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5501 - 5550 of 7257 citations since 2019

• RNA sequence and structure determinants of Pol III transcriptional termination in human cells

  Matthew S. Verosloff, et al., bioRxiv - Molecular Biology 2020

  Quote: ... and 200 μL of flow buffer supplemented to a final concentration of 5 μM DFHO dye (TOCRIS Bioscience) was added prior to analysis by flow cytometry.
• Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal Crypt

  Michael T. Shanahan, et al., bioRxiv - Molecular Biology 2020

  Quote: ... enteroids were treated with IWP2 (Tocris Bioscience, Bristol, UK, cat. 3533) and verteporfin (Sigma-Aldrich ...
• Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

  Judit García-González, et al., bioRxiv - Genetics 2020

  Quote: ... serial dilutions of the dopaminergic and serotonergic antagonist amisulpride (Tocris, Bristol, UK, 71675-86-9) were prepared to give final concentrations of 0.05 mg/L ...
• Persistent telomere cohesion protects aged cells from premature senescence

  Kameron Azarm, et al., bioRxiv - Molecular Biology 2020

  Quote: ... CHK1 inhibitor SB 218078 (Tocris, 250 nM), and CHK2 inhibitor (Sigma ...
• Neuromesodermal Progenitors Advance Network Formation of Spinal Neurons and Support Cells in Neural Ribbons In Vitro and Unprotected Survival in a Rat Subacute Contusion Model

  Zachary T. Olmsted, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2 μM CHIR99021 (Tocris Bioscience), 10 μM DAPT (Millipore Sigma) ...
• Neuromesodermal Progenitors Advance Network Formation of Spinal Neurons and Support Cells in Neural Ribbons In Vitro and Unprotected Survival in a Rat Subacute Contusion Model

  Zachary T. Olmsted, et al., bioRxiv - Neuroscience 2020

  Quote: ... 10 μM SB431542 (Tocris Bioscience), 100 nM LDN193189 (Tocris Bioscience) ...
• Neuromesodermal Progenitors Advance Network Formation of Spinal Neurons and Support Cells in Neural Ribbons In Vitro and Unprotected Survival in a Rat Subacute Contusion Model

  Zachary T. Olmsted, et al., bioRxiv - Neuroscience 2020

  Quote: ... 10 μM Y-27632 (Tocris Bioscience) was added during passages and replaced with fresh medium ...
• Neuromesodermal Progenitors Advance Network Formation of Spinal Neurons and Support Cells in Neural Ribbons In Vitro and Unprotected Survival in a Rat Subacute Contusion Model

  Zachary T. Olmsted, et al., bioRxiv - Neuroscience 2020

  Quote: ... 100 nM LDN193189 (Tocris Bioscience), 0.36 U/ml heparin (Millipore Sigma) ...
• Excitatory GABAergic modulation of calyx terminals in the vestibular sensory end organ

  Yugandhar Ramakrishna, Soroush G. Sadeghi, bioRxiv - Neuroscience 2020

  Quote: ... and XE-991 (10 µM) were purchased from Tocris Bioscience ...
• Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

  Michelle C. Ward, et al., bioRxiv - Genomics 2020

  Quote: ... 2 μM of the Wnt inhibitor Wnt-C59 (5148, Tocris Bioscience), diluted in Cardiomyocyte Differentiation Media ...
• Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

  Michelle C. Ward, et al., bioRxiv - Genomics 2020

  Quote: ... iPSC lines at 70-100% confluence in 100 mm plates were treated with 12 μM GSK3 inhibitor CHIR99021 trihydrochloride (4953, Tocris Bioscience, Bristol, UK) in 12 ml Cardiomyocyte Differentiation Media [500 mL RPMI1640 (15-040-CM ThermoFisher Scientific) ...
• Identification of determinants of differential chromatin accessibility through a massively parallel genome-integrated reporter assay

  Jennifer Hammelman, et al., bioRxiv - Genomics 2020

  Quote: ... Electroporated cells were plated in mESC media supplemented with 7.5 mM Y-27632 (Tocris). From 24 to 72 hr after electroporation ...
• Successful Correction of ALD Patient-derived iPSCs Using CRISPR/Cas9

  Eul Sik Jung, et al., bioRxiv - Neuroscience 2020

  Quote: ... when SB431542 and LDN193189 (Tocris, UK; Cat. No. #6053) were withdrawn and smoothened agonist 1μM SAG (Cayman Chemical ...
• Successful Correction of ALD Patient-derived iPSCs Using CRISPR/Cas9

  Eul Sik Jung, et al., bioRxiv - Neuroscience 2020

  Quote: ... supplemented with 10μM SB431542 (Tocris, UK; Cat. No. #1614), 1 μM LDN193189 ...
• Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model

  Yu-Han Hung, et al., bioRxiv - Genomics 2020

  Quote: ... contained 10μM Y27632 (Tocris). Matrigel was digested for 30 minutes with cold 4mM EDTA-DPBS and organoids were washed 4X with cold DPBS ...
• A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

  Ryan J. Geusz, et al., bioRxiv - Genomics 2020

  Quote: ... supplemented with 10 µm SB431542 (‘‘SB’’; Tocris) and 2 µm Dorsomorphin (‘‘DS’’ ...
• A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

  Ryan J. Geusz, et al., bioRxiv - Genomics 2020

  Quote: ... consisting of cSFDM base supplemented with 3 µm CHIR99021 (Tocris), 10 ng/mL rhKGF (R&D Systems) ...
• A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

  Ryan J. Geusz, et al., bioRxiv - Genomics 2020

  Quote: ... ‘‘CBRa’’ medium consists of cSFDM base supplemented with 3 µM CHIR99021 (Tocris), 10 ng/mL recombinant human BMP4 (rhBMP4 ...
• Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm diversification during foregut organogenesis

  Lu Han, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and passaged 1:18 onto new Geltrex-coated 24-well plates for immunocytochemistry and 12-well plates for RNA preparation in mTeSR1 with 1uM thiazovivin (Tocris) (Day -1) ...
• Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm diversification during foregut organogenesis

  Lu Han, et al., bioRxiv - Developmental Biology 2020

  Quote: ... + 6uM CHIR99021 (Tocris) +20ng/ml FGF2 (Thermo Fisher Scientific ...
• Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm diversification during foregut organogenesis

  Lu Han, et al., bioRxiv - Developmental Biology 2020

  Quote: ... 2uM RA+ 2uM PMA (Tocris) is used for 2 days ...
• Anti-tumor effects of an Id antagonist with no acquired resistance

  Paulina M. Wojnarowicz, et al., bioRxiv - Cancer Biology 2020

  Quote: ... A83-01 (Tocris, 0.5 µM) as previously described (Boj et al. ...
• Identifying strategies to target the metabolic flexibility of tumours

  Andrés Méndez-Lucas, et al., bioRxiv - Cancer Biology 2020

  Quote: ... TGF-ß type I receptor inhibitor A83-01 (Tocris), P38 inhibitor SB202190 (Sigma-Aldrich) ...
• Procentriole microtubules as drivers of centriole reduplication

  Alejandra Vasquez-Limeta, et al., bioRxiv - Cell Biology 2020

  Quote: ... 10 μM of RO3306 (Tocris; 4181) was used to inhibit Cdk1 activity and arrest cells in G2 ...
• Procentriole microtubules as drivers of centriole reduplication

  Alejandra Vasquez-Limeta, et al., bioRxiv - Cell Biology 2020

  Quote: ... MT polymerization was inhibited with 2 μM Nocodazole (Noc; Tocris; 1228). Ciliobrevin (Ciliobr ...
• Reconstitution of human kinetochore in mitotic cell extracts reveals permitted and restricted assembly steps

  Ekaterina V. Tarasovetc, et al., bioRxiv - Cell Biology 2020

  Quote: ... an Aurora B inhibitor (Tocris). The inhibitor had no significant effect on the levels of CENP-C ...
• The Initiation Knot is a Signaling Center Required for Molar Tooth Development

  Isabel Mogollón, et al., bioRxiv - Cell Biology 2020

  Quote: ... for stimulation and XAV939 (10μM; Tocris) to inhibit canonical Wnt signaling was added to the growth medium for 24h ...
• A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

  Stephen Tang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... cells were treated with a combination of furamidine (Tocris) and enzalutamide (Selleck ...
• A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

  Stephen Tang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... or MS023 (Tocris, #5713) was added at the indicated concentrations using a D300e Digital Dispenser (Tecan ...
• A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

  Stephen Tang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... furamidine (Tocris, #5202) or MS023 (Tocris ...
• A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

  Stephen Tang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... MS023 was obtained from Tocris (#5713) and dissolved to a stock concentration of 1 mM.
• A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

  Stephen Tang, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Furamidine was obtained from Tocris (#5202) and dissolved to a stock concentration of 10 mM ...
• Cdk5 and GSK3β inhibit Fast Endophilin-Mediated Endocytosis

  Antonio P. A. Ferreira, et al., bioRxiv - Cell Biology 2020

  Quote: ... Torin 1 (called ‘mTORC1i’ in this study, Tocris 4247), VX-745 (called ‘p38i’ in this study ...
• Cdk5 and GSK3β inhibit Fast Endophilin-Mediated Endocytosis

  Antonio P. A. Ferreira, et al., bioRxiv - Cell Biology 2020

  Quote: ... PD0325901 (called ‘MEKi’ in this study, Tocris 4192), PD0332991 aka Palbociclib (called ‘Cdk4/6i’ in this study ...
• Cdk5 and GSK3β inhibit Fast Endophilin-Mediated Endocytosis

  Antonio P. A. Ferreira, et al., bioRxiv - Cell Biology 2020

  Quote: ... MLR 1023 (called ‘LYNa’ in this study, Tocris 4582), PD0325901 (called ‘MEKi’ in this study ...
• Cdk5 and GSK3β inhibit Fast Endophilin-Mediated Endocytosis

  Antonio P. A. Ferreira, et al., bioRxiv - Cell Biology 2020

  Quote: ... GDC-0879 (called ‘BRAFi’ in this study, Tocris 4453), GDC-0941 (called ‘PI3Ki’ in this study ...
• Linking endoplasmic reticulum stress to polyploidy in ovarian cancer cells

  Lucile Yart, et al., bioRxiv - Cell Biology 2020

  Quote: ... STF-083010 (STF; Selleckchem, Zurich, Switzerland), 4μ8C (Selleckchem, Zurich, Switzerland), GSK2656157 (GSK; Selleckchem, Zurich, Switzerland) and Salubrinal (SAL; Tocris Biosciences, Bristol, UK).
• Bi-directional Impacts of Heterotypic Interactions in Engineered 3D Human Cardiac Microtissues Revealed by Single-Cell RNA-Sequencing and Functional Analysis

  Tracy A. Hookway, et al., bioRxiv - Bioengineering 2020

  Quote: ... 5μM IWP2 (Tocris, Bristol, UK) in RPMI/B27-was added and then removed 48h later by refreshing the medium ...
• Proliferation control of kidney interstitial cells

  Sarah S. McCarthy, et al., bioRxiv - Developmental Biology 2020

  Quote: ... IWR1 (10uM; Tocris, 3532/10), IWP2 (5uM ...
• Proliferation control of kidney interstitial cells

  Sarah S. McCarthy, et al., bioRxiv - Developmental Biology 2020

  Quote: FH535 (Tocris, 4344/10) was used at 15µM for in vitro experiments with DMEM + 2% serum as vehicle control ...
• Proliferation control of kidney interstitial cells

  Sarah S. McCarthy, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and TGFβ Receptor I Inhibitor II (25nM; Tocris were also used in this study ...
• Proliferation control of kidney interstitial cells

  Sarah S. McCarthy, et al., bioRxiv - Developmental Biology 2020

  Quote: ... IWP2 (5uM; Tocris, 3533/10) and TGFβ Receptor I Inhibitor II (25nM ...
• A molecular filter for the cnidarian stinging response

  Keiko Weir, et al., bioRxiv - Physiology 2020

  Quote: ... BAPTA (10mM, Tocris), GDPβS (1mM ...
• A molecular filter for the cnidarian stinging response

  Keiko Weir, et al., bioRxiv - Physiology 2020

  Quote: ... tubocurarine (10μM, Tocris), TEA (10mM ...
• A molecular filter for the cnidarian stinging response

  Keiko Weir, et al., bioRxiv - Physiology 2020

  Quote: ... nicotine (100μM, Tocris), tubocurarine (10μM ...
• A molecular filter for the cnidarian stinging response

  Keiko Weir, et al., bioRxiv - Physiology 2020

  Quote: ... mecamylamine (100μM, 500μM for behavioral experiments, Tocris), GdCl3 (100μM ...
• The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGF-beta; signaling in triple-negative breast cancer

  Zane A Gibbs, et al., bioRxiv - Cancer Biology 2020

  Quote: Transforming growth factor-β1 was purchased from Cell Signaling Technology (8915) and SB-431542 was purchased from Tocris Bioscience (Bristol ...
• Sequential Activation of Guide RNAs for Algorithmic Multiplexing of Cas9 Activities

  Ryan Clarke, et al., bioRxiv - Synthetic Biology 2020

  Quote: ... Cells were seeded into media containing ouabain (Tocris) at a final concentration of 0.5 μM ...
• Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3

  David M. Calcagno, et al., bioRxiv - Immunology 2020

  Quote: ... and 4-Octyl-Itaconate (Tocris Bioscience) (100uM ...
• The LRRC8A:C Heteromeric Channel Is a cGAMP Transporter and the Dominant cGAMP Importer in Human Vasculature Cells

  Lauren J. Lahey, et al., bioRxiv - Biochemistry 2020

  Quote: ... 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy] butanoic acid (DCPIB) was purchased from Tocris Bioscience and reconstituted to 50 mM in DMSO ...