 training days ...
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bioRxiv - Neuroscience 2024Quote: ... and control mice (littermates lacking Cre and/or GqDREADD genes) were given an IP injection of CNO (3 mg/kg, Tocris, Cat. No. 6329, 0.5 mg/ml in saline) >30 minutes before the assessment but was otherwise identical to the training days.
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bioRxiv - Neuroscience 2021Quote: ... NMDA receptor (R) dependency was tested by application of an NMDAR antagonist (APV 50 µM, DL-2-Amino-5-phosphonopentanoic acid, Tocris, Germany) in the bath solution ...
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bioRxiv - Pharmacology and Toxicology 2020Quote: ... and a fourth group (DZP) received 2 mg/kg diazepam (CAS #439-14-5; Tocris, 2805; German-Ponciano et al., 2020) as a pharmacological control of anxiolytic activity ...
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bioRxiv - Physiology 2021Quote: ... Picrotoxin (100 µM) was used to block GABAA-receptor-mediated currents and D-2-amino-5-phosphonovalerate (APV; 20 µMm, Tocris Bioscience), and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX ...
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bioRxiv - Neuroscience 2022Quote: ... The medium was then changed to 3N (50:50 DMEM/F12:neurobasal with N2 and B27 supplements) (Shi et al., 2012) without vitamin A with 2 µM DMH1 (Tocris, 4126), 2 µM XAV939 (Cayman Chemical ...
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bioRxiv - Neuroscience 2022Quote: ... containing 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 50 μM D,L-2-amino-5-phosphonovaleric acid (AP5) (both from Tocris, Bristol, UK) to block recurrent glutamatergic signaling.
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bioRxiv - Cell Biology 2022Quote: ... Inhibitors were resuspended in DMSO and serially diluted in medium to their final working concentration and added on day 0 (Lats1/2 inhibitor Truli40 (CSNpharm, # CSN26140) or the Limk1 inhibitor Damnacanthal41 (Tocris, # 1936)) ...
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bioRxiv - Neuroscience 2022Quote: ... Non-specific binding was measured in the presence of 2 µM of Xanthine Amine Congener (XAC, Tocris Bioscience, Bristol, United Kingdom), and the resulting values were subtracted from those obtained with [3H]DPCPX35 to determine the specific binding and normalized for protein concentration ...
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bioRxiv - Neuroscience 2023Quote: ... The following compounds were added to raCSF as indicated in the Results section: D-(-)-2-Amino-5-phosphonopentanoic acid (D-APV, 100 μM dissolved in H2O; Tocris Bioscience), (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate (MK-801 ...
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bioRxiv - Cell Biology 2024Quote: ... + 10 μM Tranylcypromine (2-PCPA) HCl (DMSO; Selleckchem S4246) + 20 μM Forskolin (DMSO; Selleckchem S2449) + 1 μM Ch 55 (DMSO; Tocris 2020) + 5 μM EPZ004777 (DMSO ...
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bioRxiv - Neuroscience 2024Quote: ... Both control and CACNA1A+/− networks at DIV49 were treated acutely with 100 µM D-2-amino-5-phosphonovalerate (D-AP5; Tocris, #0106) for 60 min ...
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bioRxiv - Immunology 2024Quote: ... The following inhibitors were added to the cells for 24 hours before harvesting: the NF-κB inhibitor JSH23 (2 µM, Tocris Bioscience), STING inhibitor H151 (5 µM ...
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bioRxiv - Cell Biology 2024Quote: ... 1.0×105 cells/cm2 for anti-fibrotic condition consisting in FibroGRO 2% FBS supplemented with 75ng/mL of bFGF and 500nM of TGF-β inhibitor (A83-01, Tocris). iPSC-cFbs were maintained for 7 days in culture replacing medium each second day ...
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bioRxiv - Neuroscience 2023Quote: ... the medium was then changed to 3N (50:50 DMEM/F12:neurobasal with N2 and B27 supplements) without vitamin A with 2 µM DMH1 (Tocris, 4126), 2 µM XAV939 (Cayman Chemical ...
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bioRxiv - Physiology 2023Quote: ... the cell medium was replaced with the experimental medium (2 ml/well) consisting of DMEM containing 1 nM of 1,25-dihydroxyvitamin D3 (Tocris; Cat. #2551), as described previously58 ...
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bioRxiv - Neuroscience 2023Quote: iPSCs were replated at a density of 2 x 104 cells/cm2 in mTeSR medium containing 10 µM Rho kinase inhibitor (Y-27632, Tocris #5849), which was removed after 24 hours ...
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bioRxiv - Molecular Biology 2024Quote: ... U2OS cells were extracted 1x PBS containing 0.2% Triton-X100 supplemented with PARP inhibitor (olaparib, 1 μM, Selleckchem #S1060) and PARG inhibitor (PDD 00017273, 1 μM, Tocris #5952) to stabilize ADP-ribosylated species for 5 min on ice prior to fixation with 3% paraformaldehyde/2% sucrose for 15 min at ambient temperature ...
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bioRxiv - Neuroscience 2024Quote: ... The chemogenetic manipulation was carried out 30 minutes after the intraperitoneal injection of CNO at a dosage of 2 mg/kg (TOCRIS Bioscience) or after the administration of saline ...
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bioRxiv - Genetics 2024Quote: ... On Day 3 (after 48 hr) media was replaced with CDM containing 2 μM of the Wnt signaling inhibitor Wnt-C59 (5148, Tocris Bioscience) in CDM ...
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bioRxiv - Bioengineering 2021Quote: ... the medium was switched to N2B27 medium supplemented with 100 ng/mL VEGFA (ProSpec, CYT-116) and 2 μM forskolin (Tocris Bioscience, 1099) for two days ...
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bioRxiv - Neuroscience 2020Quote: ... containing 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 50 μM D,L-2-amino-5-phosphonovaleric acid (AP5) to block glutamatergic signaling (both from Tocris, Bristol, UK). Experiments involving tetrodotoxin (TTX ...
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bioRxiv - Cancer Biology 2024Quote: ... mice were randomized into groups and treated daily (5 days on, 2 days off) with 1mg/kg SB290157 trifluoroacetate (Tocris, 6860/5) intra-peritoneally ...
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bioRxiv - Immunology 2024Quote: ... Bone marrow-derived macrophages were plated at 2×105 cells/mL and treated with PBS or 500 ng/mL PAM3CSK4 (Tocris Bioscience, 4633) for 6 hours ...
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bioRxiv - Developmental Biology 2024Quote: ... Between 1.5 × 106 and 3.0 × 106 cells were added to each well in 2 ml mTeSR medium with 10 μM Rho-kinase inhibitor Y-27632 dihydrochloride (Tocris, UK # 1254). To aggregate the cells into the microwells ...
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bioRxiv - Neuroscience 2020Quote: ... slices were equilibrated for 10 minutes while being continuously superfused at room temperature with oxygenated aCSF at 1-2 ml/min containing picrotoxin (50 μM, Tocris Bioscience, MO, USA) to block GABAA receptor-mediated inhibitory responses.
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bioRxiv - Neuroscience 2024Quote: ... a third group of animals were treated as those in group 2 with the addition of CB1 receptor antagonist AM251 (1 µM) (Tocris Bioscience, Bristol, UK). After 8 DIV ...
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bioRxiv - Cell Biology 2024Quote: All cell lines were washed with PBS then starved of amino acids or FBS for 2 hours before treatment with the GPCR antagonists at 1 µM: CNO (Tocris/bio-techne 6329), Isoprenaline/Carvedilol (Sigma/Merck I6504 ...
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bioRxiv - Bioengineering 2024Quote: ... FAST-STEM hiPSCs grown to 80% confluency were dissociated into single cells using TypLE for 5 minutes and seeded into the Aggrewell at a density of 1.2×105 cells per-well in 1 mL of mTesR Plus with 10 μg/mL ROCK Inhibitor Y-27632 (Tocris Bioscience, Bristol, UK; 1254) and 1% Penicillin-Streptomycin (Life Technologies ...
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bioRxiv - Bioengineering 2024Quote: ... was obtained through the administration of exponential doses with concentrations of 1 nM to 10 mM at 2 min intervals before the administration of 10 μM scopolamine (Tocris Bioscience Cat#1414/1G). After another equilibrium period ...
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bioRxiv - Neuroscience 2023Quote: ... we tested effects of an inhibitor (the spider toxin GsMTX 4; Tocris #4912 stock 50 μM in DMSO and the Piezo1 channel activator Yoda1 (Tocris 6586 10 and 20 uM, stock 20 mM in DMSO).
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bioRxiv - Neuroscience 2024Quote: Slices from 6-month-old mice were pre-incubated ≥1.5hours and then bath-perfused during dLight recording with LRRK2 kinase inhibitor MLi-2 (500 nM, Tocris 5756, 45% Captisol® in PBS) or vehicle-control (45% Captisol® in PBS 377.6µL/L aCSF) ...