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5701 - 5750 of 7257 citations since 2019

• Expression of FoxP2 in the Basal Ganglia Regulates Vocal Motor Sequences in the Adult Songbird

  Lei Xiao, et al., bioRxiv - Neuroscience 2020

  Quote: ... SKF 38393 hydrobromide (SKF) or (-)-Quinpirole hydrochloride (Qui) (#3548, #0922 and #106, Tocris, MN, USA) into Area X to simulate tonically elevated DA levels ...
• Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways

  Jelena Ostojić, et al., bioRxiv - Cell Biology 2020

  Quote: ... L-DOPA was obtained from Tocris Bioscience (3788).
• Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure

  Patricia Rueda, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... SLV-320 (Tocris, RDS334410), CGS21680 (Tocris ...
• Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure

  Patricia Rueda, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... MRS1754 (Tocris, 2752), methoxamine (Sigma-Aldrich ...
• Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure

  Patricia Rueda, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... BAY60-6583 (Tocris, 4472), 2’Me-CCPA (Tocris ...
• Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure

  Patricia Rueda, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... 2’Me-CCPA (Tocris, 2281), MRS1754 (Tocris ...
• Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure

  Patricia Rueda, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... CGS21680 (Tocris, 1063; Sigma-Aldrich, C141), BAY60-6583 (Tocris ...
• Differential homeostatic regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses

  Xiaojuan Yang, et al., bioRxiv - Neuroscience 2020

  Quote: Cultured neurons were treated for one hour with tetrodotoxin citrate (TTX, Cat. No. 1069, Tocris) or 4-aminopyridine (4-AP ...
• The Taste of Blood in Mosquitoes

  Veronica Jové, et al., bioRxiv - Neuroscience 2020

  Quote: (E)-capsaicin (Tocris #0462)
• Dopamine release and its control over early Pavlovian learning differs between the NAc core and medial NAc shell

  Claire E. Stelly, et al., bioRxiv - Neuroscience 2020

  Quote: Flupenthixol dihydrochloride (Tocris) was dissolved in sterile 0.9% NaCl ...
• Gating transitions and modulation of a hetero-octameric AMPA glutamate receptor

  Danyang Zhang, et al., bioRxiv - Neuroscience 2020

  Quote: ... protein was first incubated with 300 μM Cyclothiazide (CTZ, Tocris, Cat# 0713) for at least 30 min on ice and then quickly mixed with 1 M L-glutamate stock solution to a final concentration of 100 mM prior to loading onto the grids ...
• eNOS-dependent S-nitrosylation of the NF-κB subunit p65 has neuroprotective effects

  Ariel Caviedes, et al., bioRxiv - Neuroscience 2020

  Quote: ... 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) (Cat. N° 0190) and N5-1(1-Iminoethyl)-L-ornithine dihydrochloride (LNIO) (Cat. N° 0546) were obtained from Tocris Bioscience (Bristol ...
• Pallidal deep brain stimulation alters cortico-striatal synaptic communication in dystonic hamsters

  Marco Heerdegen, et al., bioRxiv - Neuroscience 2020

  Quote: ... the GABAA receptor antagonist gabazine (SR 95531 hydrobromide, Tocris, Wiesbaden-Nordenstadt, Germany, 5 μM) was bath-applied for 60 min after having recorded a minimum of 20 min stable baseline responses ...
• Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

  Leon Tejwani, et al., bioRxiv - Neuroscience 2020

  Quote: ... and re-plated at 1:6 ratio on Matrigel-coated plate in neural medium supplemented with 1μM CHIR99021 (Tocris), 2μM DMH1 (Tocris) ...
• Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

  Leon Tejwani, et al., bioRxiv - Neuroscience 2020

  Quote: ... and re-plated at 1:6 ratio on Matrigel-coated plate in neural medium supplemented with 3μM CHIR99021 (Tocris), 2μM DMH1 (Tocris) ...
• Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

  Leon Tejwani, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2μM DMH1 (Tocris), 2μM SB431542 (Stemgent) ...
• Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

  Leon Tejwani, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2μM DMH1 (Tocris), and 2μM SB431542 (Stemgent) ...
• Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

  Leon Tejwani, et al., bioRxiv - Neuroscience 2020

  Quote: ... mTeSR1 medium was replaced with neural medium supplemented with 3μM CHIR99021 (Tocris), 2μM DMH1 (Tocris) ...
• Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

  Leon Tejwani, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2μM DMH1 (Tocris), 2μM SB431542 (Stemgent) ...
• Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats

  RAR Drake, et al., bioRxiv - Neuroscience 2020

  Quote: ClozepineN-Oxide (Tocris, UK) was purchased and made up on the day of use in DMSO and diluted with 0.9% NaCl to a final concentration of 2.5mg.ml−1 and 5% DMSO.
• Analgesic α-conotoxins modulate GIRK1/2 channels via GABA_B receptor activation and reduce neuroexcitability

  Anuja R. Bony, et al., bioRxiv - Neuroscience 2020

  Quote: ... CGP 55845 ((2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl] (phenylmethyl) phosphinic acid hydrochloride) and GRK2i were purchased from Tocris Bioscience (Bristol ...
• Electrical synaptic transmission requires a postsynaptic scaffolding protein

  Abagael M. Lasseigne, et al., bioRxiv - Neuroscience 2020

  Quote: ... CNQX and DAP5 (20 μM, Tocris Biosciences). The M-cell input resistance was estimated by applying a hyperpolarizing-current step of −1 nA and 20 ms in duration and measuring the voltage deflection caused ...
• Voltage-gated potassium channels ensure action potential shape fidelity in distal axons

  Victoria Gonzalez Sabater, et al., bioRxiv - Neuroscience 2020

  Quote: ... and/or Tetrodotoxin (TTX, 40nM, Tocris) were supplied using a custom gravity-fed perfusion system powered ...
• A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

  Ao Dong, et al., bioRxiv - Neuroscience 2020

  Quote: ... AM251 (Tocris), LPA (Tocris) ...
• A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

  Ao Dong, et al., bioRxiv - Neuroscience 2020

  Quote: ... S1P (Tocris), ACh (Solarbio) ...
• A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

  Ao Dong, et al., bioRxiv - Neuroscience 2020

  Quote: ... LPA (Tocris), S1P (Tocris) ...
• A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

  Ao Dong, et al., bioRxiv - Neuroscience 2020

  Quote: ... NE (Tocris), 5-HT (Tocris) ...
• A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

  Ao Dong, et al., bioRxiv - Neuroscience 2020

  Quote: ... Ado (Tocris), Tyr (Sigma-Aldrich) ...
• Aberrant PARP1 Activity Couples DNA Breaks to Deregulated Presynaptic Calcium Signalling and Lethal Seizures

  Emilia Komulainen, et al., bioRxiv - Neuroscience 2020

  Quote: ... Hippocampal cells treated for PAN immunofluorescence were administered 10 μM PARG inhibitor PDD 00017273 (Tocris) in DMSO for 1 h following pre-treatment with 5 μM PARPi Ku-0058948 or DMSO vehicle ...
• Rapid recycling of glutamate transporters on the astroglial surface

  Piotr Michaluk, Janosch Heller, Dmitri A. Rusakov, bioRxiv - Neuroscience 2020

  Quote: In some FRAP experiments (see Results) we used the following drugs in the bath solution: TTX (1 μM, Tocris), MPEP (1 μM ...
• Rapid recycling of glutamate transporters on the astroglial surface

  Piotr Michaluk, Janosch Heller, Dmitri A. Rusakov, bioRxiv - Neuroscience 2020

  Quote: ... MPEP (1 μM, Tocris), NBQX (10 μM ...
• Rapid recycling of glutamate transporters on the astroglial surface

  Piotr Michaluk, Janosch Heller, Dmitri A. Rusakov, bioRxiv - Neuroscience 2020

  Quote: ... NBQX (10 μM, Tocris), LY 341495 (30 nM ...
• Rapid recycling of glutamate transporters on the astroglial surface

  Piotr Michaluk, Janosch Heller, Dmitri A. Rusakov, bioRxiv - Neuroscience 2020

  Quote: ... YM (300 nM, Tocris), Bicuculine (10 μM ...
• Rapid recycling of glutamate transporters on the astroglial surface

  Piotr Michaluk, Janosch Heller, Dmitri A. Rusakov, bioRxiv - Neuroscience 2020

  Quote: ... LY 341495 (30 nM, Tocris), YM (300 nM ...
• Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics in a high-cholesterol diet mouse model

  J. Ethan Joll II, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... Alzet minipumps (model 1004) delivering either the high-affinity 5-HT2B antagonist SB204741 (Tocris Biosciences; 1 mg kg-1d-1) or vehicle (50% dimethyl sulfoxide [Sigma-Aldrich] and polyethylene glycol-400 [Fisher Chemical] ...
• The HSPG Syndecan is a core organizer of cholinergic synapses in C. elegans

  Xin Zhou, et al., bioRxiv - Neuroscience 2020

  Quote: ... All chemicals were obtained from Sigma-Aldrich except DHβE provided by Tocris. All experiments were done at 20°C.
• Intronic enhancer region governs transcript-specific BDNF expression in neurons

  Jürgen Tuvikene, et al., bioRxiv - Neuroscience 2020

  Quote: Cultured cortical astrocytes were treated at 15 DIV with 150 μM dopamine (Tocris) to study the regulation of the BDNF gene by catecholamines or 0.15% DMSO (Sigma ...
• Intronic enhancer region governs transcript-specific BDNF expression in neurons

  Jürgen Tuvikene, et al., bioRxiv - Neuroscience 2020

  Quote: ... cultured neurons were pre-treated with 1 μM tetrodotoxin (Tocris) until the end of the experiment to inhibit spontaneous neuronal activity ...
• Kcnq2/Kv7.2 controls the threshold and bihemispheric symmetry of cortical spreading depolarization

  Isamu Aiba, Jeffrey L Noebels, bioRxiv - Neuroscience 2020

  Quote: Retigabine was obtained from Tocris and ML213 from Sigma ...
• Functional microstructure of Ca_V-mediated calcium signaling in the axon initial segment

  Anna M Lipkin, et al., bioRxiv - Neuroscience 2020

  Quote: ... Nifedipine was from Tocris. All calcium channel antagonists were prepared as stock solutions in ddH20 in glass vials ...
• The G protein-Coupled Metabotropic Glutamate Receptor 1 controls neuronal macroautophagy

  Maribel Donoso, et al., bioRxiv - Neuroscience 2020

  Quote: ... after rinsing with medium cells were incubated with vehicle or with 50 μM S-DHPG (Tocris) for 15 min at 37°C ...
• The G protein-Coupled Metabotropic Glutamate Receptor 1 controls neuronal macroautophagy

  Maribel Donoso, et al., bioRxiv - Neuroscience 2020

  Quote: ... cells were rinsed and incubated for indicated times with fresh medium with either vehicle or 10 μM BAY 36-7620 (Tocris) in the presence or absence of lysosomal inhibitors ...
• Functional microstructure of Ca_V-mediated calcium signaling in the axon initial segment

  Anna M Lipkin, et al., bioRxiv - Neuroscience 2020

  Quote: ... Ryanodine was from Tocris and was prepared as a stock solution (25 mM ...
• Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition

  Katarina Stoklund Dittlau, et al., bioRxiv - Neuroscience 2020

  Quote: ... 40 μM SB431542 (Tocris Bioscience, Bristol, UK, Cat N° 1614) and 3 μM CHIR99021 (Tocris Bioscience ...
• Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition

  Katarina Stoklund Dittlau, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 3 μM CHIR99021 (Tocris Bioscience, Cat N° 4423) for 2 days with medium changes every day (=day 0-1) ...
• A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

  Ao Dong, et al., bioRxiv - Neuroscience 2020

  Quote: ... 5-HT (Tocris), His (Tocris) ...
• Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry

  Gregory G. Grecco, et al., bioRxiv - Neuroscience 2020

  Quote: ... The bath solution for recordings contained elevated concentrations of divalent cations [4 mM Ca2+ and 4 mM Mg2+] and NMDA receptor antagonist 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) [5 mM] (Tocris biosciences, 126453-07-4). Slices were used 1.5–4.5 hours after preparation ...
• Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry

  Gregory G. Grecco, et al., bioRxiv - Neuroscience 2020

  Quote: ... MNI-caged glutamate (Tocris Bioscience, 295325-62-1) [0.2 mM] was combined with recirculating solution for all recordings ...
• Adenosine modulates extracellular glutamate levels via adenosine A2A receptors in the delayed-ethanol induced headache

  Nathan T. Fried, et al., bioRxiv - Neuroscience 2020

  Quote: ... and istradeffyline (Tocris, Bristol, UK) within the perfusate ...
• Voltage-gated potassium channels ensure action potential shape fidelity in distal axons

  Victoria Gonzalez Sabater, et al., bioRxiv - Neuroscience 2020

  Quote: ... all recordings were performed in presence of NBQX (10 µM, Tocris), Gabazine (10 µM ...